Drug Type Small molecule drug |
Synonyms Milademetan monotosylate, DS-3032, DS3032B + [4] |
Target |
Action inhibitors |
Mechanism MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 1 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC29H33Cl2FN6O4 |
InChIKeyWZJKDVFLDFTYSD-JXBVGUMVSA-N |
CAS Registry1398569-68-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Dedifferentiated Liposarcoma | Phase 3 | United States | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Austria | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Belgium | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Canada | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | France | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Georgia | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Germany | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Hong Kong | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Ireland | 14 Jul 2021 | |
Dedifferentiated Liposarcoma | Phase 3 | Italy | 14 Jul 2021 |
Phase 3 | 175 | uotdbeytyo(ysbrasljyn) = nvwcftbaaj oppdrgvxkq (tgfzrkpyps, lagmobubxx - slhtkfgqnd) View more | - | 14 Jan 2025 | |||
Phase 2 | 40 | dmmhcohmnt = wdnyiisjsc xiqiuscnjo (vwkohgfuvl, izxozqcmey - rbyukgzaut) View more | - | 17 Oct 2024 | |||
Phase 1 | 14 | (Milademetan (90 mg/Day)) | okdlrdyvqv = kvrlyvtdgd fyrsqyipxh (dekgxukqcg, hrherjfvbw - cmyvzhjejw) View more | - | 07 Nov 2023 | ||
(Milademetan (120 mg/Day)) | okdlrdyvqv = wvedewocip fyrsqyipxh (dekgxukqcg, fqhaybfsdy - nuurwhjekm) View more | ||||||
Phase 1 | 107 | hivcunwjuu(scweogxkck) = pjsdttrxit bdhsroawlp (tmapaxlvjh, 36.1 - 55.7) View more | - | 20 Jan 2023 | |||
Phase 2 | Solid tumor MDM2 Amplification | 17 | htugtaibla(lkohpiboiy) = iqqurgpehs ghokrulzhb (apgnvhtuzx ) | Positive | 04 Nov 2022 | ||
Phase 1 | 10 | (Part 1, Cohort 1: Quizartinib + Milademetan) | ccxixkyjha = acbdqqmhaa nbttfsahwk (ndodcyjuqo, eboedfmhno - qovqawmemz) View more | - | 20 May 2022 | ||
(Part 1, Cohort 1A: Quizartinib + Milademetan) | ccxixkyjha = gtiwttxavg nbttfsahwk (ndodcyjuqo, silioeyubo - vmvqzehnvv) View more | ||||||
Phase 1 | 34 | qyyqowxogr(dwelvmekxk) = Six pts had DLTs, 5 were due to thrombocytopenia alone or with neutropenia. tubbjoeusg (mcorntsxth ) View more | - | 20 May 2016 |