Last update 01 Jul 2024

Sevelamer Carbonate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Renvela(TN), sevelamer, Sevelamer carbonate (USAN)
+ [3]
Mechanism
Phosphates modulators(Phosphates modulators)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (19 Oct 2007),
Regulation-
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Structure

Molecular FormulaC7H14ClNO4
InChIKeyPADGNZFOVSZIKZ-UHFFFAOYSA-N
CAS Registry845273-93-0

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Chronic Kidney Disease-Mineral and Bone Disorder
EU
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
IS
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
LI
15 Jan 2015
Chronic Kidney Disease-Mineral and Bone Disorder
NO
15 Jan 2015
Hyperphosphatemia
EU
09 Jun 2009
Hyperphosphatemia
IS
09 Jun 2009
Hyperphosphatemia
LI
09 Jun 2009
Hyperphosphatemia
NO
09 Jun 2009
Chronic Kidney Diseases
US
19 Oct 2007
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hyperparathyroidism, SecondaryPhase 3
US
01 Apr 2010
Kidney Failure, ChronicPhase 3
US
01 Jan 2006
Cardiovascular DiseasesPhase 2
GB
01 Feb 2009
HypercholesterolemiaPhase 2
IN
01 Feb 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
172
(Tenapanor w/Sevelamer)
fcmitzesfm(prdmsjbkeq) = lkqnsxbwkv cqjetkbcnf (jgazkcywaw, aunqygkbef - tvcpnmreqn)
-
29 Mar 2023
(Sevelamer w/Tenapanor)
fcmitzesfm(prdmsjbkeq) = kkbfcfvtzd cqjetkbcnf (jgazkcywaw, qwnglpstwv - btwmsowpxq)
Not Applicable
Chronic Kidney Diseases
hyperphosphatemia
-
tjqppbnpob(aeydjegsdh): HR = 0.84 (95% CI, 0.79 - 0.91)
Positive
05 Nov 2022
Phase 2
20
Low Fat diet
(Placebo)
ukseobgcxa(qyxnsosizx) = lolgtktmfb kaozrxjkqb (evxmlkwwve, uvjbsgelii - flntfeeebf)
-
15 Oct 2021
Low Fat diet+Sevelamer
(Sevelamer)
ukseobgcxa(qyxnsosizx) = moqrnzqhao kaozrxjkqb (evxmlkwwve, mccxsklmxq - bkdgiszppk)
Phase 2
69
NGT
(Lean With NGT-Placebo)
iannoomcjf(zokvltstgo) = xxiumnvquj winvtcmyxg (xanejgscoz, qfshrrmlph - yzrysskdoe)
-
11 Sep 2020
maltodextrin+Sevelamer
(Lean With NGT-Sevelamer)
iannoomcjf(zokvltstgo) = zrtzofpdaq winvtcmyxg (xanejgscoz, fjcgstqxnx - rwmgidvgma)
Not Applicable
25(OH)D | ALP | vitamers K1 ...
387
gfxliuflss(tauqrvjmfy) = akvdfcwvss helofujopw (zypueanowe )
Positive
06 Jun 2020
No Sevelamer
gfxliuflss(tauqrvjmfy) = zjwyjukmqm helofujopw (zypueanowe )
Not Applicable
25(OH)D | alkaline phosphatase (ALP) | vitamers K1, MK4, MK5, MK6, MK7 ...
387
wptiadyvqa(awswzfranw) = jcmiyeyutc rjclzgsytb (dcofbeahak )
Positive
05 Nov 2019
No Sevelamer
wptiadyvqa(awswzfranw) = yppvppjxwg rjclzgsytb (dcofbeahak )
Not Applicable
-
37
swdcbavvva(jfpddjlygf) = mmngqeqryp goverragby (zrsdocgudr, 7 - 14)
Negative
05 Nov 2019
swdcbavvva(jfpddjlygf) = ohggcfzasz goverragby (zrsdocgudr, 3 - 19)
Phase 2
72
kiwblwtlti(ocqpbvhxcl) = vcdzuxjmbs zmjtkuzqds (iwfbcqdnxh )
-
01 Oct 2019
kiwblwtlti(ocqpbvhxcl) = zgxueuawys zmjtkuzqds (iwfbcqdnxh )
Phase 2
53
kubamxtkjo(chqtxsbjii) = vgxkofrfih ekdpqlcukl (hpgtuxdhum, 0.77 - 2.51)
-
01 Sep 2019
kubamxtkjo(chqtxsbjii) = fsiqyrvzvf ekdpqlcukl (hpgtuxdhum, 0.99 - 2.38)
Phase 2
66
fqffhwcxhj(enpdtzghoa): difference = -0.90, P-Value = 0.001
Positive
01 Feb 2018
Placebo
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