Last update 01 Nov 2024
CBP-1019
Last update 01 Nov 2024
Overview
Basic Info
Drug Type Small molecule-drug conjugates |
Synonyms Folate-TRPV6-peptide exatecan drug conjugate (Coherent) |
Target |
Mechanism FOLR1 antagonists(Folate receptor alpha antagonists), TRPV6 antagonists(Transient receptor potential cation channel subfamily V member antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
RegulationOrphan Drug (US) |
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Structure
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Related
4
Clinical Trials associated with CBP-1019Phase Ib Study of CBP-1019 in Combination With FOLFOX +/- Bevacizumab, Pembrolizumab, or Enzalutamide for Metastatic TRPV6-overexpressing Solid Tumors of Epithelial Origin
评价注射用CBP-1019在晚期胸部恶性肿瘤患者中安全性和耐受性、药代动力学及初步疗效的Ⅰ期临床研究
[Translation] A Phase I clinical study to evaluate the safety and tolerability, pharmacokinetics and preliminary efficacy of CBP-1019 for injection in patients with advanced thoracic malignancies
评价注射用CBP-1019在晚期恶性实体瘤患者中安全性和耐受性、药代动力学及初步疗效的非随机、开放、首次用于人体的国际多中心Ⅰ/Ⅱ期临床研究
[Translation] A non-randomized, open-label, first-in-human, international, multicenter Phase I/II clinical study to evaluate the safety and tolerability, pharmacokinetics, and preliminary efficacy of CBP-1019 for injection in patients with advanced malignant solid tumors
100 Clinical Results associated with CBP-1019
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100 Translational Medicine associated with CBP-1019
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100 Patents (Medical) associated with CBP-1019
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100 Deals associated with CBP-1019
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R&D Status
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Advanced Malignant Solid Neoplasm | Phase 2 | CN | 14 Mar 2023 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | US | 14 Mar 2023 | |
| Colorectal Cancer | Phase 2 | CN | 14 Mar 2023 | |
| Colorectal Cancer | Phase 2 | US | 14 Mar 2023 | |
| Esophageal Carcinoma | Phase 2 | CN | 14 Mar 2023 | |
| Esophageal Carcinoma | Phase 2 | US | 14 Mar 2023 | |
| Lung Cancer | Phase 2 | US | 14 Mar 2023 | |
| Lung Cancer | Phase 2 | CN | 14 Mar 2023 | |
| Pancreatic Cancer | Phase 2 | US | 14 Mar 2023 | |
| Pancreatic Cancer | Phase 2 | CN | 14 Mar 2023 |
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Clinical Result
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Regulation
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