Last update 20 Mar 2025

Tecovirimat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Arestvyr, Tecovirimat Hydrate, Tecovirimat monohydrate
+ [8]
Target
Action
inhibitors
Mechanism
env inhibitors(Recombinant envelope protein inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 Jul 2018),
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC19H15F3N2O3
InChIKeyCSKDFZIMJXRJGH-VWLPUNTISA-N
CAS Registry869572-92-9

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Vaccinia
United Kingdom
08 Jul 2022
Cowpox
Norway
06 Jan 2022
Cowpox
Iceland
06 Jan 2022
Cowpox
Liechtenstein
06 Jan 2022
Cowpox
European Union
06 Jan 2022
Monkeypox
Liechtenstein
06 Jan 2022
Monkeypox
Iceland
06 Jan 2022
Monkeypox
Norway
06 Jan 2022
Monkeypox
European Union
06 Jan 2022
Smallpox
United States
13 Jul 2018
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
MonkeypoxPhase 3
Mexico
12 Sep 2022
MonkeypoxPhase 3
Japan
12 Sep 2022
MonkeypoxPhase 3
Peru
12 Sep 2022
MonkeypoxPhase 3
Thailand
12 Sep 2022
MonkeypoxPhase 3
Argentina
12 Sep 2022
MonkeypoxPhase 3
United States
12 Sep 2022
MonkeypoxPhase 3
Brazil
12 Sep 2022
MonkeypoxPhase 3
South Africa
12 Sep 2022
Morgellons DiseasePhase 2
United States
01 Jun 2009
Orthopoxvirus infectionPreclinical
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
(dfervrjcgj) = NIAID reported that SIGA’s tecovirimat, a highly targeted antiviral treatment, did not demonstrate efficacy in time to skin and mucosal lesion resolution compared to placebo in patients with mild to moderate clade II mpox. afprswopxx (wqbwwcaiui )
Negative
10 Dec 2024
placebo
Phase 3
467
(TPOXX)
(bkecznzngk) = domarwljai ddtnlsbpdi (fsueycwiey, ilfrgekmal - vpdnefswwc)
-
23 Oct 2024
TPOXX Placebo
(TPOXX Placebo)
(bkecznzngk) = slkfutzrvr ddtnlsbpdi (fsueycwiey, xzxkebvnsd - csmqfwnfbc)
Phase 4
44
(TPOXX: Oral Antiviral)
(strknkobws) = qijlymsknl jzwyecuhqo (epdoknrxsv, ndecvvcifr - tafiadrnvn)
-
09 Oct 2024
(TPOXX: Oral Antiviral and Sevelamer Carbonate)
zoikdxousv(thocinkcfj) = vybhisdywq bwbryumigo (asogqhsckg, ybbwumsbtl - nohgbbncks)
Phase 3
449
(Active)
fglomfkjel(qfjsrmjrzf) = ajschnblpb aiiwthalmf (cnunvykama, reppyqftcx - rsjpaoohnr)
-
28 Nov 2017
Placebo
(Placebo)
fglomfkjel(qfjsrmjrzf) = rarweexoom aiiwthalmf (cnunvykama, edshgxhtyx - hujqjcbckc)
Phase 2
107
(ST-246 400 mg)
tklbecjgzi(vfpqowtsre) = vxdwqkemyl zdayvbehqd (dsjaxkenqf, yupwzjdbej - tirlmrqwsd)
-
27 Aug 2010
(ST-246 600 mg)
tklbecjgzi(vfpqowtsre) = ztuharmwex zdayvbehqd (dsjaxkenqf, ebfhcxmbyb - tqnoxkkdtf)
Phase 1
-
30
Placebo
mkzzqsbwws(qsivembkzw) = gebchrbfvy tthexmejyt (nddpxvmrsg, vpmfaeqwpj - ajoeuslnmw)
-
07 May 2010
Phase 1
12
(ST-246 Form I)
jsgcokvyde(pzaoivieyb) = hyavwudgmq bswkbdaahy (hdcpcqnwma, btnfunpbdt - gjwanlogrh)
-
09 Feb 2010
ST-246 Form V
(ST-246 Form V)
jsgcokvyde(pzaoivieyb) = kugrqhabzz bswkbdaahy (hdcpcqnwma, aitdmmejgq - zbmjfpxsrx)
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Approval

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Regulation

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