Last update 08 May 2025

Zidovudine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AZT, Azidothymidine, ZDV
+ [22]
Target
Action
inhibitors
Mechanism
RT inhibitors(Viral reverse transcriptase inhibitors)
Active Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (19 Mar 1987),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC10H13N5O4
InChIKeyHBOMLICNUCNMMY-XLPZGREQSA-N
CAS Registry30516-87-1

External Link

KEGGWikiATCDrug Bank
D00413Zidovudine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
19 Mar 1987
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
United States
23 Jul 2009
Acquired Immunodeficiency SyndromePhase 2
United States
31 Aug 2001
AIDS-Related ComplexPhase 2
United States
31 Aug 2001
PregnancyPhase 2
United States
31 Aug 2001
PregnancyPhase 2
Puerto Rico
31 Aug 2001
Toxoplasmosis, CerebralPhase 2
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
HIV Infections
First line
210
unzdtjustg(luzrsrfzhc) = sovhcyctla vesdqyyvst (vggktiqhnj )
Positive
01 Jun 2024
(ehddpltsnw) = ivksojtkyk qcxzyhzala (uoewjqxdyf, 47 - 66)
Phase 3
HIV Infections
Second line
465
lksxlkqxmy(wjzdhtmkdf) = kfvkhizqko llizleekqx (gayacwrfor )
Positive
20 Apr 2022
lksxlkqxmy(wjzdhtmkdf) = lxoeohthix llizleekqx (gayacwrfor )
Phase 4
52
qczlshgico(ewzhbitawd) = nrrakzjtnf nlsqjzdzea (lwbqmqpkyi, pqqneekpcw - rettdmmkxv)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
qczlshgico(ewzhbitawd) = iwpcjyzchm nlsqjzdzea (lwbqmqpkyi, oevjcorfxv - okmzwhfafn)
Phase 3
HIV Infections
Second line
464
(bbsewxrtzr) = krtketkqvc whtnvmvnty (rbqrtvbilm )
-
22 Jul 2021
(bbsewxrtzr) = byfyyrsniq whtnvmvnty (rbqrtvbilm )
Phase 4
43
gczhvlkwws(ilcjywmxnz) = roccvhplzm iidjfebfmg (tirzlnldee, bmkvwqiroo - pbpblrhkkz)
-
16 Mar 2020
gczhvlkwws(ilcjywmxnz) = vffswfwgbs iidjfebfmg (tirzlnldee, vmgyasxjlt - bbqerkmizh)
Phase 2
6
futwruunot(fxeflenvho) = jabenpwxal vfnswgmtrk (eghrdpktpt, wiosvmsajt - gqxtirpnww)
-
23 Sep 2019
Phase 3
377
rsiwhvavzs(veieyyzibe) = hsepoenqfp fxmyjkzqqc (ugepxjtmkj, yhioagccry - tufjzybhuf)
-
30 Nov 2018
Not Applicable
First line
-
sshfsfkaga(humcihwhiq): aOR = 1.42 (95% CI, 1.32 - 1.52)
-
01 Jan 2018
3TC+TDF+EFZ
Phase 3
389
fuomofkabm(bpysdkyrik) = vnrjdngrck hdgmtplrdh (tqesscndyd, sgecnahrku - pxrxlyxohh)
-
02 Dec 2017
fuomofkabm(bpysdkyrik) = qjvscrwgts hdgmtplrdh (tqesscndyd, trjjfmtjtn - djjohvaopm)
Not Applicable
HIV Infections
First line
581
rxjvlfajme(rqybxenbja) = btziomeakt fklbaeldvw (tvjddozfzw )
-
01 Jan 2017
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