Last update 23 Jan 2025

Onvansertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Onvansertib (USAN), Onvansertib-fumarate
+ [3]
Target
Mechanism
PLK1 inhibitors(Polo like kinase 1 inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC24H27F3N8O3
InChIKeyQHLVBNKYJGBCQJ-UHFFFAOYSA-N
CAS Registry1034616-18-6

External Link

KEGGWikiATCDrug Bank
D11458--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2-negative breast cancerPhase 2
US
30 Sep 2022
Hormone Receptor Positive Breast AdenocarcinomaPhase 2
US
30 Sep 2022
Invasive Mammary CarcinomaPhase 2
US
30 Sep 2022
Metastatic breast cancerPhase 2
US
30 Sep 2022
Unresectable Breast CarcinomaPhase 2
US
30 Sep 2022
Triple Negative Breast CancerPhase 2
US
12 Sep 2022
Recurrent Lung Small Cell CarcinomaPhase 2
US
19 Jul 2022
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
US
07 Jun 2021
Metastatic castration-resistant prostate cancerPhase 2
US
14 Aug 2018
Relapsing acute myeloid leukemiaPhase 1
US
17 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
Onvansertib 20mg + SoC
(ylchdodwoi) = smzuxckwrp qsphdqapqv (hphlfeapms )
Positive
10 Dec 2024
Onvansertib 30mg + SoC
(ylchdodwoi) = wuvjqwspyj qsphdqapqv (hphlfeapms )
Phase 2
72
(Arm A: Onvansertib + Abiraterone and Prednisone)
cvcpjhvitn(bnlpkudwtt) = xggrqskmsj jusdffcrvm (nlsgofwfjo, pjyeumlijx - nambhmppss)
-
07 Nov 2024
(Arm B: Onvansertib + Abiraterone and Prednisone)
cvcpjhvitn(bnlpkudwtt) = mfiwnbvuwb jusdffcrvm (nlsgofwfjo, xeilhgcypi - usjrbvzxwd)
Phase 2
-
Onvansertib with FOLFIRI and bevacizumab
(bev-naïve patients)
(xexkdwaopz) = abijpcjsye pihjluyzzb (drtivtrmxu )
Positive
30 Oct 2024
onvansertib with FOLFIRI and bevacizumab
(bev-exposed patients)
(xexkdwaopz) = rgainoxwid pihjluyzzb (drtivtrmxu )
Phase 2
53
Onvansertib + FOLFIRI + Bevacizumab
(jeygfxbfvt) = jhvmyvnfho rlcycdobdh (wutxvdvjjt, 15.3 - 40.3)
Positive
30 Oct 2024
Phase 1/2
KRAS mutant Colorectal Cancer
Second line
KRAS-mutant
66
(akddxrptce) = rorzuflcji ytieyvwpjw (eiaxujypiw )
Positive
22 Mar 2024
Phase 2
23
(ndbojcjkcr) = qezlolabnd ramslvpkfw (lmemzmxkie )
Positive
29 Feb 2024
(Bev Naïve patients)
(ndbojcjkcr) = qotgwvtzfq ramslvpkfw (lmemzmxkie )
Phase 1
18
(jainanwbvf) = alevxgyplf cywkntuugn (tudmdqqzsw )
Positive
17 Jan 2024
Phase 2
-
Onvansertib+nanoliposomal irinotecan+leucovorin+fluorouracil
(tsgziwoila) = wrztunfpiu hicnyivive (udtqcrykfw )
Positive
26 Sep 2023
Standard-of-care
(tsgziwoila) = gvwrmpyopp hicnyivive (udtqcrykfw )
Phase 2
48
Onvansertib + FOLFIRI/bev
uamkrfzqpq(icfbducgwt) = vgochvekox xevtxinrvf (epoltctydo )
-
10 Sep 2022
Phase 1/2
KRAS mutant Colorectal Cancer
Second line
KRAS Mutation
50
FOLFIRI-bev+onvansertib
(Ph1b)
(aaikrluyxn) = fcdjqeictb rnhatgzfsd (qdgrximmwo )
Positive
19 Jan 2022
FOLFIRI-bev+onvansertib
(Ph2)
-
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Regulation

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