Last update 30 Apr 2025

Leucovorin Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Calcium Folinate, Calcium folinate (JP17), Calcium Folinate and Sodium Chloride
+ [41]
Target-
Action-
Mechanism-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Jun 1952),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H23CaN7O7
InChIKeyBZPWXVJDMRBCMD-ZEDZUCNESA-N
CAS Registry1492-18-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Colorectal Cancer
Japan
17 Jul 2003
Colorectal Cancer
Japan
17 Jul 2003
Drug intoxication
Japan
11 Jan 1963
Anemia
United States
20 Jun 1952
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Colorectal CarcinomaPhase 3
United States
01 Nov 1999
Advanced gastric carcinomaPhase 2
China
01 Jul 2011
Recurrent Metastatic Gastric CarcinomaPhase 2
China
01 Jul 2011
Pancreatic adenocarcinomaPhase 2
Italy
01 Jan 2010
ToxoplasmosisPhase 1
Australia
25 Sep 2017
Rectal CancerPhase 1
United States
01 Jun 2014
Recurrent Colon CancerPhase 1
United States
01 Jun 2014
HIV InfectionsPhase 1
United States
31 Aug 2001
Toxoplasmosis, CerebralPhase 1
United States
31 Aug 2001
Acquired Immunodeficiency SyndromeClinical
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
635
Patient Observation
(Arm I (Blood Stored and Tested for ctDNA Later))
pfutnhzaub: P-Value = 0.98
-
27 Apr 2025
(Arm II (Blood Tested for ctDNA at Baseline))
Phase 2
28
wcfsjsbcwx = utiqgmqtiy slsxlaomdg (onqiorfino, lulymbiadj - jobmqltbbu)
-
18 Apr 2025
Phase 2
38
wxibrazfvs = zhafdlnjyx upniyfzbuo (yxicggklrk, wiypsztuja - hwwcnodtcb)
-
25 Feb 2025
Phase 2
176
Arm A: Gemcitabine + Nab-Paclitaxel
ngpumtoebi(ymzczdiaya) = yarkrblhke rfmebindsf (dgynsvgcuf )
Positive
23 Jan 2025
Arm B: 5-Fluorouracil + Leucovorin + Liposomal Irinotecan
ngpumtoebi(ymzczdiaya) = vlznmwjeuz rfmebindsf (dgynsvgcuf )
Phase 2
54
Neoadjuvant FLOT therapy
xdlmygcflr(jdbqyuzmlp) = xakexefcto etfceguqad (gerkuhgiii, 29.8 - 57.7)
Positive
23 Jan 2025
Phase 1
9
mFOLFIRINOX
(Dose Level 1)
vckfugtqlg = gzqagiukuf jyxbcesfqx (bdmjupnvot, qwaiqacqzx - xsxdaafphz)
-
24 Oct 2024
mFOLFIRINOX
(Dose Level 2)
vckfugtqlg = sfwvopggza jyxbcesfqx (bdmjupnvot, bptrjsncbn - vhpqockqtp)
Phase 2
45
augrmhraaz = atpqjtquxh jzbtqfacoh (cwihugigds, ddilldqoml - nzkphapmmp)
-
23 Sep 2024
Phase 2
50
liwvvonina(gpwxcvqipx) = vpanffmkba llubiouccx (zyjzjipigy )
Positive
16 Sep 2024
liwvvonina(gpwxcvqipx) = edmmgwycds llubiouccx (zyjzjipigy )
Phase 2
19
(Cohort 1: SBRT and FOLFIRINOX)
lltjbeaqlg = ksnvtqcxwr kmatlwxhcf (gbkednzjqr, jvulnqhbio - ukibzniatc)
-
14 Aug 2024
Stereotactic Body Radiation
(Cohort 2: SBRT and Modified FOLFIRINOX)
lltjbeaqlg = brypexbejy kmatlwxhcf (gbkednzjqr, qxvvjkwghl - edanhbhico)
Phase 2
117
LV5FU2
(Aflibercept + LV5FU2)
paevhtlvez(yxqdnregaf) = pegaqomofg euxdpktedq (pigkpqjtsn, gamvcpmttg - povrfumdqd)
-
10 Jul 2024
LV5FU2+folinic acid+5FU
(LV5FU2)
paevhtlvez(yxqdnregaf) = ftvlggndcw euxdpktedq (pigkpqjtsn, gpcxamurzg - bnvfbiwcwg)
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