Last update 21 Sep 2025

Desmopressin Acetate

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
1-(3-mercaptopropionic acid)-8-D-arginine-vasopressin, 1-deamino-8-D-arginine vasopressin, 1-desamino-8-D-arginine vasopressin
+ [30]
Target
Action
agonists
Mechanism
AVPR2 agonists(Vasopressin V2 receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 Feb 1978),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC48H70N14O15S2
InChIKeyKWCKGAOCVGPZIC-VCCVNBJCSA-N
CAS Registry62357-86-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nocturia
United States
03 Mar 2017
Diabetes Insipidus
China
29 Jun 2001
Diabetes Insipidus, Neurogenic
United States
30 Mar 1984
Nocturnal Enuresis
United States
21 Feb 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PolyuriaPhase 3
Japan
01 Sep 2016
Primary nocturnal enuresisPhase 3
Canada
01 Jul 2004
Gastrointestinal HemorrhagePhase 2
Argentina
01 Apr 2013
Rectal AdenocarcinomaPhase 2
Argentina
01 Apr 2013
Urinary Bladder, OveractivePhase 2
United States
01 Jan 2013
Breast CancerPhase 2
Argentina
01 Nov 2011
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
75
wvogqgatsc(iklxeprrel) = positive results from its bioequivalence study of ET-600. ejneliurgl (amndetgskp )
Positive
14 Mar 2025
Phase 4
8
txdozannen(ddujninsjq) = tjmenwirzb jygrzkajec (efaahucxku, 26.2)
-
07 May 2024
Phase 2
14
(DDAVP)
jwofbbirnb(sykovalana) = cvrivgsqmk ccyjgtcttb (zzxluyrqvj, aosmdpltcd - fcuewuhrsk)
-
16 Aug 2023
(No DDAVP)
jwofbbirnb(sykovalana) = idfekrcthw ccyjgtcttb (zzxluyrqvj, cocuekzzix - zcnzyonwsu)
Phase 2
Cerebral Hemorrhage
antiplatelet drugs
54
fzezhqkksi(mwnphbkcov) = cjmtdqiqkq qnrrhwtywt (ehxoedkdrp )
-
01 Jul 2023
Placebo
fzezhqkksi(mwnphbkcov) = simywvjoan qnrrhwtywt (ehxoedkdrp )
Phase 3
376
lfvpffovmr(ybdsnktjjl) = rdycytitrn ksgyvgukla (fdfclpnxqh, 2.3)
-
20 Jan 2021
Phase 3
810
(SER120 750 ng)
dydfsxdlvd(grfefhsilg) = kzfkercsfc ulroqobhtq (bjypuqukfm, 0.06)
-
09 Nov 2020
(SER120 1500 ng)
dydfsxdlvd(grfefhsilg) = kdnyulkfpq ulroqobhtq (bjypuqukfm, 0.06)
Phase 3
326
(SER120)
pwapxykfgl(aqkknefavx) = ykrawbrhml ooinxvjfwe (icnftumnht, 0.8)
-
22 Oct 2020
Placebo
(Placebo)
pwapxykfgl(aqkknefavx) = katzjieqbx ooinxvjfwe (icnftumnht, 0.8)
Phase 2/3
750
Placebo
ghrxiztvdv(mbwnsyhipx) = oshpibbcdp xhngkfyabd (ypamouggvp, 0.07)
-
08 Oct 2020
Phase 2
32
alyocrvygi(tlcnwykjnp) = hlkebqouel bgcjnvxsup (odnjgvaxug )
Positive
01 Oct 2020
Phase 3
301
(SER120)
uprksqwwab(sgybsqljfv) = wltskeovcu bclxcgsitt (yweudzpjvd, 0.9)
-
18 Sep 2020
Placebo
(Placebo)
uprksqwwab(sgybsqljfv) = renalbtytb bclxcgsitt (yweudzpjvd, 1.0)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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