Trabectedin

James Christensen, Ph.D., and Nancy Whiting, Pharm.D., join Board of Directors George Demetri, M.D., to serve as first member of Clinical Advisory Board SAN DIEGO--(BUSINESS WIRE)-- Boundless Bio, a clinical stage, next-generation precision oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, today announced the appointment of two new members to its Board of Directors and the establishment of its Clinical Advisory Board. Industry veterans James (“Jamie”) Christensen, Ph.D., Chief Scientific Officer of Mirati Therapeutics, and Nancy Whiting, Pharm.D., Chief Executive Officer of Recludix Pharma, will join Boundless Bio’s Board of Directors. George Demetri, M.D., Director of the Sarcoma Center at the Dana-Farber Cancer Institute, will serve as the first member of the company’s Clinical Advisory Board. “We are thrilled to welcome these highly accomplished professionals who bring deep oncology drug development experience to Boundless Bio,” said Zachary Hornby, President and Chief Executive Officer of Boundless Bio. “Jamie and Nancy are incredibly valuable additions to our Board of Directors, having each led the discovery, development, and regulatory approvals of multiple approved cancer medicines. George is a world-renowned leader in the clinical translation of innovative treatment strategies for cancer, and his appointment establishes our Clinical Advisory Board. Together, their involvement and experience will prove invaluable as we continue to advance the Phase 1/2 clinical trial of BBI-355, progress additional ecDNA-directed therapeutic candidates (ecDTx) into the clinic, and initiate drug discovery programs arising from our Spyglass platform for identifying novel ecDNA targets." Appointment of Jamie Christensen, Ph.D., and Nancy Whiting, Pharm.D., to Board of Directors Dr. Jamie Christensen has served as the Chief Scientific Officer of Mirati Therapeutics, a publicly traded precision oncology company, since 2013 and is responsible for drug discovery, translational research, drug manufacturing, and companion diagnostics research. At Mirati, Dr. Christensen leads activities related to the discovery and advancement of the company’s clinical and preclinical programs, including Mirati’s first approved product, Krazati®(adagrasib). Prior to Mirati, Dr. Christensen was the Head of Oncology Precision Medicine and a member of the executive leadership team in the Oncology Research Unit at Pfizer. He joined Pfizer in 2003, where his responsibilities included leading oncology nonclinical research and translational sciences for programs including Sutent® (sunitinib malate) and Xalkori® (crizotinib). Prior to Pfizer, Dr. Christensen held positions at SUGEN/Pharmacia as a group leader in preclinical research and exploratory development. He began his career in the pharmaceutical industry at Warner Lambert/Parke-Davis. Dr. Christensen has authored or co-authored over 150 peer-reviewed research articles in scientific journals including Science, Nature, Cancer Cell, Cancer Discovery, New England Journal of Medicine, and many others. He received his Ph.D. at North Carolina State University and his B.S. in biology from Northern Illinois University. Dr. Nancy Whiting is the Chief Executive Officer of Recludix Pharma, a private company developing novel treatments for inflammatory disease and cancer, and has an established track record in all phases of oncology drug development. Prior to Recludix, Dr. Whiting was a 15-year veteran of Seagen where she served most recently as Executive Vice President of Corporate Strategy, Alliances, and Communication. Prior to this role at Seagen, Dr. Whiting served as Executive Vice President of Development, Senior Vice President of Clinical Development and Medical Affairs, and Head of Experimental Medicine. During her tenure at Seagen, Dr. Whiting played a central role in the development and regulatory approvals of cancer medicines Adcetris® (brentuximab vedotin), Padcev® (enfortumab vedotin-ejfv), Tukysa® (tucatinib) and Tivdak® (tisotumab vedotin). Prior to her career in the pharmaceutical industry, Dr. Whiting practiced as a clinical oncology pharmacist at the Seattle Cancer Care Alliance. Dr. Whiting serves on the Board of Directors of Caribou Biosciences. She received her Pharm.D. from the University of Washington and completed her undergraduate degree at the University of British Columbia. Appointment of George Demetri, M.D., to Clinical Advisory Board Dr. George Demetri currently serves as the Quick Family Chair in Medical Oncology and Director of the Sarcoma Center at Dana-Farber Cancer Institute, as well as Professor of Medicine at Harvard Medical School and Co-Director of the Ludwig Center at Harvard. He has dedicated his career to translational and clinical research aimed at developing clinical therapeutics from scientific mechanisms to treat life-threatening cancers. Dr. Demetri is a pioneer in the development of multiple targeted cancer therapies, and research from his collaborative efforts has resulted in FDA and worldwide regulatory approvals of several cancer therapies, including Gleevec® (imatinib), Sutent® (sunitinib), Stivarga® (regorafenib), Votrient® (pazopanib), Yondelis® (trabectedin), and Tazverik® (tazemetostat). Dr. Demetri received his undergraduate degree in biochemistry from Harvard College and M.D. from Stanford University School of Medicine, after which he completed his internal medicine residency and chief residency at the University of Washington Hospitals in Seattle and subsequently trained in medical oncology at the Dana-Farber Cancer Institute and Harvard Medical School. He is also a member of the Science Policy and Government Affairs Committee of the American Association for Cancer Research, for which he served as the immediate past chair. About Boundless Bio Boundless Bio is a clinical-stage precision oncology company dedicated to unlocking a new paradigm in cancer therapeutics to address the significant unmet need in patients with oncogene amplified tumors by targeting extrachromosomal DNA (ecDNA), a root cause of oncogene amplification observed in more than 14% of cancer patients. Boundless Bio is developing the first ecDNA-directed therapy (ecDTx), BBI-355, which is being evaluated in a Phase 1/2 clinical trial, and has multiple other pipeline programs advancing in preclinical development and discovery. To date, Boundless Bio has raised more than $250 million from leading life sciences investors. For more information, visit . Follow us on LinkedIn and Twitter.

BOSTON, Aug. 28, 2023 (GLOBE NEWSWIRE) -- Elicio Therapeutics, Inc. (Nasdaq: ELTX), a clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer, today announced the appointment of Megan Filoon as General Counsel and Dr. Thian Kheoh as Senior Vice President of Biometrics. Ms. Filoon will oversee all company legal affairs including corporate governance and compliance functions. Dr. Kheoh will provide biostatistical leadership and strategic guidance into the development of the Company’s product candidate portfolio including the ongoing AMPLIFY-201 and AMPLIFY-7P trials of the lead asset, ELI-002. “Megan and Thian are joining us at an exciting time following our recent transition to a public company and as we continue to advance our lead clinical cancer vaccine candidate, ELI-002, for patients with mKRAS-driven cancers,” said Robert Connelly, Chief Executive Officer at Elicio Therapeutics. “Megan and Thian further strengthen an outstanding leadership team and their expertise will be invaluable in strengthening our legal and compliance functions, and processing data from our AMPLIFY trials, respectively.” Megan Filoon most recently served as the General Counsel and Corporate Secretary for Molecular Templates, Inc., a publicly traded, oncology-focused biotech, where she was responsible for providing legal counsel to the company’s board of directors and management team and advising on corporate governance, securities, employment, and real estate matters, among other areas. In this role, Ms. Filoon was responsible for managing the legal, human resources and administrative departments. She joined Molecular Templates as Corporate Counsel and during her time there, held roles of increasing responsibility, becoming General Counsel in February 2022. Prior to joining Molecular Templates, Ms. Filoon was a corporate associate at Blank Rome LLP, where she represented public and private companies in mergers and acquisitions, asset sales, securities offerings, business formation and corporate governance matters. She earned her Juris Doctor from Rutgers School of Law, where she was the Business Editor of the Rutgers Journal of Law and Public Policy, and her Bachelor of Arts in history and political science from Boston University. Thian Kheoh, Ph.D., has over 30 years of drug development and clinical trial experience in the biopharmaceutical industry. He most recently served as Vice President of Biometrics at Mirati Therapeutics where he led the Biometrics team in obtaining the FDA approval of KRAZATI® for KRAS G12C NSCLC patients. Prior to Mirati, he held roles of increasing responsibility at Tocagen, Janssen, Cougar Biotechnology, Biogen-Idec (now Biogen), TAP and Warner Lambert-Parke Davis. His work focused on exploring the application of statistical methodologies in preclinical and clinical studies, introducing novel statistical principles to trial design and strategic planning to bring effective drugs to cancer patients. Dr. Kheoh played an integral role in a number of successful global regulatory submissions and approvals of products that include ERLEADA®, DARZALEX®, OMNICEF®, SYLVANT®, VELCADE®, YONDELIS®, ZYTIGA® and the label expansion of RITUXAN®. Before joining the biopharmaceutical industry, he was an assistant professor at the University of Central Florida conducting research and providing lectures in Statistics. Dr. Kheoh earned his Ph.D. from the University of Western Ontario, Canada. About Elicio Therapeutics Elicio Therapeutics is a clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer. By combining expertise in immunology and immunotherapy, Elicio is engineering investigational Amphiphile (AMP) immunotherapies intended to precisely target and fully engage the lymph nodes, the site in our bodies where the immune response is orchestrated. Elicio is engineering lymph node-targeted AMPlifiers, immunomodulators, adjuvants and vaccines for an array of aggressive cancers. Cautionary Note on Forward-Looking Statements Certain statements contained in this communication regarding matters that are not historical facts, are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995, known as the PSLRA. These include statements regarding Elicio’s planned clinical programs and statements regarding management’s intentions, plans, beliefs, expectations or forecasts for the future, and therefore, you are cautioned not to place undue reliance on them. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. Elicio undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise, except to the extent required by law. We use words such as “anticipates,” “believes,” “plans,” “expects,” “projects,” “future,” “intends,” “may,” “will,” “should,” “could,” “estimates,” “predicts,” “potential,” “continue,” “guidance,” and similar expressions to identify these forward-looking statements that are intended to be covered by the safe-harbor provisions of the PSLRA. Such forward-looking statements are based on our expectations and involve risks and uncertainties; consequently, actual results may differ materially from those expressed or implied in the statements due to a number of factors, including, but not limited to Elicio’s plans to research, develop and commercialize its current and future product candidates. New factors emerge from time to time, and it is not possible for us to predict all such factors, nor can we assess the impact of each such factor on the business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements. These risks are more fully discussed in the current report on Form 8-K that was filed with the SEC on June 2, 2023 and Elicio’s periodic reports and other documents filed from time to time with the SEC. Forward-looking statements included in this release are based on information available to Elicio as of the date of this release. Elicio does not undertake any obligation to update such forward-looking statements to reflect events or circumstances after the date of this release, except to the extent required by law. Media ContactGloria GasaaturaLifeSci Communicationsggasaatura@lifescicomms.com646-970-4688 Investor Relations ContactHeather DiVecchiaElicio TherapeuticsIR@elicio.com857-209-0153