A Phase 1 Study of Fosbretabulin in Combination With Everolimus in Neuroendocrine Tumors (Grades 1-3) That Have Progressed After at Least One Prior Regimen for Metastatic Disease

This is a single center, open label, phase I study involving grade I-III gastroenteropancreatic neuroendocrine tumors, consisting of a dose escalation Part A followed by an expansion cohort Part B. On Part A Patients will be treated with daily oral everolimus. Fosbretabulin will be administered IV either q3 weekly or q weekly based on PO CRM cohort. Part B: Once the investigators have established an MTD in Part A, the investigators will be treating 15 more patients at that dose combination. The primary and secondary objectives of the expansion cohort will be similar to Part A of the study, i.e., to establish a safety profile of the experimental drug combination and to collect and assess efficacy data. Patients will be treated with concurrent everolimus and fosbretabulin for 12 weeks.

Start Date06 Mar 2017

Sponsor / Collaborator

University of Kentucky

NCT01701349

/ WithdrawnPhase 3

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Fosbretabulin Tromethamine (CA4P) in Combination With Paclitaxel and Carboplatin in Anaplastic Thyroid Carcinoma (FACT2)

This is a multicenter, double-blind, placebo-controlled, randomized study of fosbretabulin given with chemotherapy (paclitaxel and carboplatin) compared to placebo given with chemotherapy (paclitaxel and carboplatin) in subjects with anaplastic thyroid cancer (ATC). The primary objective of the study is to determine overall survival. A maximum of 300 subjects will be recruited from approximately 75 multinational sites of which approximately 35 will be located in the United States.

Start Date01 Mar 2015

Sponsor / Collaborator

Oncotelic Therapeutics, Inc.

NCT02279602

/ CompletedPhase 2

Rollover for Study OX4218s, A P2 Study to Investigate Safety and Activity of Fosbretabulin Tromethamine in the Treatment of Well-Differentiated, Low-to-Intermediate-Grade Unresectable, Recurrent or Metastatic PNET or GI-NET With Elevated Biomarkers

Subjects achieving a clinical response in study OX4218s with a biomarker reduction or symptom response are eligible to enroll in this rollover study to continue once every three weeks fosbretabulin infusions for up to one year.

Start Date01 Dec 2014

Sponsor / Collaborator

Oncotelic Therapeutics, Inc.

100 Clinical Results associated with Disodium combretastatin A-4 3-O-Phosphate

100 Translational Medicine associated with Disodium combretastatin A-4 3-O-Phosphate

100 Patents (Medical) associated with Disodium combretastatin A-4 3-O-Phosphate

531

Literatures (Medical) associated with Disodium combretastatin A-4 3-O-Phosphate

01 Aug 2026·British Journal of Pharmacology

Delivery of nano‐formulated drugs to solid tumours is selectively increased by co‐application of the vascular disrupting agent CA4P

Article

Author: Marinković, Petar ; Vollaire, Julien ; Thorn‐Seshold, Julia ; Höfner, Georg ; Josserand, Veronique ; Kitowski, Annabel ; Sperling, Stefanie ; Thorn‐Seshold, Oliver ; Bajic, Danica ; Rubey, Marina ; Coll, Jean‐Luc ; Hotz, Jasmin ; Klar, Kathrin ; Heise, Constanze

Background and purpose:

Nano‐formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to selectively enhance tumour delivery are lacking. We investigated whether subtherapeutic vascular disruption could be repurposed to transiently enhance tumour delivery of nano‐formulated agents.

Experimental approach:

Fluorescent reporter nanoparticles and the clinically approved nano‐formulations Caelyx (doxorubicin) and Onivyde (irinotecan) were administered in combination with subtherapeutic doses of the vascular disrupting agent (VDA) combretastatin A4‐phosphate (CA4P). Biodistribution, pharmacokinetics and therapeutic efficacy were assessed using longitudinal in vivo imaging and drug quantification via LC‐MS/MS (liquid chromatography‐tandem mass spectrometry) in syngeneic murine 4T1 breast cancer models.

Key results:

Co‐administration of CA4P increased tumour accumulation of nano‐formulated agents by up to threefold without increasing exposure in healthy organs. This effect was observed across reporter particles and both chemotherapeutic formulations but was not retained after repeated treatments. Consequently, CA4P co‐treatment did not improve tumour growth inhibition under standard multi‐dose therapeutic regimens.

Conclusions and implications:

Low‐dose vascular disruption can transiently and selectively enhance tumour delivery of nano‐formulated agents but does not improve therapeutic efficacy with repeated dosing. This strategy may therefore be best suited to single‐dose applications, such as diagnostic imaging or delivery studies, rather than sustained cancer therapy.

01 Jul 2026·NMR IN BIOMEDICINE

A Comparison of the Tofts and Linear Reference Region Models for DCE MRI When Monitoring Vascular Disruption in a Preclinical Tumor Model

Article

Author: Dhakan, Chetan B. ; Pagel, Mark D. ; Flask, Chris A. ; MacAskill, Christina J. ; Schuler, F. William ; Khaled, Alia S. ; De La Cerda, Jorge

ABSTRACT:

Dynamic contrast‐enhanced magnetic resonance imaging (DCE MRI) can assess changes in tumor vascular perfusion. We compared the Tofts model and the linear reference region model (LRRM) for analyses of DCE MRI for evaluating changes in vascular perfusion to combretastatin A‐4 phosphate (CA4P) in a 4T1 tumor model to determine which model can better evaluate changes in vascular perfusion induced by CA4P. Five female BALB/c mice inoculated with 4T1 murine breast cancer cells underwent DCE MRI at 24 h before CA4P treatment and at 3‐and 24‐h post‐treatment. DCE MRI was performed using a 7‐T preclinical MRI scanner. Pharmacokinetics parameters were derived using the Tofts model that relies on an arterial input function (AIF) and the LRRM that employs muscle as a reference tissue. We measured Ktrans , RKtrans , and kep across whole tumors, tumor peripheries, and cores at each time point. Both models identified vascular disruption 3‐h post‐treatment with partial recovery at 24 h, as expected. The LRRM measured treatment‐induced changes in RKtrans with more significance relative to changes in Ktrans measured by the Tofts model, whereas the Tofts model measured changes in kep with more significance relative to the LRRM, based on the % standard deviation of measurements within the cohort, the p ‐values, and the effect sizes in treatment‐induced changes for these measurements. Measurements of treatment‐induced changes in Ktrans and RKtrans were more significant than measurements of changes in kep . Therefore, our study showed that the LRRM is more reliable than the Tofts model when assessing tumor vascular perfusion. Considering that the LRRM uses a muscle region of interest in place of an AIF, the LRRM has strong advantages for clinical translation.

01 Jun 2026·MAGNETIC RESONANCE IN MEDICINE

Dynamic Contrast Enhanced—Magnetic Resonance Fingerprinting ( DCE ‐ MRF ) Improves Detection of Induced Vascular Perfusion Reduction in a Mouse Breast Cancer Model

Article

Author: Mark A. Griswold ; Mark D. Pagel ; Michael Kavran ; Bernadette O. Erokwu ; Christina J. MacAskill ; Gopalakrishnan Ramamurthy ; Guanhua Wang ; Chetan B. Dhakan ; Barbara J. Schiemann ; Chunying Wu ; William P. Schiemann ; Andrew Dupuis ; Xin Yu ; Chris A. Flask ; Yilun Sun ; Yuran Zhu

ABSTRACT:

Purpose:

Dynamic contrast‐enhanced MRI (DCE‐MRI) can assess tumor perfusion using pharmacokinetic models. However, poor DCE‐MRI reproducibility from reliance on conventional T 1 ‐weighted MRI has limited clinical translation. We evaluated whether Dynamic Contrast Enhanced‐Magnetic Resonance Fingerprinting (DCE‐MRF), which directly generates quantitative T 1 relaxation time constant maps, provides improved precision and statistical power for detecting treatment‐induced vascular changes compared to conventional DCE‐MRI.

Methods:

Twenty female mice bearing orthotopic 4 T1 breast tumors were randomly assigned to DCE‐MRF ( n = 12) or conventional DCE‐MRI ( n = 8) cohorts. Both methods acquired matched spatial and temporal resolution (23‐s) T 1 measurements at baseline, 3 h, and 48 h post‐treatment with combretastatin A4 phosphate (120 mg/kg), a known vascular disrupting agent. Perfusion assessments were obtained with a pharmacokinetic Linear Reference Region Model ( RKtrans and kep,T ) and model‐independent initial area under the curve assessments and compared using Wilcoxon signed‐rank tests and Hedges' g effect sizes.

Results:

DCE‐MRF demonstrated 1.3‐to‐5.1‐fold larger effect sizes for RKtrans across all regions and timepoint comparisons, and 1.3‐to‐1.9‐fold larger effect sizes for tumor rim kep,T compared to conventional DCE‐MRI. RKtrans and kep,T at 3 h post‐treatment in all regions, detected significant vascular recovery for whole tumor RKtrans and both whole tuomor and tumor rim for kep,T at 48 h, whereas DCE‐MRI only detected significant changes at 3 h.

Conclusions:

DCE‐MRF's improved measurement precision and increased effect size translates directly to enhanced statistical power for detecting treatment‐induced vascular changes, positioning it as a more reproducible tumor perfusion assessment for animal models and eventually cancer patients.

News (Medical) associated with Disodium combretastatin A-4 3-O-Phosphate

16 Apr 2026

·www.globenewswire.com

Oncotelic Therapeutics Reports FY 2025 Results Highlighting $249M Net Income and JV Pipeline Progress

AGOURA HILLS, Calif., April 16, 2026 (GLOBE NEWSWIRE) -- Oncotelic Therapeutics, Inc. (OTCQB:OTLC) (“Oncotelic”, the “Company” or “We”), a clinical-stage biopharmaceutical company developing drugs for the treatment of orphan oncology indications, as well as antisense and small molecule injectable drugs for the treatment of cancer, today announced its financial results for the fiscal year ended December 31, 2025 (“FY 2025”), as compared to the fiscal year ended December 31, 2024 (“FY 2024”). The financial results are based on the 2025 Annual Report on Form 10-K (“Form 10-K”) as filed with the Securities and Exchange Commission (“SEC”) on April 15, 2026. The Company recorded net income after tax of approximately $249.0 million, compared to a net loss of approximately $4.8 million in the prior year. The net income was primarily driven by a non-cash increase in the estimated fair value of the Company’s investment in GMP Biotechnology Limited (“GMP Bio”), its joint venture (“JV”), of approximately $365.4 million, as determined by an independent third-party ASC-compliant valuation, partially offset by a deferred income tax provision of approximately $111.6 million. Highlights for FY 2025 and thereafter: 2025 marked a transformational year for Oncotelic, highlighted by the successful completion of its first combination immunotherapy trial, the formalization of Sapu Bio and Sapu Nano, subsidiaries of GMP Bio, in which the Company has 45% equity interests. Additional achievements included dedicated development platforms, expansion of the Company’s AI-enabled research capabilities, and continued advancement of its joint venture programs. Joint Venture Valuation and Investment In November 2025, the Company recorded a non-cash increase in the fair value of its investment in GMP Biotechnology Limited based on an independent third-party valuation, resulting in a gain of approximately $365.4 million and a carrying value of approximately $388.0 million. This increase reflects estimated development progress and market-based assumptions and does not represent product revenue or cash received. A corresponding deferred income tax liability of approximately $111.6 million was recorded. Sapu Bio and Sapu Nano: Dual-Platform Strategy During 2025, GMP Bio formalized its two primary subsidiaries. Sapu Bio concentrates on OT-101 (TGFβ2 antisense) clinical development, regulatory advancement, and biomarker-driven positioning. Sapu Nano serves as the dedicated nanomedicine arm of the JV, advancing the Deciparticle™ platform into clinical-stage assets, partnerships, and commercialization. Together they form a diversified and scalable development platform. Deciparticle™ Nanoparticle Platform The Deciparticle™ platform utilizes ultra-small amphiphilic constructs (below ~20 nanometers) enabling enhanced tumor penetration and distribution. The JV is advancing six candidates: Sapu-001 (paclitaxel), Sapu-003 (everolimus), Sapu-004 (carboplatin), Sapu-005 (palbociclib), and Sapu-006 (docetaxel), in addition to OT-101. Everolimus formulation development is complete with a global clinical trial enrolling in Australia. Palbociclib and docetaxel INDs are expected in 2026. The platform is protected by more than 15 patent families. OT-101 Clinical Program In March 2025, we completed a Phase 1 clinical trial (NCT04862767) evaluating OT-101 in combination with IL-2 in Seoul, South Korea for advanced or metastatic solid tumors. The combination showed a tolerable safety profile with no unexpected safety signals. The JV plans to advance OT-101 plus IL-2 into further studies exploring synergies with checkpoint inhibitors such as PD-1 blockers. Separately, the JV initiated a Phase 2/3 trial for OT-101 in pancreatic cancer and is actively enrolling participants. Over ten patent families have been filed related to TGFβ2 as a prognostic indicator for cancer survival. PDAOAI (“AI”) Platform PDAOAI, the Company’s proprietary AI-enabled knowledge platform, was significantly expanded during 2025 into a core infrastructure layer supporting research, biomarker discovery, and regulatory documentation. By late 2025, PDAOAI evolved into a large-scale knowledge platform built around a TGF-β-centric biomedical corpus of over 100,000 curated abstracts with semantic retrieval and cross-referencing capabilities. PDAOAI contributed to at least seven peer-reviewed publications during 2025 across biomarker discovery, tumor microenvironment analysis, nanoparticle drug delivery, and clinical outcome correlations — spanning ovarian, breast, pancreatic, hepatocellular, and glioblastoma tumor types. Notably, the Company identified a novel biomarker signature (High RICTOR / Low RPTOR) predictive of sensitivity to intravenous everolimus based on analysis of over 9,000 tumor samples. GMP Manufacturing Facility The JV’s GMP manufacturing facility in San Diego continued full-scale operations during 2025 under its Drug Manufacturing License from the State of California. The facility utilizes a streamlined “one-pot” manufacturing process for bulk drug production through to finished product, with capabilities for both nonclinical and Phase 1 clinical trial material production. In early 2025, the Company partnered with Shanghai Medicilon, Inc. to access its rapid IND development platform supporting up to 20 IND projects. Results of Operations Below is a presentation of our financial results comparing FY 2025 to FY 2024 and based on our results published in our Form 10-K filed with the SEC on April 15, 2026. FY 2025 compared to FY 2024 Financial Results Overview ONCOTELIC THERAPEUTICS, INC. AND SUBSIDIARIES CONSOLIDATED STATEMENTS OF OPERATIONS For the Year Ended December 31, 2025 2024 Operating expenses: Research and development $4,357 $- General and administrative 3,182,242 376,013 Goodwill impairment (See note 2 and 3) - 3,200,000 Total operating expenses 3,186,599 3,576,013 Income/(Loss) from operations (3,186,599) (3,576,013)Other income (expense): Change in fair value of investment in GMP Bio 365,346,775 - Interest expense, net (885,488) (857,723)Reimbursement for expenses - related party - 22,937 Change in fair value of derivative on debt 353,572 (280,402)Loss on debt conversion (1,058,976) (88,258)Miscellaneous income 5,631 - Total other income (expense) 363,761,514 (1,203,446)Net income (loss) before income taxes 360,574,915 (4,779,459)Provision for income taxes (111,550,000) - Net income (loss) after income taxes 249,024,915 (4,779,459)Net income (loss) before non-controlling interests 249,024,915 (4,779,459)Net loss attributable to non-controlling interests (254,917) (255,527)Net income (loss) attributable to Oncotelic Therapeutics, Inc. $249,279,832 $(4,523,932) Basic net income (loss) per share attributable to common stock $0.59 $(0.01)Basic weighted average common stock outstanding 421,045,524 404,396,473 Basic and diluted net income (loss) per share attributable to common stock $0.59 $(0.01)Basic and diluted weighted average common stock outstanding 422,234,747 404,396,473 We recorded a higher net income per basic share of $0.59 for the year ended December 31, 2025, as compared to net loss per basic share of $0.01 for the year ended December 31, 2024. The Company had no product revenue for either period. We recorded net income of approximately $249.3 million attributable to Oncotelic Therapeutics, Inc. for the year ended December 31, 2025, compared to a net loss of approximately $4.5 million for the year ended December 31, 2024. The higher net income was primarily due to recording a non-cash increase in the estimated fair value of our investment in GMP Bio of approximately $365.3 million, based on an independent third-party ASC-compliant valuation. This non-cash gain was partially offset by a provision for deferred income taxes of approximately $111.6 million, higher general and administrative expenses of approximately $2.8 million primarily driven by stock-based compensation of approximately $2.4 million incurred for common stock and preferred stock issued in connection with services and approximately $0.2 million to settle litigation related to an ex-employee, higher loss on conversion of debt of approximately $1.0 million, partially offset by a favorable change in the value of derivatives on debt of approximately $0.6 million and lower interest expense of approximately $28 thousand. All operational costs associated with OT-101 and the nanoparticle platform are substantially covered by the JV, significantly reducing our direct financial burden until such time we make a determination to commence development of our own compounds. “The independent third-party valuation of our JV’s pipeline represents a significant milestone for the Company and validates the strategic investments we have made since forming the joint venture in 2022. With the successful completion of our Phase 1 OT-101/IL-2 combination trial, the advancement of six Deciparticle™ nanoparticle candidates into various stages of development, and the continued expansion of our PDAOAI platform which contributed to seven peer-reviewed publications this year, the underlying value drivers are tangible and progressing. We are now focused on the next phase of value realization — advancing the JV toward a potential Hong Kong IPO, pursuing a national exchange uplisting for the Company, and converting our pipeline progress into clinical and commercial milestones,” said Vuong Trieu, CEO of Oncotelic. “The progress made by the Company, through GMP Bio, the joint venture with Dragon, over such a short period of time is very impressive. We expect to continue to see significant progress and shareholder value creation by the Company through our ownership in GMP Bio,” said Amit Shah, CFO of Oncotelic. About Oncotelic Oncotelic (f/k/a Mateon Therapeutics, Inc.), was formed in the State of New York in 1988 as OXiGENE, Inc., was reincorporated in the State of Delaware in 1992, and changed its name to Mateon Therapeutics, Inc. in 2016, and Oncotelic Therapeutics, Inc. in November 2020. Oncotelic conducts business activities through Oncotelic and its wholly-owned subsidiaries, Oncotelic, Inc., a Delaware corporation, PointR Data, Inc. (“PointR”), a Delaware corporation, Pet2DAO, Inc., a Delaware corporation; and EdgePoint AI, Inc. (“Edgepoint”), a Delaware Corporation for which there are non-controlling interests, (Oncotelic, Oncotelic Inc., PointR, Pet2DAO and Edgepoint are collectively called the Company). The Company is currently developing OT-101, in addition to five additional compounds, for various cancers and COVID-19 through its joint venture GMP Bio, with Dragon, Artemisinin for COVID-19 and AI technologies for clinical development and manufacturing. In addition, GMP Bio is developing 5 additional nanoparticle compounds in the JV, which has the potential of significant revenues and value. The Company also acquired apomorphine for Parkinson’s Disease, erectile dysfunction and female sexual dysfunction. In addition, the Company is evaluating the further development of its product candidates OXi4503, as a treatment for acute myeloid leukemia and myelodysplastic syndromes, and CA4P, in combination with a checkpoint inhibitor for the treatment of advanced metastatic melanoma. The Company is also planning to address the animal health industry through Pet2DAO. Our principal corporate office is in the United States at 29397 Agoura Road, Suite 107, Agoura Hills, CA 91301 (telephone: 650-635-7000). Our internet address is www.oncotelic.com. Oncotelic’s Cautionary Note on Forward-Looking Statements Any statements contained in this Press Release that are not statements of historical fact are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may,” “will,” “should,” “expect,” “intend,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “potential,” “continue,” “assumption” or the negative of these terms or other comparable terminology. Statements concerning: our expectations on the timing, success of the JV’s product approvals, commercialization of the JVs products and results of operations of the JV: our expectations on the timing, success, or valuation our JV’s planned initial public offering; the timing, success or continuing valuation of our equity interest in the JV; our ability to secure future debt or equity financing needed to meet operating costs; the timing, costs and other limitations involved in obtaining regulatory approval for any product candidate; the expected efficacy of our product candidates compared to competitive products; anticipated results of our research and development programs as well as preclinical and clinical trials; expected market size, market acceptance for our product candidates; our ability to enter into future partnerships, joint ventures or other corporate transactions, ability of us being able to obtain additional resources, including debt or equity funding, and the expected benefits to be derived from those transactions; the anticipated impact of regulatory and legislative changes in the United States and foreign countries on our product candidates and operations; anticipated trends in revenues, operating expenses or financial position and results of operations; and our estimates regarding anticipated operating income or losses, future performance, future revenues and projected expense; are all forward-looking statements. Forward-looking statements reflect current views about future events and are based on our currently available financial, economic and competitive data and on current business plans. Forward-looking statements are not guarantees of future performance and our actual results may differ significantly from the results discussed or implied in the forward-looking statements. Factors that might cause such differences include, but are not limited to, the factors included in “Risk Factors,” in our Form 10K and the other registration statements and reports that we file with the SEC. The forward-looking statements contained in this press release are based on our current expectations and beliefs concerning future developments and their potential effects on us. We undertake no obligation to update or revise any forward- looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. You should consider the inherent limitations on, and risks associated with, forward-looking statements and not unduly rely on the accuracy of predictions contained in such forward-looking statements. This press release may also include market data related to our business and industry. These market data may include projections that are based on a number of assumptions. While we believe these assumptions to be reasonable and sound as of the date of this press release, if these assumptions turn out to be incorrect, actual results may materially differ from the projections based on these assumptions. As a result, the markets for our product candidates may not grow at the rates projected by these data, or at all. The failure of these markets to grow at these projected rates may have a material adverse effect on our business, results of operations, financial condition and the market price of our common stock. In addition, the Company expects to remeasure the fair value of its investment in GMP Biotechnology Limited on a quarterly basis in accordance with applicable accounting standards, including Accounting Standards Codification (“ASC”) 820, Fair Value Measurement. Such remeasurements are based on significant estimates and assumptions, including clinical development progress, regulatory milestones, market conditions, and comparable company data. As a result, the value of this investment, and the corresponding impact on the Company’s financial statements, may fluctuate materially from period to period, including based on the success or failure of drug development activities within the joint venture pipeline. These fluctuations are non-cash in nature and may not be indicative of the Company’s underlying operating performance or future cash flows. Investor & Media ContactOncotelic Therapeutics, Inc.Investor Relationsir@oncotelic.com Corporate CommunicationsIBNAustin, Texaswww.InvestorBrandNetwork.com512.354.7000 OfficeEditor@InvestorBrandNetwork.com

Phase 1Financial Statement

15 Dec 2025

·www.globenewswire.com

Oncotelic Therapeutics and Brush and Key Foundation Announce Publication in International Journal of Molecular Sciences Highlighting Context-Dependent Biomarkers in Liver and Pancreatic Cancer

AGOURA HILLS, Calif., Dec. 15, 2025 (GLOBE NEWSWIRE) -- Oncotelic Therapeutics, Inc. (OTCQB: OTLC) in collaboration with the Brush and Key Foundation, today announced the publication of a peer-reviewed research article in the International Journal of Molecular Sciences titled “Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter.” Chang, W.-H.; Shah, D.; Myers, S.; Potts, M.; Qazi, S.; Trieu, V. International Journal of Molecular Sciences 2025, 26, 11920. The study presents a comprehensive, data-driven analysis of two emerging biomarkers—DNMT3A (DNA methyltransferase 3A) and GMPS (guanine monophosphate synthetase)—across hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC). By integrating survival outcomes, transcriptomic profiling, and tumor microenvironment (TME) analyses from more than 7,000 patients, the authors demonstrate that the prognostic significance of these biomarkers is highly context-dependent, shaped by immune composition, metabolic reprogramming, and innate immune sensing pathways. Training the Next Generation of Scientists The publication also reflects the educational mission of the Brush and Key Foundation, which supports young scholars through mentored research experiences that bridge scientific inquiry, critical thinking, and professional development. The paper’s author- Drashya Shah, an intern supported by the Brush and Key Foundation, shared the following reflection: “My experience working with the Brush and Key Foundation for Young Artists has been truly valuable and enriching. Throughout the research and writing process, I received consistent guidance and insightful feedback at every stage, which helped me refine my ideas and present my findings with clarity and precision. This collaborative environment not only strengthened the quality of my paper but also significantly boosted my confidence as a researcher. The skills and knowledge I gained through this journey are lifelong, and I will undoubtedly carry them forward into my future education and professional work. I am deeply grateful to everyone involved for their unwavering support and encouragement.” “This work exemplifies how advanced bioinformatics, translational oncology, and structured mentorship can intersect to generate meaningful scientific insight,” said Dr. Vuong Trieu, co-author and contributor to the study. “Equally important, it demonstrates how hands-on research training helps prepare the next generation of scientists.” Dr. Wen-Han Chang, corresponding author, added, “The work highlights why biomarkers cannot be interpreted in isolation. Tumor context—immune composition, metabolic state, and innate sensing—fundamentally alters prognostic meaning and therapeutic opportunity.” About the Brush and Key Foundation The Brush and Key Foundation is a nonprofit organization dedicated to mentoring and educating young scholars through hands-on research, structured guidance, and interdisciplinary learning. The foundation emphasizes critical thinking, scientific communication, and real-world research experience to help students build durable skills applicable to future academic and professional pursuits. About Oncotelic Oncotelic (f/k/a Mateon Therapeutics, Inc.), was formed in the State of New York in 1988 as OXiGENE, Inc., was reincorporated in the State of Delaware in 1992, and changed its name to Mateon Therapeutics, Inc. in 2016, and Oncotelic Therapeutics, Inc. in November 2020. Oncotelic is seeking to leverage its deep expertise in oncology drug development to improve treatment outcomes and survival of cancer patients with a special emphasis on rare pediatric cancers. Oncotelic has rare pediatric designation for Diffuse Intrinsic Pontine Glioma “DIPG” (through OT-101) through its 45% joint venture, melanoma (through CA4P), and Acute Myeloid Leukemia “AML” (through OXi 4503). Oncotelic also acquired PointR Data Inc. in November 2019. Oncotelic acquired AL-101, during the 4th quarter of 2021, for the intranasal delivery of apomorphine. We intend to develop AL-101 for the treatment of Parkinson Disease ("PD"). Over 60,000 new patients are being diagnosed with PD in the United States and currently there are over 1 million patients in the US and expected to increase to over 1.2 million by 2030. In addition, approximately 10 million suffer from this disease globally. https://www.parkinson.org/Understanding-Parkinsons/Statistics. AL-101 is also being developed for Erectile Dysfunction ("ED"). ED is the most prevalent male sexual disorder globally. The percentages of men affected by ED are as follows: 14.3-70% of men aged 60 years, 6.7-48% of men aged 70 years, and 38% of men aged 80 years (Geerkens MJM et al. (2019). Eur Urol Focus. pii: S2405-4569(19)30079-3). However, with the increasing administration of PDE5 inhibitors in clinical practice, it was found that approximately 30-35% of ED patients are treatment failures (McMahon CN et al. (2006). BMJ, 332: 589-92). AL-101 is designed to target treatment failure ED patients who do not respond to PDE5 inhibitors. Through similar mechanism of action, AL-101 is being developed for Female Sexual Dysfunction ("FSD"). Female sexual dysfunction is a prevalent problem, afflicting approximately 40% of women and there are few treatment options. FSD is more typical as women age and is a progressive and widespread condition. (Allahdadi, KJ et al. (2009) Cardiovascular & hematological agents in medicinal chemistry, 7(4), 260-269). There is no available drug for the treatment of FSD. In June 2019, the U.S. Food and Drug Administration approved Vyleesi (bremelanotide) to treat acquired, generalized hypoactive sexual desire disorder ("HSDD") in premenopausal women. This is the only available drug treatment. Vyleesi has essentially replaced the only other drug for HSDD - however, it has a long list of drug-drug interactions, including commonly used antidepressants, such as fluoxetine and sertraline. In addition, it has a black box warning regarding its use with alcohol, a combination that has been associated with hypotension and syncopal episodes. Therefore, there is an urgent need for effective therapy against FSD and HSDD. Oncotelic's Cautionary Note on Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934 (the “Exchange Act”) that involve substantial risks and uncertainties. We generally identify forward-looking statements by terminology such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “would,” “intend,” “target,” “aim,” “project,” “believe,” “estimate,” “predict,” “potential,” “seek,” “indicate,” or “continue” or the negative of these terms or other similar words, although not all forward-looking statements contain these words. Forward-looking statements include, but are not limited to, statements regarding our or our management’s expectations, hopes, beliefs, intentions or strategies regarding the future, such as our estimates regarding anticipated operating income or losses, future performance, future revenues and projected expense, including that to fund our clinical and other development programs; our liquidity and our expectations regarding our needs for and ability to raise additional capital; our ability to continue as a going concern; our ability to select and capitalize on commercially desirable product opportunities as a result of limited financial resources; our ability to manage our expenses effectively and raise the funds needed to continue our business; our ability to retain the services of our current or future executive officers, directors and principal consultants; the competitive nature of our industry and the possibility that our products or product candidates may become obsolete or may not generate revenues as expected or at all; our ability to obtain and maintain regulatory approval of our existing products and any future products we may develop; the development of and the process of commercializing AI/Blockchain and other technologies for supporting the development of OT- 101 and Artemisinin for COVID-19, OT-101, including development of OT-101, Artemisinin, OXi4503, CA4P and our 2021 in-licensing of apomorphine; the initiation, timing, progress and results of our preclinical and clinical trials, research and development programs; regulatory and legislative developments in the United States and foreign countries; the timing, costs and other limitations involved in obtaining regulatory approval for any product; the further preclinical or clinical development and commercialization of our product candidates; the entering into any corporate transactions to develop our products through partnerships, joint ventures or other corporate transactions; our ability to make a proposed initial public offering between us and our joint-venture partners for the joint venture, statements about future plans related to the operations of the JV, taking the JV into an initial public offering or the success thereof: building and the success of our nanoparticle platform and the related success of launching the platform; the expected valuation of the JV, and therefore a corresponding increase in the valuation of the Company, by virtue of it’s ownership in the JV; the success of the launch of Pet2DAO, a corporation with a DAO infrastructure, the success of Pet2DAO and the plans surrounding the pet and animal health, the ability for the Company to register the tokens of Pet2DAO, the actual filing of a registration statement and approval of the tokens as registrable securities with the Securities and Exchange Commission (“SEC”) through a registration statement, the ability of the tokens to be tradable or any value such tokens may have if they become tradable; our ability to obtain and maintain orphan drug exclusivity for some of our product candidates; the potential benefits of our product candidates over other therapies; our ability to enter into and maintain any collaboration with respect to product candidates; our ability to continue to develop or commercialize our products or product candidates in the event any license agreements in place with third parties expire or are terminated; the performance and conduct of third parties, including our third-party manufacturers and third party service providers used in our clinical trials; our ability to obtain and maintain intellectual property protection for our products and operate our business without infringing upon the intellectual property rights of others; the potential liability exposure related to our products and our insurance coverage for such exposure; our ability to form alliances with other third parties to develop the products in our pipeline through partnerships, joint ventures, mergers or acquisitions; the successful development of our sales and marketing capabilities; the size and growth of the potential markets for our products and our ability to serve those markets; the rate and degree of market acceptance of any future products; the volatility of the price of our common stock; the ability to achieve secondary trading of our stock in certain states; the dilutive effects of potential future equity issuances; our expectation that no dividends will be declared on our common stock in the foreseeable future; our ability to maintain an effective system of internal controls; the payment and reimbursement methods used by private or governmental third-party payers; our ability to retain adequate staffing levels; unfavorable global economic conditions; unfavorable global epidemic and pandemic conditions; a failure of our internal computer systems or those of our contractors and consultants; potential misconduct or other improper activities by our employees, contractors or consultants; the ability of our business continuity and disaster recovery plans to protect us in the event of a natural disaster; and other factors discussed elsewhere in this document or any document incorporated by reference herein or therein. Contact Information:For Oncotelic Therapeutics, Inc.:Investor Relationsir@oncotelic.com

AcquisitionDrug Approval

04 Dec 2025

·www.globenewswire.com

Oncotelic and Sapu Nano Announce DeciparticleTM Led Biomarker Framework Identifying Tumors Most Likely to Respond to IV Sapu003, an Intravenous Everolimus Nanomedicine

AGOURA HILLS, Calif., Dec. 04, 2025 (GLOBE NEWSWIRE) -- Oncotelic Therapeutics, Inc. (OTCQB: OTLC) 45% owned Joint Venture, Sapu Nano today announced new biomarker data identifying a molecular signature that predicts sensitivity to Sapu003, the company’s intravenous Deciparticle™ formulation of everolimus. These data will be presented at the 2025 San Antonio Breast Cancer Symposium (SABCS) Dec 9-12. This work describes the first prospective biomarker framework for intravenous everolimus and establishes a foundation for mTOR therapy targeted to the patient populations most likely to benefit. The analysis, which evaluated more than 9,000 patient tumor samples across 20 cancer types, revealed that tumors exhibiting a High-RICTOR / Low-RPTOR gene-expression pattern show a significantly greater dependency on mTOR signaling and are therefore, more likely to respond to potent mTOR inhibition delivered by IV Sapu003. High-RICTOR / Low-RPTOR Signature Identifies Patients Most Likely to Benefit The biomarker analysis demonstrated that: Tumors with elevated RICTOR (mTORC2 activation) and suppressed RPTOR (limited mTORC1 scaffolding) show heightened reliance on mTORC2-AKT survival signaling.These tumors exhibit increased glycolytic flux, elevated metabolic stress markers, and reduced compensatory feedback, making them vulnerable to systemically distributed everolimus.This phenotype/genotype was strongly enriched in: HR+/HER2- breast cancerLung adenocarcinomaGastric cancerRenal cell carcinomaOvarian cancerAML and T-cell malignancies Across multiple datasets, patients with this signature had significantly worse survival with standard therapy, but showed predicted sensitivity to Sapu003. Why IV Sapu003 Unlocks Biomarker-Driven mTOR Therapy Oral everolimus is limited by: Low and variable bioavailabilityHigh GI accumulationmTORC1-biased inhibitionLack of biomarker selection Sapu003 overcomes these barriers by delivering: 67× lower GI accumulationHigh tissue penetration into metabolically active tumorsUnchanged intrinsic metabolism, preserving pharmacologic specificity This enables, for the first time, biomarker-enriched patient selection for an mTOR inhibitor. Management Commentary “Up to now mTOR inhibitor therapy has lacked an empirical patient selection strategy beyond tumor type,” said Dr. Seymour Fein, Chief Medical Officer of Sapu Nano. “The High-RICTOR/Low-RPTOR signature gives us, for the first time, a molecular map of which patients are most likely to benefit. The potential for targeting a more sensitive patient population combined with the consistent pharmacokinetic profile of Sapu003 administered intravenously creates an entirely new therapeutic opportunity for mTOR-driven cancers.” About the Biomarker Discovery Approach The SABCS analysis integrated: 9,000+ TCGA and MET500 tumor transcriptomesmTOR pathway co-expression networksMetabolic clustering of glycolysis-addicted tumorsSurvival modeling across multiple cancer typesPredictive modeling of everolimus pathway dependency This systems-biology approach allowed identification of mTORC2-dominant tumors that would be poorly targeted by oral everolimus but potentially responsive to IV Sapu003. About Sapu003 Sapu003 is a novel intravenous nanoparticle formulation of everolimus engineered using Sapu Nano’s proprietary Deciparticle™ technology. It is designed to overcome the poor bioavailability, intestinal toxicity, and variable patient exposure seen with oral everolimus while enabling reliable, predictable weekly IV dosing. About the Deciparticle™ Platform The Deciparticle™ platform is a proprietary nanotechnology engineered to encapsulate hydrophobic molecules as uniform, sub-20 nm nanoparticles for intravenous administration. The platform improves systemic exposure, reduces GI deposition, and supports precision delivery while maintaining manufacturability at clinical scale. About Sapu Nano Sapu Nano is a clinical-stage biotechnology company developing Deciparticle™ nanomedicine therapeutics designed to optimize the delivery of hydrophobic oncology agents and peptide-based therapeutics. The company operates an integrated ISO-5 cGMP manufacturing facility supporting rapid progression from formulation to clinical trial supply. For more information, visit www.sapunano.com. About Oncotelic Oncotelic (f/k/a Mateon Therapeutics, Inc.), was formed in the State of New York in 1988 as OXiGENE, Inc., was reincorporated in the State of Delaware in 1992, and changed its name to Mateon Therapeutics, Inc. in 2016, and Oncotelic Therapeutics, Inc. in November 2020. Oncotelic is seeking to leverage its deep expertise in oncology drug development to improve treatment outcomes and survival of cancer patients with a special emphasis on rare pediatric cancers. Oncotelic has rare pediatric designation for Diffuse Intrinsic Pontine Glioma “DIPG” (through OT-101) through its 45% joint venture, melanoma (through CA4P), and Acute Myeloid Leukemia “AML” (through OXi 4503). Oncotelic also acquired PointR Data Inc. in November 2019. Oncotelic acquired AL-101, during the 4th quarter of 2021, for the intranasal delivery of apomorphine. We intend to develop AL-101 for the treatment of Parkinson Disease ("PD"). Over 60,000 new patients are being diagnosed with PD in the United States and currently there are over 1 million patients in the US and expected to increase to over 1.2 million by 2030. In addition, approximately 10 million suffer from this disease globally. https://www.parkinson.org/Understanding-Parkinsons/Statistics. AL-101 is also being developed for Erectile Dysfunction ("ED"). ED is the most prevalent male sexual disorder globally. The percentages of men affected by ED are as follows: 14.3-70% of men aged 60 years, 6.7-48% of men aged 70 years, and 38% of men aged 80 years (Geerkens MJM et al. (2019). Eur Urol Focus. pii: S2405-4569(19)30079-3). However, with the increasing administration of PDE5 inhibitors in clinical practice, it was found that approximately 30-35% of ED patients are treatment failures (McMahon CN et al. (2006). BMJ, 332: 589-92). AL-101 is designed to target treatment failure ED patients who do not respond to PDE5 inhibitors. Through similar mechanism of action, AL-101 is being developed for Female Sexual Dysfunction ("FSD"). Female sexual dysfunction is a prevalent problem, afflicting approximately 40% of women and there are few treatment options. FSD is more typical as women age and is a progressive and widespread condition. (Allahdadi, KJ et al. (2009) Cardiovascular & hematological agents in medicinal chemistry, 7(4), 260-269). There is no available drug for the treatment of FSD. In June 2019, the U.S. Food and Drug Administration approved Vyleesi (bremelanotide) to treat acquired, generalized hypoactive sexual desire disorder ("HSDD") in premenopausal women. This is the only available drug treatment. Vyleesi has essentially replaced the only other drug for HSDD - however, it has a long list of drug-drug interactions, including commonly used antidepressants, such as fluoxetine and sertraline. In addition, it has a black box warning regarding its use with alcohol, a combination that has been associated with hypotension and syncopal episodes. Therefore, there is an urgent need for effective therapy against FSD and HSDD. Oncotelic's Cautionary Note on Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934 (the “Exchange Act”) that involve substantial risks and uncertainties. We generally identify forward-looking statements by terminology such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “would,” “intend,” “target,” “aim,” “project,” “believe,” “estimate,” “predict,” “potential,” “seek,” “indicate,” or “continue” or the negative of these terms or other similar words, although not all forward-looking statements contain these words. Forward-looking statements include, but are not limited to, statements regarding our or our management’s expectations, hopes, beliefs, intentions or strategies regarding the future, such as our estimates regarding anticipated operating income or losses, future performance, future revenues and projected expense, including that to fund our clinical and other development programs; our liquidity and our expectations regarding our needs for and ability to raise additional capital; our ability to continue as a going concern; our ability to select and capitalize on commercially desirable product opportunities as a result of limited financial resources; our ability to manage our expenses effectively and raise the funds needed to continue our business; our ability to retain the services of our current or future executive officers, directors and principal consultants; the competitive nature of our industry and the possibility that our products or product candidates may become obsolete or may not generate revenues as expected or at all; our ability to obtain and maintain regulatory approval of our existing products and any future products we may develop; the development of and the process of commercializing AI/Blockchain and other technologies for supporting the development of OT- 101 and Artemisinin for COVID-19, OT-101, including development of OT-101, Artemisinin, OXi4503, CA4P and our 2021 in-licensing of apomorphine; the initiation, timing, progress and results of our preclinical and clinical trials, research and development programs; regulatory and legislative developments in the United States and foreign countries; the timing, costs and other limitations involved in obtaining regulatory approval for any product; the further preclinical or clinical development and commercialization of our product candidates; the entering into any corporate transactions to develop our products through partnerships, joint ventures or other corporate transactions; our ability to make a proposed initial public offering between us and our joint-venture partners for the joint venture, statements about future plans related to the operations of the JV, taking the JV into an initial public offering or the success thereof: building and the success of our nanoparticle platform and the related success of launching the platform; the expected valuation of the JV, and therefore a corresponding increase in the valuation of the Company, by virtue of it’s ownership in the JV; the success of the launch of Pet2DAO, a corporation with a DAO infrastructure, the success of Pet2DAO and the plans surrounding the pet and animal health, the ability for the Company to register the tokens of Pet2DAO, the actual filing of a registration statement and approval of the tokens as registrable securities with the Securities and Exchange Commission (“SEC”) through a registration statement, the ability of the tokens to be tradable or any value such tokens may have if they become tradable; our ability to obtain and maintain orphan drug exclusivity for some of our product candidates; the potential benefits of our product candidates over other therapies; our ability to enter into and maintain any collaboration with respect to product candidates; our ability to continue to develop or commercialize our products or product candidates in the event any license agreements in place with third parties expire or are terminated; the performance and conduct of third parties, including our third-party manufacturers and third party service providers used in our clinical trials; our ability to obtain and maintain intellectual property protection for our products and operate our business without infringing upon the intellectual property rights of others; the potential liability exposure related to our products and our insurance coverage for such exposure; our ability to form alliances with other third parties to develop the products in our pipeline through partnerships, joint ventures, mergers or acquisitions; the successful development of our sales and marketing capabilities; the size and growth of the potential markets for our products and our ability to serve those markets; the rate and degree of market acceptance of any future products; the volatility of the price of our common stock; the ability to achieve secondary trading of our stock in certain states; the dilutive effects of potential future equity issuances; our expectation that no dividends will be declared on our common stock in the foreseeable future; our ability to maintain an effective system of internal controls; the payment and reimbursement methods used by private or governmental third-party payers; our ability to retain adequate staffing levels; unfavorable global economic conditions; unfavorable global epidemic and pandemic conditions; a failure of our internal computer systems or those of our contractors and consultants; potential misconduct or other improper activities by our employees, contractors or consultants; the ability of our business continuity and disaster recovery plans to protect us in the event of a natural disaster; and other factors discussed elsewhere in this document or any document incorporated by reference herein or therein. Contact Information:For Oncotelic Therapeutics, Inc.:Investor Relationsir@oncotelic.com

AcquisitionDrug Approval

100 Deals associated with Disodium combretastatin A-4 3-O-Phosphate

External Link

KEGG	Wiki	ATC	Drug Bank
-	Disodium combretastatin A-4 3-O-Phosphate	-	DB12577

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Ovarian Cancer	Phase 3	United States	Oncotelic Therapeutics, Inc.	01 Jun 2016
Ovarian Cancer	Phase 3	Belgium	Oncotelic Therapeutics, Inc.	01 Jun 2016
Ovarian Cancer	Phase 3	Germany	Oncotelic Therapeutics, Inc.	01 Jun 2016
Anaplastic Thyroid Carcinoma	Phase 3	United States	Oncotelic Therapeutics, Inc.	01 Aug 2007
Anaplastic Thyroid Carcinoma	Phase 3	Israel	Oncotelic Therapeutics, Inc.	01 Aug 2007
Anaplastic Thyroid Carcinoma	Phase 3	Italy	Oncotelic Therapeutics, Inc.	01 Aug 2007
Anaplastic Thyroid Carcinoma	Phase 3	Russia	Oncotelic Therapeutics, Inc.	01 Aug 2007
Anaplastic Thyroid Carcinoma	Phase 3	United Kingdom	Oncotelic Therapeutics, Inc.	01 Aug 2007
Fallopian Tube Carcinoma	Phase 3	-	Azanta A/S	-
Gastric Neuroendocrine Tumor	Phase 2	United States	Oncotelic Therapeutics, Inc.	01 Dec 2014

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02055690 (PAZOFOS, Pubmed \| Obstet Gynecol Surv \| Gynecol Oncol) Manual	Phase 2	Recurrent ovarian cancer	21	Pazopanib+Fosbretabulin	uutdaepiuv(mzvlkzoidv) = vhvoaohzcc zadfipwies (zecuibmfba, 4.1 - NE)	Positive	01 Mar 2020
				Pazopanib	uutdaepiuv(mzvlkzoidv) = vnmyfzhfhs zadfipwies (zecuibmfba, 1.0 - 8.1)
NCT02279602 (OX4219 \| OX4219s, Corporate Publications) Manual	Phase 2	Neuroendocrine Tumors \| Gastrointestinal Neoplasms	7	Disodium combretastatin A-4 3-O-Phosphate	zadxommkqw(mxdgsuxaqh) = anemia, abdominal pain, fatigue, hypertension, and ALT and AST increases sczcnbgjjb (gkjxpguejt ) View more	Positive	20 Jan 2017
NCT00653939 (FALCON, CTgov)	Phase 2	Squamous non-small cell lung cancer	63	Carboplatin+Paclitaxel+Bevacizumab (Arm 1: Chemotherapy+Bevacizumab)	trwllhgdis(prbfcontnx) = ogkinaquba euonjswcka (jdkzbccuyq, diupgykedo - weobnfegnf) View more	-	09 Feb 2015
				Carboplatin+Paclitaxel+Bevacizumab+Fosbretabulin (Arm 2: Active Comparator+Fosbretabulin)	trwllhgdis(prbfcontnx) = mgsufghwhe euonjswcka (jdkzbccuyq, walywhhhan - aaxywziccg) View more
NCT00507429 (FACT, CTgov)	Phase 2/3	Anaplastic Thyroid Carcinoma	80	Carboplatin+Paclitaxel+CA4P (Arm 1, Active: CA4P + Carboplatin + Paclitaxel)	pqhjeykoyk(bedbucykew) = iblkrmbekf noerflagdn (svpzqjnwje, gabodjdiga - ffhmfjsola) View more	-	09 Jun 2014
				Carboplatin+Paclitaxel (Arm 2, Comparator: Carboplatin + Paclitaxel)	pqhjeykoyk(bedbucykew) = uhlbtembza noerflagdn (svpzqjnwje, ohmiskyhly - bmvrgorfrf) View more
NCT01570790 (Pubmed \| BMC Pharmacol Toxicol)	Phase 1/2	Wet age-related macular degeneration	8	CA4P at a dose of 27 mg/m2	ubunbxdjqc(oeeujezmag) = rvllkvsirp rbxpyowmus (aeeaeczsqw ) View more	-	14 Jan 2013
				CA4P at a dose of 36 mg/m2	ubunbxdjqc(oeeujezmag) = kvuhunrktx rbxpyowmus (aeeaeczsqw ) View more
NCT00507429 (FACT, ASCO2011)	Phase 2/3	Anaplastic Thyroid Carcinoma	80	CA4P + Carboplatin + Paclitaxel	thxnyeiozc(iensaobqxu) = tnrciuhcid idtubqpgth (zndlhrrhlf ) View more	Positive	20 May 2011
				Carboplatin + Paclitaxel	thxnyeiozc(iensaobqxu) = wlujmasfyn idtubqpgth (zndlhrrhlf ) View more
NCT00653939 (FALCON, ASCO2011)	Phase 2	Non-Small Cell Lung Cancer	63	CA4P + carboplatin + paclitaxel + bevacizumab	lwzlkxdewq(jifvrtbgvr) = more common on the CA4P Arm qabjivzgxi (iayltoccqd ) View more	-	20 May 2011
				carboplatin + paclitaxel + bevacizumab
NCT00653939 (FALCON, ASCO2010)	Phase 2	Non-Small Cell Lung Cancer	50	CA4P + C + P + B	xhbnzwrobk(tnslonlivu) = wyensbyajt reirviqnjm (wxrzsnhzwl ) View more	Positive	20 May 2010
				C + P + B	xhbnzwrobk(tnslonlivu) = scbezrsfqu reirviqnjm (wxrzsnhzwl ) View more
NCT00060242 (Phase II Trial of Fosbretabulin, Pubmed \| Thyroid)	Phase 2	Anaplastic Thyroid Carcinoma	26	Fosbretabulin 45 mg/m(2)	aojwdxytlw(zgnfngiqmb) = wqjplvfvzt cacxcxlpyz (euwyxtkeln ) View more	-	01 Mar 2009
ASCO2008 Manual	Phase 1	Advanced Malignant Solid Neoplasm	-	Combretastatin A4 phosphate (CA4P) 45mg/m2	aibejmvhvv(wmbajbpscy) = xxxkcazhgd brugmiodju (ftzosdltzl )	Positive	20 May 2008
				Combretastatin A4 phosphate (CA4P) 54mg/m2	aibejmvhvv(wmbajbpscy) = kwjmrbkwnu brugmiodju (ftzosdltzl )

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis