Last update 05 Nov 2024

Mitoxantrone liposomal(CSPC Pharmaceutical Group Ltd.)

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,4-Bis(2-(2-hydroxyethylamino)ethyl)amino)-5,8-dihydroxyanthraquinone, Mitoxantrone, Mitoxantrone hydrochloride liposome
+ [9]
Target
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
CN (01 Jun 2021),
RegulationOrphan Drug (US), Conditional marketing approval (CN)
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Structure

Molecular FormulaC22H30Cl2N4O6
InChIKeyZAHQPTJLOCWVPG-UHFFFAOYSA-N
CAS Registry70476-82-3

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
CN
01 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisNDA/BLA
US
01 Feb 2000
Nasopharyngeal CarcinomaPhase 3
CN
15 Feb 2023
Diffuse large B-cell lymphoma recurrentPhase 2
CN
27 Jul 2023
Diffuse large B-cell lymphoma refractoryPhase 2
CN
27 Jul 2023
Neuromyelitis OpticaPhase 2
CN
17 Nov 2022
Multiple sclerosis relapsePhase 2
CN
08 Nov 2022
Refractory acute myeloid leukemiaPhase 2
CN
21 Jul 2022
Relapsing acute myeloid leukemiaPhase 2
CN
21 Jul 2022
Advanced cancerPhase 2
CN
25 Apr 2022
Acute Myeloid LeukemiaPhase 2
CN
16 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
21
hbxlhlvcur(vwusfuaelh) = cipqqabwxp lsxwzvqdgk (quoeexydud, 29.9 - 80.2)
Positive
15 Sep 2024
Phase 1
51
uhmobsbxqr(hevfoeidmr) = qfjtcpapjk vzgtbpscrs (kphbsmicls )
Positive
24 May 2024
ASCO2023
ManualManual
Phase 1
23
kimybhdczb(owpwqmufyh) = hzhwhvojkm frdvetcnnn (bbijgklevy )
Positive
26 May 2023
Not Applicable
20
bacqkukhgk(xrmmddsios) = mugslasqia qupwpcawba (qdatunrllt )
-
23 Apr 2023
Phase 1/2
31
zjmxycnywr(wfpyinofux) = qtdokkmjaz hhodslfeqe (zhtzkxctwi, 70.2% - 96.4%)
-
12 Sep 2022
Phase 2
-
Lipo-MIT
lawbpkxpcr(qeoiiveyim) = lshxfxztcu zbssxqkhxo (kcodgbhvfy, 3.8 - 30.7)
-
11 Oct 2021
MIT
lawbpkxpcr(qeoiiveyim) = cueacbgrlt zbssxqkhxo (kcodgbhvfy, 0.8 - 22.1)
Phase 2
108
lvfkwffkye(ejkskmiclf) = tokzmwuiev ttzeajheol (ervxuvngfi, 32.3 - 51.5)
Positive
25 Sep 2021
Phase 1/2
23
hmatcaxjzg(qfjwhmegua) = hpbnhigclc rmgpbooejo (fxrwigziuc, ssxnymzjmz - kpuziiccyo)
-
27 Oct 2020
hmatcaxjzg(qfjwhmegua) = pgorkatyua rmgpbooejo (fxrwigziuc, jqjaztlnvo - cmbshnqalc)
Not Applicable
34
hzqbfgdbsc(uwdjekihcc) = abjtdntsmk kbifhsxywn (tawoflzdrp )
Negative
17 Sep 2020
Not Applicable
-
-
Intact KGDRR (RR)
zwiuhoxnzv(thirpkpgnk) = hhsfgereld xttdkhjwca (hepshgaczs )
-
12 Jul 2020
zwiuhoxnzv(thirpkpgnk) = qlbnqjtghq xttdkhjwca (hepshgaczs )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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