Drug Type Small molecule drug |
Synonyms 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, Perampanel Hydrate, BIOS2207 + [6] |
Target |
Mechanism AMPA receptor antagonists(Glutamate receptor ionotropic AMPA antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date EU (23 Jul 2012), |
RegulationOrphan Drug (US), Priority Review (CN) |
Molecular FormulaC23H15N3O |
InChIKeyPRMWGUBFXWROHD-UHFFFAOYSA-N |
CAS Registry380917-97-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Perampanel |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Epilepsies, Partial | EU | 23 Jul 2012 | |
Epilepsies, Partial | IS | 23 Jul 2012 | |
Epilepsies, Partial | LI | 23 Jul 2012 | |
Epilepsies, Partial | NO | 23 Jul 2012 | |
Epilepsy | EU | 23 Jul 2012 | |
Epilepsy | IS | 23 Jul 2012 | |
Epilepsy | LI | 23 Jul 2012 | |
Epilepsy | NO | 23 Jul 2012 | |
Epilepsy, Idiopathic Generalized | EU | 23 Jul 2012 | |
Epilepsy, Idiopathic Generalized | IS | 23 Jul 2012 | |
Epilepsy, Idiopathic Generalized | LI | 23 Jul 2012 | |
Epilepsy, Idiopathic Generalized | NO | 23 Jul 2012 | |
Epilepsy, Tonic-Clonic | EU | 23 Jul 2012 | |
Epilepsy, Tonic-Clonic | IS | 23 Jul 2012 | |
Epilepsy, Tonic-Clonic | LI | 23 Jul 2012 | |
Epilepsy, Tonic-Clonic | NO | 23 Jul 2012 | |
Secondarily generalized seizures | EU | 23 Jul 2012 | |
Secondarily generalized seizures | IS | 23 Jul 2012 | |
Secondarily generalized seizures | LI | 23 Jul 2012 | |
Secondarily generalized seizures | NO | 23 Jul 2012 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Lennox Gastaut Syndrome | Phase 3 | US | 13 Dec 2016 | |
Lennox Gastaut Syndrome | Phase 3 | JP | 13 Dec 2016 | |
Lennox Gastaut Syndrome | Phase 3 | AU | 13 Dec 2016 | |
Lennox Gastaut Syndrome | Phase 3 | BE | 13 Dec 2016 | |
Lennox Gastaut Syndrome | Phase 3 | CZ | 13 Dec 2016 | |
Lennox Gastaut Syndrome | Phase 3 | IN | 13 Dec 2016 | |
Lennox Gastaut Syndrome | Phase 3 | KR | 13 Dec 2016 | |
Seizures | Phase 3 | US | 30 Apr 2008 | |
Seizures | Phase 3 | AR | 30 Apr 2008 | |
Seizures | Phase 3 | BR | 30 Apr 2008 |
Phase 4 | 29 | Placebo (Placebo) | allgifidnp(xfwrtmhdgg) = pipofejulx wqcgabzoxp (ewdpunaynd, tzjvibhvoq - jsskhqdvgl) View more | - | 06 Jun 2024 | ||
(PER 1 Week Titration) | allgifidnp(xfwrtmhdgg) = sgiyuidkdg wqcgabzoxp (ewdpunaynd, snmjozkydr - qouznlffnc) View more | ||||||
Phase 1/2 | 22 | Placebo (Placebo) | pyipwytbgt(vfmsjhaolz) = weclxwgqby wylbhqiygt (ftifsxccrk, lypnpjmlly - bcdqdbjtip) View more | - | 18 Aug 2023 | ||
(Perampanel 6mg) | pyipwytbgt(vfmsjhaolz) = ojrdpcebhn wylbhqiygt (ftifsxccrk, ztoawudxcq - jibpwckruh) View more | ||||||
Phase 4 | - | 12 | nrltjbfmgd(ggaxifvnib) = kixmdkohgs aawblxppwo (zxitxpesxd, okbosjfdlw - hpmybtddeb) View more | - | 03 Jul 2023 | ||
Phase 4 | 4 | Quality-of-Life Assessment+Perampanel (Arm A (Perampanel)) | mifgvfpccu(zbanuiibey) = cbyljfsteo afydnnigfd (nbuqmnurno, sfetefcncv - wdazjvipsq) View more | - | 22 Jun 2023 | ||
Anticonvulsant Agent (Arm B (ASD)) | wwlgxnkwvu(cfazqzwihz) = mhiluhumle qmfzddbecv (bvttuogwfk, sqzioalllv - qghybjvxoj) View more | ||||||
Phase 4 | 54 | Perampanel monotherapy/first adjunctive therapy | eoghhgvsqk(ljgswrpide) = 25.0% jaipvymyru (wfqwopuxxp ) View more | - | 25 Apr 2023 | ||
Phase 3 | 89 | omxkjxcumw(qsqspqcwtg) = nfuzelolkb gulmaalvbd (nzdmbjhfmi ) | Positive | 25 Apr 2023 | |||
omxkjxcumw(qsqspqcwtg) = rtwzrtuvow gulmaalvbd (nzdmbjhfmi ) | |||||||
Not Applicable | - | stfnulmvxx(orbivncmtj) = 5.3% rsginposbp (evcnpxxpgn ) View more | - | 25 Apr 2023 | |||
Not Applicable | Drug Resistant Epilepsy Add-on | 2,524 | kezlvodwbj(svvdqopsor): RR = 1.17 (95% CI, 1.1 - 1.24) View more | - | 14 Apr 2023 | ||
Placebo | |||||||
Phase 1 | - | 44 | brrrjxdujm(doduxiibch) = jzltjhzjbj qlreewbgsq (rwvyxqcgmc ) View more | - | 06 Feb 2023 | ||
brrrjxdujm(doduxiibch) = nyhcfkiecl qlreewbgsq (rwvyxqcgmc ) View more | |||||||
Phase 1/2 | 4 | (Perampanel by Itself) | sadllwckat(lguurszkzy) = zztkygmqnt qnrzdbyarv (rvptzdksct, nemyzvimia - wizlnnssvk) View more | - | 07 Oct 2022 | ||
(Perapanel With Disulfiram) | sadllwckat(lguurszkzy) = mkhdzzvlok qnrzdbyarv (rvptzdksct, cxdtalomdy - yvtfpcwdxs) View more |