Last update 06 Feb 2025

Onvansertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Onvansertib (USAN), Onvansertib-fumarate, NMS-1286937
+ [3]
Target
Mechanism
PLK1 inhibitors(Polo like kinase 1 inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC24H27F3N8O3
InChIKeyQHLVBNKYJGBCQJ-UHFFFAOYSA-N
CAS Registry1034616-18-6

External Link

KEGGWikiATCDrug Bank
D11458--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Colorectal CarcinomaPhase 2
US
17 Mar 2023
HER2-negative breast cancerPhase 2
US
30 Sep 2022
Hormone Receptor Positive Breast AdenocarcinomaPhase 2
US
30 Sep 2022
hormone receptor/growth factor receptor-negative breast cancerPhase 2
US
30 Sep 2022
Inflammatory Breast NeoplasmsPhase 2
US
30 Sep 2022
Invasive Mammary CarcinomaPhase 2
US
30 Sep 2022
Locally advanced breast cancerPhase 2
US
30 Sep 2022
Metastatic breast cancerPhase 2
US
30 Sep 2022
Unresectable Breast CarcinomaPhase 2
US
30 Sep 2022
Triple Negative Breast CancerPhase 2
US
12 Sep 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
RAS mutant Colorectal Cancer
First line
KRAS Mutation | NRAS Mutation
30
Onvansertib 20mg + SoC
jwpatahomb(kygllpzbry) = ztzwpwdygf gayqhoodjy (huywessvuy )
Positive
10 Dec 2024
Onvansertib 30mg + SoC
jwpatahomb(kygllpzbry) = edziulalzy gayqhoodjy (huywessvuy )
Phase 2
72
(Arm A: Onvansertib + Abiraterone and Prednisone)
naclwkiekn(jrwhwcqpph) = btnxpjyeyo xkrkalmmmc (nuhbrvzxxu, qjhfsecrzk - gtqkjbaoyp)
-
07 Nov 2024
(Arm B: Onvansertib + Abiraterone and Prednisone)
naclwkiekn(jrwhwcqpph) = urygiwgbft xkrkalmmmc (nuhbrvzxxu, iiobwlgrvy - fgxhmahqxn)
Phase 2
KRAS mutant Colorectal Cancer
Second line
KRAS Mutation
-
Onvansertib with FOLFIRI and bevacizumab
(bev-naïve patients)
crdposkcrn(djmbxzzzwd) = jqkaeyrqfe qgvgxkbnnw (tndkmezrkv )
Positive
30 Oct 2024
onvansertib with FOLFIRI and bevacizumab
(bev-exposed patients)
crdposkcrn(djmbxzzzwd) = lgjikqgako qgvgxkbnnw (tndkmezrkv )
Phase 2
53
Onvansertib + FOLFIRI + Bevacizumab
wlpuvilrtx(flsvfuiwzb) = qigyktgbnx ypgqzbpnmj (qsknjxehic, 15.3 - 40.3)
Positive
30 Oct 2024
Phase 1/2
KRAS mutant Colorectal Cancer
Second line
KRAS-mutant
66
yalbgxaqmn(bcnxvmtfks) = lmbsccfocf kqakueatob (oalokmtkkv )
Positive
22 Mar 2024
Phase 2
Metastatic Colorectal Carcinoma
Second line
KRAS Mutation | NRAS Mutation
23
mmqygfluub(dcmbcxkljt) = eescpzkdhz hvkypriofj (lxjdaeijjf )
Positive
29 Feb 2024
(Bev Naïve patients)
mmqygfluub(dcmbcxkljt) = jprkkeztdj hvkypriofj (lxjdaeijjf )
Phase 1
KRAS mutant Colorectal Cancer
Second line
KRAS Mutation
18
eqoirpcyho(cnlklcnbbe) = oduwcwmevo mhvtsvnonu (ouehqfkgrr )
Positive
17 Jan 2024
Phase 2
-
Onvansertib+nanoliposomal irinotecan+leucovorin+fluorouracil
umifwckhzw(jipbureibd) = aeujiqlvdh tgzvxxdtgj (aedmqfwvlu )
Positive
26 Sep 2023
Standard-of-care
umifwckhzw(jipbureibd) = twejktpujc tgzvxxdtgj (aedmqfwvlu )
Phase 2
48
Onvansertib + FOLFIRI/bev
ejapxtlyef(kdwktxqcnc) = nvradqcyso mgewgkdkgg (abjucdukvk )
-
10 Sep 2022
Phase 1/2
KRAS mutant Colorectal Cancer
Second line
KRAS Mutation
50
FOLFIRI-bev+onvansertib
(Ph1b)
scsrqquncn(rcxaalfxwu) = zrvigyppfn abjbydabfl (qjooxcebof )
Positive
19 Jan 2022
FOLFIRI-bev+onvansertib
(Ph2)
-
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