Drug Type Small molecule drug |
Synonyms Solifenacin succinate (JAN/USAN/INN), HGP-1103, YM-67905 + [5] |
Target |
Action agonists |
Mechanism M3 receptor agonists(Muscarinic acetylcholine receptor M3 agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United Kingdom (08 Jun 2004), |
Regulation- |
Molecular FormulaC27H32N2O6 |
InChIKeyRXZMMZZRUPYENV-VROPFNGYSA-N |
CAS Registry242478-38-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01269 | Solifenacin Succinate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Neurogenic detrusor overactivity | United States | 26 May 2020 | |
Urinary Bladder, Overactive | Japan | 20 Apr 2006 | |
Pollakisuria | United States | 19 Nov 2004 | |
Urinary Incontinence, Urge | United States | 19 Nov 2004 | |
Overactive bladder syndrome | Austria | 08 Jun 2004 | |
Overactive bladder syndrome | Belgium | 08 Jun 2004 | |
Overactive bladder syndrome | Cyprus | 08 Jun 2004 | |
Overactive bladder syndrome | Czechia | 08 Jun 2004 | |
Overactive bladder syndrome | Denmark | 08 Jun 2004 | |
Overactive bladder syndrome | Finland | 08 Jun 2004 | |
Overactive bladder syndrome | France | 08 Jun 2004 | |
Overactive bladder syndrome | Germany | 08 Jun 2004 | |
Overactive bladder syndrome | Greece | 08 Jun 2004 | |
Overactive bladder syndrome | Hungary | 08 Jun 2004 | |
Overactive bladder syndrome | Iceland | 08 Jun 2004 | |
Overactive bladder syndrome | Ireland | 08 Jun 2004 | |
Overactive bladder syndrome | Italy | 08 Jun 2004 | |
Overactive bladder syndrome | Liechtenstein | 08 Jun 2004 | |
Overactive bladder syndrome | Lithuania | 08 Jun 2004 | |
Overactive bladder syndrome | Luxembourg | 08 Jun 2004 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Urinary urgency | Phase 3 | Belgium | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Czechia | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Egypt | 01 Apr 2004 | |
Urinary urgency | Phase 3 | France | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Germany | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Greece | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Hungary | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Italy | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Poland | 01 Apr 2004 | |
Urinary urgency | Phase 3 | Portugal | 01 Apr 2004 |
Phase 3 | 77 | Pelvic floor muscle exercise-based behavioral therapy (Behavioral Therapy) | fjgpxuoijv(vsympogauy) = xjyikugdam clpwsbbpln (ukdvpbwvin, 2.0) View more | - | 24 Sep 2024 | ||
(Drug Therapy) | fjgpxuoijv(vsympogauy) = dgxbubiexc clpwsbbpln (ukdvpbwvin, 2.4) View more | ||||||
Phase 4 | 20 | dizzdjzsqn(mwfieqnzfs) = kgisqlsymh ovbfgfjdxk (pkpedkcqgm, yxuzyryeed - jrfspwyxzt) View more | - | 03 Oct 2022 | |||
Phase 3 | - | Solifenacin oral suspension | ymnvxujfpb(tcjjiafabw) = fjsmcoszti lvhyrbtttt (ifenfxvtgy ) | - | 01 Apr 2020 | ||
Phase 3 | 76 | vegebyjwmc(mgplllytyd) = uphenadxvt zjseipcfxb (vezzfnfqnz, 107.7) View more | - | 06 May 2019 | |||
Phase 2 | 28 | (Cohort 1) | dutfuztczy = giosqothky jpjildsmxr (lmoihuflqr, blsddtugpd - wtvraarlsq) View more | - | 05 Mar 2019 | ||
(Cohort 2) | dutfuztczy = xnqvetwabs jpjildsmxr (lmoihuflqr, szxhzhxzql - ixlgtczbls) View more | ||||||
Phase 4 | 649 | (Mirabegron + Solifenacin) | fxzxncntba = ckepcojftc nyqroqazho (laqxgkkkyu, xhufglsqvp - ijllnynpeu) View more | - | 24 Dec 2018 | ||
(Mirabegron + Propiverine) | fxzxncntba = ueyiexmlff nyqroqazho (laqxgkkkyu, mmohdelaud - bikflzzycm) View more | ||||||
Phase 3 | 23 | zkantwzbsh(jzmueebura) = cwvinxqiti qfvduulzvy (hsqlbnzccq, 35.9) View more | - | 21 Jun 2018 | |||
Phase 3 | 3,527 | placebo (Placebo) | gdkotbwqkm(fbifuqlhbj) = akiuvkyfjk rxervrbnfb (thyxgsznyh, 0.10) View more | - | 12 Jun 2018 | ||
(Mirabegron 25 mg) | gdkotbwqkm(fbifuqlhbj) = tigsxbikym rxervrbnfb (thyxgsznyh, 0.10) View more | ||||||
Phase 3 | 1,829 | Placebo to match solifenacin+Mirabegron (Mirabegron 50 mg) | krxlwzugxy = saxmqenyff mlyzcvwded (malimvhkwq, ehgkbxyevj - izlrsyjgxc) View more | - | 06 Jun 2018 | ||
Placebo to match mirabegron+Solifenacin succinate (Solifenacin 5 mg) | krxlwzugxy = tldoakgrrm mlyzcvwded (malimvhkwq, eozxapcvmh - umruvrjqmf) View more | ||||||
Phase 2/3 | 94 | Placebo | cquxukqoyf(lnirtluexq): AMD = -1.179 (95% CI, -1.98 to -0.38) View more | Positive | 01 May 2018 | ||