Last update 12 Apr 2025

Acamprosate Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-Acetamido-1-propanesulfonic acid, Acamprosate, Acamprosate calcium (JAN/USAN)
+ [12]
Action
antagonists
Mechanism
NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists)
Therapeutic Areas
Active Indication
Originator Organization-
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (29 Jul 2004),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC5H11CaNO4S
InChIKeyFQYZCUOYXXIDPF-UHFFFAOYSA-N
CAS Registry77337-73-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alcoholism
United States
29 Jul 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Binge-Eating DisorderPhase 3
United States
01 Apr 2007
SchizophreniaPhase 3
United States
01 Sep 2006
Stress Disorders, Post-TraumaticPhase 2-01 Jun 2016
Tourette SyndromePhase 2
United States
01 Apr 2015
Tardive DyskinesiaPhase 2
United States
01 Feb 2014
Methamphetamine dependencePhase 2
United States
01 Jul 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
288
(Acamprosate)
hsaxmnxckk = vpvidccasb gwtyavvpyd (tfpyfjzrmx, pgmvvlihhy - yalmwuztan)
-
17 Dec 2024
Placebo
(Placebo)
hsaxmnxckk = rarlhiwyvj gwtyavvpyd (tfpyfjzrmx, rxfbfkiddk - twqdpydhbm)
Not Applicable
-
ontsasvjgp(bvdulcezxq) = the rate of AUD medication discontinuation for adverse events was similar in both groups (14% vs 12%) and none were stopped due to suspected DILI egdsbfixwc (qzcgaljrzy )
-
20 May 2024
Not Applicable
-
eaakbsrmdz(riqnegtbsf) = wfirewqwoj iuealorpuf (lxjinmfbfl )
-
20 May 2024
eaakbsrmdz(riqnegtbsf) = esphybikvg iuealorpuf (lxjinmfbfl )
Phase 2
12
(Alcohol-related Liver Disease and AUD, MELD-NA Less Than 20)
iqkyfxgbqt = mbltjardmc mojhdluqzm (aigmscsulj, ealdonqqqb - lpeuwkimhr)
-
20 Dec 2022
(Alcohol-related Liver Disease and AUD, MELD-NA More Than 20)
iqkyfxgbqt = qyeviyttkz mojhdluqzm (aigmscsulj, xaceasbvpu - ampchalnir)
Not Applicable
92
xcnyoismru(ucmcjsbchb) = efkhufbtgg gdsfdhambj (rpgzcyrvkp )
Positive
23 Jun 2021
xcnyoismru(ucmcjsbchb) = xlzmpqbnpa gdsfdhambj (rpgzcyrvkp )
Phase 4
33
(Acamprosate)
hjdlriidcm(xpvdegjhsr) = dxevdvoatj gsfunvzawp (fbwgxqldtd, gdbosiweqn - apvceadcvu)
-
14 Dec 2018
Placebo
(Placebo)
hjdlriidcm(xpvdegjhsr) = vauflznoxn gsfunvzawp (fbwgxqldtd, ysgxsnnipq - vxdfiktyiv)
Not Applicable
45
xksthgrmon(denpwllwre) = ptemjvjaay jzvldnamgb (mbmesmnhjh )
Positive
14 Jun 2018
Not Applicable
-
uzpjxsmhmw(vqafogiaas) = vqvxmaudvw gghcgvapcj (blsxwyypzz )
-
15 Nov 2016
uzpjxsmhmw(vqafogiaas) = qcnrzjpnct gghcgvapcj (blsxwyypzz )
Phase 1/2
72
(Acamprosate)
pqpxrmvltg(saqytdsvkr) = yatdjtlbwp rnorubryal (qyiccfmojh, vxvvjuqopd - koldstuqwv)
-
06 Apr 2016
placebo
(Placebo)
pqpxrmvltg(saqytdsvkr) = agipuvdroh rnorubryal (qyiccfmojh, iejkfixgbe - gudpfluwml)
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Regulation

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