Drug Type Small molecule drug |
Synonyms ZN C3, ZN-C3 |
Target |
Mechanism WEE1 inhibitors(Serine/threonine-protein kinase WEE1 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationFast Track (US), Orphan Drug (US), Rare Pediatric Disease (US) |
Molecular FormulaC29H34N8O2 |
InChIKeyOXTSYWDBUVRXFF-LJAQVGFWSA-N |
CAS Registry2376146-47-1 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Triple Negative Breast Cancer | Phase 2 | US | 01 May 2024 | |
Triple Negative Breast Cancer | Phase 2 | US | 01 May 2024 | |
Pancreatic Ductal Adenocarcinoma | Phase 2 | US | 16 Nov 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | US | 27 Feb 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | AU | 27 Feb 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | DE | 27 Feb 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | HU | 27 Feb 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | IT | 27 Feb 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | PL | 27 Feb 2023 | |
Metastatic Colorectal Carcinoma | Phase 2 | ES | 27 Feb 2023 |
Phase 1 | 31 | zwxdrhznna(skozfldold) = rmzjhxfpan jrgwcxgaqp (tggqzffeqe ) | Positive | 24 May 2024 | |||
NCT04516447 (ASCO2023) Manual | Phase 1 | 94 | cjsgsyepjq(fgrnuszjkp) = neutropenia (44.4), thrombocytopenia (30.3), anemia (12.1), leukopenia (11.1), fatigue (10.1), diarrhea (6.1), nausea (5.1), and vomiting (5.1) rfytihowli (dzdrxwlqvs ) | Positive | 26 May 2023 | ||
Phase 1 | 12 | jqsaunfsek(ufdqssyary) = gqmallyuaq kiwrvsuvqa (akhmlstidu ) View more | Positive | 15 Jun 2022 | |||
NCT04516447 (AACR2022) Manual | Phase 1 | 41 | total | bwstbqjlum(cjjzymjhhu) = nausea 7.3%, neutropenia 34.1%, thrombocytopenia 17.1%, anemia 9.8%, diarrhea 2.4%, fatigue 2.4%, vomiting 9.8%, leukopenia 7.3%, abdominal pain 7.3%, hypoalbuminemia 2.4%, alanine aminotransferase increased 7.3%, and hypomagnesemia 2.4% imhsqjabul (srtbppzldv ) View more | Positive | 15 Jun 2022 | |
Phase 1 | 39 | zxbhatqpch(xcpdzixxtj) = zwiofjfvit hnngcteodv (jruyjnvods ) View more | Positive | 10 Apr 2021 |