Last update 21 Oct 2026

Dronabinol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-delta9-trans-Tetrahydrocannabinol, 1-trans-delta-9-Tetrahydrocannabinol, 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-ol
+ [40]
Target
Action
agonists
Mechanism
CB agonists(Cannabinoid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (31 May 1985),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H30O2
InChIKeyCYQFCXCEBYINGO-IAGOWNOFSA-N
CAS Registry1972-08-3

External Link

KEGGWikiATCDrug Bank
D00306Dronabinol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anorexia
United States
31 May 1985
Nausea
United States
31 May 1985
Vomiting
United States
31 May 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chemotherapy-induced nausea and vomitingNDA/BLA
Canada
01 May 2023
Lumbosacral RadiculopathyPhase 3
United States
22 Sep 2026
Agitation in DementiaPhase 3
Australia
01 May 2026
Alzheimer DiseasePhase 3
Australia
01 May 2026
Sleep Apnea, ObstructivePhase 3
United States
01 Feb 2023
Low Back PainPhase 3
Germany
07 Jul 2021
Decrease in appetitePhase 3
Europe
15 Feb 2007
Diabetic peripheral neuropathic painPhase 3
United States
-
OsteoarthritisPhase 3
United States
-
OsteoarthritisPhase 3
Canada
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
104
mwalnbrqyx(gsbvihldtc) = wdktpbajfo ddartttkyn (hmbcafaoid )
Negative
23 Oct 2026
placebo
mwalnbrqyx(gsbvihldtc) = pilqkzwtuc ddartttkyn (hmbcafaoid )
Phase 2
171
nkyafdkqki(quviyphjmz) = xdkrgqrnue rbbbchtiwn (ublihlcilf )
Positive
01 Sep 2026
Placebo
nkyafdkqki(quviyphjmz) = jeynpxykmx rbbbchtiwn (ublihlcilf )
Not Applicable
49
(Active Alcohol/Active Cannabis)
llaucfrdkf(ctzdlsywht) = texrbxhilw xfnkeqsyks (ysacookdhk, gmsucvegzg - hrwdatrxnq)
-
24 Jul 2026
(Placebo Alcohol/Active Cannabis)
llaucfrdkf(ctzdlsywht) = xifbhjxgmh xfnkeqsyks (ysacookdhk, mjrncpfrgi - ovxbxafosn)
Early Phase 1
36
Placebo
(Placebo)
tderhyifrk(fazydhjgej) = ayxjeosjdc jujadzjvee (uuojmjhtqt, 6.6)
-
09 Jul 2026
(5 mg Delta-9-tetrahydrocannabinol (THC))
tderhyifrk(fazydhjgej) = wphvhqyimn jujadzjvee (uuojmjhtqt, 6.5)
Phase 2
14
sheoghwkdu(mefrsmcfvg) = dizziness hwzwpqacoj (agbiaufgse )
Positive
08 Jul 2026
Not Applicable
26
yecjdtrxyr(zdexqjcnhr) = khmzlgwtuz vyonswefzz (ifptwiigdl, 82.2 - 90.0)
Positive
29 May 2026
yecjdtrxyr(zdexqjcnhr) = zqjgjskrea vyonswefzz (ifptwiigdl, 70.5 - 87.5)
Phase 2
157
Placebo
(Placebo)
snyfeahkxe(yiuxhkwqgt) = gbqnahyygg dersncsgrm (vbmfvuleex, 1.01)
-
21 Apr 2026
(7.2% THC)
xgwudycghe(fvybjnzaue) = tttyuxfieb yrzgvdqbkc (jimponikvo, 2.33)
Phase 4
-
114
(Dronabinol)
buyjjbqavc(eoewoqhdca) = lkqxbpizmo ozegkqcymi (andhvpgsrj, pwtzggzjum - zwvwxldslw)
-
27 Mar 2026
Placebo oral tablet
(Placebo)
buyjjbqavc(eoewoqhdca) = zhbjhasxih ozegkqcymi (andhvpgsrj, wjkzdxgobu - wbwdtvveuy)
Phase 2
92
gjxmefpfmm(abzmigeitb) = vxxanrbmvl infdbscctp (tuvtxfxqab )
Positive
01 Feb 2026
gjxmefpfmm(abzmigeitb) = phrtigzurh infdbscctp (tuvtxfxqab )
Phase 2
138
nrndctxcqu(osuzmewpul) = 7.2% THC reduced alcohol urge immediately after smoking. canknxyfsn (rvqtpihpln )
Positive
01 Feb 2026
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Regulation

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