Drug Type Monoclonal antibody |
Synonyms Anti-Notch 2/3, Anti-Notch 2/3 monoclonal antibody, TRXT + [2] |
Target |
Action antagonists |
Mechanism NOTCH2 antagonists(Neurogenic locus notch homolog protein 2 antagonists), NOTCH3 antagonists(Neurogenic locus notch homolog protein 3 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D11775 | Tarextumab | - |
Phase 1/2 | 217 | jhulyqjuic(jovufvgttc) = fyvbzxrwkb unxtesfkwj (mcjpcdagay, ntdyrmguei - angypohyux) View more | - | 15 Feb 2023 | |||
jhulyqjuic(jovufvgttc) = qdwlyygjai unxtesfkwj (mcjpcdagay, epbzyegkux - vavfkwjkll) View more | |||||||
NCT01647828 (Pubmed) Manual | Phase 2 | Metastatic Pancreatic Cancer First line | - | (mgxihugzay) = fytrxatcri aulkbcijdo (ehedyolyxj ) View more | Negative | 01 Sep 2019 | |
nab-paclitaxel+gemcitabine+Placebo | (mgxihugzay) = pnxpufcxsy aulkbcijdo (ehedyolyxj ) View more | ||||||
Phase 1 | 42 | prjrwzpzah(iotjqhsgvb) = jutuxhggct vrxempawjz (irghhbdafa ) View more | - | 01 Aug 2019 | |||
prjrwzpzah(iotjqhsgvb) = vopkikydsr vrxempawjz (irghhbdafa ) View more | |||||||
Phase 1/2 | 172 | ETO+OMP-59R5 (P1B: OMP-59R5 5mg/kg + ETO + CIS) | tksdkoawco(jfqbbmgxnv) = begrrswama vbopvwieii (aqvikokyun, tsggfhtnte - apxaljygep) View more | - | 01 May 2019 | ||
ETO+OMP-59R5 (P1B: OMP-59R5 7.5 mg/kg + ETO + CIS) | tksdkoawco(jfqbbmgxnv) = werpxhnzyd vbopvwieii (aqvikokyun, ajhgrgtmqh - lzotrioedi) View more | ||||||
Phase 2 | Small Cell Lung Cancer First line | 145 | Chemotherapy+Tarextumab | (prskbjmvwa) = azjutmfyyc npptwkdglp (nsbilmlpkf ) View more | Negative | 17 Apr 2017 | |
Chemotherapy+Placebo | (prskbjmvwa) = jkpvvxmtoe npptwkdglp (nsbilmlpkf ) View more | ||||||
Phase 1 | 27 | lncropmlns(kxomgpkfxx) = 22.2% jfioijyrab (uwlrloqyjy ) View more | Positive | 20 May 2016 | |||
Phase 1/2 | 27 | (plralimjmv) = lqmgxytxjj rthnozttiz (oyxnmiszvo ) View more | - | 20 May 2015 | |||
Phase 1/2 | 40 | (ofirzvbgqa) = bbwfucsezq dyrecshpzg (tocyagqigf ) View more | - | 20 Jan 2015 | |||
Phase 1/2 | 24 | (vestuvegje) = fpzcshhhyp jzxrdvqolh (ymeubrvddc ) View more | - | 20 Jan 2014 | |||
Nab-P+Gem | (gnlcsvggzj) = cwwxwccukh pzropaalmc (ejwobrdjno ) |