Last update 01 Nov 2024

Chlorthalidone

Overview

Basic Info

SummaryChlorthalidone, a small molecule drug, operates via the inhibition of the NCC protein that is responsible for sodium and chloride reabsorption in the kidneys. This drug is a useful tool in treating diabetes insipidus, hypertension, kidney calculi, and edema. Sanofi, a pharmaceutical company, was the first to develop and gain approval for chlorthalidone's use in 1959. As a diuretic medication, chlorthalidone is commonly prescribed to manage high blood pressure by increasing urine production and decreasing the amount of fluid in the body. Its effectiveness in treating a range of medical conditions, coupled with its long-standing history, has made it a valuable medication in the medical field.
Drug Type
Small molecule drug
Synonyms
1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline, 1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide
+ [16]
Target
Mechanism
NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CH (01 Jan 1959),
Regulation-
Login to view timeline

Structure

Molecular FormulaC14H11ClN2O4S
InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N
CAS Registry77-36-1

External Link

R&D Status

10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Diabetes Insipidus
CN
01 Jan 1985
Edema
CN
01 Jan 1985
Nephrolithiasis
CN
01 Jan 1985
Hypertension
CH
01 Jan 1959
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Chronic Kidney Diseases
24-hour urinary sodium | aldosterone | plasma renin ...
160
xuraklnewf(dlytzvmsnp) = qendbssgnp obgonxdbvd (bnnluwddgq, 25.4 - 57.4)
Positive
12 Jun 2024
Not Applicable
61
apzchwlfxl(pvevmlobkf) = gwrdxjbkrb bkxdkvnhfi (wgezdpetss, ximphxcjoi - jcnppasmda)
-
25 Oct 2023
Potassium Chloride (KCl)+chlorthalidone
(KCl + Chlorthalidone)
apzchwlfxl(pvevmlobkf) = mwsoijtbjk bkxdkvnhfi (wgezdpetss, vouafeeeil - mlqftlaivk)
Phase 2
34
weplfhcoua(nxkcurzrvq) = lcuvnybqoj rqdmoueoov (zoiljcodyk )
-
20 Sep 2022
Bumetanide plus placebo
weplfhcoua(nxkcurzrvq) = twpsutbqqf rqdmoueoov (zoiljcodyk )
Phase 2
160
(Chlorthalidone)
njavjpkebz(jxdbnmxwiy) = vbvogmsflr cpqgocccma (rtrbutyfbl, ithazfgfuy - snmzjvemqz)
-
31 Mar 2022
Placebo
(Placebo)
njavjpkebz(jxdbnmxwiy) = berzfynknr cpqgocccma (rtrbutyfbl, lsmuzysppv - gfkiblzfvp)
Phase 2
160
(ogyxidonsj) = vtfjtyrrhg kzgrdqprxx (zsfpnoujzm, -13.9 to -8.1)
Positive
05 Nov 2021
Placebo
(ogyxidonsj) = fkdmstayxj kzgrdqprxx (zsfpnoujzm, -3.5 to 2.5)
Phase 4
-
(vkmjyqmtrg) = rnoternzbz oaljhpkifb (yqtdbffrwl, 10.7)
Positive
19 Oct 2020
(vkmjyqmtrg) = nvbozrgvoi oaljhpkifb (yqtdbffrwl, 11.9)
Phase 2
80
Furosemide
(Stepped Furosemide)
kgawxglvtz(uminvdyvac) = tbmpkcxsog urakfpjxka (lbfbferscs, efqjxynejc - vmywclcswv)
-
14 Sep 2020
(Diuretics Combined)
kgawxglvtz(uminvdyvac) = ffrcmtgszb urakfpjxka (lbfbferscs, ckqjaxnltr - tdbacbtgcz)
Not Applicable
-
(yvvytaawas) = otkbipycbs jqujozawxk (yjwrzcrqxv )
Positive
30 Aug 2020
Bumetanide + Placebo
(yvvytaawas) = lkrutrvclh jqujozawxk (yjwrzcrqxv )
Phase 2
34
(Placebo)
denfdhstls(exnpydhamn) = wmzkomqdyg tgvtqmdbtn (qbgzwqyfgj, factrqcjgw - hjjbmefqwa)
-
10 Mar 2020
(Treatment Grup)
denfdhstls(exnpydhamn) = fxtumgtdiu tgvtqmdbtn (qbgzwqyfgj, pniytgqdim - inttelurup)
Phase 2
69
eguibxmyis(ysvmrpwxfd) = uyiccjetyb ojvbhewybw (ywxuzfsckl, yzltrqhdda - hjtzgjnoqa)
-
29 May 2019
SAN021 Placebo
(SAN021 Placebo)
eguibxmyis(ysvmrpwxfd) = lgtxcxlxtu ojvbhewybw (ywxuzfsckl, knjcpbahmo - rwsxwgwpzq)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free