Delving into the Latest Updates on Berberine sulfate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Mechanism-

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC20H19NO8S

InChIKeyJISRTQBQFQMSLG-UHFFFAOYSA-M

CAS Registry633-66-9

AN OPEN LABEL,BALANCED, SINGLE-DOSE,MULTI-TREATMENT, TWO PERIOD,TWO-WAY CROSSOVER, COMPARATIVE ORAL BIOAVAILABILITY STUDY OF THYMOPRO 50 MG BIOSNEDS (0.001004 G THYMOQUINONE/ML), BERBERISOL 500 MG BIOSNEDS (0.010046 G BERBERINE HCL/ML),RESVERASOL 1000 MG BIOSNEDS (0.020048 G RESVERATROL/ML),BIOQUERCETIN 475 MG BIOSNEDS (0.010045 G QUERCETIN/ML) ANDBIOBUTYRIN 500 MG BIOSNEDS (0.010096 G TRIBUTYRIN/ML) MANUFACTURED BY VERDANT NATURE SP Z.O.O., WITH CONVENTIONAL RESVERATROL EXTRACT 1000 MG (2 X 500 MG CAPSULE) DISTRIBUTED BY BIOLAB, CONVENTIONAL QUERCETIN 475 MG CAPSULE DISTRIBUTED BY SWANSON HEALTH PRODUCTS, CONVENTIONAL TRIBUTYRIN 500 MG CAPSULE DISTRIBUTED BY DEVA NUTRITION, CONVENTIONAL THYMOQUINONE 50 MG CAPSULE DISTRIBUTED BY TRIQUETRA HEALTH AND CONVENTIONAL BERBERINE 500 MG CAPSULE DISTRIBUTED BY MEDFUTURE IN HEALTHY ADULT HUMAN SUBJECTS UNDER FASTING CONDITIONS - Nil

Start Date07 Oct 2024

Sponsor / Collaborator

Verdant Nature LLC.

CTRI/2024/06/069426

/ Not yet recruitingNot Applicable

Single dose, crossover bioavailability study to compare the Formulation A Berberine 95 percent with Formulation B Berberine 95 percent plus Turmeric and Formulation C Berberine 70 percent with Formulation D Berberine 70 percent plus Turmeric in healthy adult human subjects. - NIL

Start Date11 Jul 2024

Sponsor / Collaborator-

ChiCTR2200057554

/ SuspendedEarly Phase 1IIT

Berberine and rifaximin effects for small intestinal bacterial overgrowth: an investigator initiated, double-arm, open-label, randomized clinical trial - BRIFE-SIBO

Start Date14 Mar 2022

Sponsor / Collaborator

Peking University Third Hospital

100 Clinical Results associated with Berberine sulfate

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100 Translational Medicine associated with Berberine sulfate

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100 Patents (Medical) associated with Berberine sulfate

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6,068

Literatures (Medical) associated with Berberine sulfate

01 Dec 2025·Molecular Biology Reports

Synergistic inhibitory effect of atmospheric pressure plasma and berberine on non‑small cell lung cancer cells via inducing apoptosis

Article

Author: Ming, Huiyun ; Song, Wencheng ; Zhou, Han ; Dai, Haiming ; Lu, Tingting

BACKGROUNDNon-small cell lung cancer (NSCLC) is a type of lung cancer, the incidence and mortality rate have been high, and the use of monotherapy is easy to make patients develop tolerance. Atmospheric pressure plasma (APP) is an emerging technology for killing cancer cells in recent years, and combination of berberine (BBR) mechanism has not been fully elucidated for NSCLC. The article's primary goal is to investigate the effect of combination on NSCLC and its associated characterization.METHODS AND RESULTSAntiproliferative effects were detected by cell viability assay and colony formation, and flow cytometry analysis of apoptosis and cycling showed that the combination synergistically induced apoptosis. Then, extracellular reactive oxygen species (ROS)levels and DCFH-DA-based kits examined intracellular ROS levels, and their effects on mitochondrial membrane potential were measured. Study reveals that co-induced apoptosis is associated with ROS accumulation. Subsequently, Western blotting (WB) detected the expression of epidermal growth factor receptor (EGFR), and the important signaling pathway proteins Ras/ERK and AKT/mTOR. Results showed that it could downregulation of EGFR protein expression and inhibit of activation of ERK/AKT signaling pathways. Simultaneous wound healing assay and epithelial-to-mesenchymal transition (EMT) marker detection were performed for the assessment of migration and EMT ability of NSCLC cells. Combination therapy inhibited migration and EMT of NSCLC cells.CONCLUSIONThe results of this study show that the combination can synergistically induce apoptosis of NSCLC by regulating ROS production. EGFR downregulation and AKT/ERK signaling pathway inhibition are linked to the synergistic effect.

01 Apr 2025·Talanta

Berberine-based hypercrosslinked polymer: Advanced solid-phase microextraction for high-throughput analysis of aristolochic acids in environmental water and herbal plants

Article

Author: Li, Lixin ; Zhang, Zhenqiang ; Zeng, Huahui ; Zhang, Zhiyu ; Yang, Cheng ; Hu, Kai ; Zhao, Di ; Zhang, Shusheng

In this study, a novel berberine based anion-exchanged hypercrosslinked polymer (BBR-HCPs) was synthesized via Friedel-Crafts alkylation using dimethoxymethane as a cross-linking agent. The proposed BBR-HCPs polymer exhibited excellent adsorption capacities for aristolochic acids (AAs). Moreover, there are various interactions such as hydrophobic, π-π stacking, hydrogen bonding, and electrostatic interactions between BBR-HCPs and AAs. A solid phase microextraction (SPME) coating, prepared with BBR-HCPs as the sorbent and polyacrylonitrile (PAN) as the binder, was applied for the determination of AAs in herbal plants using a 24-well plate for high-throughput, with instrumental analysis carried out via high performance liquid chromatography with diode array detector (HPLC-DAD). The optimized and validated BBR-HCPs-SPME/HPLC-DAD method exhibited excellent linearity over range of 5-400 ng mL^-1 with R² > 0.9974. Detection limits (S/N = 3) for AAs were found to be 0.03-0.150 ng mL^-1, with recoveries ranging from 82.6 to 117.8 % and relative standard deviations (RSDs) less than 10.49 %. This study underscores the potential of BBR-HCPs as a promising adsorbent for selective extraction and enrichment of AAs while introducing a reliable novel strategy for monitoring trace amounts of AAs in water and herbal plant samples.

01 Mar 2025·Food Chemistry

Sprayable, washable, and light-perceptible hydrogels with AIE activity constructed by co-assembly of natural glycyrrhizic acid and berberine for fruit preservation

Article

Author: Zang, Jiachen ; Sun, Jishuai ; Zhang, Tuo ; Zhao, Guanghua ; Lv, Chenyan

The decay of fruits poses a great challenge to the global food industry, exacerbating food shortages, environmental pollution, and health hazards, while attempts to mitigate this issue with chemical additives often lead to additional health and environmental concerns. To address this, GL and BBR were co-assembled into nanofibrils hydrogels for fruit preservation, driven by hydrogen bonding and electrostatic interactions. The obtained GL/BBR hydrogels exhibit AIE activity and generate ROS under white light, providing strong bactericidal effects against E. coli and S. aureus. Notably, the hydrogels sprayed on the fruit's surface are transparent, block UV rays, and are easily washable, allowing the fruit's cleanliness to be visually inspected through fluorescence under ultraviolet light. With excellent biocompatibility, GL/BBR hydrogels maintain fruit freshness and quality, significantly extending storage life compared to untreated groups. These properties make them promising bioactive materials for sustainable fruit preservation.

100 Deals associated with Berberine sulfate

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R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


DDW2024	Not Applicable	Blind Loop Syndrome	-	Berberine 400 mg	aldeuqsggt(zrwwuwowae) = There was no significant difference in adverse events between BBR and RIF (12.0% vs. 9.52%, P=0.790) owjoxsvvkl (eyivovduwv )	-	20 May 2024
				Rifaximin 400 mg
NCT02548832 (CTgov)	Phase 3	Hyperlipidemia, Familial Combined	36	Berberine (Berberine)	fzplznbemh(tlpijyuqoi) = ncworezrxv dmtnoqouqr (fmqvfbfxys, aofclqiaux - qkbpjcwgvv) View more	-	24 Feb 2023
				Bezafibrate (Bezafibrate)	fzplznbemh(tlpijyuqoi) = nazyfvamyw dmtnoqouqr (fmqvfbfxys, yaqldwdgaz - osbeximesi) View more
ESMO2022	Not Applicable	-	-	Berberine	sqvcvrypey(xpjzmlhxlr) = mxgjuyxkvz ismkjfhpji (avnytlrmcl )	-	10 Sep 2022
				Dapagliflozin	sqvcvrypey(xpjzmlhxlr) = yawtocabre ismkjfhpji (avnytlrmcl )
AAI2019	Not Applicable	Rheumatoid Arthritis	-	Berberine 1 mg/kg	qblnvirhut(sxlkikxcdv) = huxrjaugrx rboqmwlwls (cpbxcjfzwp )	-	01 May 2019
				berberine (Vehicle control)	qblnvirhut(sxlkikxcdv) = uslyojujrx rboqmwlwls (cpbxcjfzwp )