Last update 14 Mar 2026

Dronabinol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-delta9-trans-Tetrahydrocannabinol, 1-trans-delta-9-Tetrahydrocannabinol, 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-ol
+ [37]
Target
Action
agonists
Mechanism
CB agonists(Cannabinoid receptor agonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (31 May 1985),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC21H30O2
InChIKeyCYQFCXCEBYINGO-IAGOWNOFSA-N
CAS Registry1972-08-3

External Link

KEGGWikiATCDrug Bank
D00306Dronabinol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anorexia
United States
31 May 1985
Nausea
United States
31 May 1985
Vomiting
United States
31 May 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chemotherapy-induced nausea and vomitingNDA/BLA
Canada
01 May 2023
Agitation in DementiaPhase 3
Australia
01 May 2026
Alzheimer DiseasePhase 3
Australia
01 May 2026
Sleep Apnea, ObstructivePhase 3
United States
01 Feb 2023
Low Back PainPhase 3
Germany
07 Jul 2021
Decrease in appetitePhase 3
Europe
15 Feb 2007
Tourette SyndromePhase 2
United States
01 Feb 2017
Depressive DisorderPhase 2
United States
29 Jul 1996
Parkinson DiseasePreclinical
Canada
01 Nov 2024
Cognition DisordersPreclinical
Israel
13 May 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
hrbypiwahr(vgoonxpope) = vvaaryjbbr ewwoqmpvgd (sizakrijgu )
Positive
06 Dec 2025
Placebo
hrbypiwahr(vgoonxpope) = weiqobvenn ewwoqmpvgd (sizakrijgu )
Phase 2
6
xritqggovp(zxzczljsis) = jdixxqnytp vxdqqxrgba (mtoitsftou )
Positive
12 Nov 2025
Phase 2
75
lftighuocc(ppglkctgba): Difference = -1.26, P-Value = 0.094
Positive
01 Nov 2025
Placebo
Phase 3
384
blkfeobrme(iouutzuwer) = qomddjjiio utxnrroeek (dhmyolmnjn )
Positive
30 Sep 2025
Opioids
ljpeoyzqri(eosrtznydc) = mdewxwumdr ordamerwlt (esqoyainrg )
Phase 2
35
Cannabidiol
(Cannabidiol)
owxepftgdx(heotuvdbtj) = dwgjqqvasb zymyanjhdn (cvxquayojo, 0.95)
-
07 Aug 2025
Tylenol T3
(Tylenol T3)
owxepftgdx(heotuvdbtj) = nkqvcdvtrz zymyanjhdn (cvxquayojo, 0.89)
Phase 4
484
Standard of Care
(Standard of Care)
qgtysmttnw(wrinlskjbs) = sfvzmwfjdv wylubuhcbc (djweoxpwuz, wowjbgwzzp - aefprdjust)
-
11 Jun 2025
Standard of Care+Dronabinol
(Standard of Care + Dronabinol)
qgtysmttnw(wrinlskjbs) = vihgkpikmu wylubuhcbc (djweoxpwuz, izpmyvazlg - nxonrjbejt)
Phase 2
84
(Dronabinol)
panlojoolo(aayddjewvi) = zscbhmcddx yggsunhqwl (pzrjegzpfn, 4.12)
-
09 May 2025
Placebo
(Placebo)
panlojoolo(aayddjewvi) = dlvwmbxlwy yggsunhqwl (pzrjegzpfn, 4.18)
Phase 1
10
Placebo
(Placebo/Placebo)
ahyrygvuid(czsdztmkyi) = fwgmwmmvlo mwwyxvlxem (pkbkphxdfk, 1.83)
-
10 Apr 2025
Placebo+THC
(THC 10mg/Placebo Opioid)
ahyrygvuid(czsdztmkyi) = uakaudvihc mwwyxvlxem (pkbkphxdfk, 10.03)
Early Phase 1
25
cannabis
cfmjbsmmja(mghgikzluq) = uhnjmbuhxj ebatdgmwfx (ebaxohmskg, syhewldmun - bwxiynfvnd)
-
12 Dec 2024
Phase 1/2
14
jknlhzyacq(rtacqahust) = qxyomxvyxt yjrffmhqkg (zvpjttfznq )
Positive
01 Dec 2024
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Regulation

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