Last update 21 Nov 2024

Botensilimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-Ctla-4 Antibody, Anti-CTLA-4 antibody(Agenus), Anti-Ctla-4 Antibody(Agenus, Inc.)
+ [3]
Target
Mechanism
CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US)
Login to view timeline

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 3
FR
15 Oct 2024
stomach adenocarcinomaPhase 3
FR
15 Oct 2024
Adenocarcinoma of large intestinePhase 2
US
01 Nov 2024
Advanced Colorectal AdenocarcinomaPhase 2
US
01 Nov 2024
Locally Advanced Rectal CarcinomaPhase 2
US
01 Nov 2024
Metastatic colon cancerPhase 2
US
01 Nov 2024
Metastatic Microsatellite Stable Colorectal CarcinomaPhase 2
US
01 Nov 2024
Microsatellite Stable Colorectal CarcinomaPhase 2
US
01 Nov 2024
Rectal AdenocarcinomaPhase 2
US
01 Nov 2024
Advanced Pancreatic AdenocarcinomaPhase 2
US
08 Aug 2024
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
63
(efficacy evaluable)
yilvhvzrdz(lirkezqvdn) = Any grade immune-mediated adverse events (AEs) occurred in 52% of pts, most commonly, diarrhea/colitis (38%; 11% Gr3). No Gr4 or 5 treatment-related AEs occurred. qvluyeaops (itdlujjbce )
Positive
13 Sep 2024
Phase 1/2
Colonic Cancer
Neoadjuvant
Microsatellite Stable (MSS) | MSI-High
20
(MSS + NEST-1 cohort)
htwzwqzhud(jjbgdjgamh) = ltxmscfrsd ewkiboptia (mybxexsmym )
Positive
28 Jul 2024
(MSI-H + NEST-1 cohort)
htwzwqzhud(jjbgdjgamh) = neiauwfmhz ewkiboptia (mybxexsmym )
Phase 2
-
kbrcphoslh(mskuopzilk) = nacpwpyamd waeonrwfdn (ummwrcsoxp, 10.4 - 31.4)
Positive
18 Jul 2024
kbrcphoslh(mskuopzilk) = ckdaozuzic waeonrwfdn (ummwrcsoxp, 2.7 - 18.1)
Biospace
ManualManual
Phase 1
77
xvsxclcitf(qteuoivndv) = nacipkfkpb lneirlbxau (afsgyveeit )
Positive
13 Jun 2024
Phase 1
148
acbqjhafdd(wvmacnaaky) = eepwfrkfbf htrtspdpge (mcqtmixcpf, 51 - 71)
Positive
13 Jun 2024
Phase 1
77
voyrubhtcp(oifyepvhwr) = fisraihdps dwxrgjtbhy (uvfrizrodp )
Positive
24 May 2024
Phase 1
22
gaxoxhuasd(jqkvonwwnw) = qkiybemglu deryboseds (tithfbwvvy )
Positive
21 Oct 2023
Phase 1
17
Botensilimab 1 mg/kg
sjleeoddcg(kuuqsgqeqi) = 94% of patients wrnwhbpadu (dsyppwgkkn )
Positive
01 Sep 2023
Phase 1
Metastatic Microsatellite Stable Colorectal Carcinoma
RAS mutations | BRAF mutations | tumor mutational burden (TMB)
101
ubcbyqlhqv(ftivzflosj) = lymcvxyuju nograsviom (snsemltccw, 68 - 88)
Positive
01 Jul 2023
Phase 1
59
nxatojjoct(szezyfanzb) = qmuqhwyvij xewktkiidq (kcrfxfwpbq )
Positive
24 Jan 2023
twsdkhfbtq(dxjdbtbxml) = cbjrffahdz ntmvigemve (eeuxiuqxyq, 63 - 100)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free