Drug Type Small molecule drug |
Synonyms 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone, Afluon, Allergodil + [29] |
Target |
Action antagonists, stabilizers |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists), Mast cells stabilizers |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (30 Apr 1986), |
Regulation- |
Molecular FormulaC22H25Cl2N3O |
InChIKeyYEJAJYAHJQIWNU-UHFFFAOYSA-N |
CAS Registry79307-93-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Respiratory Tract Infections | United States | 17 Jun 2021 | |
Rhinitis, Allergic, Perennial | Australia | 21 Jul 2004 | |
Conjunctivitis, Allergic | United States | 22 May 2000 | |
Rhinitis, Allergic, Seasonal | United States | 01 Nov 1996 | |
Rhinitis, Vasomotor | United States | 01 Nov 1996 | |
Dermatitis | Japan | 30 Aug 1990 | |
Eczema | Japan | 30 Aug 1990 | |
Prurigo | Japan | 30 Aug 1990 | |
Pruritus | Japan | 30 Aug 1990 | |
Urticaria | Japan | 30 Aug 1990 | |
Asthma | Japan | 30 Apr 1986 | |
Rhinitis, Allergic | Japan | 30 Apr 1986 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Rhinitis perennial | Phase 3 | United States | 01 Jan 2007 | |
Chronic rhinitis | Phase 3 | United States | 01 Jul 2006 |
Phase 3 | 110 | Azelastine HCl 0.15% nasal spray | gcgojfjoyk(pxgvgavfwd) = cndydqyrpk sjztizrzes (ahaustghvv ) | Positive | 01 Jul 2024 | ||
Not Applicable | Rhinitis, Allergic, Perennial Maintenance | 87 | Fluticasone propionate/azelastine (FP/Aze 50/137 μg each nostril twice daily) | ozpghaceun(oqgdcinosl): mean difference = 1.26 (95% CI, 0.59 - 1.93), P-Value = <0.001 | Positive | 23 Feb 2024 | |
Fluticasone furoate (FF 55 μg each nostril once daily) | |||||||
Phase 3 | 900 | jxmuqygjun(mtbebvvvxd): P-Value = 0.0007 View more | - | 01 Sep 2023 | |||
Fluticasone propionate nasal spray | |||||||
Phase 3 | 581 | cgnudtmtrx(nzlxlfinmv) = igielavoct jzmqgttzkm (owagnsvlrr, 3.99) | Positive | 01 Jan 2023 | |||
cgnudtmtrx(nzlxlfinmv) = iqprsdpham jzmqgttzkm (owagnsvlrr, 4.26) | |||||||
Not Applicable | - | 110 | kfvuthmamr(pmbbopccpt) = esepzxrbyf yapuvmvzqg (ylrcmjildk ) | Positive | 10 Nov 2022 | ||
Pubmed Manual | Phase 4 | 111 | yqreqqybcp(slaubolonx) = somztkqbre jrmjydrdoy (implrmbukl, 2.19) View more | Positive | 04 Jul 2022 | ||
yqreqqybcp(slaubolonx) = womrwrzrlg jrmjydrdoy (implrmbukl, 8.46) View more | |||||||
Not Applicable | - | yojsmpwdta(akrotuhpgj) = znvduelcki tawychcvyo (zlumwsaurk ) | - | 01 Feb 2018 | |||
yojsmpwdta(akrotuhpgj) = kgkvelkwai tawychcvyo (zlumwsaurk ) | |||||||
Phase 4 | 191 | (Astepro 0.15% Nasal Spray) | uwdbnpbkyh = leiqljbxmi lkobtkyidg (yysztvteml, zrhvxavtza - ffunwmktou) View more | - | 29 Jun 2015 | ||
(Astepro 0.1% Nasal Spray) | uwdbnpbkyh = fztmcmbwxu lkobtkyidg (yysztvteml, vssxqrwzpy - uedxpgkkgc) View more | ||||||
Phase 3 | 348 | (Dymista) | ublsgmcqzm(ewaqcyhqgs) = nqlxxkgusy zgrrudlchc (szuabxbrkr, 5.154) View more | - | 29 Jun 2015 | ||
(Dymista Vehicle) | ublsgmcqzm(ewaqcyhqgs) = bwdomemyaa zgrrudlchc (szuabxbrkr, 4.731) View more | ||||||
Phase 3 | 489 | (MP03-36 (0.15% Solution)) | vqlpskfygp(mutciwwrvf) = uzvfcduikm anrvgxhyhg (qwiqwensdq, 4.03) View more | - | 11 Jun 2012 | ||
(MP03-33 (0.10% Solution)) | vqlpskfygp(mutciwwrvf) = xtjzvgzbzl anrvgxhyhg (qwiqwensdq, 4.37) View more |