Last update 21 Nov 2024

Mitoxantrone liposomal(CSPC Pharmaceutical Group Ltd.)

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone, Mitoxantrone, Mitoxantrone hydrochloride liposome
+ [9]
Target
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jun 2021),
RegulationConditional marketing approval (CN), Orphan Drug (US)
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Structure

Molecular FormulaC22H30Cl2N4O6
InChIKeyZAHQPTJLOCWVPG-UHFFFAOYSA-N
CAS Registry70476-82-3
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
CN
01 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nasopharyngeal CarcinomaPhase 3
CN
15 Feb 2023
Peripheral T-cell lymphoma unspecified refractoryPhase 3
CN
14 Apr 2021
Peripheral T-cell lymphoma unspecified recurrentPhase 2
CN
02 Apr 2018
Refractory NK-Cell Lymphoma, UnclassifiablePhase 2
CN
02 Apr 2018
Non-Hodgkin LymphomaPhase 2
US
01 Aug 2016
Cutaneous T-Cell LymphomaPhase 2
CN
10 May 2016
Diffuse Large B-Cell LymphomaPhase 2
CN
01 Dec 2015
Breast CancerPhase 2
CN
26 Oct 2015
Metastatic breast cancerPhase 2
CN
01 Jun 2015
Multiple SclerosisPhase 2
US
01 Feb 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
21
(rpqxbzfwna) = sraubjlcgy hknrkpxqfh (ryvvgcnpsm, 29.9 - 80.2)
Positive
15 Sep 2024
Phase 1
51
(umbtkyerzs) = mvtenikhua pchtnvhnjw (elqzxfowww )
Positive
24 May 2024
Phase 2
16
ddtseddtaj(lmcknfzrjk) = jfdoynmwfh qkoxnaseqm (nndnfsqnsr, avkqnolwgk - mvwfgvspqw)
-
18 Apr 2024
ASH2023
ManualManual
Not Applicable
18
(elrrutxewh) = afdckkbhln fuxaugjlut (tjtmaegmxs )
Positive
10 Dec 2023
Not Applicable
82
(xnomozlluu) = 73.2% mvkrytrndr (qonsqmfryz )
Positive
31 May 2023
Not Applicable
58
uiphvxzfwi(pjmkxshoma) = 15% of those had some evidence of cardiotoxicity, with an ejection fraction of < 50% or 10% decrease from baseline. Of the participants with changes in ejection fraction, 67% had received prior anthracycline therapy and 33% had received a total lifetime dose of doxorubicin exceeding the recommended 500 mg/m² limit swfsidxafl (uctdeanmdy )
Negative
31 May 2023
ASCO2023
ManualManual
Phase 1
23
(omuknnzbmr) = yfiqinehxv blrkplxwid (pjvezkhojk )
Positive
26 May 2023
Not Applicable
20
(sbuevhkzcy) = otqudlrvup ixmuunqewp (imooqfetpp )
-
23 Apr 2023
Phase 3
200
(CPI-613 + HD Cytarabine and Mitoxantrone)
(gfrtzxihxn) = jsfxbtzmno jxlytjvosx (ooicxausqm, byurwsnkoj - jivyyabear)
-
13 Dec 2022
(Control (HAM) and Control Sub-groups (MEC and FLAG))
(gfrtzxihxn) = ncfnvfmcmf jxlytjvosx (ooicxausqm, fjawamyryd - oslnljvnmm)
Phase 1/2
31
(guzddrbewc) = vvkzssqkax bykilylawi (fzvcosavkw, 70.2% - 96.4%)
-
12 Sep 2022
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Regulation

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