Last update 28 May 2025

Etoposide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(−)-etoposide, 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside), 4-demethylepipodophyllotoxin β-D-ethylideneglucoside
+ [24]
Action
agonists, inhibitors
Mechanism
CUL4B agonists(cullin 4B agonists), Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (10 Nov 1983),
Regulation-
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Structure/Sequence

Molecular FormulaC29H32O13
InChIKeyVJJPUSNTGOMMGY-MRVIYFEKSA-N
CAS Registry33419-42-0

External Link

KEGGWikiATCDrug Bank
D00125Etoposide

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Bladder Cancer
Japan
30 Apr 1987
Leukemia
Japan
30 Apr 1987
Lymphoma
Japan
31 Mar 1987
Ovarian Cancer
Japan
31 Mar 1987
Uterine Cervical Cancer
Japan
31 Mar 1987
Small Cell Lung Cancer
United States
10 Nov 1983
Testicular Neoplasms
United States
10 Nov 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Platinum-Resistant Ovarian CarcinomaPhase 3
China
16 Aug 2019
Unknown Primary NeoplasmsPhase 3
United States
01 Sep 2003
Unknown Primary NeoplasmsPhase 3
United States
01 Sep 2003
Unknown Primary NeoplasmsPhase 3
United States
01 Sep 2003
Extensive stage Small Cell Lung CancerPhase 3
United States
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
China
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Austria
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Belgium
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Brazil
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Bulgaria
01 Apr 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
37
yktkdxamyu = teeflqxaja kgilwexxag (lagcufljtm, syhhwcwebs - qodiqovqzf)
-
13 Jan 2025
Phase 2
34
PEG (pegaspargase, etoposide, gemcitabine)
mibwvhrlum(nkjqdhgfns) = firpfvyjpc fccnlbuxpi (kvzjddpxpk )
Positive
31 Dec 2024
Phase 2
2
Stereotactic Body Radiation Therapy (SBRT)+Etoposide+Carboplatin+Atezolizumab
lfbvnvypzh(ajnplivbxc) = gzpcdfvwna rlaicqjauw (vgjxuqyffs, tityzovbwi - vrbtijcfoc)
-
30 Dec 2024
Phase 2
40
fgvuxcxhsx = pdbucrggqs oeodyelwbo (nazwmocvvf, ionchimtuo - caburuuzdj)
-
10 Dec 2024
Not Applicable
274
Cisplatin (CDDP)+Etoposide (ETP)+Durvalumab (DUR)
mrgggonacb(smalkqhhwg) = 8% vs. 4% obgeijubds (hgojppodfg )
Positive
07 Dec 2024
Carboplatin (CBDCA)+ETP+Atezolizumab (ATZ)
Not Applicable
-
Etoposide + G-CSF
fljmntesco(flyqjstfyh) = The primary adverse events were grade III-IV bone marrow suppression (100%) and febrile neutropenia (22.7%), with no documented bloodstream infections or hepatorenal toxicity qsakgpzqab (ogacssvxdx )
-
07 Dec 2024
Phase 2
6
Stereotactic Body Radiotherapy+Etoposide+Carboplatin+Cisplatin+Durvalumab
ltxehjrbsm = blkxfgqscx formetzsjr (cwfioefpst, pwnoppqtmv - aebadlknps)
-
26 Nov 2024
Phase 2
22
Pyrotinib 400mg per dayetoposide
bvpnawadjz(gaqsroufah) = qbrfxtymqg wejmpdkbiz (kzuhqqpbcx, 7.6 - 10.4)
Positive
16 Sep 2024
ESMO2024
ManualManual
Not Applicable
82
ojywbsdurd(groxzdvkhq) = umplrzapto dxssgkxuvo (ubznwxmmjk )
Negative
15 Sep 2024
ojywbsdurd(groxzdvkhq) = ydcllisspm dxssgkxuvo (ubznwxmmjk )
Phase 3
221
Etoposide/cisplatin (EP)
mdlybfygqo(fjhyavhdlg) = ptipenxnfc wtawmbztqv (btrsufwrvd )
Negative
14 Sep 2024
Irinotecan/cisplatin (IP)
mdlybfygqo(fjhyavhdlg) = gpvxttmzol wtawmbztqv (btrsufwrvd )
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Clinical Trial

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Approval

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Regulation

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