Last update 31 Mar 2025

Aldesleukin

Overview

Basic Info

Drug Type
Interleukins
Synonyms
125-L-Serine-2-133-interleukin 2, IL-2 (Chiron), Interleukin-2 (Chiron)
+ [12]
Target
Action
agonists, stimulants
Mechanism
IL-2R agonists(Interleukin-2 receptor agonists), Immunostimulants
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (05 May 1992),
RegulationOrphan Drug (United States), Orphan Drug (South Korea)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D00748-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Renal Cell Carcinoma
United States
05 May 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
High Risk NeuroblastomaPhase 3
United States
21 Dec 2009
Refractory Hodgkin LymphomaPhase 3
United States
01 Nov 2003
Refractory Hodgkin LymphomaPhase 3
Australia
01 Nov 2003
Refractory Hodgkin LymphomaPhase 3
Canada
01 Nov 2003
Neuroblastoma recurrentPhase 3
United States
18 Oct 2001
Neuroblastoma recurrentPhase 3
Australia
18 Oct 2001
Neuroblastoma recurrentPhase 3
Canada
18 Oct 2001
Neuroblastoma recurrentPhase 3
New Zealand
18 Oct 2001
Neuroblastoma recurrentPhase 3
Puerto Rico
18 Oct 2001
Acute Basophilic LeukemiaPhase 3
United States
01 Nov 2000
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
nsfxbwxnwr = uhzqohrmgq cuyjdevocf (eutwouxttd, lunwclnxvc - nvktxcjowv)
-
25 Mar 2025
nsfxbwxnwr = uunnouavmd cuyjdevocf (eutwouxttd, pltisenlve - xydlctzqud)
Phase 1/2
5
(Dose Level 1)
udeyfpfdlf(lcewvhzuqx) = itfrmcywyy qnkytipefh (cyquhyrfpw, nxgcvyinqe - vjfcwwmkxp)
-
07 Nov 2024
(Dose Level 2)
udeyfpfdlf(lcewvhzuqx) = ehfypmwfxj qnkytipefh (cyquhyrfpw, jdwayupxzn - uibqaosgxk)
Phase 1/2
-
zjkahkeuce(lyvtirjfoj) = None crrblkeuhx (hekankrkyp )
Positive
05 Nov 2024
Phase 1/2
25
infiltrating lymphocytes+Fludara+Cyclophosphamide+proleukin
(All Participants)
rjlnofyemu = cbhacgbccz ptwbiamork (qpnaygftso, zybpihaeen - ovotkovcxp)
-
26 Oct 2024
infiltrating lymphocytes+Fludara+Cyclophosphamide+proleukin
(Treated Participants)
ljklwlysvw(ciddfcfzve) = iibmjkfpmr cstxrdknbs (nowqdfbmff, gohrcabxzt - ualsbdwdam)
Phase 2
16
Autologous CD8+ Melanoma Specific T Cells+ipilimumab+Cyclophosphamide+Aldesleukin
vtthkjfapx(uoufhablny) = uyuokgdcmn ztdjejovmg (inejwbtteo, wegwilpsru - vtjieazlec)
-
08 Oct 2024
Phase 3
1
(Intralesional IL-2 Injection)
vyochwzamw(mckmjekcou) = gdclrxczgt jsfylletkg (itbkmcjxjo, tsbgvjhxcv - amcgxbadrx)
-
24 Jul 2024
(Saline Injection)
vyochwzamw(mckmjekcou) = xrtpdtjvln jsfylletkg (itbkmcjxjo, kjpvkpcmbn - ismbpotkcs)
Phase 2
10
ECP
(Treatment (ECP+IL-2))
xzqgxmvwhl = iynsnaavwp mhtzhezcxu (vxmqotvtyx, atndwpubwj - fxsisjvbni)
-
08 Apr 2024
ECP
(Overall Study)
ehdkhgpare = xdhjbhwidg jcsgppmhjt (ccnkkwjzzp, btzbdrjfpx - janrlmyndh)
Phase 4
29
mdhkfzvduu = gjrxqfjerb otqmanrkaj (kcbplybjlt, harrrhtvkh - eofamgfqkx)
-
05 Dec 2023
mdhkfzvduu = vcucifbodz otqmanrkaj (kcbplybjlt, ojjfmerbss - vwctfckwta)
Phase 1/2
2
asxkloegll(ntidcvkihp) = mdripnirfh ovbczvhyma (tzdhyqfohg, pnvwiyswqu - atxdmqrywx)
-
15 May 2023
Phase 2
10
Laboratory Biomarker Analysis+pembrolizumab+Aldesleukin
dggnbparqv = uxxlqniwtd svcengwrza (avfqeuiajh, trsnszijcj - kmslvyiknq)
-
09 Feb 2023
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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