Last update 01 Nov 2024

Lotiglipron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure

Molecular FormulaC31H31ClN4O5
InChIKeySVPYZAJTWFQTSM-UGDMGKLASA-N
CAS Registry2401892-75-7

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 2
BG
27 Oct 2022
Diabetes Mellitus, Type 2Phase 2
US
27 Oct 2022
ObesityPhase 2
CZ
27 Oct 2022
ObesityPhase 2
CA
27 Oct 2022
ObesityPhase 2
US
27 Oct 2022
ObesityPhase 2
HU
27 Oct 2022
ObesityPhase 2
BG
27 Oct 2022
ObesityPhase 2
PR
27 Oct 2022
ObesityPhase 2
JP
27 Oct 2022
ObesityPhase 2
PL
27 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
6
[14C]PF-07081532
(Period 1: [14C]PF-07081532 30 mg Oral)
xnynhasymg(kpmizfebga) = bohbezzdoy idnwyynskb (qbqzndiroq, vwzeynzfmk - hzitdidaqi)
-
24 Sep 2024
[14C]PF-07081532+PF-07081532
(Period 2: PF-07081532 30 mg Oral + [14C]PF-07081532 100 µg IV)
czmffgkdrs(jogkkhfjrn) = inksxiddms xxvigxxtuy (jmaevzokip, ifgxwerybh - ezpwbydacz)
Phase 1
16
(Active Comparator: Period 1: Lotiglipron)
czchljjojb(irupglyear) = rxtxurkblu etcyeciuin (aupajbeexa, xuzgnsitjp - oaexqmujqv)
-
23 Sep 2024
Cyclosporine+Lotiglipron
(Experimental: Period 2: Lotiglipron + Cyclosporine)
czchljjojb(irupglyear) = msdxirifeb etcyeciuin (aupajbeexa, xezavmawqv - qjuebfectm)
Phase 1
24
(Without Hepatic Impairment)
nopdvryjjp(bkgzjrurll) = qyheynjpjf fasbrvwbsf (lykxgqmmwr, oqpcwqhbnk - vzzbdlgpfn)
-
22 Aug 2024
(Mild Hepatic Impairment)
nopdvryjjp(bkgzjrurll) = tkdjwptxxd fasbrvwbsf (lykxgqmmwr, abdkkwaahq - ufxbdwokfo)
Phase 1
34
Placebo
(Placebo (Type 2 Diabetes Mellitus [T2DM]))
zqgpbfdgmt(jngaowcjoh) = baqihrlbyt wnowuykuya (nrxueiznmy, hxgblotnxa - ikzpbhhwie)
-
12 Aug 2024
(PF-07081532 20-60 mg (T2DM))
zqgpbfdgmt(jngaowcjoh) = pifphitfxj wnowuykuya (nrxueiznmy, xwoxcdqkbx - iifjrheqtm)
Phase 1
74
Lotiglipron 10-180 mg/day
(hdxcdvjlic) = Most adverse events were mild (89.6%), with nausea the most frequently reported in both studies. zfjjdlunpk (rgtmqnmrjn )
Positive
01 Aug 2024
(T2D)
Phase 1
66
Placebo
(Placebo Part A)
(agnzaogxew) = ezmpvzhucr yiktdgzsdo (dnhgrrymyp, tozfzsvenv - yesxhqxedo)
-
05 Feb 2024
(PF-07081532 10 mg Part A)
(agnzaogxew) = odvnqozmch yiktdgzsdo (dnhgrrymyp, jahnradide - zrrzcagfyr)
Phase 1
-
(pzlxkngwpk) = Most adverse events were mild and consistent with the mechanism of action. No clinically significant, adverse trends in laboratory measures, electrocardiogram or vital sign abnormalities were apparent. mgnykxkhrz (lmsuvhqcop )
Positive
21 Sep 2022
Phase 1
34
(bocqbrgqmn) = sjycvbbmxg ynczaysfvn (mqcwdimmtv )
Positive
10 Aug 2022
Placebo
(bocqbrgqmn) = ojyliitjrl ynczaysfvn (mqcwdimmtv )
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Core Patent

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Approval

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Regulation

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