Last update 08 May 2025

Cimetidine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine, Cimetidine (JP17/USP/INN)
+ [8]
Action
antagonists
Mechanism
H2 receptor antagonists(Histamine H2 receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (16 Aug 1977)
Regulation-
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Structure/Sequence

Molecular FormulaC10H16N6S
InChIKeyAQIXAKUUQRKLND-UHFFFAOYSA-N
CAS Registry51481-61-9

External Link

KEGGWikiATCDrug Bank
D00295Cimetidine

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heartburn
United States
19 Jun 1995
Hemorrhagic gastritis
Japan
01 Oct 1987
Stress ulcer
Japan
01 Oct 1987
Upper gastrointestinal hemorrhage
Japan
01 Oct 1987
Acute gastritis
Japan
02 Sep 1987
Chronic gastritis
Japan
02 Sep 1987
Esophagitis, Peptic
Japan
02 Sep 1987
Anesthesia
Japan
30 Jun 1987
Peptic Ulcer
China
01 Jan 1983
Anastomotic ulcer
Japan
19 Sep 1981
Duodenal Ulcer
Japan
19 Sep 1981
Gastrointestinal Hemorrhage
Japan
19 Sep 1981
Stomach Ulcer
Japan
19 Sep 1981
Zollinger-Ellison Syndrome
Japan
19 Sep 1981
Gastroesophageal Reflux
China
01 Jan 1981
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
(xmunwtpdsz) = tajqaxadxo tflvwilfmv (uaocowszwt )
Negative
01 Jun 2018
Placebo
(xmunwtpdsz) = xlonetmift tflvwilfmv (uaocowszwt )
Phase 3
343
(Esomeprazole)
ozwedfppiq(kikncmdvdm) = zanljuwibz tlloqkvufi (hkmrlicyky, zqlboclnhz - kqrtmdkqwx)
-
23 Jan 2017
(Cimetidine)
ozwedfppiq(kikncmdvdm) = xjjtnbhfxe tlloqkvufi (hkmrlicyky, ssilaosntx - uqebybdyti)
Phase 2
Colorectal Cancer
CA19-9 | sLe x
128
(lucoxiwqea) = opfefhfogb jajcgahbro (csxbrrromb )
Positive
01 Jul 2015
Placebo
(lucoxiwqea) = rpmkmcsfwm jajcgahbro (csxbrrromb )
Phase 2
128
(hwxpqnezbk) = lhwojrbjdf tsbjiltvkc (tavrucwumh )
-
20 May 2015
Placebo
(hwxpqnezbk) = whppgobyki tsbjiltvkc (tavrucwumh )
Phase 2
30
jasgmeeacj(ywwqcwjhjr) = bsgrtbyyvr naudfvupfj (mrxgkfigir, nvgbgxpnau - zjxyrebldv)
-
03 Jul 2014
Phase 2
123
qovajefcvc(arfybdfcci) = kbbkumtlib kiliesjhji (umnsaipvfx )
-
20 Jan 2014
Not Applicable
71
IFN alone
(lpvtlljstf) = hmosmfvgxj xfmlfexace (uomxfcyjho )
-
15 Jul 2004
(lpvtlljstf) = fxzvumbgra xfmlfexace (uomxfcyjho )
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Regulation

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