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HELSINKI, Finland, Feb. 16, 2023 (GLOBE NEWSWIRE) -- Valo Therapeutics Oy (ValoTx), the developer of novel, adaptable immunotherapies for cancer and infectious diseases, announces it has been granted European patents EP3768305 and EP3768830, issued by the European Patent Office (EPO) on 7 February 2023. The patents cover the pharmaceutical composition and method of use for the treatment of cancer for ValoTx’s lead product PeptiCRAd-1 (Peptide-coated Conditionally Replicating Adenovirus-1). These two patents cover its lead virus VALO-D102 and the peptides coating the virus, MAGE-A3 and NY-ESO-1. PeptiCRAd-1 is a first-in-class cancer immunotherapy drug candidate that is designed to stimulate systemic tumor-directed cytotoxic T-cell responses in cancer patients. Combined with its local immune modulation effect at the tumor site, it has the potential to deliver synergistic clinical outcomes in combination with immune checkpoint inhibitors. A Phase 1 trial is now open for enrollment for PeptiCRAd-1 in combination with pembrolizumab in melanoma, triple-negative breast cancer and non-small cell lung cancer. Dr. Sari Pesonen, CSO at ValoTx, commented, “Securing these important patents underscores our innovative oncolytic adenovirus approach, which enhances tumor-specific T-cell responses in cancer patients using an oncolytic virus combined with target peptides. These granted patents will allow us to further capitalize upon our powerful platform that uses VALO-D102 virus as a backbone for novel PeptiCRAds using alternative peptides.” EP3768305 - Modified Oncolytic Adenoviruses: https://register.epo.org/application?number=EP19712178 EP3768830 - Cancer Therapy: https://register.epo.org/application?number=EP19712179 About ValoTx Valo Therapeutics Oy (Helsinki) is an immunotherapy company that is developing antigen-coated oncolytic viruses and vaccine vectors as therapeutic vaccines against cancer and infectious disease. The ValoTx lead platform, PeptiCRAd (Peptide-coated Conditionally Replicating Adenovirus), was developed out of the laboratory of Professor Vincenzo Cerullo at the University of Helsinki. It turns oncolytic adenoviruses into powerful activators of systemic anti-tumor cytotoxic T-cell immunity without the need to generate and manufacture multiple genetically modified viruses. PeptiCRAd-1 is the company’s lead product made up of its virus VALO-D102 coated with MAGE-A3 and NY-ESO-1 peptides. The company is also developing PeptiCHIP, PeptiENV and PeptiVAX, among other neoantigen strategies. Novel microchip based PeptiCHIP technology rapidly identifies a tumor’s ‘fingerprints’ to drive development of novel personalized immunotherapies. PeptiENV is expected to improve the therapeutic response to oncolytic enveloped viruses in the treatment of multiple forms of cancer, while PeptiVAX is a program to develop a novel, adaptable anti-infectives vaccination platform. Watch our film explaining the PeptiCRAd technology. For more information see our website and follow us on LinkedIn. Contacts Valo Therapeutics Oy Matthew VaughanEmail: info@valotx.com Scius Communications (for ValoTx) Katja Stout+44 778 943 5990Email: katja@sciuscommunications.com Daniel Gooch+44 774 787 5479Email: daniel@sciuscommunications.com

Stefan J. Scherer and Chris Garcia/courtesy of 3T Biosciences With $40 million in hand, Bay Area-based 3T Biosciences launched Thursday with a technology platform its leadership team believes can change the future of treatment for solid tumors and immune-mediated diseases. Newly-tapped CEO Stefan J. Scherer is a veteran of Novartis’ oncology division and former chief medical officer of Cellectis. He told BioSpace he was drawn to 3T because of its approach to providing a safer and more efficacious treatment for these diseases. Scherer said the company’s 3T-TRACE platform (T-Cell Receptor Antigen and Cross-Reactivity Engine) and TCR-mimetic (TCRm) discovery platform have the combined potential to generate therapeutics aimed at pHLA targets that are “devoid of off-target cross-reactivity targeting.” He added that the $40 million in Series A financing puts the company in a position to rapidly develop its investigational assets. It will also enable 3T to build toward clinical studies that can validate the company’s innovative approach toward targeting solid tumors, he said. By leveraging the immune system’s capabilities to “recognize, target and destroy cancer cells,” 3T’s technology program is capable of advancing potentially safer and more effective next-generation therapies against difficult-to-treat cancers, the company noted in its announcement. The Ultimate One-Two Punch The 3T-TRACE platform is designed to identify the most prevalent and immunogenic targets in solid tumors through a combination of high-diversity target libraries and active machine learning. Scherer said it can identify novel shared TCR targets of productive immune responses against solid tumors and other diseases. He noted that the platform can screen TCRs and TCRms for specificity and off-target cross-reactivities. “It is the ultimate one-two punch to enhance the discovery pipeline from novel target discovery to best-in-class pHLA targeting therapeutics,” Scherer said. “By using evolutionarily adapted immune responses against cancer, we can discover the best immunogenic targets that can be generalized for multiple tumor indications and across patient populations.” In addition to those platforms, 3T licensed a precise antibody-based peptide-HLA therapeutic discovery platform and development-stage MAGE-A3T-cell receptor (TCR)-T assets. Scherer noted that in the past, there have been multiple toxicity concerns surrounding MAGE-A3 assets taken into the clinic. “We have an unprecedented combination of technology that can address these issues,” and allow for the development of a safe and efficacious therapeutic, he said. The financing round was led by Westlake Village BioPartners with participation from Lightspeed Venture Partners. From an investment standpoint, Westlake saw “a nice confluence of biology and the appropriate amount of machine learning algorithms” able to handle the massive datasets necessary to achieve 3T’s drug design goals, Sean Harper, co-founding managing director at Westlake told BioSpace. Harper is also a new member of the 3T board of directors. He said the 3T technologies can discover new peptide targets capable of unlocking the intracellular changes that occur in cancer cells. From there, the company can develop therapeutics that de-risk concerns of cross-reactivities, Harper added. The precise antibody-based peptide-HLA therapeutic discovery platform was licensed from the labs of Chris Garcia, a Stanford University scientist known for his research on the molecular and structural biology of cell surface receptors. Garcia, who sits on 3T’s scientific advisory board, said the three technologies at the company’s disposal “all kind of fit together” and have everything under one roof. That will give 3T a leg up when it seeks to drive one of its anti-cancer assets into the clinic, Garcia added. The combination platforms should allow the company to prepare an Investigational New Drug Application with the U.S. Food and Drug Administration within 18 to 24 months, Scherer predicted. He noted that this is an aggressive timeline for a young company. A TCR-Mimic Pipeline The company has already developed one molecule into candidate position that could be at IND status next year, Scherer said. This is in addition to more than a dozen novel targets. “We’re not just another TCR-mimic discovery company; there’s a whole pipeline here,” Garcia said. Harper concurred. He said the three-legged platform of 3T's technology propels the company to the role of industry leader in TCR targeting and therapeutics discovery for the treatment of solid tumors. “It enables us to address one of the biggest challenges in cancer treatment, developing next-generation therapies for solid tumors and other immune-mediated diseases,” he added. Even as the company emerges from stealth, Harper noted that it could be in line to forge a “high-quality deal” with one or two big pharma partners. This, he said, could not only benefit the company financially but also raise its pro