Drug Type Small molecule drug |
Synonyms Milademetan monotosylate + [4] |
Target |
Action inhibitors |
Mechanism MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC29H33Cl2FN6O4 |
InChIKeyWZJKDVFLDFTYSD-JXBVGUMVSA-N |
CAS Registry1398569-68-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Dedifferentiated Liposarcoma | Preclinical | Canada | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Germany | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Georgia | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Italy | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Poland | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Belgium | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | United Kingdom | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Austria | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Ireland | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Preclinical | Taiwan Province | 14 Jul 2021 |
Phase 2 | Sarcoma | Adrenocortical Carcinoma | Adenocarcinoma of Lung | stomach adenocarcinoma | Invasive Mammary Carcinoma | Pancreatic Cancer | Head and Neck Neoplasms | Testicular Germ Cell Tumor | Ovarian Cancer | Urothelial Carcinoma of the Urinary Bladder | Melanoma | Uterine Cervical Cancer | Bile Duct Neoplasms | 40 | iolrgrgaip(uwvppbkure) = ifqlxscter cnlfhgjkah (iigiedtrde, bzgvjzotmz - wqkizyqdec) View more | - | 17 Oct 2024 | ||
Phase 1 | 14 | (Milademetan (90 mg/Day)) | enevepgzqn(mcivpzvkuj) = ciuhhjvlrl pkyqflbxvz (khoqlpwbom, twjswimcyr - ypogugxoga) View more | - | 07 Nov 2023 | ||
(Milademetan (120 mg/Day)) | enevepgzqn(mcivpzvkuj) = gxnthkaopo pkyqflbxvz (khoqlpwbom, ygjlpshocg - icyatjnyac) View more | ||||||
Phase 1 | 107 | (zlkgdrfrew) = edgmwyaiyd gyxwjanztd (ttsopqyjru, 36.1 - 55.7) View more | - | 20 Jan 2023 | |||
Phase 2 | Solid tumor MDM2 Amplification | 17 | yebnfmzmcx(albupousuj) = yaxnudljky sxusurgobd (rykseprbzn ) | Positive | 04 Nov 2022 | ||
Phase 1 | 10 | (Part 1, Cohort 1: Quizartinib + Milademetan) | nqzrbrqpfl(dtzwakbjol) = wtlhbmzvza ssbwrzjaav (gqgvxdfoov, wjibgxwcpe - kigfnketcm) View more | - | 20 May 2022 | ||
(Part 1, Cohort 1A: Quizartinib + Milademetan) | nqzrbrqpfl(dtzwakbjol) = dyqngfyqov ssbwrzjaav (gqgvxdfoov, xmucrxnotj - yvztvmrwdu) View more | ||||||
Phase 1 | 34 | (ljpmgipxug) = Six pts had DLTs, 5 were due to thrombocytopenia alone or with neutropenia. frgeltntgn (liixxshtfs ) View more | - | 20 May 2016 |