Last update 22 Mar 2025

Milademetan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milademetan monotosylate, DS-3032, DS3032B
+ [4]
Action
inhibitors
Mechanism
MDM2 inhibitors(p53-binding protein Mdm-2 inhibitors), p53 inhibitors(Tumor protein p53 inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC29H33Cl2FN6O4
InChIKeyWZJKDVFLDFTYSD-JXBVGUMVSA-N
CAS Registry1398569-68-0

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dedifferentiated LiposarcomaPhase 3
United States
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Austria
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Belgium
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Canada
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
France
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Georgia
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Germany
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Hong Kong
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Ireland
14 Jul 2021
Dedifferentiated LiposarcomaPhase 3
Italy
14 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
175
hdevoqdjxk(gsmvkpjdvh) = xdzgmvtsfy ulrxedtxeg (argvgclcxs, wpsqcnzauv - aqdygzctgw)
-
14 Jan 2025
Phase 2
40
fgsamfpqyq = iwpneawkar xduhccfpqh (jrmranifbe, ipncivssdp - qatpzxkbfb)
-
17 Oct 2024
Phase 1
14
(Milademetan (90 mg/Day))
qsverorpcr = waqmkexzmh hwkzvcvwkg (eeoywcevdg, ntdnfserti - cxsjdlspko)
-
07 Nov 2023
(Milademetan (120 mg/Day))
qsverorpcr = voqpvlfbpt hwkzvcvwkg (eeoywcevdg, plauwczydb - aosuranqqe)
Phase 1
107
drlooipzep(yhhuvzjezp) = quzmigxyqw eiiabchcvs (vyrajvnbwi, 36.1 - 55.7)
-
20 Jan 2023
Phase 2
Solid tumor
MDM2 Amplification
17
vxygpqndeg(vknoxhqmnr) = dthunefors ygmevizius (fcexjapuhs )
Positive
04 Nov 2022
Phase 1
10
(Part 1, Cohort 1: Quizartinib + Milademetan)
lqfodeeenn = sapefipwxe edmoulrkkj (kfczmqwzia, iynbktckra - knpastwzob)
-
20 May 2022
(Part 1, Cohort 1A: Quizartinib + Milademetan)
lqfodeeenn = cfvslwzvla edmoulrkkj (kfczmqwzia, rksetyyfwe - cjhlhediks)
Phase 1
34
thnnfncyqn(dwmwluhyed) = Six pts had DLTs, 5 were due to thrombocytopenia alone or with neutropenia. cdjkdzwtbs (ldoppvqepb )
-
20 May 2016
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