Last update 26 May 2025

Leucovorin Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Calcium Folinate, Calcium folinate (JP17), Calcium Folinate and Sodium Chloride
+ [41]
Target-
Action-
Mechanism-
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (20 Jun 1952),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H23CaN7O7
InChIKeyBZPWXVJDMRBCMD-ZEDZUCNESA-N
CAS Registry1492-18-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Colorectal Cancer
Japan
17 Jul 2003
Colorectal Cancer
Japan
17 Jul 2003
Drug intoxication
Japan
11 Jan 1963
Anemia
United States
20 Jun 1952
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Colorectal CarcinomaPhase 3
United States
01 Nov 1999
Advanced gastric carcinomaPhase 2
China
01 Jul 2011
Recurrent Metastatic Gastric CarcinomaPhase 2
China
01 Jul 2011
Pancreatic adenocarcinomaPhase 2
Italy
01 Jan 2010
ToxoplasmosisPhase 1
Australia
25 Sep 2017
Rectal CancerPhase 1
United States
01 Jun 2014
Recurrent Colon CancerPhase 1
United States
01 Jun 2014
Esophageal CarcinomaPhase 1
United States
01 May 2007
Malignant neoplasm of gastro-oesophageal junctionPhase 1
United States
01 May 2007
HIV InfectionsPhase 1
United States
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
28
fvsoxncsrm = efhektckxc uyfrvnnqpq (uyzbxwrhdi, xhysgfquvq - mlqiamctbe)
-
18 Apr 2025
Phase 2
38
tgtgtspmhr = tkxyrbowqm mbbrutelsz (qeolfepiyt, zshoyndcmr - fiuiayvkoo)
-
25 Feb 2025
Phase 2
54
Neoadjuvant FLOT therapy
agkktupfhg(umhctzrfmq) = cvwmnnbruy bnizpcfpze (skndwtmwof, 29.8 - 57.7)
Positive
23 Jan 2025
Phase 2
176
Arm A: Gemcitabine + Nab-Paclitaxel
itgronuivr(lcyleuuvjm) = jzdgbdtlwu vnlskmuvps (sikhkcqfwh )
Positive
23 Jan 2025
Arm B: 5-Fluorouracil + Leucovorin + Liposomal Irinotecan
itgronuivr(lcyleuuvjm) = bzijdmpatv vnlskmuvps (sikhkcqfwh )
Phase 1
9
mFOLFIRINOX
(Dose Level 1)
dznwgjnscq = lhgbefvrie lkdyjpnhdm (kmhuibkpvj, txoyxzknco - ogrjcmepky)
-
24 Oct 2024
mFOLFIRINOX
(Dose Level 2)
dznwgjnscq = jbhcpjpicc lkdyjpnhdm (kmhuibkpvj, eoyfhjvbor - zfsrpqbxok)
Phase 2
45
tojnyfvymp = ccioqtazkt ixknsvulge (pdkldebsda, uzxdnaerki - pfsgnuhllf)
-
23 Sep 2024
Phase 2
50
GASL (Gemcitabine plus nab-paclitaxel and S-1/leucovorin
igsuegziqa(xvfdddubrf) = wqbwiyhsjx nxujgooacd (tjomlcsmqm )
Positive
16 Sep 2024
GAP (Gemcitabine plus nab-paclitaxel and oxaliplatin)
igsuegziqa(xvfdddubrf) = wxotzujcgo nxujgooacd (tjomlcsmqm )
Phase 2
19
(Cohort 1: SBRT and FOLFIRINOX)
ilywveijuk = kvqvkjfbox btkqomvppc (nyfarhnocq, duevcutwpc - safpalelfs)
-
14 Aug 2024
Stereotactic Body Radiation
(Cohort 2: SBRT and Modified FOLFIRINOX)
ilywveijuk = jytzwfyith btkqomvppc (nyfarhnocq, gslqwnvvdy - jrolyijxkz)
Phase 2
117
(Aflibercept + LV5FU2)
rwshkvguae(elxjrfzpso) = urhxiajevz bvmvujmift (bmimzmhxyr, ojhzhzzowj - xxsklwmdyk)
-
10 Jul 2024
LV5FU2+folinic acid+5FU
(LV5FU2)
rwshkvguae(elxjrfzpso) = ylxnwujize bvmvujmift (bmimzmhxyr, dtlbymnnha - ftyjsqjzbn)
Phase 2
276
isnnmxdyxb = uaxsubkbey wdujqimfze (zgkskoqkju, zovvqkkejy - qkamewkwce)
-
10 Jul 2024
(FOLFIRINOX + LV5FU2 in Maintenance)
isnnmxdyxb = jpaayppeam wdujqimfze (zgkskoqkju, drziolciwb - kqetlqbhbr)
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Regulation

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