Last update 01 Nov 2024

RMC-4630

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SHP2, Vociprotafib, Vociprotafib(USAN)
+ [3]
Target
Mechanism
SHP2 inhibitors(Src homology phosphotyrosyl phosphatase 2 inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC20H27ClN6O2S
InChIKeyHISJAYUQVHMWTA-BLLLJJGKSA-N
CAS Registry2172652-48-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neoplasm MetastasisPhase 2
NL
09 Jun 2020
Neoplasm MetastasisPhase 2
CL
09 Jun 2020
Neoplasm MetastasisPhase 2
NL
09 Jun 2020
Neoplasm MetastasisPhase 2
US
09 Jun 2020
Neoplasm MetastasisPhase 2
US
09 Jun 2020
Neoplasm MetastasisPhase 2
US
09 Jun 2020
Neoplasm MetastasisPhase 2
AR
09 Jun 2020
Neoplasm MetastasisPhase 2
AU
09 Jun 2020
Neoplasm MetastasisPhase 2
ES
09 Jun 2020
Colorectal CancerPhase 2
JP
28 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
113
(Intermittent RMC-4630 80mg (D1D4) + Cobimetinib 20mg QD (21/7))
sxpzplkihc(dilvyypsgq) = heirjiltga uthfldnsow (ajlwwxaoek, nypnrekuws - mizgcbgqop)
-
26 Jun 2023
(Intermittent RMC-4630 80mg (D1D4) + Cobimetinib 40mg QD (21/7))
sxpzplkihc(dilvyypsgq) = gdwqwcxgrq uthfldnsow (ajlwwxaoek, zpkxwhogyz - suqlnqtouw)
Phase 1
Solid tumor
KRAS Mutation
104
overall
(xgopsbupbh) = 200 mg D1D2, delivering a 400 mg weekly dose intensity lukfqtjimn (pqwyqfyyhj )
Positive
10 Apr 2021
(KRAS MUT NSCLC)
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Core Patent

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Approval

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Regulation

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