Feasibility of a Decentralized Double-Blind Randomized Controlled Trial of Zinc and Nicotinamide Riboside for the Treatment of Idiopathic Pulmonary Fibrosis

The goal of this clinical trial is to learn if a clinical trial for idiopathic pulmonary fibrosis (IPF) can recruit and retain participants from their home to study whether a combination of zinc and nicotinamide riboside can treat iIPF. The main questions are:
Can the investigators recruit participants, and can participants complete study procedures without physically coming into specific clinical trial sites? Can people with IPF experience improvement in symptoms, quality of life, or functioning if they are take these supplements? The investigators will compare zinc and nicotinamide riboside to matched placebos (look-alike substances that contain no drug) to see if these supplements treat symptoms or lung function in people with IPF.
Participants will:
Take drug these supplements twice a day for 24 weeks. Complete pulmonary function testing and six minute walk tests with their own pulmonologists every 12 weeks. Complete a high resolution CT scan at the start and end of the study. Complete video study visits with the research team every 4 weeks. Complete surveys about their symptoms and the number of times they take the medication.

Start Date01 Jan 2025

Sponsor / Collaborator

Cedars-Sinai Health System

NCT04614714 / Not yet recruitingPhase 2/3IIT

Nicotinamide Riboside and Milk Production in the NICU

Breastfeeding has well-established immunity and developmental benefits for newborns, yet mothers of preterm infants often struggle to provide sufficient breast milk. The investigators hypothesize that supplementing mothers of preterm infants with nicotinamide riboside (NR) during early postpartum will result in increased milk production. NR is a unique precursor to NAD+, which functions in whole-body metabolism, including that which supports the elevated energy demands of lactation. In lactating rats, NR supplementation improved milk quantity and quality, with metabolic benefits for the mother and lasting protective advantages for the offspring. No studies have been conducted to date that explore the short- or long-term use of NR for increasing milk supply in lactating women. This study will follow a small cohort of women and very preterm infants in the NICU throughout two intervention phases-- one in which each mother will randomly receive either NR or a placebo, then the opposite treatment-- to determine the effect of maternal NR supplementation on expressed milk volume and other markers of metabolism.

Start Date01 Dec 2024

Sponsor / Collaborator

University of California, Davis

NCT06324877 / Not yet recruitingNot ApplicableIIT

Single Arm Open-label Clinical Trial in Ataxia-telangiectasia to Test the Effects of Nicotinamide Riboside on Ataxia Scales, Immune Function, and Neurofilament Light Chain.

Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain. Study population: 6-10 patients with Ataxia-Telangiectasia. Dose: Nicotinamide riboside 25 mg/kg/day in 3 equal divided doses.
Primary endpoint: Scales for assessment and rating of ataxia (SARA), and International Cooperative Ataxia Rating Scale (ICARS). Improvement of at least ½ standard deviation in key clinical scales which includes either; a) significant improvement in total combined scores from the SARA and ICARS scales, and /or b) significant improvements any aspects of the SARA and ICARS scales individually, especially pertaining to; Postural and gait improvements, Improved syllable speed and articulation, Improved fine motor skills.
Secondary endpoints: Serum analysis of neurofilament light chain (Nfl), Type 1 Interferon (INFs) epigenetic signature

Start Date01 May 2024

Sponsor / Collaborator

The University of Queensland

100 Clinical Results associated with Nicotinamide riboside

100 Translational Medicine associated with Nicotinamide riboside

100 Patents (Medical) associated with Nicotinamide riboside

889

Literatures (Medical) associated with Nicotinamide riboside

01 Jan 2025·Biosensors and Bioelectronics

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

Article

Author: Wang, Pei ; Yu, Qiuliyang ; Huang, Guan ; Chen, Liuqing ; Liu, Kaijing ; Cheng, Wenxiang

Nicotinamide mononucleotide (NMN) is the direct precursor and a major booster of NAD⁺ with increasing applications in NAD⁺- and aging-related pathologies. However, measuring live cell NMN dynamics was not possible, leaving key questions in NMN uptake and intracellular regulation unanswered. Here we developed genetically encoded bioluminescent and fluorescent sensors to quantify subcellular NMN in live cells by engineering specific NMN-responsive protein scaffolds fused to luciferase and fluorescent proteins. The sensor dissected the multimechanistic uptake of exogenous NMN and nicotinamide riboside (NR) in live cells and further measured the NMN levels across different subcellular compartments, as well as the perturbed NMN/NAD⁺ ratios by external supplements. Moreover, we measured the NMN regulation by NAD(H) hydrolase Nudts and peroxisomal carrier Pxmp2 and identified Slc25a45 as a potential mitochondrial NMN regulator for its unique fingerprint on the local NMN/NAD⁺ ratio. Collectively, the genetically encoded sensors provide a useful tool for visualizing NMN metabolism.

31 Dec 2024·Adipocyte

Function of NAD metabolism in white adipose tissue: lessons from mouse models

Review

Author: Kwon, So Young ; Park, Yoon Jung

Nicotinamide Adenine Dinucleotide (NAD) is an endogenous substance in redox reactions and regulates various functions in metabolism. NAD and its precursors are known for their anti-ageing and anti-obesity properties and are mainly active in the liver and muscle. Boosting NAD+ through supplementation with the precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), enhances insulin sensitivity and circadian rhythm in the liver, and improves mitochondrial function in the muscle. Recent evidence has revealed that the adipose tissue could be another direct target of NAD supplementation by attenuating inflammation and fat accumulation. Moreover, murine studies with genetically modified models demonstrated that nicotinamide phosphoribosyltransferase (NAMPT), a NAD regulatory enzyme that synthesizes NMN, played a critical role in lipogenesis and lipolysis in an adipocyte-specific manner. The tissue-specific effects of NAD+ metabolic pathways indicate a potential of the NAD precursors to control metabolic stress particularly via focusing on adipose tissue. Therefore, this narrative review raises an importance of NAD metabolism in white adipose tissue (WAT) through a variety of studies using different mouse models.

01 Dec 2024·Life Science Alliance

NAD⁺depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia

Article

Author: Vasam, Goutham ; Green, Alex ; Bainbridge, Shannon A ; Cariaco, Yusmaris ; Menzies, Keir J ; Nik-Akhtar, Abolfazl ; Jahan, Fahmida

Preeclampsia (PE) is a hypertensive disorder of pregnancy and a major cause of maternal/perinatal adverse health outcomes with no effective therapeutic strategies. Our group previously identified distinct subclasses of PE, one of which exhibits heightened placental inflammation (inflammation-driven PE). In non-pregnant populations, chronic inflammation is associated with decreased levels of cellular NAD+, a vitamin B3 derivative involved in energy metabolism and mitochondrial function. Interestingly, specifically in placentas from women with inflammation-driven PE, we observed the increased activity of NAD+-consuming enzymes, decreased NAD+content, decreased expression of mitochondrial proteins, and increased oxidative damage. HTR8 human trophoblasts likewise demonstrated increased NAD+-dependent ADP-ribosyltransferase (ART) activity, coupled with decreased mitochondrial respiration rates and invasive function under inflammatory conditions. Such adverse effects were attenuated by boosting cellular NAD+levels with nicotinamide riboside (NR). Finally, in an LPS-induced rat model of inflammation-driven PE, NR administration (200 mg/kg/day) from gestational days 1–19 prevented maternal hypertension and fetal/placental growth restriction, improved placental mitochondrial function, and reduced inflammation and oxidative stress. This study demonstrates the critical role of NAD+in maintaining placental function and identifies NAD+boosting as a promising preventative strategy for PE.

News (Medical) associated with Nicotinamide riboside

26 Sep 2024

·www.businesswire.com

ChromaDex to Participate in a Fireside Chat at the Lytham Partners Fall 2024 Investor Conference

LOS ANGELES--( BUSINESS WIRE )--ChromaDex Corp. (NASDAQ:CDXC), the global authority on nicotinamide adenine dinucleotide (NAD+) with a focus on healthy-aging research, today announced that Rob Fried, CEO of ChromaDex and Founder of Tru Niagen, will participate in a fireside chat moderated by Sean McGowan, Senior Analyst at Roth Capital Partners, at the Lytham Partners Fall 2024 Investor Conference. Wesley Yu, Vice President of Finance at ChromaDex, and Mr. Fried will also host virtual one-on-one meetings with investors. Company Webcast The webcasted fireside chat will take place at 1:15 PM ET on Tuesday, October 1, 2024. The webcast can be accessed at https://app.webinar.net/7yrd0odReoK or on the Company's website at chromadex.com. The webcast will also be available for replay following the event. 1x1 Meetings Mr. Fried and Mr. Yu will participate in virtual one-on-one meetings throughout the event. To arrange a meeting with management, please contact Lytham Partners at 1x1@lythampartners.com or register for the event at https://lythampartners.com/fall2024invreg . Further information on the conference is available at https://lythampartners.com/fall2024 . For additional information on ChromaDex, visit www.chromadex.com . About ChromaDex: ChromaDex Corp. (NASDAQ:CDXC) is the global authority on nicotinamide adenine dinucleotide (NAD+), with a focus on the science of healthy aging. The ChromaDex team, comprised of world-renowned scientists, works with independent investigators from esteemed universities and research institutions around the globe to uncover the full potential of NAD+. A vital coenzyme found in every cell of the human body, NAD+ declines with age and exposure to other everyday stressors. NAD+ depletion is a contributor to age-related changes in health and vitality. Setting the benchmark as the gold standard in scientific rigor, safety, quality, and transparency, ChromaDex is the innovator behind its clinically proven flagship ingredient, Niagen (patented nicotinamide riboside, or NR), the most efficient and superior-quality NAD+ booster available. Niagen is the active ingredient in ChromaDex’s consumer products, sold as the brand Tru Niagen ® , the number one healthy-aging NAD+ supplement in the United States † . Clinically proven to increase NAD+ levels, Tru Niagen is helping people around the world transform the way they age (available at www.truniagen.com ). ChromaDex’s robust patent portfolio protects NR and other NAD+ precursors. ChromaDex maintains a website at www.chromadex.com , to which ChromaDex regularly publishes copies of its press releases, news, and financial information. † Based on the top-selling dietary supplement brands by revenue per the largest U.S. e-commerce marketplace (as of 3/1/2023-2/29/2024).

Oligonucleotide

01 Jul 2024

·www.biospace.com

ChromaDex to Join Russell 2000® Index

ChromaDex continues to drive innovation and growth with its proprietary Tru Niagen® supplement, backed by strong financial performance and a robust intellectual property portfolio LOS ANGELES--(BUSINESS WIRE)-- ChromaDex Corp. (NASDAQ:CDXC), the global authority on nicotinamide adenine dinucleotide (NAD+) research with a focus on healthy aging, today announced its inclusion in the Russell 2000® Index as part of the annual reconstitution of the Russell stock indexes. This inclusion will be effective at the opening of U.S. equity markets on Monday, July 1, 2024, based on the preliminary list of additions posted on Friday, May 24, 2024. Rob Fried, CEO of ChromaDex and Founder of Tru Niagen commented, "Joining the Russell 2000 Index reflects our sustained growth and leadership in NAD+ research. Tru Niagen® is the gold standard NAD+ supplement, backed by scientific rigor, the highest quality standards, and a robust intellectual property portfolio. This achievement underscores our commitment to driving long-term value for our shareholders as we expand our global footprint, innovate with new products, and advance the science of healthy aging." The annual Russell indexes reconstitution captures the 4,000 largest U.S. stocks as of Friday, June 28, 2024, ranking them by total market capitalization. Membership in the U.S. all-cap Russell 3000® Index, which lasts for one year, guarantees automatic inclusion in either the large-cap Russell 1000® Index or the small-cap Russell 2000® Index, along with the appropriate growth and value style indexes. FTSE Russell primarily determines index membership based on objective market-capitalization rankings and style attributes. The ChromaDex team, comprised of world-renowned scientists, works with independent investigators from esteemed universities and research institutions around the globe to uncover the full potential of NAD+. A vital coenzyme found in every cell of the human body, NAD+ declines with age and exposure to other everyday stressors, which contributes to age-related changes in health and vitality. Setting the benchmark as the gold standard in scientific rigor and quality in the dietary supplement space, ChromaDex is the innovator behind its clinically proven flagship ingredient, Niagen® (patented nicotinamide riboside, or NR). Clinically proven to increase NAD+ levels, Niagen is the most efficient and superior-quality NAD+ booster helping people transform the way they age. Food-grade Niagen is available in the consumer dietary supplement Tru Niagen®, the number one healthy-aging oral NAD+ supplement in the United States*, and through partnerships with global retailers and distributors. Pharmaceutical-grade Niagen will soon be available through FDA-registered 503B outsourcing facilities and will be administered at clinics pursuant to a valid prescription. Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $10.5 trillion in assets are benchmarked against Russell's U.S. indexes. FTSE Russell, a leading global index provider, administers these indexes. For more information on the Russell 2000® Index and the Russell indexes reconstitution, please visit the Russell Reconstitution Section on the FTSE Russell website. Learn more about ChromaDex by visiting . Forward Looking Statements: This release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities and Exchange Act of 1934, as amended, including statements related to ChromaDex’s inclusion in the Russell 2000® Index as part of the annual reconstitution of the Russell stock indexes. Statements that are not a description of historical facts constitute forward-looking statements and may often, but not always, be identified by the use of such words as "expects," "anticipates," "intends," "estimates," "plans," "potential," "possible," "probable," "believes," "seeks," "may," "will," "should," "could" or the negative of such terms or other similar expressions. Risks that contribute to the uncertain nature of these forward-looking statements include the impact of the COVID-19 pandemic on our business and the global economy; our history of operating losses and need to obtain additional financing; the growth and profitability of our product sales; our ability to maintain sales, marketing and distribution capabilities; changing consumer perceptions of our products; our reliance on a single or limited number of third-party suppliers; and the risks and uncertainties associated with our business and financial condition. More detailed information about ChromaDex and the risk factors that may affect the realization of forward-looking statements is set forth in ChromaDex's Annual Report on Form 10-K for the fiscal year ended December 31, 2023, ChromaDex's Quarterly Reports on Form 10-Q and other filings submitted by ChromaDex to the SEC, copies of which may be obtained from the SEC's website at . Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and actual results may differ materially from those suggested by these forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement and ChromaDex undertakes no obligation to revise or update this release to reflect events or circumstances after the date hereof. About ChromaDex: ChromaDex Corp. (NASDAQ:CDXC) is the global authority on nicotinamide adenine dinucleotide (NAD+), with a focus on the science of healthy aging. The ChromaDex team, comprised of world-renowned scientists, works with independent investigators from esteemed universities and research institutions around the globe to uncover the full potential of NAD+. A vital coenzyme found in every cell of the human body, NAD+ declines with age and exposure to other everyday stressors. NAD+ depletion is a contributor to age-related changes in health and vitality. Setting the benchmark as the gold standard in scientific rigor and quality in the dietary supplement space, ChromaDex is the innovator behind its clinically proven flagship ingredient, Niagen® (patented nicotinamide riboside, or NR). Clinically proven to increase NAD+ levels, Niagen is the most efficient and superior-quality NAD+ booster helping people transform the way they age. Food-grade Niagen is manufactured by ChromaDex and is available in the consumer dietary supplement Tru Niagen®, the number one healthy-aging oral NAD+ supplement in the United States* (available at ). Pharmaceutical-grade Niagen will be available through FDA-registered 503B outsourcing facilities and will be administered at clinics pursuant to a valid prescription ( ). ChromaDex’s robust patent portfolio protects NR and other NAD+ precursors. ChromaDex maintains a website at , to which ChromaDex regularly publishes copies of its press releases, news, and financial information. *Based on the top-selling dietary supplement brands by revenue per the largest U.S. e-commerce marketplace (as of 3/1/2023-2/29/2024). View source version on businesswire.com: Contacts ChromaDex Media Contact: Kendall Knysch, Senior Director of Media Relations & Partnerships 310-388-6706 ext. 689 kendall.knysch@chromadex.com ChromaDex Investor Relations Contact: Ben Shamsian Lytham Partners 646-829-9701 shamsian@lythampartners.com Source: ChromaDex Corporation View this news release online at:

24 Jun 2024

·www.prnewswire.com

Hi-Tech Pharmaceuticals to Launch Highly Purified NMN+ NR Product

NORCROSS, Ga., June 24, 2024 /PRNewswire/ -- Hi-Tech Pharmaceuticals, Inc., a specialty pharmaceutical and dietary supplement company, today announced plans to launch a highly purified NMN+NR product following the recent successful completion of a pilot scale launch last year. β-Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin, which is believed to significantly improve health and wellness. NMN is a natural compound found in the human body and is constantly being metabolized. It is also found in trace amounts in certain foods. NMN serves as a precursor to NAD+, which is a coenzyme found in all living cells, and is required for the body's core biological processes, including the human body's energy production, metabolism, and gene expression. Nicotinamide Riboside (NR) is a naturally occurring molecule found in all cells and a natural building block for NAD⁺ production. NR is designed to elevate NAD⁺ levels, maintain cellular function, and enhance vitality and longevity.† Together, this combination being designed by Hi-Tech highlights that a multi-target strategy for NAD⁺ restoration such as the use of a precursor in combination with inhibitors and/or activators acting at other key points in the NAD⁺ network may be the optimum approach to NAD⁺ restoration." NMN+NR are precursors for NAD⁺, which plays a key role in many vital processes, including:Energy production† DNA repair† Regulation of genes† Cellular health and vitality† Immune function† Regulation of the sleep-wake cycle† Fortunately, NAD+ levels, which naturally decline with age, can be replenished by with high quality NMN+NR supplements. Potential benefits of restoring NAD+ levels include slowing the adverse impacts of aging, support for an improved cardiovascular function, and aiding wellness, a healthy weight management regimen and endurance. Cyclosome ® Delivery Standard NMN and NR have limited absorption due to extensive metabolism and low stability.† To address this issue, Hi-Tech uses an advanced liposomal+cyclodextrin delivery system (Cyclosome ®) designed to improve the bioavailability, created for better absorption, and a slower release into the bloodstream.† Jared Wheat, Hi-Tech's CEO, commented, "We are gearing up to launch a highly purified NMN+NR product given the success of our recent pilot launch and high market demand. We expect to leverage Hi-Tech Pharma's proven track record of providing superior ingredients to ensure that customers are buying a high-quality, pure NMN+NR supplement whenever they see our brand. We see NMN+NR as a natural fit for our comprehensive healthcare category, which is an ideal non-medicine therapy; and a new star for our portfolio, which already boasts dozens of products with our proprietary Cyclosome ® delivery system, giving us added revenue stability, visibility and the product pipeline needed to support the Company's continued growth." About Hi-Tech: Hi-Tech Pharmaceuticals is an enormously successful company that creates, manufactures and sells high-quality products. Hi-Tech has been able to increase its market share in the United States through the acquisition of sixteen acquisitions in recent years, which included the manufacturing bases of Synergy Nutritional Industries in 2005 and Nittany Pharmaceuticals in Pennsylvania in 2012.Hi Tech also acquired many large brands such as: APS Nutrition, ALR, FormuTech Nutrition, Sports One, Innovative Laboratories, LG Sciences, iForce Nutrition, Prime Nutrition, Top Secret Nutrition, and EAS. Hi-Tech healthcare products based upon its proprietary Cyclosome® Technology. Hi-Tech's recent strategy has been, and according to its leaders will continue to be, growth through Merger and Acquisition activity. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease. Media Contact: Brandon Schopp 770-797-9959 [email protected] SOURCE Hi-Tech Pharmaceuticals, Inc.

AcquisitionOligonucleotide

100 Deals associated with Nicotinamide riboside

External Link

KEGG	Wiki	ATC	Drug Bank
-	Nicotinamide riboside	A11HA01	DB14933

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Head and Neck Neoplasms	Phase 3	US	ChromaDex, Inc.	08 Nov 2019
Metastatic breast cancer	Phase 3	US	ChromaDex, Inc.	08 Nov 2019
Metastatic endometrial cancer	Phase 3	US	ChromaDex, Inc.	08 Nov 2019
Peripheral Nervous System Diseases	Phase 3	US	ChromaDex, Inc.	08 Nov 2019
Platinum-Resistant Ovarian Carcinoma	Phase 3	US	ChromaDex, Inc.	08 Nov 2019
Acute febrile illness	Phase 2	NO	ChromaDex, Inc.	01 Oct 2019
Critical Illness	Phase 2	NO	ChromaDex, Inc.	01 Oct 2019
Inflammation	Phase 2	NO	ChromaDex, Inc.	01 Oct 2019
Peripheral Arterial Disease	Phase 2	-	ChromaDex, Inc.	-
Ataxia Telangiectasia	Phase 1	NO	Sykehuset Innlandet HF	05 Jun 2019

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Biospace Manual	Phase 2	Peripheral Arterial Disease	90	Nicotinamide Riboside	(vfixuemksl) = ytiqwwelhd gllacsisdb (xdfwrpnnsy )	Positive	24 Jun 2024
				Nicotinamide Riboside combination with resveratrol	-
NCT04112043 (CTgov)	Phase 1	Hypertension	147	Walking Exercise+Nicotinamide Riboside (NR) (NR Plus Walking Exercise)	nakqjluqlu(rtqscrixvs) = hitxioqvkg ubpssqjlhc (ovdbsitndt, ksuhtfbqkn - ftpfreullu) View more	-	06 Jun 2024
				Walking Exercise (Walking Exercise Plus Placebo)	nakqjluqlu(rtqscrixvs) = fcgqdvgqyt ubpssqjlhc (ovdbsitndt, naxxbxkwpb - bkbomwgixl) View more
NCT03912220 (CTgov)	Phase 2	Small Fiber Neuropathy	45	Nicotinamide riboside (Nicotinamide Riboside)	fdbnpltupk(pwgrhzllvh) = naobzswurk kpcpsvamvg (sufxqiplff, fpbpdocchl - jmlqvengis) View more	-	06 Jun 2024
				Placebo Oral Tablet (Placebo)	fdbnpltupk(pwgrhzllvh) = mtxyocnvcl kpcpsvamvg (sufxqiplff, fjhxgsnbym - grqsppodym) View more
NCT03151707 (CTgov)	Phase 4	-	11	Nicotinamide Riboside	whtaslpafc(wsgfhyapwb) = eojovwleew zgmbncllrb (nwuipkefkv, kwztdvyxdo - gpnjizgpdx) View more	-	05 Mar 2024
NCT04818216 (NIRVANA, CTgov)	Phase 2	COVID-19 \| Acute Kidney Injury	28	Placebo (Placebo Group)	tndgvjzmev(cxustrotir) = axvincrarl xnhpbrwpyd (kzwagsadgu, qepmzadhay - ustqctjkli) View more	-	26 Dec 2023
				Nicotinamide riboside (Nicotinamide Riboside Group)	tndgvjzmev(cxustrotir) = wuvjaelksk xnhpbrwpyd (kzwagsadgu, olgvvgjmoa - ddoipjzhuj) View more
Biospace Manual	Phase 1	Parkinson Disease	20	Niagen 3000 mg	(utcdeejmin) = High-dose NR was safe and well-tolerated with no related adverse events. rmlwhznpjd (iipxgniomk ) View more	Positive	30 Nov 2023
				placebo
NCT03642990 (CTgov)	Phase 2	Metastatic endometrial cancer \| Metastatic breast cancer \| Peripheral Nervous System Diseases \| Head and Neck Neoplasms \| Platinum-Resistant Ovarian Carcinoma	5	Nicotinamide Riboside	xpztqfpudq(uvufohwvor) = dhiuxeespf simdjetgbr (zokvaityxs, wjwcnmasri - pkrdvrhcmm) View more	-	12 Apr 2023
ESC2021	Not Applicable	-	-	Nicotinamide Riboside	hvcparcccu(onscmuktrx) = befdjctvvt wiwnmjcnyf (rqlvevxeyc )	-	27 Aug 2021

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