Last update 29 Mar 2025

Azenosertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ZN C3, ZN c3, ZN-C3
+ [1]
Target
Action
inhibitors
Mechanism
WEE1 inhibitors(Serine/threonine-protein kinase WEE1 inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Rare Pediatric Disease (United States)
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Structure/Sequence

Molecular FormulaC29H34N8O2
InChIKeyOXTSYWDBUVRXFF-GDLZYMKVSA-N
CAS Registry2376146-48-2

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Triple-Negative Breast CarcinomaPhase 2
United States
01 May 2024
Advanced Pancreatic AdenocarcinomaPhase 2
United States
16 Nov 2023
Pancreatic Ductal AdenocarcinomaPhase 2
United States
16 Nov 2023
Colorectal CancerPhase 2
China
07 Jun 2023
Acute Myeloid LeukemiaPhase 2
United States
01 Dec 2022
Fallopian Tube CarcinomaPhase 2
United States
17 Feb 2022
Fallopian Tube CarcinomaPhase 2
Australia
17 Feb 2022
Fallopian Tube CarcinomaPhase 2
France
17 Feb 2022
Fallopian Tube CarcinomaPhase 2
Poland
17 Feb 2022
Ovarian Serous TumorPhase 2
United States
17 Feb 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
TP53 mutations
139
Azenosertib 300mg QD
ovwyvndkge(efikzupwfd) = wkwnbjyhsn evuijhzpit (aepfitdjum )
Positive
28 Apr 2025
Placebo
ovwyvndkge(efikzupwfd) = gxfhqujcgx evuijhzpit (aepfitdjum )
Phase 2
102
Azenosertib 400mg QD 5:2 dose
eucsetdfou(etceqeeygt) = akmogwnskq kxxiwfrmwo (daicfhozyp, 21.0 - 50.9)
Positive
15 Mar 2025
Not Applicable
-
-
ayixmicgvc(qrapmlyexk) = significant increase in cleaved caspase-3 behoglpjuo (atlgpnfoxq )
-
15 Sep 2024
Phase 1
31
ojzfvqumre(hhueigzgld) = vckdyetiaa oitwahkrqc (oipqjztocv )
Positive
24 May 2024
Phase 1
94
hrxsoxkysv(rczxtvwkxj) = neutropenia (44.4), thrombocytopenia (30.3), anemia (12.1), leukopenia (11.1), fatigue (10.1), diarrhea (6.1), nausea (5.1), and vomiting (5.1) eugcqqxqej (shymcnqgpx )
Positive
26 May 2023
Phase 1
12
tnoaeqeiol(gnmmsodtwt) = skjjmwnocd mcyzazjnwu (fdvwkzzvec )
Positive
15 Jun 2022
Phase 1
41
total
qkpfvitrvr(zpvrlfjxaa) = nausea 7.3%, neutropenia 34.1%, thrombocytopenia 17.1%, anemia 9.8%, diarrhea 2.4%, fatigue 2.4%, vomiting 9.8%, leukopenia 7.3%, abdominal pain 7.3%, hypoalbuminemia 2.4%, alanine aminotransferase increased 7.3%, and hypomagnesemia 2.4% uhyitxrpqx (dwtcwybbpo )
Positive
15 Jun 2022
Phase 1
39
actcqhmojs(vegxkbqvrj) = tgsubtentk jhnaorsjex (hmhypfdikh )
Positive
10 Apr 2021
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