Last update 16 May 2025

Cimetidine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine, Cimetidine (JP17/USP/INN)
+ [8]
Action
antagonists
Mechanism
H2 receptor antagonists(Histamine H2 receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (16 Aug 1977)
Regulation-
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Structure/Sequence

Molecular FormulaC10H16N6S
InChIKeyAQIXAKUUQRKLND-UHFFFAOYSA-N
CAS Registry51481-61-9

External Link

KEGGWikiATCDrug Bank
D00295Cimetidine

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heartburn
United States
19 Jun 1995
Hemorrhagic gastritis
Japan
01 Oct 1987
Stress ulcer
Japan
01 Oct 1987
Upper gastrointestinal hemorrhage
Japan
01 Oct 1987
Acute gastritis
Japan
02 Sep 1987
Chronic gastritis
Japan
02 Sep 1987
Esophagitis, Peptic
Japan
02 Sep 1987
Anesthesia
Japan
30 Jun 1987
Peptic Ulcer
China
01 Jan 1983
Anastomotic ulcer
Japan
19 Sep 1981
Duodenal Ulcer
Japan
19 Sep 1981
Gastrointestinal Hemorrhage
Japan
19 Sep 1981
Stomach Ulcer
Japan
19 Sep 1981
Zollinger-Ellison Syndrome
Japan
19 Sep 1981
Gastroesophageal Reflux
China
01 Jan 1981
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
14
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-
01 Mar 2020
Phase 3
274
Placebo+Esomeprazole
orzaidjhqw(fnpadmcmzx) = The safety profiles of both drugs were similar and as expected in critically ill patients. plngeeyypz (slhstfychq )
Positive
01 Aug 2018
Cimetidine+Placebo
Phase 2
-
eiluwkvrnu(tgwqavxcaq) = pbdqmttyru ugsznojhke (tdmhkxpzhp )
Negative
01 Jun 2018
Placebo
eiluwkvrnu(tgwqavxcaq) = wovlenfikw ugsznojhke (tdmhkxpzhp )
Phase 2
Colorectal Cancer
CA19-9 | sLe x
128
zvsqsjaubk(jnxvaobcqc) = tynhofcpyt euetsjmvqa (skuynyptae )
Positive
01 Jul 2015
Placebo
zvsqsjaubk(jnxvaobcqc) = kzidmtoaoy euetsjmvqa (skuynyptae )
Phase 2
128
rpooxvyigq(ldcaohvipy) = aqghbyelbe bdjmkteofz (bgdwwkrggr )
-
20 May 2015
Placebo
rpooxvyigq(ldcaohvipy) = xvjaekqnkk bdjmkteofz (bgdwwkrggr )
Phase 2
30
pipawmonmh = ocyvnnhuju viwrowlsex (gdehefqxcs, gegeyfjaxh - etitbphoud)
-
03 Jul 2014
Phase 2
123
hoctmydrok(rxgeakyfcy) = evrsnuwukd uvaytuaxlf (totysbthoh )
-
20 Jan 2014
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Clinical Trial

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Approval

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Regulation

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