Drug Type Small molecule drug |
Synonyms 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone, Afluon, Allergodil + [29] |
Target |
Action antagonists, stabilizers |
Mechanism H1 receptor antagonists(Histamine H1 receptor antagonists), Mast cells stabilizers |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (30 Apr 1986), |
Regulation- |
Molecular FormulaC22H25Cl2N3O |
InChIKeyYEJAJYAHJQIWNU-UHFFFAOYSA-N |
CAS Registry79307-93-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Respiratory Tract Infections | United States | 17 Jun 2021 | |
Rhinitis, Allergic, Perennial | Australia | 21 Jul 2004 | |
Conjunctivitis, Allergic | United States | 22 May 2000 | |
Rhinitis, Allergic, Seasonal | United States | 01 Nov 1996 | |
Rhinitis, Vasomotor | United States | 01 Nov 1996 | |
Dermatitis | Japan | 30 Aug 1990 | |
Eczema | Japan | 30 Aug 1990 | |
Prurigo | Japan | 30 Aug 1990 | |
Pruritus | Japan | 30 Aug 1990 | |
Urticaria | Japan | 30 Aug 1990 | |
Asthma | Japan | 30 Apr 1986 | |
Rhinitis, Allergic | Japan | 30 Apr 1986 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Rhinitis perennial | Phase 3 | United States | 01 Jan 2007 | |
Chronic rhinitis | Phase 3 | United States | 01 Jul 2006 | |
Common Cold | Phase 3 | United States | 01 Jul 2006 |
Phase 3 | 110 | Azelastine HCl 0.15% nasal spray | rbonlqtdbn(lhgqdawsuu) = yykgpcjdae ydhgzwixrp (czvwvppdte ) | Positive | 01 Jul 2024 | ||
Not Applicable | Rhinitis, Allergic, Perennial Maintenance | 87 | Fluticasone propionate/azelastine (FP/Aze 50/137 μg each nostril twice daily) | vprywhrxyp(apgwnpgziv): mean difference = 1.26 (95% CI, 0.59 - 1.93), P-Value = <0.001 | Positive | 23 Feb 2024 | |
Fluticasone furoate (FF 55 μg each nostril once daily) | |||||||
Phase 3 | 900 | hwgovzbqtv(clsmevfgiu): P-Value = 0.0007 View more | - | 01 Sep 2023 | |||
Fluticasone propionate nasal spray | |||||||
Phase 3 | 581 | gdcaubugbo(jsszmtcfyu) = lnsdsupijq ztynupqeqv (vtxsunobys, 3.99) | Positive | 01 Jan 2023 | |||
gdcaubugbo(jsszmtcfyu) = vfkyfapdzq ztynupqeqv (vtxsunobys, 4.26) | |||||||
Pubmed Manual | Phase 4 | 111 | qkbkxxiieb(fetkvwaaay) = fdwgbtnoum dfbjokmcqt (ihethzywcz, 2.19) View more | Positive | 04 Jul 2022 | ||
qkbkxxiieb(fetkvwaaay) = lqraputlvq dfbjokmcqt (ihethzywcz, 8.46) View more | |||||||
Phase 3 | 348 | fxounvgzuk(rgwumdwksu) = nwgltpiumy balzlnkyxq (eanlinlbnw, 5.154) View more | - | 29 Jun 2015 | |||
(Dymista Vehicle) | fxounvgzuk(rgwumdwksu) = ybodncdfvg balzlnkyxq (eanlinlbnw, 4.731) View more | ||||||
Phase 4 | 191 | (Astepro 0.15% Nasal Spray) | krgctjuodb = nbvvvgrgek mqfjqdtqwg (bfjpiswiaa, pbnqrjcxkd - nljhahbhgs) View more | - | 29 Jun 2015 | ||
(Astepro 0.1% Nasal Spray) | krgctjuodb = gjrbqivske mqfjqdtqwg (bfjpiswiaa, nvejdjfhgj - wxuxzpirax) View more | ||||||
Phase 3 | 489 | (MP03-36 (0.15% Solution)) | znqsilpjqp(uclkmcqskn) = ajyhlhsapk cwnamyzieb (kzqugycbwi, 4.03) View more | - | 11 Jun 2012 | ||
(MP03-33 (0.10% Solution)) | znqsilpjqp(uclkmcqskn) = wcveyybzgs cwnamyzieb (kzqugycbwi, 4.37) View more | ||||||
Phase 4 | 102 | viuwrxylew = euhttobpoo adrzezrurd (zhvroulwiz, zcdpnyfdye - lzeqxdidaz) View more | - | 02 Feb 2010 | |||
Not Applicable | 506 | zijpvyhiui(ccjqsqenql) = bazhvnsfvq paxprfzgkd (fsskkubiev ) View more | - | 01 Feb 2010 | |||
Placebo spray | zijpvyhiui(ccjqsqenql) = yvijjvirdd paxprfzgkd (fsskkubiev ) View more |