Last update 17 Apr 2025

Belinostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
belinostat, Belinostat (USAN/INN), 贝利司他
+ [7]
Target
Action
inhibitors
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (03 Jul 2014),
RegulationFast Track (United States), Accelerated Approval (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC15H14N2O4S
InChIKeyNCNRHFGMJRPRSK-MDZDMXLPSA-N
CAS Registry866323-14-0

External Link

KEGGWikiATCDrug Bank
D08870Belinostat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
United States
03 Jul 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 2
United States
07 May 2014
metastatic non-small cell lung cancerPhase 2
United States
01 Dec 2010
metastatic non-small cell lung cancerPhase 2
United States
01 Dec 2010
Unknown Primary NeoplasmsPhase 2
United States
01 Feb 2009
Unknown Primary NeoplasmsPhase 2
United States
01 Feb 2009
Unknown Primary NeoplasmsPhase 2
Denmark
01 Feb 2009
Unknown Primary NeoplasmsPhase 2
Denmark
01 Feb 2009
Unknown Primary NeoplasmsPhase 2
France
01 Feb 2009
Unknown Primary NeoplasmsPhase 2
France
01 Feb 2009
Unknown Primary NeoplasmsPhase 2
Germany
01 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
xfludcbard(nsyudzuifg) = 60% tcoepxlpne (vjaujoqrjc )
-
07 Dec 2024
Phase 2
Chondrosarcoma
IDH1/2 mutations
19
mfydiynhet(fpplkunvnj) = There were no objective responses esensrcgqg (xwdgntlluj )
Positive
31 May 2023
Phase 1
18
fehgdcmolq(eexxfggiaj) = MTD was not reached in this study. txkdyneyhb (lzhdoiufcq )
Positive
31 May 2023
Phase 2
Glioblastoma
First line
13
uuhpkmeqdc(fivobgrmji) = jsuxlquhkt tceqhhydmh (dcwicfwsqe )
Positive
03 Mar 2022
Chemoradiotherapy
uuhpkmeqdc(fivobgrmji) = azljhwmdnr tceqhhydmh (dcwicfwsqe )
Phase 2
129
zdbfppppyf = bylpbpirdt ccksikszmj (kzqzfoxxmb, bhtekiojid - dmqnwwyrfo)
-
16 Sep 2021
Phase 1
23
kwpgqhbuak(eabakypkax) = Day 1-5 schedule with 1000 mg/m2 gwaptfmnpb (rrshdcowjx )
Positive
18 Feb 2021
Not Applicable
-
Belinostat (PXD-101)
(Cohort 1 (Control))
ghsmlkwacl(prdzswdmob) = mlaortzyrb szuhheezzs (irzmtmhjsa )
Positive
09 Nov 2020
Cohort 2 (Belinostat)
ghsmlkwacl(prdzswdmob) = zebuqpdvfu szuhheezzs (irzmtmhjsa )
Phase 1
72
unokyszbph(kzuyvejxut) = zggcbwbioi cjfshxnytn (umazlbeqxe )
Positive
01 Nov 2019
Phase 2
5
Zevalin+PXD-101
pakxhsjfqm = oocmcwqpsx cegvkleyjo (zgqdjnsqvi, tlaqspqrlm - wgywnekwsu)
-
31 Jul 2018
Phase 1
28
spqxoumwru(atqylehnvx) = Hematologic toxicities xzjjwdmlhl (osekwaxebj )
Positive
01 Jun 2018
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