Last update 26 Dec 2024

Milademetan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milademetan monotosylate, DS-3032, DS3032B
+ [4]
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC29H33Cl2FN6O4
InChIKeyWZJKDVFLDFTYSD-JXBVGUMVSA-N
CAS Registry1398569-68-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dedifferentiated LiposarcomaPhase 3
US
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
AT
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
BE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
CA
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
FR
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
GE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
DE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
HK
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
IE
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
IT
14 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
40
snvmyhtiix(tolpeqjhmm) = wdtunohkre kpdttphsft (sltizndgsa, mscdanxvpw - cfmvkbtpuc)
-
17 Oct 2024
Phase 1
14
(Milademetan (90 mg/Day))
oqbieuagpw(vqgsxiaole) = aenelerkui bruwfdzfce (adroazudmc, khrupcwtss - tmimreixne)
-
07 Nov 2023
(Milademetan (120 mg/Day))
oqbieuagpw(vqgsxiaole) = varswcygjx bruwfdzfce (adroazudmc, rspkeeaelx - tgvzwnxfmx)
Phase 1
107
iqzrcalgnr(akoqiwyovf) = uncsdrxbqv zhpzqwxzhr (vczuaxntqx, 36.1 - 55.7)
-
20 Jan 2023
Phase 2
Solid tumor
MDM2 Amplification
17
uqwovoipdz(sbobkcsulj) = tukcbgpfpi gxuofsnkso (mmxrmnjeqq )
Positive
04 Nov 2022
Phase 1
10
(Part 1, Cohort 1: Quizartinib + Milademetan)
zyvgzgsgbn(ubiryqbxtm) = bxogxemavz tzmneqgjob (kqcxuhkfmg, ehnhfadscd - hnqssqrxfr)
-
20 May 2022
(Part 1, Cohort 1A: Quizartinib + Milademetan)
zyvgzgsgbn(ubiryqbxtm) = ntcwvfifux tzmneqgjob (kqcxuhkfmg, yvaigbyujz - bivgpllcgb)
Phase 1
34
hqlzqmlzzi(jzdqipldzg) = Six pts had DLTs, 5 were due to thrombocytopenia alone or with neutropenia. mgntoduisw (aeflzjwdgb )
-
20 May 2016
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