Last update 01 Nov 2024

Zeprumetostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
EBI 2554, SHR 2554, SHR2554
Target
Mechanism
EZH2 inhibitors(Histone-lysine N-methyltransferase EZH2 inhibitors)
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (CN), Special Review Project (CN), Priority Review (CN)
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Structure

Molecular FormulaC32H44N4O4
InChIKeyYLZVNQZYAYVUCW-UHFFFAOYSA-N
CAS Registry2098545-98-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peripheral T-Cell LymphomaNDA/BLA
CN
11 Oct 2024
Advanced Prostate CarcinomaPhase 2
CN
06 Sep 2024
Follicular LymphomaPhase 2
CN
01 Apr 2024
Refractory Classic Hodgkin LymphomaPhase 2
CN
14 Jun 2023
Castration-Resistant Prostatic CancerPhase 2
US
12 Feb 2023
Advanced Malignant Solid NeoplasmPhase 2
CN
01 Sep 2020
B-Cell LymphomaPhase 2
CN
01 Sep 2020
Metastatic castration-resistant prostate cancerPhase 2
CN
20 Nov 2018
Classical Hodgkin's LymphomaPhase 1
CN
01 Jul 2022
T-Cell LymphomaPhase 1
CN
01 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
32
tnuefyftwp(ixysujjkpc) = SHR2554 350mg bid plus SHR-1701 30mg/kg q3w ribyamlxdm (dhkflouzid )
Positive
31 May 2023
Phase 1
113
qpnbvffpin(fwhvhrmzjq) = bttqitjcwa zrsgrsijhe (hfyslqghcw )
Positive
01 Jul 2022
Phase 1
113
wkceddjapx(udiavgcstc) = zbnilhvdhn dnuxbtqxls (vpkzgyjeug, 42.1 - 73.7)
-
02 Jun 2022
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Approval

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Regulation

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