Last update 06 Jun 2025

Somatropin(Genentech, Inc.)

Overview

Basic Info

Drug Type
Hormone
Synonyms
Nutrophin, Nutropin Aq, NutropinAq
+ [9]
Target
Action
agonists
Mechanism
GHR agonists(Growth hormone receptor agonists)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (06 Apr 1979)
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Renal function impairment with growth failure
European Union
15 Feb 2001
Renal function impairment with growth failure
Iceland
15 Feb 2001
Renal function impairment with growth failure
Liechtenstein
15 Feb 2001
Renal function impairment with growth failure
Norway
15 Feb 2001
Dwarfism
United States
29 Dec 1995
Idiopathic short stature
United States
29 Dec 1995
Chronic Kidney Diseases
United States
09 Mar 1994
Growth Disorders
United States
09 Mar 1994
Growth hormone deficiency
United States
09 Mar 1994
Turner Syndrome
United States
09 Mar 1994
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
United States
01 Jul 2010
HIV InfectionsPhase 3
United States
01 Feb 2006
Pituitary DiseasesPhase 3
Belgium
01 Jun 2004
Pituitary DiseasesPhase 3
Czechia
01 Jun 2004
Pituitary DiseasesPhase 3
Denmark
01 Jun 2004
Pituitary DiseasesPhase 3
Finland
01 Jun 2004
Pituitary DiseasesPhase 3
France
01 Jun 2004
Pituitary DiseasesPhase 3
Germany
01 Jun 2004
Pituitary DiseasesPhase 3
Greece
01 Jun 2004
Pituitary DiseasesPhase 3
Italy
01 Jun 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
42
rhGH
(Baseline Predicted Adult Height)
ryctqobsbe(fvjasbgfdk) = axbsksdbaw mzutawcaro (recuapvqyz, 5.9)
-
05 Oct 2023
Not Applicable
201
Adherent to daily somatropin therapy
ktxaqrngpm(rlzslfpmml) = eslyrxbnki bicmziixre (wyiwizkfph, 8.9 - 9.9)
-
22 Sep 2021
Non-adherent to daily somatropin therapy
ktxaqrngpm(rlzslfpmml) = maipnkomkb bicmziixre (wyiwizkfph, 6.6 - 8.5)
Phase 3
251
vvansenirf(nxamzlzrna) = rvwyvyqoky fdpdqziixk (dviqifnsti, 161.86)
-
09 Aug 2018
Not Applicable
13
rhGH group
osxtuqbgab(jrilpisiqj) = rcxxvrvbqy xexdjpcsgy (fqlccabreq )
-
18 Sep 2014
osxtuqbgab(jrilpisiqj) = glkgsqfiqk xexdjpcsgy (fqlccabreq )
Not Applicable
12
dptqfgzfxt(sdpuungixh) = abgmzymyep oubelchjro (ymxujrtlyn )
Positive
18 Sep 2014
Not Applicable
Dwarfism, Pituitary
exon 3 deleted (d3-GHR) genetic polymorphism of GH receptor (GHR)
111
xuduphyiaz(uinkztnbps) = rylhcghbuv fmabqribrj (vazlsxifge )
-
18 Sep 2014
xuduphyiaz(uinkztnbps) = shsovadecr fmabqribrj (vazlsxifge )
Not Applicable
142
growth hormone+Nutropin
(Male on GH)
tiqrksgznj(hcbbjjqmun) = pmmvhgazku nmyfdhvxoy (lupmazdsnz, 0.5)
-
06 Mar 2014
Placebo Growth Hormone
(Male on Placebo)
tiqrksgznj(hcbbjjqmun) = mqumyanpsf nmyfdhvxoy (lupmazdsnz, 0.3)
Phase 1
5
jahhkbxvju(lhtstdjbjy) = vgkywcnkua iyqwjxizkg (fccekwmpxx, obiiijtlzp - lhwfbiumpt)
-
15 Jan 2013
Phase 2
21
Growth Hormone
(Recombinant Human Growth Hormone Group)
staresmegj(kvwfmxlfep) = smqtxxpqws ybgdssqwps (opfaufmuio, 16.7)
-
16 Oct 2012
Placebo
(Placebo Group)
staresmegj(kvwfmxlfep) = ttyhwlurxt ybgdssqwps (opfaufmuio, 7.1)
Phase 2
22
(Growth Hormone Plus Cortecosteroid)
vhbzryubad(loqbncswqb) = nehtfqnbbe dxhzkcffow (gjpbusiwle, 8)
-
16 Sep 2011
cortecosteroid
(Cortecosteroids Alone)
vhbzryubad(loqbncswqb) = agucnxezhp dxhzkcffow (gjpbusiwle, 10)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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