Comparison of ultrasound guided hydrodissection with dextrose versus normal saline for treatment of carpal tunnel syndrome: A Randomized Controlled Trial - NIL

Start Date19 Oct 2024

Sponsor / Collaborator-

NCT06635174 / Enrolling by invitationNot ApplicableIIT

Efficacy of 50% Oral Dextrose As Pain Relief in Newborns Before Bladder Catheterization

The aim of this study is to determine the effect of 50% oral dextrose in reducing pain before Bladder Catheterization.
This study will answer the following question
Is there any effect of 50% dextrose in reducing pain response to infants from age 1-90 days undergoing bladder catheterization during their visit in emergency department it is double blind randomized control trial comparing 2ml 50% dextrose as oral solution with placebo 2ml of normal water
Primary Objective
- To evaluate the impact of administrating oral glucose on pain control compared with placebo in blood pressure , Heart rate, respiratory rate and oxygen saturation before and after the procedure
Secondary Objectives
* To compare random blood sugar before and after the procedure
* To compare the incident and the duration of crying in both groups
administration of oral solution 2ml of solutions to be administered orally as drops at tip of the tongue after that will wait for 2 minutes before the procedure start , after 2 minutes from the oral solution , the procedure will start

Start Date09 Oct 2024

Sponsor / Collaborator-

CTRI/2024/09/073714 / Not yet recruitingPhase 2/3

Oral dextrose gel for prevention of hypoglycemia in small for gestation age neonates A randomized controlled trial - NIL

Start Date22 Sep 2024

Sponsor / Collaborator

Government Medical College Jammu

100 Clinical Results associated with Dextrose

100 Translational Medicine associated with Dextrose

100 Patents (Medical) associated with Dextrose

5,352

Literatures (Medical) associated with Dextrose

31 Dec 2024·Journal of Oral Microbiology

The effect of different sweeteners on the oral microbiome: a randomized clinical exploratory pilot study

Article

Author: Keijser, Bart J F ; van der Plas, Derek W K ; Zakis, Davis R ; Crielaard, Wim ; Volgenant, Catherine M C ; Brandt, Bernd W ; van der Waal, Suzette V ; Zaura, Egija

IntroductionThe aim of the study was to evaluate the modulating effects of five commonly used sweetener (glucose, inulin, isomaltulose, tagatose, trehalose) containing mouth rinses on the oral microbiome.MethodsA single-centre, double-blind, parallel randomized clinical trial was performed with healthy, 18-55-year-old volunteers (N = 65), who rinsed thrice-daily for two weeks with a 10% solution of one of the allocated sweeteners. Microbiota composition of supragingival dental plaque and the tongue dorsum coating was analysed by 16S RNA gene amplicon sequencing of the V4 hypervariable region (Illumina MiSeq). As secondary outcomes, dental plaque red fluorescence and salivary pH were measured.ResultsDental plaque microbiota changed significantly for two groups: inulin (F = 2.0239, p = 0.0006 PERMANOVA, Aitchison distance) and isomaltulose (F = 0.67, p = 0.0305). For the tongue microbiota, significant changes were observed for isomaltulose (F = 0.8382, p = 0.0452) and trehalose (F = 1.0119, p = 0.0098). In plaque, 13 species changed significantly for the inulin group, while for tongue coating, three species changed for the trehalose group (ALDEx2, p < 0.1). No significant changes were observed for the secondary outcomes.ConclusionThe effects on the oral microbiota were sweetener dependant with the most pronounced effect on plaque microbiota. Inulin exhibited the strongest microbial modulating potential of the sweeteners tested. Further full-scale clinical studies are required.

01 Nov 2024·Journal of Perinatology

The impact of implementation of oral dextrose gel on the incidence of multiple hypoglycemia events in the well newborn nursery

Article

Author: Groves, Alan ; Yuan, Yingchao ; Vaidyanathan, Lakshmy ; Reid, Davika

OBJECTIVEEvaluate the impact of 40% oral dextrose gel (DG) for management of neonatal hypoglycemia (NH) on the incidence of multiple hypoglycemic events in the well-baby nursery.STUDY DESIGNA retrospective chart review of 738 at-risk infants in 2 cohorts before (Cohort 1) and after (Cohort 2) DG implementation. Primary outcome was the incidence of ≥2 hypoglycemic episodes. Secondary outcomes were number of lowest median glucose level, and incidence of NICU admission.RESULTSThere were 384 and 354 at-risk newborns in Cohorts 1 & 2. The incidence of developing ≥2 hypoglycemia episodes significantly decreased following DG implementation [62(42.5%) vs 29(25.9%), p = 0.0058]. There were no differences in lowest glucose level [37 (14-45) vs 37 (10-45), p = 0.31], and NICU admission rate [31 (21.2%) vs 21 (18.8%), p = 0.62].CONCLUSIONSImplementation of DG lowers the incidence of subsequent hypoglycemia episodes.

01 Nov 2024·Diagnostic Cytopathology

Validation of a novel alcohol‐free preservative solution in comparison with conventional prefixation on quality of serous body fluid smears

Article

Author: Ambalaparambil, Anagha ; Gochhait, Debasis ; Siddaraju, Neelaiah ; Perumal, Prasanna Venkadesa

AbstractBackgroundWe describe a novel alcohol‐free preservative composed of glucose, mannitol, disodium hydrogen orthophosphate, thymol, and distilled water (glucose‐mannitol–disodium dihydrogen orhtophosphate‐thymol [GMDT] preservative) in appropriate proportion as an alternative to alcohol prefixation (APF) of body fluids.ObjectivesTo assess the cytomorphologic preservation and staining quality of serous body fluid smears generated by GMDT preservative and compare it with smears processed by standard 50% APF.MethodologyThe study comprised 151 effusion samples. Each sample was equally divided into four tubes. Equal volumes of APF and GMDT preservatives were added to the first two tubes and left at room temperature for 24 h. Similarly, the corresponding preservatives were added to the third and fourth tubes and stored for 48 h. Two smears were prepared from the centrifuged sediments of each tube (all four tubes) and stained with May‐Grünwald Giemsa and Papanicolaou (Pap) stains. Using a three‐tiered scoring system, the smear examination was blinded to assess the extent of cellular preservation and the staining quality by two cytotechnologists and two cytopathologists. Statistical analysis was performed by STATA 16.0.ResultsSamples processed with the GMDT preservative at 24 h showed better cytoplasmic preservation and smear background, while nuclear features and staining quality showed no difference between the two preservatives. Mild cytoplasmic and nuclear degenerative changes were noted with the GMDT at 48 h, while all four parameters remained similar with APF at 24 and 48 h.ConclusionsThe newly developed alcohol‐free, GMDT preservative, could be a feasible and cost‐effective alternative to 50% APF, preferably when samples are processed within 24 h.

News (Medical) associated with Dextrose

22 Jun 2024

·www.globenewswire.com

Aphaia Pharma Announces Positive Results from Phase 2 Trial Evaluating its Lead Drug Formulation for Prediabetes Treatment

Primary endpoint met, showing that APHD-012 improves glucose tolerance in individuals with a pathological oral glucose tolerance test (OGTT) after 6 weeks of administrationThe results provide proof-of-concept for clinical efficacy of Aphaia’s oral glucose formulation, designed to restore endogenous nutrient-sensing pathways in the gastrointestinal tractThe study confirms that APHD-012 is well tolerated, with no serious adverse events observedAdditional results from a Phase 2 trial evaluating Aphaia’s formulation in individuals with obesity are expected in H2 2024 ZUG, Switzerland, SAN JUAN, Puerto Rico and TORONTO, June 20, 2024 (GLOBE NEWSWIRE) -- Aphaia Pharma, a clinical-stage company harnessing precision-targeted drug formulations to restore endogenous endocrine balance for the treatment of obesity and associated metabolic diseases, today announced that its Phase 2 trial evaluating the company’s lead oral glucose formulation for prediabetes treatment met its primary endpoint. The trial showed a statistically significant improvement in glucose tolerance in individuals with a pathological Oral Glucose Tolerance Test (OGTT) after 6 weeks of APHD-012 administration compared to placebo, with a positive safety profile. "We are excited to demonstrate for the first time that the mechanism of action of APHD-012 translates into clinical efficacy,” said Steffen-Sebastian Bolz, M.D., Ph.D., chief scientific officer of Aphaia Pharma. “In addition to showcasing the potential of our oral glucose formulation to manage prediabetes progression, it also underscores its promise to deliver clinical benefits across various indications (e.g., diabetes, obesity, among others), given its mechanism of action in restoring natural hormone release patterns in the intestine. We look forward to analyzing the upcoming data from our ongoing Phase 2 trial of APHD-012 in individuals with obesity and associated metabolic diseases to determine the best strategic path forward.” Christian Sina, M.D., professor of Medicine at University of Luebeck, director of the Institute of Nutritional Medicine at UKSH, Germany, and principal investigator of the trial, added, “I am highly impressed with the data. It marks the first instance of a drug demonstrating effectiveness in OGTT with a positive safety profile, which is crucial for a medication aimed at disease prevention. Preventing diabetes is a priority in healthcare programs due to the significant health and economic burden associated with this disease. Despite efforts in diet and exercise, effective therapies to prevent or delay the onset of type 2 diabetes are currently lacking, posing a challenge for individuals who do not respond to lifestyle changes. I eagerly anticipate supporting the next steps for the program, which has the potential to open a new avenue for prediabetes treatment.” Key Trial Results include: In a group of healthy, prediabetic and diabetic patients, APHD-012 (6 weeks treatment) reduced OGTT blood glucose levels at 120 minutes post-challenge from 9.00.6 to 7.90.6 mmol/L (n=23, p=0.01); placebo treatment in the same patients had no significant effect (8.80.4 mmol/L versus 8.50.6 mmol/L; p=0.33)A subgroup analysis appears to show that APHD-012 has a larger effect size in prediabetic patients (8.70.4 to 6.80.5 mmol/L; n=12, p=0.003); placebo had no significant effect in this subgroup (8.60.4 versus 8.20.6 mmol/L; p=0.25).In a further analysis of prediabetic patients, APHD-012 treatment reduced OGTT area under the curve (AUC 0-120 minutes) from 126147 to 116336 min*mmol/L (p=0.004, n=12); the placebo treatment had no significant effect on AUC in this subgroup (125045 to 122553 min*mmol/L; p=0.47).In all diabetic patients included, APHD-012 treatment reduced OGTT blood glucose levels at 120 minutes post-challenge (from 13.20.7 to 11.60.5 mmol/L; n=5, p=0.0006); placebo was not effective in this group (11.40.5 versus 12.00.6 mmol/L; p=0.59).A total of 13 adverse events (AEs) were reported for 8 subjects (27%) during the 6 weeks of APHD-012 treatment, while 7 AEs were reported for 5 subjects (17%) taking placebo treatment; no serious AEs occurred during the course of the study. The Phase 2 trial (NCT05803772) (EudraCT 2022-003205-29) was a randomized, double-blind, placebo-controlled, multi-center proof-of-concept study that evaluated the safety and efficacy of APHD-012 (12g dose of Aphaia’s oral glucose formulation) in approximately 30 adults with prediabetes, diabetes or healthy individuals in a cross-over design. Patients were randomized to receive a once daily dose of either APHD-012 or APHD-012P, a matching placebo, for six weeks, followed by a washout period of 4 weeks, and subsequent crossover to the other opposite treatment arm for another 6 weeks. The primary endpoint of the trial is APHD-012’s ability to improve glucose tolerance in individuals with a pathological oral glucose tolerance test (OGTT) after 6 weeks of administration. The Oral Glucose Tolerance Test (OGTT) is a diagnostic test used to assess how well the body processes glucose by measuring blood glucose levels after consuming a glucose-rich drink. In individuals with diabetes and prediabetes, blood glucose levels are higher than normal due to their inability to metabolize glucose effectively. About PrediabetesPrediabetes is a serious health condition where blood sugar levels are elevated but not yet in the type 2 diabetes range. Prediabetes is becoming increasingly common and affects more than 10% of the population in Europe, the U.S. and Asia. Individuals with prediabetes are at increased risk of developing type 2 diabetes or associated complications, such as stroke or cardiovascular disease. While lifestyle changes can help prevent the progression from prediabetes to diabetes, there is a clear medical need for new therapeutic approaches to help control disease evolution before diabetes, cardiovascular disease and other metabolic disorders manifest. About Aphaia’s drug candidateAphaia’s lead drug candidate is a proprietary oral glucose formulation designed to be released at discrete parts of the small intestine to restore endogenous nutrient-sensing signaling pathways and stimulate the release of the broad spectrum of enteric hormones that control multiple homeostatic functions like appetite, hunger, satiety, glucose metabolism and energy expenditure. This includes glucagon-like-peptide 1 (GLP-1), peptide tyrosine-tyrosine (PYY), glicentin and oxyntomodulin (OXM) among others. About Aphaia PharmaAphaia Pharma is a clinical-stage biopharmaceutical company with headquarters in Switzerland, Canada and Puerto Rico. It harnesses proprietary precision-targeted drug formulations to restore endogenous hormone release from nutrient-sensing cells in the gastrointestinal tract to treat and prevent metabolic disorders such as obesity and associated diseases. Aphaia’s lead drug candidate, an oral glucose formulation, has been shown to safely restore endogenous hormone release in individuals with obesity. It is being evaluated in two Phase 2 trials, one for chronic weight management in individuals with obesity and the second to improve glucose tolerance in individuals with prediabetes. The versatile design of Aphaia’s technology platform provides an opportunity for the development of treatments for multiple disease patterns. Aphaia Investor ContactGünter JuchoChief Financial Officerjucho@aphaiapharma.com Media ContactMadelin HawtinLifeSci CommunicationsAphaiaPharma@lifescicomms.com

Phase 2Clinical Result

13 Jun 2024

·www.globenewswire.com

Aphaia Pharma Completes Enrollment in Arm 2 of Phase 2 Trial in Individuals with Obesity

Enrollment has been completed for the last four cohorts evaluating the contribution of circadian effects in weight loss treatment using Aphaia’s formulationTopline data anticipated in Q3 and Q4 2024 for Arm 1 and Arm 2 of the trial, respectively ZUG, Switzerland and SAN JUAN, Puerto Rico and TORONTO, June 13, 2024 (GLOBE NEWSWIRE) -- Aphaia Pharma, a clinical-stage company harnessing precision-targeted drug formulations to restore endogenous endocrine balance for the treatment of obesity and associated metabolic diseases, today announced that it has completed enrollment in the second arm of its Phase 2 trial, which is evaluating the safety and efficacy of two separate doses of Aphaia’s formulation, or their respective placebos, twice per day to induce weight loss in individuals with obesity. The company had already completed enrollment in Part 1 of the trial, evaluating a once-daily 12g dose of its oral glucose formulation (APHD-012), in April. "We are pleased to have completed enrollment for Arm 2 on schedule, allowing us to report topline data in Q4 2024, following Arm 1 data in Q3 2024,” said Steffen-Sebastian Bolz, M.D., Ph.D., chief scientific officer of Aphaia Pharma. “There is a large unmet need for treatment solutions for patients with obesity beyond hormone replacement therapy. We believe in the potential of our targeted oral glucose formulation to deliver long-term benefits for patients with minimal side effects, given its capacity to restore the endogenous release of the full spectrum of metabolically active hormones involved in satiety and glucose metabolism. Arm 2 of the trial will further allow us to refine the dosing regimen to optimize treatment response should we confirm an effect of circadian rhythm on treatment efficacy.” The Phase 2 trial (NCT05385978) is a randomized, double-blind, placebo-controlled, proof-of-concept study assessing the safety and efficacy of Aphaia’s oral glucose formulation in adults with obesity. It is comprised of two arms: Arm 1 includes two cohorts totaling 174 patients randomized to receive a once-daily dose of either APHD-012 (12g of Aphaia’s glucose formulation) or APH-012P, a matching placebo, prior to main daily meals for six (Cohort 1) or twelve months (Cohort 2). Arm 2 includes four cohorts with a total of 54 additional patients randomized to receive either 6g (APHD-006) or 8g (APHD-008) of Aphaia’s glucose formulation or their respective placebos twice per day. The primary endpoint of the trial is the change from baseline in percent weight compared to placebo. The study will also evaluate exploratory secondary endpoints, which are hallmarks of multiple metabolic diseases closely associated with obesity. About Aphaia’s drug candidateAphaia’s lead drug candidate is a proprietary oral glucose formulation designed to be released at discrete parts of the small intestine to restore endogenous nutrient-sensing signaling pathways and stimulate the release of the broad spectrum of enteric hormones that control multiple homeostatic functions like appetite, hunger, satiety, glucose metabolism and energy expenditure. This includes glucagon-like-peptide 1 (GLP-1), peptide tyrosine-tyrosine (PYY), glicentin and oxyntomodulin (OXM) among others. About Aphaia PharmaAphaia Pharma is a clinical-stage biopharmaceutical company with headquarters in Switzerland, Canada and Puerto Rico. It harnesses proprietary precision-targeted drug formulations to restore endogenous hormone release from nutrient-sensing cells in the gastrointestinal tract to treat and prevent metabolic disorders such as obesity and associated diseases. Aphaia’s lead drug candidate, an oral glucose formulation, has been shown to safely restore endogenous hormone release in individuals with obesity. It is being evaluated in two Phase 2 trials, one for chronic weight management in individuals with obesity and the second to improve glucose tolerance in individuals with prediabetes. The versatile design of Aphaia’s technology platform provides an opportunity for the development of treatments for multiple disease patterns. Aphaia Investor ContactGünter JuchoChief Financial Officerjucho@aphaiapharma.com Media ContactMadelin HawtinLifeSci CommunicationsAphaiaPharma@lifescicomms.com

Phase 2

02 May 2024

·www.pharmaceutical-technology.com

Biotechs face upward battle with recruiting patients on obesity trials

Aphaia Pharma’s CEO Steffen Sebastian-Bolz discussed problems with obesity trial patient recruitment. Credit: Alexey Krukovsky via Getty Images, Following plans to add cohorts in an ongoing Phase II weight-loss study, Aphaia Pharma’s CSO Steffen-Sebastian Bolz says there are now rising challenges with the recruitment of patients in obesity trials . Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. 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Reports Gene Therapy Market Size, Share, Trends, Analysis and Forecast by R... Premium Insights The gold standard of business intelligence. Find out more Related Company Profiles Eli Lilly and Co View all Submit Visit our Privacy Policy for more information about our services, how GlobalData may use, process and share your personal data, including information on your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address. Thank you. You will receive an email shortly. Please check your inbox to download the Report. As per a 25 April press release, Aphaia Pharma has begun recruitment for four more cohorts in its weight-loss trial, investigating two formulations— 6g (APHD-006) and 8g (APHD-008)— of its therapy APDH-012. Bolz anticipates topline data in October. “It has become increasingly difficult to recruit patients because the [weight loss] space is absolutely crowded,” says Bolz. He explains that with the boom in obesity therapeutic development , pharmaceutical companies are running more and more clinical trials that extend past the usual Phase III programmes. He also highlights trials designed to evaluate cardiovascular risk as examples of this. Bolz says there is a “large discrepancy” between trial recruitment for large pharmaceutical companies and small biotech companies, as the financial incentives to participate in such trials can vary massively. Furthermore, obesity is a condition that has fewer official patient organisations than other medical conditions that can often be a useful resource for patient recruitment, he adds. Aphaia has just successfully completed recruitment for the first two cohorts of its weight loss study. In the last few years, the US Food and Drug Administration (FDA) has approved several therapies for weight loss and diabetes , including Eli Lilly’s Zepbound (tirzepatide) and Novo Nordisk’s Wegovy (semaglutide). Thus far, Eli Lilly has published data from eight studies investigating tirzepatide for obesity and type 2 diabetes, but the company has plans to release data from several ongoing and upcoming studies in the next few years. See Also: Novo Nordisk aims for market domination, boasts $1.5bn obesity sales in Q1 ePRO vs eCOA: Understanding the nuances in clinical trials Bolz says that Aphaia Pharma has not had trouble with recruitment due to its drug’s unique mechanism of action, which leads to very few side effects. APHD-012 gives a targeted release of glucose that restores endogenous nutrient-sensing signalling pathways and triggers the release of enteric hormones related to the systems for appetite, hunger, satiety, glucose metabolism, and energy expenditure. This includes hormones such as glucagon-like peptide 1 (GLP-1), peptide tyrosine-tyrosine (PYY), glicentin and oxyntomodulin (OXM). Furthermore, Bolz highlighted the company’s efforts to form a tight relationship with its CRO partners and medical centres, enabling Aphaia to reach out to patients through its partners’ networks. He adds that through this method, centres can also forward essential drug information to the patients, increasing compliance. The oral therapy is currently being assessed in a Phase II weight-loss trial (NCT05385978) and a Phase II prevention trial for prediabetic patients (NCT05803772). The Swiss biotech is developing and investigating the therapy in the US, Canada, Puerto Rico, Germany, and the country of Georgia. Free Report How is the Biopharmaceutical industry evolving? 2021 was a year of continued innovation and change in the Biopharmaceutical industry. As the COVID-19 pandemic continues to take its toll on businesses worldwide, it’s time to look for new ways to create value, prepare for the future, and remain competitive in the ever-changing landscape. GlobalData’s expansive report examines the business environment and trends that shape the Biopharmaceutical industry. We highlight the most impactful emerging technologies, as well as the industry, regulatory, and macroeconomic factors that influence growth prospects. Access the report to: Benchmark the impact of major themes on the Biopharmaceutical industry. Gain a deeper "on the ground" perspective through exclusive opinions and analysis from industry respondents. Evaluate the effects of COVID-19 on the sector. Download the full report to understand what to expect and how to align your strategies for success. 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Phase 2Phase 3

100 Deals associated with Dextrose

External Link

KEGG	Wiki	ATC	Drug Bank
D02325	Dextrose	-	DB09341

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Water-Electrolyte Imbalance	US	Baxter Healthcare Corp.	25 Jan 1971

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Glucose Intolerance	Phase 2	US	Aphaia Pharma AG	01 Apr 2023
Prediabetic State	Phase 2	US	Aphaia Pharma AG	01 Apr 2023
Obesity	Phase 2	DE	Aphaia Pharma AG	01 Jul 2022
Obesity	Phase 2	PR	Aphaia Pharma AG	01 Jul 2022

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01369147 (CTgov)	Phase 2	Critical Illness	12	Enteral feeding+Propofol+Clevidipine+Dextrose-containing IV Fluids (Parenteral Nutrition Energy Dose at 0.6 x Measured REE)	dpvawoaqtf(vyubrnoboz) = gjrcngetvh pxjldwpblf (qoroglhnly, chflbpflhl - ujqmgsjgad) View more	-	10 Jun 2022
				Enteral feeding+Propofol+Clevidipine+Dextrose-containing IV Fluids (Parenteral Nutrition Energy Dose at 1.0 x Measured REE)	dpvawoaqtf(vyubrnoboz) = ywwvunswgo pxjldwpblf (qoroglhnly, aojbvnmsdo - jsdxobnoso) View more
ADA2021	Not Applicable	Hypoglycemia	10	Glucose	cswcnsusmr(axrcnrryhb) = tbojpnezfo gxammcrtrp (rsxtymkknh ) View more	-	01 Jun 2021
ADA2020	Not Applicable	Diabetes Mellitus, Type 2	12	Tofogliflozin	(nezusnrwhu) = cykzmxjcdf nfpoeufkas (jxoeavnysw )	-	01 Jun 2020
				Tofogliflozin (No administration of drugs)	(nezusnrwhu) = cexlzkdsdk nfpoeufkas (jxoeavnysw )
ASN2019	Not Applicable	Hyperkalemia	142	Intravenous Insulin and Dextrose 50%	zlhyywnbhj(cidmvveqlz) = wstpgdzlud nbeznyazjl (oxqmychwfe, 1.67 - 16.0) View more	Positive	05 Nov 2019
NCT03095651 (5160-002 \| MK-5160-002, CTgov)	Phase 1	Diabetes Mellitus, Type 2 \| Diabetes Mellitus, Insulin-Dependent, 2	33	Placebo to Glargine+MK-5160 16 nmol/kg+Dextrose (T1DM MK-5160 16 Nmol/kg)	izgbkqmllp(yjdjjwwvla) = kbhgckcwmz dndxwbsyxu (cxufgeossf, wnbocfkfmc - yugebyqqev) View more	-	01 Apr 2019
				Placebo to Glargine+MK-5160 32 nmol/kg+Dextrose (T1DM MK-5160 32 Nmol/kg)	izgbkqmllp(yjdjjwwvla) = jytbrejmze dndxwbsyxu (cxufgeossf, yzbrbosvxn - pbpvhwmmic) View more
NCT05548738 (Pubmed \| J Altern Complement Med)	Phase 2/3	Leg/buttock pain	32	Caudal Epidural D5W	(hhjculirpe) = wgrglkppqu prjdzbslng (casxlrvxxu )	Positive	01 Dec 2018
NCT00578669 (CTgov)	Phase 3	Depressive Disorder, Major \| Nicotine Dependence	206	Fluoxetine (Sequential Fluoxetine)	rxyxhvatnn(jtcljxjkyq) = jzxyxucvok dzopmptytg (pshehvahzo, uojclmlenf - jtjogpmmam) View more	-	16 Oct 2018
				nicotine+placebo+Dextrose (Sequential Placebo)	rxyxhvatnn(jtcljxjkyq) = tkkvhdoogc dzopmptytg (pshehvahzo, fnovuzxcti - dhcljhkjam) View more
Pubmed	Not Applicable	Low Back Pain	35	5% Dextrose	rfzksztxuy(xzclelzwbe) = cqdrjepftp tzysnruqcz (pyajtxkuek ) View more	-	06 Dec 2016
				0.9% Saline	rfzksztxuy(xzclelzwbe) = ypgtaycyew tzysnruqcz (pyajtxkuek ) View more
ESPE2014	Not Applicable	Diabetes Mellitus	-	Coated Pellets With Controlled Glucose Release	abuzwqyqff(jrcejxpzws) = igdxfoerbj ovfdautxfc (mtasvudjbx ) View more	Positive	18 Sep 2014
ARVO2014	Not Applicable	-	-	glucose	(oiqjkptpme) = kqzlueznhs yqgbbimffh (xxmcfpfrkv, 832.5)	-	01 Apr 2014
				glucose	(oiqjkptpme) = walehtvncm yqgbbimffh (xxmcfpfrkv, 432.05)

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