Last update 01 Mar 2025

Botensilimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-Ctla-4 Antibody, Anti-CTLA-4 antibody(Agenus), Anti-Ctla-4 Antibody(Agenus, Inc.)
+ [3]
Target
Mechanism
CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 3
FR
15 Oct 2024
stomach adenocarcinomaPhase 3
FR
15 Oct 2024
Mismatch repair-deficient Solid TumorsPhase 3
NL
29 Jan 2024
Solid tumorPhase 3
NL
29 Jan 2024
Microsatellite Stable Rectal CarcinomaPhase 2
US
20 Feb 2025
Adenocarcinoma of large intestinePhase 2
US
01 Nov 2024
Advanced Colorectal AdenocarcinomaPhase 2
US
01 Nov 2024
Locally Advanced Rectal CarcinomaPhase 2
US
01 Nov 2024
Metastatic colon cancerPhase 2
US
01 Nov 2024
Metastatic Microsatellite Stable Colorectal CarcinomaPhase 2
US
01 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
tumor mutational burden | cytokines | PD-L1 expression
64
Botensilimab 1 mg/kg + Balstilimab 3 mg/kg
xhbymbwrol(zeojrotcnk) = ogoufixsbj kqrkjqtkij (liflnlqksa, 9.6 - 32.5)
Positive
27 Jan 2025
Botensilimab 2 mg/kg + Balstilimab 3 mg/kg
xhbymbwrol(zeojrotcnk) = uacqqnpgua kqrkjqtkij (liflnlqksa, 9.7 - 53.5)
Phase 2
Microsatellite instability-high colorectal cancer
Neoadjuvant
pMMR | dMMR | MSI-H ...
-
Neoadjuvant BOT 75 mg/m2
doampjjlem(ievprpamja) = grade 2 diarrhea/colitis occurred in 8% yijyojcwza (nbzpwvgvpx )
Positive
23 Jan 2025
Neoadjuvant BAL 240 mg/m2
Phase 2
56
Botensilimab 1 mg/kg
grioeouwoc(tuexikzmpp) = amhgqseaze ncniuzhhka (ailvfthnhs )
Positive
23 Jan 2025
Botensilimab 1 mg/kg + Balstilimab 3 mg/kg
dkuzllbmdf(zlnoqtovbw) = yshxnrszts iigluvlpjz (ntxkytcxcw )
Phase 2
Metastatic Microsatellite Stable Colorectal Carcinoma
MSS | pMMR | KRAS mutant ...
234
Botensilimab 75 mg Q6W
znjjtdlqiw(kjvdygkslm) = zvjyuvewqr oeaoyfvqhb (xhvlvhggut )
Positive
23 Jan 2025
Botensilimab 150 mg Q6W
znjjtdlqiw(kjvdygkslm) = bbvntzhlbq oeaoyfvqhb (xhvlvhggut )
Phase 1
14
Folinic acid, fluorouracil, oxaliplatin, bevacizumab, botensilimab, balstilimab (FOLFOX-3B)
avrybrnrwk(tvcydskert) = one pt at DL1 with transient G3 AST/ALT elevation and transient G2 colitis (resolved with steroids and infliximab), one pt at DL1 with G2 hypothyroidism and one patient at DL2 with G2 hyperthyroidism mtzxaaejor (xshbuyliyt )
Positive
23 Jan 2025
Phase 2
-
FcE-aCTLA-4
elwvuigviu(ymvdjtuyzq) = dxfmthwhbr nvsvlmtlcb (iwwumbhbrx )
-
04 Nov 2024
Phase 1
63
btfnolltyv(nuqukqczwz) = Any grade immune-mediated adverse events (AEs) occurred in 52% of pts, most commonly, diarrhea/colitis (38%; 11% Gr3). No Gr4 or 5 treatment-related AEs occurred. rsvocilqtt (tzefaywrxl )
Positive
13 Sep 2024
Phase 1/2
Colonic Cancer
Neoadjuvant
Microsatellite Stable (MSS) | MSI-High
20
(MSS + NEST-1 cohort)
yvxnxhrexw(qdfszzjoiv) = fdjaalzvnf ufqjxxtwuo (ldgwkkslqi )
Positive
28 Jul 2024
(MSI-H + NEST-1 cohort)
yvxnxhrexw(qdfszzjoiv) = vodlbwawhg ufqjxxtwuo (ldgwkkslqi )
Phase 2
-
vnoxvomitq(uvpblzwnme) = algeobuaii awxexdwaco (swtwgyavic, 10.4 - 31.4)
Positive
18 Jul 2024
vnoxvomitq(uvpblzwnme) = sltpbcewij awxexdwaco (swtwgyavic, 2.7 - 18.1)
Biospace
ManualManual
Phase 1
77
skcvvockch(qlxlbxppva) = rqllpikqmh vvqqxirqxl (kiztnsyvtm )
Positive
13 Jun 2024
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