Delving into the Latest Updates on Sigma-Tau Industrie Farmaceutiche Riunite SpA with Synapse

Overview

Tags

Nervous System Diseases

Other Diseases

Neoplasms

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	4
Neoplasms	3
Endocrinology and Metabolic Disease	2
Infectious Diseases	2
Immune System Diseases	2
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	8

Top 5 Target	Count

CRAT(carnitine O-acetyltransferase)	2
MYD88(MYD88 innate immune signal transduction adaptor)	1
COX(Cyclooxygenases)	1
HSP90(Heat shock 90kDa proteins)	1
HDACs(Histone deacetylase)	1

The primary purpose of the trial is to observe and compare the overall response rate (ORR) of ABVD regimen and standard BEACOPP regimen in the treatment of patients with advanced Hodgkin's lymphoma. The secondary purpose of the trial is to evaluate the safety of procarbazine hydrochloride capsules (Natulan) in Chinese patients with advanced Hodgkin's lymphoma.

Start Date26 Dec 2016

Sponsor / Collaborator

Sigma-Tau Industrie Farmaceutiche Riunite SpA

[+2]

CTR20160151

/ CompletedPhase 2

Istaroxime治疗急性失代偿性心力衰竭的有效性和安全性临床研究——一项多中心、随机、双盲、安慰剂平行对照的临床研究

[Translation] Clinical study on the efficacy and safety of Istaroxime in the treatment of acute decompensated heart failure: a multicenter, randomized, double-blind, placebo-controlled clinical study

与安慰剂比较，24小时静脉输注2 种剂量(0.5 和1.0 μg/kg/min)Istaroxime 治疗急性失代偿性心力衰竭(ADHF)的意大利患者和中国患者，评价一种具有正性肌力和舒张活性并且可以改善心肌收缩--舒张循环的新型药物的安全性、耐受性和有效性。所有意大利患者与部分中国患者也将进Istaroxime 及其代谢物的的药代动力学研究。

[Translation]

Compared with placebo, 2 doses (0.5 and 1.0 μg/kg/min) of Istaroxime were infused intravenously for 24 hours in Italian and Chinese patients with acute decompensated heart failure (ADHF) to evaluate the safety, tolerability and efficacy of a new drug with positive inotropic and diastolic activity and can improve myocardial contraction-diastolic cycle. All Italian patients and some Chinese patients will also undergo a pharmacokinetic study of Istaroxime and its metabolites.

Start Date24 Nov 2016

Sponsor / Collaborator

Zhaoke Pharmaceutical (Hefei) Co., Ltd.

[+2]

CTR20150366

/ CompletedPhase 1

盐酸丙酰左卡尼汀片在中国健康受试者的开放、单臂、自身对照、三周期递增单次给药的安全性和药代动力学研究

[Translation] An open-label, single-arm, self-controlled, three-cycle ascending single-dose safety and pharmacokinetic study of propionyl-L-carnitine hydrochloride tablets in Chinese healthy subjects

用于评价盐酸丙酰左卡尼汀片在中国健康受试者中单次给药的临床药代动力学特征和安全性，为药物上市注册提供依据。

[Translation]

Used to evaluate the clinical pharmacokinetic characteristics and safety of a single dose of propionyl-L-carnitine hydrochloride tablets in healthy Chinese subjects, and provide a basis for drug registration.

Start Date02 Sep 2015

Sponsor / Collaborator

Hefei Zhaofeng Keda Pharmaceutical Co., Ltd. Guangzhou Branch

[+1]

100 Clinical Results associated with Sigma-Tau Industrie Farmaceutiche Riunite SpA

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0 Patents (Medical) associated with Sigma-Tau Industrie Farmaceutiche Riunite SpA

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750

Literatures (Medical) associated with Sigma-Tau Industrie Farmaceutiche Riunite SpA

01 Mar 2025·Neuroscience

Retraction of “Acetyl-l-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy” [Neuroscience 167(4) (2010) 1168–1174]

Author: Vivoli, E ; Koverech, A. ; Ghelardini, C ; Bartolini, A. ; Benatti, P ; Nicolai, R. ; Ghelardini, C. ; Koverech, A ; Vivoli, E. ; Salvicchi, A ; Di Cesare Mannelli, L ; Bartolini, A ; Di Cesare Mannelli, L. ; Nicolai, R ; Benatti, P. ; Salvicchi, A.

01 Jul 2021·Soil Mechanics and Foundation Engineering

Comprehensive Automated Geotechnical Monitoring System and Experience in its Application in the Construction of Underground Facilities

Author: A. N. Simutin ; A. A. Pichugin ; G. M. Medvedev ; E. A. Khoteev ; P. S. Milchevskii ; V. E. Merkin

This article provides basic information about the automated system Monitron developed at the Research Center "Tonnelnaya assotsiatsiya" and "Sigma Tau" as well as integrated systems for measuring vibrations and the stress-strain state of structures. This article also presents application of Monitron in a sometypical tunneling facilities.

01 Jun 2021·Journal of Physics: Conference Series

Experience in effective changing of the tunneling parameters according to the data of automated hydrostatic levels to minimize the impact on the operating section of the Moscow Metro (from the experience of the organization)

Author: G M Medvedev ; E A Khoteev

AbstractDue to the intensive development of the underground space of Moscow and the increasing requirements for environmental protection, there is a need for continuous high-precision monitoring of the settlements of existing structures of normal and higher levels of responsibility. Moreover, if points of observation of the structure are located in an open space, then traditional geodetic methods (using optical levels, tacheometers) cannot ensure the continuity of observations (for example, in case of heavy rain, fog, snowfall or smoke). This, in turn, does not allow us to promptly respond to emergencies and take measures to prevent them. The article discusses the experience of automated real-time monitoring using Monitron hydrostatic leveling system to prevent an emergency during the construction of a collector tunnel with a diameter of 4.0 m under one of the Moscow Metro lines.

100 Deals associated with Sigma-Tau Industrie Farmaceutiche Riunite SpA

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100 Translational Medicine associated with Sigma-Tau Industrie Farmaceutiche Riunite SpA

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

1

Phase 3 Clinical

Approved

4

29

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Stepronin	Bronchitis More	Approved
Acetyl-L-carnitine ( CRAT )	Dementia More	Approved
Amtolmetin Guacil ( COX )	Inflammation More	Approved
Levocarnitine ( CRAT )	Carnitine palmitoyltransferase deficiency More	Approved
Procarbazine Hydrochloride ( DNA )	Hodgkin's Lymphoma More	Phase 3