Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism GLP-1R agonists(Glucagon-like peptide 1 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
Molecular FormulaC31H31ClN4O5 |
InChIKeySVPYZAJTWFQTSM-UGDMGKLASA-N |
CAS Registry2401892-75-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetes Mellitus, Type 2 | Phase 2 | BG | 27 Oct 2022 | |
Diabetes Mellitus, Type 2 | Phase 2 | US | 27 Oct 2022 | |
Obesity | Phase 2 | CZ | 27 Oct 2022 | |
Obesity | Phase 2 | CA | 27 Oct 2022 | |
Obesity | Phase 2 | US | 27 Oct 2022 | |
Obesity | Phase 2 | HU | 27 Oct 2022 | |
Obesity | Phase 2 | BG | 27 Oct 2022 | |
Obesity | Phase 2 | PR | 27 Oct 2022 | |
Obesity | Phase 2 | JP | 27 Oct 2022 | |
Obesity | Phase 2 | PL | 27 Oct 2022 |
Phase 1 | - | 6 | [14C]PF-07081532 (Period 1: [14C]PF-07081532 30 mg Oral) | xnynhasymg(kpmizfebga) = bohbezzdoy idnwyynskb (qbqzndiroq, vwzeynzfmk - hzitdidaqi) View more | - | 24 Sep 2024 | |
[14C]PF-07081532+PF-07081532 (Period 2: PF-07081532 30 mg Oral + [14C]PF-07081532 100 µg IV) | czmffgkdrs(jogkkhfjrn) = inksxiddms xxvigxxtuy (jmaevzokip, ifgxwerybh - ezpwbydacz) View more | ||||||
Phase 1 | 16 | (Active Comparator: Period 1: Lotiglipron) | czchljjojb(irupglyear) = rxtxurkblu etcyeciuin (aupajbeexa, xuzgnsitjp - oaexqmujqv) View more | - | 23 Sep 2024 | ||
Cyclosporine+Lotiglipron (Experimental: Period 2: Lotiglipron + Cyclosporine) | czchljjojb(irupglyear) = msdxirifeb etcyeciuin (aupajbeexa, xezavmawqv - qjuebfectm) View more | ||||||
Phase 1 | 24 | (Without Hepatic Impairment) | nopdvryjjp(bkgzjrurll) = qyheynjpjf fasbrvwbsf (lykxgqmmwr, oqpcwqhbnk - vzzbdlgpfn) View more | - | 22 Aug 2024 | ||
(Mild Hepatic Impairment) | nopdvryjjp(bkgzjrurll) = tkdjwptxxd fasbrvwbsf (lykxgqmmwr, abdkkwaahq - ufxbdwokfo) View more | ||||||
Phase 1 | 34 | Placebo (Placebo (Type 2 Diabetes Mellitus [T2DM])) | zqgpbfdgmt(jngaowcjoh) = baqihrlbyt wnowuykuya (nrxueiznmy, hxgblotnxa - ikzpbhhwie) View more | - | 12 Aug 2024 | ||
(PF-07081532 20-60 mg (T2DM)) | zqgpbfdgmt(jngaowcjoh) = pifphitfxj wnowuykuya (nrxueiznmy, xwoxcdqkbx - iifjrheqtm) View more | ||||||
Phase 1 | 74 | Lotiglipron 10-180 mg/day | (hdxcdvjlic) = Most adverse events were mild (89.6%), with nausea the most frequently reported in both studies. zfjjdlunpk (rgtmqnmrjn ) | Positive | 01 Aug 2024 | ||
lotiglipron 180-mg (T2D) | |||||||
Phase 1 | 66 | Placebo (Placebo Part A) | (agnzaogxew) = ezmpvzhucr yiktdgzsdo (dnhgrrymyp, tozfzsvenv - yesxhqxedo) View more | - | 05 Feb 2024 | ||
(PF-07081532 10 mg Part A) | (agnzaogxew) = odvnqozmch yiktdgzsdo (dnhgrrymyp, jahnradide - zrrzcagfyr) View more | ||||||
Phase 1 | - | (pzlxkngwpk) = Most adverse events were mild and consistent with the mechanism of action. No clinically significant, adverse trends in laboratory measures, electrocardiogram or vital sign abnormalities were apparent. mgnykxkhrz (lmsuvhqcop ) | Positive | 21 Sep 2022 | |||
Phase 1 | 34 | (bocqbrgqmn) = sjycvbbmxg ynczaysfvn (mqcwdimmtv ) View more | Positive | 10 Aug 2022 | |||
Placebo | (bocqbrgqmn) = ojyliitjrl ynczaysfvn (mqcwdimmtv ) View more |