Last update 17 Dec 2024

Fremanezumab-VFRM

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-calcitonin gene-related peptide monoclonal antibody, Anti-CGRP monoclonal antibody, fremanezumab
+ [9]
Target
Mechanism
CGRP antagonists(Calcitonin gene-related peptide antagonists)
Therapeutic Areas
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (14 Sep 2018),
Regulation-
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External Link

KEGGWikiATCDrug Bank
-Fremanezumab-VFRM

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Migraine Disorders
US
14 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cluster HeadachePhase 3
US
17 Jan 2017
Cluster HeadachePhase 3
AU
17 Jan 2017
Cluster HeadachePhase 3
CA
17 Jan 2017
Cluster HeadachePhase 3
FI
17 Jan 2017
Cluster HeadachePhase 3
DE
17 Jan 2017
Cluster HeadachePhase 3
IL
17 Jan 2017
Cluster HeadachePhase 3
IT
17 Jan 2017
Cluster HeadachePhase 3
NL
17 Jan 2017
Cluster HeadachePhase 3
PL
17 Jan 2017
Cluster HeadachePhase 3
ES
17 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
237
glqbqbtxbk(mrzvjarvqc) = dcipwzdayz upxjlnzzcu (rzpajeihrx )
Positive
04 Dec 2024
Placebo
glqbqbtxbk(mrzvjarvqc) = lbaupkfbqc upxjlnzzcu (rzpajeihrx )
Phase 3
235
ypaeuxuzqc(gzeagdmtpe) = The trial met its primary end point with AJOVY (fremanezumab) achieving a statistically significant superior efficacy over 12 weeks of treatment compared to placebo. byqbckeuwt (clrgsnbesz )
Met
Positive
18 Jul 2024
Placebo
Not Applicable
-
-
ktxrhjinkg(wbtvikykzv) = 170; 15.8% ihvgmpddjp (pfofyytdwe )
-
09 Apr 2024
Not Applicable
-
einrmcimwc(dknnfmyicm) = iygfskchze poujzspatp (jfdmcrztlm, 4.92)
-
09 Apr 2024
Phase 3
2,437
(BMI-high)
wzdkylknfp(omenhylorv) = qdbnbliatj jvapvaqcdp (wczthaelnw )
Positive
06 Dec 2023
fremanezumab
(BMI-normal)
wzdkylknfp(omenhylorv) = ijllmuwajo jvapvaqcdp (wczthaelnw )
Not Applicable
20
ydrlwxinos(xykkqfhsvq) = xopikajyjw otbecrlxbl (lofzynvhap )
Positive
25 Apr 2023
Not Applicable
574
stjtvregsc(nydtsfxyaz) = 1 experienced a drug-related serious adverse event of dysphonia pukivivxum (udiwidtzkp )
Positive
25 Apr 2023
Not Applicable
-
glheztedjc(ushsusbhca) = No serious adverse events were noted in our cohort in the 6 months of anti-CGRP mAb use. The most common side effects being injection site pain/reactions (38/95) and constipation (35/95) sierjcfmse (mgiviqlrpf )
-
25 Apr 2023
Not Applicable
3,217
Fremanezumab monthly dosing
sruzrghtlv(crcuscjldf) = bzlqpcvops wpylkhlmlc (hhygabfydr, 7.28)
Positive
25 Apr 2023
Fremanezumab quarterly dosing
sruzrghtlv(crcuscjldf) = ypwvieagzf wpylkhlmlc (hhygabfydr, 7.28)
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Regulation

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