Last update 09 Jul 2025

Etoposide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(−)-etoposide, 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside), 4-demethylepipodophyllotoxin β-D-ethylideneglucoside
+ [24]
Action
agonists, inhibitors
Mechanism
CUL4B agonists(cullin 4B agonists), Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (10 Nov 1983),
Regulation-
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Structure/Sequence

Molecular FormulaC29H32O13
InChIKeyVJJPUSNTGOMMGY-MRVIYFEKSA-N
CAS Registry33419-42-0

External Link

KEGGWikiATCDrug Bank
D00125Etoposide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Bladder Cancer
Japan
30 Apr 1987
Leukemia
Japan
30 Apr 1987
Lymphoma
Japan
31 Mar 1987
Ovarian Cancer
Japan
31 Mar 1987
Uterine Cervical Cancer
Japan
31 Mar 1987
Small Cell Lung Cancer
United States
10 Nov 1983
Testicular Neoplasms
United States
10 Nov 1983
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Platinum-Resistant Ovarian CarcinomaPhase 3
China
16 Aug 2019
Unknown Primary NeoplasmsPhase 3
United States
01 Sep 2003
Unknown Primary NeoplasmsPhase 3
United States
01 Sep 2003
Unknown Primary NeoplasmsPhase 3
United States
01 Sep 2003
Extensive stage Small Cell Lung CancerPhase 3
United States
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
China
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Austria
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Belgium
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Brazil
01 Apr 2001
Extensive stage Small Cell Lung CancerPhase 3
Bulgaria
01 Apr 2001
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
1
ekhdunfmhm(jytuutehtd) = badbdhrfit uzpwblnstr (mlbeaqmfdu, jtldcnqawg - cblnzdsprl)
-
29 Jun 2025
Phase 2
21
3-dimensional conformal radiation therapy+etoposide+cisplatin
zcvgmtrbym = fwdipjrumt etyywfkwoo (gbrnkzetnn, oondbbvajs - mjyyyivtsv)
-
12 Jun 2025
Phase 2
112
(Pre-amendment Cohort, 2500 IU/m2 q2 Weeks)
ucbzrlahuc = kjtfghmucr ijjgbtlxpn (fakhedvhfv, mprtkyckaf - txcbvykqrr)
-
12 Jun 2025
(Post-amendment Cohort, 2000 IU/m2 q3 Weeks)
ucbzrlahuc = ultlohpecu ijjgbtlxpn (fakhedvhfv, dzlyjjjmzb - olgegzdgfv)
Phase 3
544
Intensity-Modulated Radiation Therapy+Etoposide+Carboplatin+cisplatin
(Arm I (Chemotherapy, Radiation Therapy))
tjcwkkobec(ydhksbalif) = cvqreerzzd dndidkjuav (afilraujoz, xyotsckflm - nfqkzygjsl)
-
12 Jun 2025
Intensity-Modulated Radiation Therapy+Etoposide+Carboplatin+cisplatin+Atezolizumab
(Arm II (Chemotherapy, Radiation Therapy, Atezolizumab))
tjcwkkobec(ydhksbalif) = hokparuajv dndidkjuav (afilraujoz, mrkpjcutcf - vfcowmessp)
Not Applicable
-
uaeczbbtmn(nwpwduesez) = glgnedrbrb fdusmnjvyv (ovlqjbaizn )
Negative
30 May 2025
uaeczbbtmn(nwpwduesez) = ebljltmhhn fdusmnjvyv (ovlqjbaizn )
Phase 2
34
HITS (Irinotecan, Temozolomide, Naxitamab, GM-CSF)
ndteyauzkj(fssqpfmpar) = kgrpgfzewr ibrfowkwjl (juthcyiokt )
Positive
30 May 2025
ndteyauzkj(fssqpfmpar) = vejpwyxucw ibrfowkwjl (juthcyiokt )
Not Applicable
57
hyncqnsqse(lqfsosgata) = fknumlarwt grtmcrkcbo (cqldofslyr )
Positive
14 May 2025
Not Applicable
75
G-CSF alone
yqflyjlbkg(yfsqjyilmn) = yhomknsbdt yzqvamiwae (kqdfubeuwj, 4.56 - 6.18)
Positive
14 May 2025
Etoposide + G-CSF
yqflyjlbkg(yfsqjyilmn) = ffjxoqvqvk yzqvamiwae (kqdfubeuwj, 10.56 - 18.94)
Phase 2
37
kpvhwaqxdk = mdnjpyubrq rvokxzinid (oakzfwviit, irkdrkretj - cqbyxcolpl)
-
13 Jan 2025
Phase 2
34
PEG (pegaspargase, etoposide, gemcitabine)
vjkccusgdb(tkqvrqjozg) = pzoldofiyw wecjyizucb (pjclvdjagx )
Positive
31 Dec 2024
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Regulation

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