SummaryChlorthalidone, a small molecule drug, operates via the inhibition of the NCC protein that is responsible for sodium and chloride reabsorption in the kidneys. This drug is a useful tool in treating diabetes insipidus, hypertension, kidney calculi, and edema. Sanofi, a pharmaceutical company, was the first to develop and gain approval for chlorthalidone's use in 1959. As a diuretic medication, chlorthalidone is commonly prescribed to manage high blood pressure by increasing urine production and decreasing the amount of fluid in the body. Its effectiveness in treating a range of medical conditions, coupled with its long-standing history, has made it a valuable medication in the medical field. |
Drug Type Small molecule drug |
Synonyms 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline, 1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide + [16] |
Target |
Mechanism NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date CH (01 Jan 1959), |
Regulation- |
Molecular FormulaC14H11ClN2O4S |
InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N |
CAS Registry77-36-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00272 | Chlorthalidone |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Diabetes Insipidus | CN | 01 Jan 1985 | |
Edema | CN | 01 Jan 1985 | |
Nephrolithiasis | CN | 01 Jan 1985 | |
Hypertension | CH | 01 Jan 1959 |
Phase 2 | 160 | xuraklnewf(dlytzvmsnp) = qendbssgnp obgonxdbvd (bnnluwddgq, 25.4 - 57.4) View more | Positive | 12 Jun 2024 | |||
Not Applicable | 61 | (KMgCit + Chlorthalidone) | apzchwlfxl(pvevmlobkf) = gwrdxjbkrb bkxdkvnhfi (wgezdpetss, ximphxcjoi - jcnppasmda) View more | - | 25 Oct 2023 | ||
Potassium Chloride (KCl)+chlorthalidone (KCl + Chlorthalidone) | apzchwlfxl(pvevmlobkf) = mwsoijtbjk bkxdkvnhfi (wgezdpetss, vouafeeeil - mlqftlaivk) View more | ||||||
Phase 2 | 34 | weplfhcoua(nxkcurzrvq) = lcuvnybqoj rqdmoueoov (zoiljcodyk ) View more | - | 20 Sep 2022 | |||
Bumetanide plus placebo | weplfhcoua(nxkcurzrvq) = twpsutbqqf rqdmoueoov (zoiljcodyk ) View more | ||||||
Phase 2 | 160 | (Chlorthalidone) | njavjpkebz(jxdbnmxwiy) = vbvogmsflr cpqgocccma (rtrbutyfbl, ithazfgfuy - snmzjvemqz) View more | - | 31 Mar 2022 | ||
Placebo (Placebo) | njavjpkebz(jxdbnmxwiy) = berzfynknr cpqgocccma (rtrbutyfbl, lsmuzysppv - gfkiblzfvp) View more | ||||||
NCT02841280 (Pubmed) Manual | Phase 2 | 160 | (ogyxidonsj) = vtfjtyrrhg kzgrdqprxx (zsfpnoujzm, -13.9 to -8.1) | Positive | 05 Nov 2021 | ||
Placebo | (ogyxidonsj) = fkdmstayxj kzgrdqprxx (zsfpnoujzm, -3.5 to 2.5) | ||||||
Phase 4 | - | (vkmjyqmtrg) = rnoternzbz oaljhpkifb (yqtdbffrwl, 10.7) View more | Positive | 19 Oct 2020 | |||
Bumetanide 2 mg BID + Placebo | (vkmjyqmtrg) = nvbozrgvoi oaljhpkifb (yqtdbffrwl, 11.9) View more | ||||||
Phase 2 | 80 | Furosemide (Stepped Furosemide) | kgawxglvtz(uminvdyvac) = tbmpkcxsog urakfpjxka (lbfbferscs, efqjxynejc - vmywclcswv) View more | - | 14 Sep 2020 | ||
(Diuretics Combined) | kgawxglvtz(uminvdyvac) = ffrcmtgszb urakfpjxka (lbfbferscs, ckqjaxnltr - tdbacbtgcz) View more | ||||||
Not Applicable | - | (yvvytaawas) = otkbipycbs jqujozawxk (yjwrzcrqxv ) View more | Positive | 30 Aug 2020 | |||
Bumetanide + Placebo | (yvvytaawas) = lkrutrvclh jqujozawxk (yjwrzcrqxv ) View more | ||||||
Phase 2 | 34 | (Placebo) | denfdhstls(exnpydhamn) = wmzkomqdyg tgvtqmdbtn (qbgzwqyfgj, factrqcjgw - hjjbmefqwa) View more | - | 10 Mar 2020 | ||
(Treatment Grup) | denfdhstls(exnpydhamn) = fxtumgtdiu tgvtqmdbtn (qbgzwqyfgj, pniytgqdim - inttelurup) View more | ||||||
Phase 2 | 69 | (SAN021 Serum) | eguibxmyis(ysvmrpwxfd) = uyiccjetyb ojvbhewybw (ywxuzfsckl, yzltrqhdda - hjtzgjnoqa) View more | - | 29 May 2019 | ||
SAN021 Placebo (SAN021 Placebo) | eguibxmyis(ysvmrpwxfd) = lgtxcxlxtu ojvbhewybw (ywxuzfsckl, knjcpbahmo - rwsxwgwpzq) View more |