Last update 20 Mar 2025

Ifebemtinib

Overview

Basic Info

Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Breakthrough Therapy (China)
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Structure/Sequence

Molecular FormulaC28H28F4N6O4
InChIKeyULMMVBPTWVRPSI-UHFFFAOYSA-N
CAS Registry1227948-82-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Platinum-Resistant Ovarian CarcinomaPhase 3
Hong Kong
29 Aug 2022
Platinum-Resistant Ovarian CarcinomaPhase 3
China
29 Aug 2022
Locally Advanced Malignant Solid NeoplasmPhase 2
China
10 Mar 2022
Ovarian Epithelial CarcinomaPhase 2
China
10 Mar 2022
Squamous Cell Carcinoma of Head and NeckPhase 2
China
10 Mar 2022
Triple Negative Breast CancerPhase 2
China
10 Mar 2022
Fallopian Tube CarcinomaPhase 2
China
27 Jul 2020
Ovarian Serous AdenocarcinomaPhase 2
China
27 Jul 2020
Primary peritoneal carcinomaPhase 2
China
27 Jul 2020
high grade serous adenocarcinoma of ovaryDiscovery
China
27 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
KRAS G12C mutation Solid Tumors
Second line | First line
48
Ifebemtinib (100mg qd) + D-1553 (600mg bid)
(mzhbgczwtz) = 7 pts (14.6%) had ifebemtinib-related SAEs, and 6 (12.5%) were also considered D-1553 related. nrfdcuogxe (npvvxknxht )
Positive
14 Sep 2024
(KRAS G12C mutant metastatic CRC)
NEWS
ManualManual
Phase 1/2
33
(hglaukuhrf) = omzpxgyiei zxfuxyypkd (cdblyyqafx )
Positive
03 Jun 2024
Phase 1/2
33
ifebemtinib (IN10018) 100D-1553
tklxjhammt(etodrbkwjf) = Four subjects (12.1%) had ifebemtinib-related SAEs (diarrhea, enteritis, oedema peripheral and proteinuria) as assessed by investigators, and all SAEs were also considered D-1553 related. lqctfcnukq (moqoxzcryo )
Positive
24 May 2024
Phase 1
61
(scbnhksuxr) = jtgmglreca qutkaubgwp (ssxhnblgsc )
Positive
22 Oct 2023
Phase 1/2
26
(pzfatwyxsc) = pfoqfdzakp gsbgcvwiuu (gghytzzokh, 2.1 - 48.4)
Positive
21 Oct 2023
(pzfatwyxsc) = cdidgtrhif gsbgcvwiuu (gghytzzokh, 3.8 - 42.8)
Phase 1
50
(uzmzufyzvt) = wfngwdkyew vniiohfcnd (sroaxvhezq )
Positive
11 Nov 2022
Phase 1
50
IN10018 100mg QD + PLD 40mg/m2 Q4W
(cguxmcuxyf) = nggbhjygez gbzaajmvje (zrxqkrjexj, 38.7% - 70.2%)
Positive
21 Sep 2022
ASCO2022
ManualManual
Phase 1
42
(beogmfxqtp) = ubzfjvwqwx duhyjpnqzo (sfrvkoefyq, 37.4 - 74.5)
Positive
02 Jun 2022
(patients who had at least 6 months of follow up)
(beogmfxqtp) = dqgksuqzsz duhyjpnqzo (sfrvkoefyq, 40.8 - 84.6)
Phase 1
96
(200 mg QD)
(ihczvnrrqn) = dbuzplynjh xjemmgolma (ynppqrqafk )
Positive
01 Feb 2019
(yqtgpyupff) = aerliefilc dpvctzabis (xzajygndfw )
Phase 1
21
(obgqqwddjz) = ftcptrxgon mivjizdfwd (beoflmmofa )
Positive
01 Feb 2019
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