Preservative-free Fixed-dose Combination of Tafluprost 0.0015% / Timolol 0.5% in Patients With Open-angle Glaucoma or Ocular Hypertension: Clinical Effectiveness, Tolerability and Safety in a Real World Setting

The primary objective of this study is to assess the effectiveness of Tafluprost / Timolol in controlling ocular hypertension, as measured by mean change in intra-ocular pressure (IOP) from baseline to after 6 months of treatment from initiation, in patients with open angle glaucoma (OAG) or ocular hypertension (OHT), who do not respond sufficiently to initial topical treatment, in routine clinical practice.

Start Date01 Sep 2021

Sponsor / Collaborator

Santen Pharmaceutical Co., Ltd.

NCT04489810

/ CompletedNot Applicable

GlutDigest - Enzymes-assisted Gluten Digestion

This study evaluates the impact of two dietary supplements (Elevase® and DE111®) and of oatmeal properties on the digestion of gluten and starch and on the glycemic response.

Start Date19 Oct 2020

Sponsor / Collaborator

Teagasc

[+1]

NCT04489836

/ CompletedNot Applicable

GlutDigest - Enzymes-assisted Gluten Digestion (Pilot Study)

This is a pilot, feasibility study to evaluate, test and optimize sample analysis procedures and protocols before the full-scale, crossover study is conducted.

Start Date31 Aug 2020

Sponsor / Collaborator

Deerland Enzymes, Inc.

[+2]

100 Clinical Results associated with Tafluprost/Timolol Maleate

100 Translational Medicine associated with Tafluprost/Timolol Maleate

100 Patents (Medical) associated with Tafluprost/Timolol Maleate

Literatures (Medical) associated with Tafluprost/Timolol Maleate

03 Dec 2024·Beneficial Microbes

Bacillus subtilis DE111 partially reverses endothelial dysfunction in western-diet fed mice

Article

Author: Brown, G.D. ; Wei, Y. ; Stark, G.C. ; Graham, E.L. ; Risk, B.D. ; Gentile, C.L. ; Weir, T.L. ; Zhang, M.

Abstract:

Imbalances in the gut microbiome have emerged as an important factor in endothelial dysfunction, a significant risk factor for cardiovascular disease. Thus, interventions targeting the microbiome may prove helpful in preventing or reversing this impairment. We previously reported that spore-forming Bacillus subtilis DE111 improved endothelial function in a cohort of healthy, non-obese humans after a four-week intervention. Building on these promising results, the present study sought to investigate whether administering B. subtilis DE111 could reverse endothelial dysfunction in mice with diet-induced obesity. Male C57BL/6J mice were fed a Western diet (WD; n = 24) or standard diet (SD; n = 24) for ten weeks to induce endothelial dysfunction, after which half of the animals in each group (n = 12) were allocated to receive B. subtilis DE111 (hereafter, PB) formulated into the diet for an additional eight weeks. Outcomes included endothelial-dependent arterial dilation, glucose tolerance, body weight changes, microbiota profiles, and assessments of intestinal permeability and mucosal immunity markers. Furthermore, a cell culture model of gut barrier function was used to assess the effects of PB on gut barrier integrity. PB treatment significantly attenuated WD-induced mesenteric endothelial-dependent arterial dilation, independent of changes in other cardiometabolic parameters or changes in gut barrier function. In vitro trans-epithelial electrical resistance of the Caco-2 cell culture confirmed that neither PB-conditioned media nor faecal waters from B. subtilis-treated human stool resulted in gut barrier improvements, nor did they protect against inflammation-associated barrier disruptions. Unsurprisingly, microbiota analysis revealed significant differences in Shannon’s alpha diversity of WD-fed animals compared to SD. These data suggest that PB consumption significantly attenuated WD diet-induced endothelial dysfunction; however, the underlying mechanisms of this protection were not determined. Improvement in endothelial function was independent of PB-mediated changes to body weight or gut barrier function. Further studies should explore B. subtilis-mediated immune responses or metabolite production as mechanisms underlying these endothelial protective effects.

23 Feb 2023·Beneficial microbes

Acute physiological effects following Bacillus subtilis DE111 oral ingestion – a randomised, double blinded, placebo-controlled study

Article

Author: Khokhlova, E. ; Buckley, M. ; Phipps, C. ; Mazhar, S. ; Colom, J. ; Brodkorb, A. ; Simon, A. ; Rea, K. ; Freitas, D. ; Deaton, J.

Previous studies using ileostomy samples from study participants demonstrated that the spore-forming probiotic Bacillus subtilis DE111® can germinate in the small intestine as early as 4 hours after ingestion. Metabolomics, proteomics and sequencing technologies, enabled further analysis of these samples for the presence of hypoglycaemic, hypolipidemic, antioxidant, anti-inflammatory and antihypertensive molecules. In the DE111 treatment group, the polyphenols trigonelline and 2,5-dihydroxybenzoic acid, orotic acid, the non-essential amino acid cystine and the lipokine 12,13-diHome were increased. DE111 also reduced acetylcholine levels in the ileostomy samples, and increased the expression of leucocyte recruiting proteins, antimicrobial peptides and intestinal alkaline phosphatases of the brush border in the small intestine. The combination of B. subtilis DE111 and the diet administered during the study increased the expression of the proteins phosphodiesterase ENPP7, ceramidase ASAH2 and the adipokine Zn-alpha-2-glycoprotein that are involved in fatty acid and lipid metabolism. Acute B. subtilis DE111 ingestion had limited detectable effect on the microbiome, with the main change being its increased presence. These findings support previous data suggesting a beneficial role of DE111 in digestion, metabolism, and immune health that appears to begin within hours of consumption.

01 May 2022·FASEB JOURNAL

RETRACTED: Bacillus Subtilis DE111 Improves Endothelial Dependent Vascular Dilation in Mice Fed a Western Diet

Article

Author: Risk, Briana D.

Vascular dysfunction often precedes the development of cardiovascular disease in which data from our lab and others suggest a role of the gut microbiome in the development of this defect. In a pilot study of healthy humans, we observed that the spore‐based probiotic, Bacillus Subtilis DE111(DE111), improved reactive hyperemia index (RHI) scores, indicating improved vascular dilation. To further explore whether DE111 impacts cardiovascular function, the current study examined its efficacy in a diet‐induced obesity model in mice. Male C57/BJ mice were fed a standard diet (SD; n=24) or Western diet (WD; n=24) for 8 weeks to induce vascular dysfunction and were then further divided such that (n=12) half of the animals on each diet received 1billion colony forming units per day (CFU/d) of DE111. Weekly body weight was measured until termination at 6 months of age. WD and WD+DE111 mice exhibited similar increases in body weight (SD: 31.2±2.3 vs WD: 47.4±3.3 and WD+DE111: 45.7±4.0) and impairments in glucose tolerance compared to SD mice (SD: 237.1±68.0 vs WD: 410±26.9 and WD+DE111: 460±116.8, p<0.05). A 28% decrease in vessel dilation was observed with mice on a WD as compared to mice on a SD after addition of the endothelial‐dependent dilator acetylcholine (AUC, 918.3±49.25, p<0.05). However, the addition of DE111 improved endothelial mediated vessel dilation in mice fed a WD+DE111 (AUC, 991.7±47.9, p<0.05). This increase was observed independent of body weight changes and improvement in glucose tolerance. In conclusion, the addition of DE111 increased endothelial‐dependent dilation in mice fed a WD. Further analyses are underway to establish the mechanisms of this gut‐vasculature crosstalk, but our animal and human studies both suggest that the novel probiotic, DE111 may support cardiovascular health.

News (Medical) associated with Tafluprost/Timolol Maleate

10 Oct 2023

·synapse.patsnap.com

Inventory of GPCR Targeted Drugs Applying for Listing (I)

This article will review currently applied listed GPCR-targeting drugs, and the associated popular GPCR class targets and drug development opportunities worth paying attention to. 1.Eli Lilly: TirzepatideTarget:GIPR + GLP-1R Tirzepatide is a novel GIPR and GLP-1R dual agonist developed by Eli Lilly. In preclinical and clinical trials, compared to selective GLP-1 receptor agonists, GIP/GLP-1 dual agonists have been shown to better control blood sugar and reduce weight. Therefore, it is receiving increasing attention as a new therapeutic drug for controlling blood sugar and weight. In 2022, Tirzepatide was approved for the first time in the United States for the treatment of adult type II diabetes as an adjunct to diet and exercise. Subsequently, Tirzepatide was approved in the European Union and Japan for the treatment of type II diabetes. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. 2.ChemoCentryx: AvacopanTarget:C5aR Avacopan(Tavneos) is an orally administered, first-in-class selective complement 5a receptor (C5aR) antagonist, discovered and developed by ChemoCentryx. This drug is used as an adjunctive therapy for ANCA-associated vasculitis in adult patients. Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a rare ("oligo-immune") systemic small-vessel vasculitis, with an estimated incidence of 3 per 100,000 annually, characterized by the presence of ANCAs in the serum. The entire course of AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and drug-induced AAV. Despite its complex pathophysiology, research over the past approx. 20 years has determined the crucial role of the alternative complement pathway, particularly the interaction of C5a with the C5aR receptor in AAV. Avacopan was first approved for marketing in Japan on September 27, 2021, and was subsequently approved in the United States, European Union, Canada, and Australia for the treatment of adult patients with ANCA-associated vasculitis, granulomatosis with polyangiitis, and microscopic polyangiitis. In addition, research is ongoing for other potential clinical indications, such as hidradenitis suppurativa and C3 glomerulopathy. 3.Pfizer: Rimegepant Sulfate Target:CGRP Receptor Rimegepant is an orally administered CGRP receptor antagonist used for the acute treatment of migraine in adults, with or without aura. Initially developed by the BMS(BMS-742413), the newly established biotech company Biohaven Pharmaceutical acquired the exclusive global development and commercialization rights to Rimegepant in 2016. The Biohaven team conducted a series of clinical studies and analyses around Rimegepant and developed the derivative migraine nasal spray drug, Zavegepant. In May 2022, Pfizer announced that it would acquire Biohaven for a total cash consideration of approximately 11.6 billion USD. Rimegepant was first approved for marketing in the United States on February 27, 2020, and subsequently received approval in Israel, the United Arab Emirates, Kuwait, the European Union, and Iceland, among others. Currently, the drug is being tested in clinical trials for conditions like chronic sinusitis, nasal polyps, and trigeminal neuralgia. 4. Glenmark:RYALTRISTarget:H1R+GR RYALTRIS is a new compound prescription nasal spray developed by the Indian pharmaceutical company, Glenmark. This medication has the dual efficacy of activating glucocorticoid receptor (GR) and antagonizing histamine H1 receptor (H1R). Mometasone is a moderately potent synthetic corticosteroid that acts as a glucocorticoid receptor agonist, possessing anti-inflammatory, anti-itch, and vasoconstrictive properties. Olopatadine, on the other hand, is an antagonist of histamine H1 receptors used for the treatment of allergic conjunctivitis and rhinitis. Since histamine is the primary inflammatory mediator causing inflammation and allergic reactions, Olopatadine works by blocking the action of histamine receptors. Compared to other anti-allergic ophthalmic drugs, Olopatadine does not interfere with the cell membrane, thus offering good comfort and tolerability. RYALTRIS was first approved for marketing in Australia in 2019, and subsequently received approval for listing in South Africa, the UK, the US, Canada, and other countries. In 2019, Grand Pharmaceutical and Glenmark signed an exclusive licensing agreement, in which Glenmark granted Grand Pharmaceutical the exclusive rights to sell RYALTRIS in China. Glenmark would be responsible for the manufacture and supply of the authorized product, while Grand Pharmaceutical would be in charge of the clinical trials and registration work for the authorized product in China and can exclusively sell the approved product in China for 20 years upon approval. 5. Amgen:ErenumabTarget:CGRP Erenumab is a human monoclonal antibody developed by Amgen and is the first monoclonal antibody drug targeting GPCR approved by the FDA. Erenumab can specifically bind to and antagonize the Calcitonin Gene-Related Peptide Receptor (CGRPR), thus preventing migraines. In April 2017, Amgen announced an expanded commercial collaboration with Novartis on Erenumab, which is being studied for the prevention of migraine. This expanded business cooperation is based on the global neuroscience collaboration established by Novartis and Amgen in 2015 in the areas of Alzheimer's disease and migraine. Novartis initiated two clinical trials in China in 2019 to evaluate the safety and efficacy of Erenumab injection in the treatment of migraines. Erenumab was first approved for marketing in the United States in 2018, and was subsequently approved in Australia, Iceland, Norway, Switzerland, Canada, and Japan. In addition to the treatment of migraines, clinical trial research is ongoing for other indications, including headaches, hot flashes, temporomandibular joint dysfunction syndrome, stable angina. 6. Kyowa Kirin:EvocalcetTarget:CaSR Evocalcet is a Calcium-Sensing Receptor (CaSR) agonist developed by Kyowa Kirin, used for the treatment of hypercalcemia, secondary hyperparathyroidism, and other related conditions. Kyowa Kirin has applied for two clinical trials in China to evaluate the effectiveness of Evocalcet in treating secondary hyperparathyroidism in patients undergoing maintenance dialysis for chronic kidney disease. As of now, Evocalcet has only been approved for marketing in Japan. 7. Otsuka Pharmaceutical: BrexpiprazoleTarget:5-HT1A+5-HT2A+D2R Brexpiprazole is a serotonin-dopamine activity modulator developed by Otsuka Pharmaceutical, used as an adjunctive treatment for severe depression, schizophrenia, and agitation associated with dementia caused by Alzheimer's disease. Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist, known as a serotonin-dopamine activity modulator. It has a high affinity for serotonin, dopamine, and alpha-adrenergic receptors. Structurally, Brexpiprazole is very similar to another atypical antipsychotic drug, Aripiprazole, but Brexpiprazole has a different affinity for binding with dopamine and serotonin receptors. Compared to Aripiprazole, Brexpiprazole is less likely to produce adverse reactions mediated by partial agonist, such as extrapyramidal symptoms, due to its lower intrinsic activity at the D2 receptor. Brexpiprazole was first approved in the United States in 2015, and subsequently approved in Canada, Japan, and the European Union. In addition to treating depression, this drug is undergoing global clinical trials and research for multiple indications including agitation, schizophrenia, Alzheimer's disease, and performance anxiety. 8. Santen: TapcomTarget:PTGFR+βAR Tapcom is a combination eye drop medication containing Tafluprost and Timolol Maleate, developed by Santen. Tafluprost is a prostaglandin analogue used in ophthalmology to reduce intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Chemically, Tafluprost is a fluorinated analogue of prostaglandin F2-α. Timolol is a non-selective beta-adrenergic antagonist, used for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Tapcom was first approved for marketing in Japan in 2013, and subsequently received approval in countries including Iceland, France, Poland, and Germany. 9. Takeda:TeduglutideTarget:GLP-2R Teduglutide is a glucagon-like peptide-2 (GLP-2) analog developed by the British rare disease pharmaceutical giant, Shire Development, for the treatment of patients with short bowel syndrome (SBS) who require parenteral nutrition support. Teduglutide is comprised of 33 amino acids, and is manufactured using strains of E. coli that have been modified through DNA recombinant technology. Teduglutide differs from GLP-2 by one amino acid (alanine is replaced with glycine). This substitution results in Teduglutide having a longer duration of action than endogenous GLP-2 and a higher resistance to hydrolysis by the enzyme dipeptidyl peptidase-4. Teduglutide first received regulatory approval within the European Union in 2012, followed by approval in the United States and Japan, in all cases for the treatment of SBS. In 2019, Takeda Pharmaceuticals spent an astounding £46 billion to acquire Shire Development, in a move that has been dubbed as a "snake swallowing an elephant" merger in the pharmaceutical world. This acquisition propelled Takeda Pharmaceuticals into the list of top 10 global biopharmaceutical companies. Clinical research on the application of Teduglutide for the treatment of Crohn's Disease and kidney disorders was discontinued due to this acquisition. 10. AstraZeneca: Duaklir GenuairTarget:M3R+β2AR Duaklir Genuair is a combined Aclidinium Bromide/Formoterol Fumarate inhalation powder developed by AstraZeneca. This medication is used as a maintenance bronchodilator to alleviate the symptoms of disease in adults with chronic obstructive pulmonary disease (COPD). Among them, Aclidinium bromide is a novel long-acting muscarinic antagonist, and Formoterol fumarate is a long-acting β2 receptor agonist. Duaklir Genuair is administered by the Genuair dry powder inhaler twice a day and is the first combined medication that has shown a statistically significant improvement over monotherapy in terms of shortness of breath. Duaklir Genuair was first approved in the European Union in 2012, and subsequently in the United States in 2019, for the treatment of chronic obstructive pulmonary disease.

17 May 2023

·www.businesswire.com

True Health Solutions for Women’s Evolving Microbiomes: TruBiotics® Launches Women’s Probiotics

PHOENIX--( BUSINESS WIRE )-- PanTheryx , an integrative digestive and immune health company, today launches two new TruBiotics® probiotics, specifically for women— TruBiotics Women's Capsules for Digestive/Vaginal/Bone Health and TruBiotics Women's Sugar-Free Gummies with Collagen for Digestive/Urinary/Hair, Skin & Nails Health. These novel formulas were designed to target women in different stages of life and provide multi-benefit health solutions for maintaining healthy vaginal and gut microbiomes while supporting other female health concerns, such as bone, urinary tract, hair, skin, and nail health. "Most women don’t realize the importance of maintaining their gut health as it impacts so many other areas of the body. Also, 70 percent of the immune system is in the digestive tract demonstrating the importance of keeping the gut healthy,” says Dr. Keri Marshall, Chief Medical Officer of Virtu Health Solutions and Medical and Scientific Consultant to PanTheryx. “From puberty to pregnancy and through the menopausal years, a woman’s body continually goes through changes. Multi-benefit product solutions like those from TruBiotics can help give women the foundation to build a healthy gut microbiome while supporting their overall health. I’m excited to partner with TruBiotics on this launch; educating women and health care practitioners about the effectiveness and role each of these new products can play to support specific health needs.” True Innovation to Support Women’s Health TruBiotics Women’s probiotics are a unique blend of probiotics, vitamins, minerals, and herbs that support women’s overall health at different ages. When taken daily, the probiotics provide numerous benefits that support women’s evolving microbiomes and different health needs. For women concerned with vaginal health and bone density, particularly during menopause, the new TruBiotics Women's Capsules is a specially formulated, all-in-one probiotic that has been clinically studied to address these health stressors. The formula includes: Bifidobacterium animalis (BB-12®‡), one of the most scientifically studied strains of beneficial bacteria for digestive health Lactobacillus reuteri (RC-14®‡) and Lactobacillus rhamnosus (GR-1®‡), the two most clinically studied probiotic strains to help keep vaginal Ph and yeast in balance Calcium and Vitamin D3 to support bone health and optimal immune health For women taking a proactive approach to their overall and female-related health needs, TruBiotics Sugar-Free Gummies support optimal digestive health and contain cranberry for urinary health and collagen and biotin for added beauty benefits. This probiotic features: Bacillus subtilis (DE111®‡‡) – the most clinically researched bacillus probiotic for digestive and immune health 500mg of cranberry fruit extract to help guard the urinary tract against unwanted bacteria A powerful combination of Collagen, Biotin, and Vitamin C to help maintain hair, skin, and nail health Prebiotic fiber, isomalto-oligosaccharides, acts as food for and benefits the probiotics This great-tasting cranberry-raspberry gummy is the only probiotic gummy on the market with collagen that has no sugar and is free of gluten and gelatin. Understanding Women’s Evolving Health Needs In time for Women’s Health Month, the brand commissioned a survey among women, conducted by OnePoll, to better understand women’s sentiments around the most unexpected parts of aging, how their health needs change over time, and how they address them. The Understanding Aging Women’s Health Concerns and Needs survey found that over three-fourths of women (77%) noticed certain body changes over the past decade, but less than a third (30%) felt "very prepared" for them. As women mature, three in five (60%) say they are being more proactive about their everyday health concerns and are taking more vitamins/supplements than they previously did to help combat signs of aging. The survey also found: All women, no matter their age group, experienced digestive challenges as they age Women between 43 and 77 said wrinkles and weakening of eyesight (34%), thinning/graying of hair (35%), and body aches (36%) were other leading changes they noticed The top body changes that women felt were most disruptive were digestive challenges (21%), such as constipation, weight gain (20%), and memory challenges (19%) Women are not primarily relying on their primary care doctors or ObGyns to provide them with age-related health information and are turning to registered dietitians and integrative medicine practitioners (40%) as well as online health websites like WebMD and Mayo Clinic (40%) for help “As Gen X and Millennial women enter different life stages and more mature years, their microbiomes and overall wellness needs change and require different nutrients to optimize their health,” said Pam Cebulski, general manager, consumer brands, PanTheryx, distributor of TruBiotics. “This is why we created TruBiotics Women’s probiotics, to be unique solutions for women at different life stages. As a leading probiotic brand in the U.S., we are excited to bring these new, science-backed, multi-benefit formulas to market that align naturally with the proactive, health-conscious woman as her needs evolve.” Rounding out the brand’s offering for the whole family, TruBiotics Women's Capsules and TruBiotics Women's Sugar-free Gummies are now available online and in-store at select retailers nationwide. For more information about TruBiotics and its products, please visit www.trubiotics.com . ‡BB12, RC14 and GR1 are registered trademarks of Chr. Hansen A/S. ‡‡ DE111 is a registered trademark of ADM. About PanTheryx PanTheryx™ is a nutrition and biotechnology company committed to the global commercialization of health and wellness solutions for the human and animal health markets. From leading cutting-edge research to supplying best-in-class ingredients, to commercializing category-leading consumer brands, PanTheryx is dedicated to delivering revolutionary approaches for digestive, immune, and microbiome health. As the world’s largest colostrum producer, PanTheryx provides its proprietary ColostrumOne® and La Belle® Colostrum ingredients to its partners serving the global human and animal health markets. In addition to the products it develops with its partners, the PanTheryx portfolio of consumer brands includes TruBiotics®, Goodgut®, Life’s First Naturals and DiaResQ®. For more information, please visit www.pantheryx.com . Methodology This random double-opt-in survey of 2,050 U.S. women ages 18+ was commissioned by TruBiotics between April 13 and April 14, 2023. It was conducted by market research company OnePoll , whose team members are members of the Market Research Society and have corporate membership to the American Association for Public Opinion Research ( AAPOR ) and the European Society for Opinion and Marketing Research ( ESOMAR ).

16 Apr 2021

·www.globenewswire.com

BioFit Probiotic Review: Risky Scam or Real Customer Results (April 2021 Updates)

New York, NY, April 15, 2021 (GLOBE NEWSWIRE) -- Important April 2021 Update: BioFit originally launched on December 31, 2020 by Nature's Formulas as a seven ingredient blend of highly touted probiotic strains that are known to help restore gut health and body weight management optimization naturally. Led by a star studded lineup of powerful ingredients in the BioFit probiotic formula, each weight loss pill contains an impressive 5.75 billion colony forming units (CFUs) that is meant to provide real relief towards digestion, excess belly bloat and gas. And the more recent announcement has found that the primary ingredient, Bacillus subtilis probiotic (DE111), has now been accepted by the FDA on the GRAS list (generally recognized as safe) as well as receiving full health authority approval for health claims alluding to its ability to promotes growth of healthy gastrointestinal flora, supports growth of beneficial gut bacteria, supports and improves digestive health in children and adults and reduces total blood cholesterol or blood LDL cholesterol. But there is so much more this BioFit probiotic review update covers, along with the incredible risk-free option to buy BioFit probiotic weight loss pills directly from the GoBioFit.com website for a limited time discount price that is backed by an industry leading 180-day money back guarantee that puts the onus on the product to perform or simply request a refund at zero cost or extra risk today. This important April 2021 update about the BioFit weight loss pills from Nature's Formula will also address the circulating concerns about fake BioFit probiotic supplements online that are causing serious negative side effects and adverse reactions that every consumer must know about before making a purchase today. The personal health and wellness industry spent a staggering $3.31 trillion dollars in 2020 alone, with over $24 billion dollars in the weight loss supplementation market. So how did Nature's Formulas BioFit probiotic formula climb to the top of the charts for natural weight loss benefits without the risky side effects? This review will cover everything you need to know in order to make an informed, educated decison today. BioFit is a top quality probiotic weight loss supplement by Nature's Formula that uses seven key gut healing strains that work to balance digestive issues, boost immunity and balance hormones. Found exclusively at the official website of GoBioFit.com only, the Nature's Formula BioFit probiotic is led by Chrissie Miller and a team of qualified experts in the area of whole body wellness and healthy nutrition supplementation. By now, everyone should know that a lack of probiotics in the body can cause various health and psychological problems. Common issues include erratic sleep patterns, irregular moods, cravings for sugary, unhealthy foods, gas, constipation, bloating, diarrhea, cramping (after meals), and weight management. Overall, probiotics help boost the body’s ability to function well. Based on the lifestyle, the number of probiotics in the body can decrease, leading to the problems mentioned above. Fortunately, a new dietary supplement exists to supply the body with probiotics that can help the body lose weight quickly and keep it healthy. This review is about BioFit Probiotic Dietary Supplement. This all-natural formulation supplies the body with good bacteria and rids it of the bad bacteria that cause health problems. Read on to discover more about the product. What is BioFit Probiotic Formula? BioFit is an all-natural dietary supplement that is made to supply the body with the essential group of bacteria known as probiotics. When bad bacteria accumulate in the digestive system, they deliver toxins that eventually cause digestive upset. In that situation, many other health issues are bound to arise, including unnecessary weight gain, bloat, and many more. BioFit works effectively to supply the body with probiotics, an essential group of bacteria supporting good health. Probiotics play a crucial role in all body processes, one of which is to keep the gut flora balanced. According to the creators of BioFit, the product can help users shed extra weight without the need to change their lifestyle. BioFit users can improve their gut’s health, as the product helps reduce stomach acid caused by bad bacteria. Consequently, users get rid of digestive issues and develop a stronger immune system. They also lower the chances of heart attack and acquire the necessary vitamins and minerals that the body needs. Importantly, BioFit provides effective results without having to get involved in strenuous workouts or crazy dieting. The producers believe that users who take the supplement regularly and follow the recommended dose are likely to lose at least three pounds in their fat frame per week. How Does BioFit Work? The BioFit Probiotic formula works by providing the body with the right amount and types of probiotics that improve gut health and boost the body's weight loss process. The formula supports the body to generate more probiotic microorganisms in the system to support the gut's functions. Additionally, BioFit helps protect users from stomach-related concerns that arise from unhealthy lifestyles and other bad eating habits. Based on its formula, BioFit Probiotic increases the weight loss process's speed without any lifestyle change. Since it enables the body to balance the number of probiotics in the gut, it equally increases the body's fat absorption process. BioFit contains a miracle strain L-Casei, which greatly contributes to its success. When used accordingly, it enables the body to generate more lively hormones and increase energy levels. It relieves users from mental stress and anxiety and supports heart prosperity. However, the BioFit formula is not restricted to weight loss only. According to the creators, the formula is so powerful it can help users get deep sleep, which is even important in the weight loss process. BioFit Ingredients BioFit contains all-natural ingredients that work together to fight bad bacteria and replace them with good ones. The following are its key ingredients: Lactobacillus Casei This probiotic is found in the intestines, mouth, and genitals. It deals with many health issues, including lactose intolerance. Additionally, L. Casei helps in digesting even the hard-to-digest foods. It also regulates bowel movements. Bacillus Subtilis This microorganism delivers several amazing benefits to the intestine’s microflora. For instance, it boosts the number of good bacteria, including lactic acid bacteria, and decreases bad bacteria like coliforms. Consequently, it lowers the risk of food-borne diseases. Lactobacillus Rhamnosus This special ingredient in BioFit works to help users lose weight, according to one study. Lactobacillus Plantarum This microorganism delivers antioxidant properties and leads to a healthy intestinal permeability. It restrains bad bacteria that create gas in the intestines, which is a great benefit for IBS people. Besides, this probiotic strain stabilizes the pattern of digestive enzymes, leading to a balanced gut microbe. Lactobacillus Acidophilus This microorganism reduces bad cholesterol levels. It helps deal with diarrhea when used alongside other probiotics and reduces IBS symptoms. Besides, it promotes weight loss, among other benefits. Bifidobacterium Longum This strain of probiotics is multifunctional. It eases gastrointestinal, infectious, and immunological diseases. Besides, it balances the gut microbiota and improves the overall intestinal environment. Bifidobacterium Breve This microorganism works together with other probiotics to help the immune system to remain healthy. Besides, it improves skin health and respiratory system health. Importantly, it prevents the primary culprits that cause yeast infections in women. Other ingredients included in the BioFit formula are medium-chain triglycerides, maltodextrin, and vegetable cellulose. Click Here to Buy BioFit Probiotic Supplement from the Official Website for the Lowest Prices Online Today! Benefits of Using BioFit The BioFit probiotic delivers much more health benefits than just helping with just weight loss: Overall, BioFit not only focuses on weight loss, but keys in on optimal digestion, enhanced immunity and can result in even more energy as well. Instead, it also helps keep other bodily systems healthy and in good working condition. When the body has its probiotic levels balanced, all the systems and processes work harmoniously, which leads to a healthier, happier life. Try the Number One Probiotic Supplement for Weight Loss in 2021, Nature's Formula BioFit right now! Why You Need BioFit Supplement For many people, one of the most difficult battles to fight is to eliminate unwanted weight. However, they can’t give up because it has everything to do with their health. If they stop trying, their health would be at risk. Being obese does not cause only health problems. It brings along mental health issues, including low self-esteem, depression, and a feeling of embarrassment. At the worst levels, being overweight brings the debilitating condition of diabetes. This condition is life-threatening and irreversible. It changes the life of the victim forever. Additionally, diabetes threatens vision, mobility and can cause sudden death. Diabetes also causes PCOS, which is another common disease for overweight people. It causes infertility in women. The creators of BioFit believe that losing weight naturally is one of the most challenging tasks. Those who are struggling with this problem often limit their intake of food. They exercise daily. However, BioFit probiotic was created to help users lose weight naturally by supporting digestion and increasing their metabolism. With healthy, active digestion and metabolism, it’s easier to develop rapid and effective weight loss. According to the creators, BioFit is a 100 percent natural dietary supplement. It has no side effects. Additionally, the formula is manufactured in a GMP-certified facility in the U.S.A. under stiff hygiene conditions. Importantly, BioFit comes with a moneyback guarantee, which makes it a completely risk-free investment. Advantages of Using BioFit BioFit is an all-natural dietary formula that supports healthy digestion, reduces bloating, and helps balance and maintain healthy gut bacteria. According to the manufacturers, the supplement is so effective it delivers a range of benefits within just a short time. Used as directed, users enjoy the benefits of improved digestion and a healthy gut environment free from common digestive issues. BioFit contains the Lactobacillus ingredient, which specifically supports insulin regulation, helps with weight loss, and reduces junk food cravings. It’s a Lactobacillus powerhouse. BioFit contains four special strains of Lactobacillus in its formulation. These ingredients work together to help users achieve their weight loss goals and maintain a healthy life. Requires no refrigeration Probiotics that require refrigeration often get damaged during shipping. BioFit is a unique form of probiotic that doesn’t require refrigeration. This ensures it maintains the same quality from the lab to the consumer. High CFU strain The human body contains more than 100 trillion bacteria at any given time. Simultaneously, the body requires a lot of new bacteria to create an impact on the Gut Microbiome. BioFit contains more than 40 billion CFUs towards this cause. Possible Downsides of BioFit Formula How to Use BioFit BioFit is available in the form of capsules that users should take orally. The manufacturer recommends one capsule a day with a glass of water. It’s important to note that individual results may vary, as each body is unique. However, the manufacturers say a greater percentage of users achieve the listed benefits. According to the manufacturers, more than 27,000 people have used the supplement and recorded positive results. They saw weight loss, improved digestive health, and a boost in their immune system. All the same, consumers should consult their doctor for professional advice if they are already on some medications. How and Where to Buy BioFit BioFit is currently available for sale on the official website at GoBioFit.com, where customers are guaranteed the original product, which delivers the best results. One bottle of BioFit contains 30 vegetarian capsules, which should serve a consumer for one month. The current prices are: All orders come with free shipping across the US. Importantly, if you order today, the manufacturer offers huge savings. Additionally, the creators are committed to their customers’ results. For those who find the supplements ineffective and fail to meet their expectations, there’s a 100% moneyback guarantee. The manufacturers offer a solid 90-day moneyback guarantee. Customers have to decide within this period whether the product works for them or not. If it fails to meet their expectations, they can simply return their orders to the company and get a full refund. However, the manufacturers allow only unused bottles for refunds. Why Buying BioFit Probiotic Supplement is Risk-Free Today The only way to buy the official Biofit probiotic formula is through the merchant platform Clickbank. Payments through Clickbank have the leverage of being put for refund, and Chrissie Miller, along with the creators of Biofit have a very generous 180-day refund policy for complete peace of mind and customer confidence. Referring to the transaction ID is necessary when requesting a refund. You will need to track the same from your bank statement where the order will be seen under the name of CLKBANK*COM. *Note: In usual conditions, refund is credited in one business day. Having said that, if the order has been delivered to you physically, then the refund is initiated in 19 days. This makes it extremely easy to try Biofit probiotic supplementation for yourself to see how well this formula can work for you today. Frequently Asked Questions Is it safe to use BioFit alongside other medications? Probiotics are made to help eliminate harmful bacteria that should not be in the body. They might not work well with some medications. It’s advisable to seek professional help from a physician to determine whether BioFit is the best option. How should consumers take BioFit? The manufacturer recommends one serving of BioFit per day to get the best results. Users are advised to take one supplement each day with a glass of water to promote better digestion. Can BioFit work for anyone? Yes, BioFit is an all-natural dietary supplement, which is safe and pure. It contains only essential bacterial strains that are safe for the body. How long does one bottle of BioFit last? The manufacturers advise consumers to get through a complete 30 days before they can get another bottle. If a user decides to increase the dose to more than one pill per day, they can finish the bottle faster. However, increasing the dose requires the approval of a physician. At checkout, consumers can how many bottles they want. What are probiotics? Probiotics are a particular community of essential bacteria strains that help the digestive system to dispel toxins that may cause inflammation, irritation, and interruptions in the digestive process. Are probiotics safe? The Food and Drug Administration agency considers probiotics safe in supplements, fermented foods, and other sources. They don’t damage the intestines. Final Verdict BioFit Probiotic dietary formula claims to deliver a safer way to lose weight. Additionally, the product helps users improve their health. BioFit operates on the principle that an unhealthy body cannot shed weight as effectively as a healthy body does. The problem is usually traced back to the imbalance of essential bacteria in the gut. According to many scientific studies, people struggling with obesity have shown greater concentrations of certain bacterial strains. This is where a probiotic supplement like BioFit comes in handy. This product claims to balance the concentration of essential bacterial strains in the gut leading to stronger immunity and an improved digestive system. In closing, there are absolutely zero reported side effects of Biofit probiotic supplementation as the seven ingredient blend of gut healing strains are all-natural and ready to help assist the body in restoring immunity, digestion and managing a healthy body weight daily. Just make sure to avoid all fake Biofit scams online are there are many copy cat weight loss probiotics trying to lure in consumers with cheap counterfeit filled with inferior ingredients that will cause side effects. The only risky scam threats consumers should be weary of is the fake BioFit probiotic pills offered on Amazon, Ebay, Walmart and other third party marketplace platforms. Chrissie Miller, Nature's Formulas and the BioFit supplement is only available via the official website that will guarantee ultimate consumer protection, customer satisfaction and user results as they can only ensure every single pill has been tested by independent third party labs for purity, potency and overall quality. Make sure to capitalize on the three free bonuses included with your order of BioFit Probiotic today: Act Now and Take Full Advantage of the Top Selling, Most Recommended Weight Loss Probiotic Formula Today Official Website: Contact Details: BioFit ProBiotic Email: support@goBiofit.com Phone: 1-866-460-6008 (24/7) About MarketingByKevin.com This product review is published by Marketing By Kevin. Marketing By Kevin reviews are researched and formulated by a group of experienced natural health advocates with years of dedication and determination to finding the highest quality health products and wellness programs available. It should be noted that any purchase derived from this resource is done at your own peril. It is recommended to consult with a qualified professional healthcare practitioner before making an order today if there are any additional questions or concerns. Any order finalized from this release’s links are subject to the entire terms and conditions of the official website’s offer. The researched information above does not take any direct or indirect responsibility for its accuracy. Affiliate Disclosure: The links contained in this product review may result in a small commission to Marketing By Kevin if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products. Disclaimer: Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. Product support: support@goBiofit.com Media Contact: info@marketingbykevin.com Attachment

100 Deals associated with Tafluprost/Timolol Maleate

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KEGG	Wiki	ATC	Drug Bank
-	-	S01ED51	-

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Glaucoma	Japan	Santen SAS	20 Sep 2013
Ocular Hypertension	Japan	Santen SAS	20 Sep 2013

Developing

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Indication	Highest Phase	Country/Location	Organization	Date
Glaucoma, Open-Angle	NDA/BLA	China	Santen Pharmaceutical (China) Co. Ltd.	08 Feb 2023

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03612817 (Pubmed \| Expert Opin Pharmacother)	Phase 4	Glaucoma, Open-Angle	42	Preserved latanoprost	mkwotxzcua(eddnbmbtfl) = Hyperemia was more common with preserved latanoprost (21.4 vs. 7.1%; P = 0.031) twjnuvcacd (gzhbgbinvp )	-	01 Dec 2018
AAO2016	Not Applicable	Ocular Hypertension \| Glaucoma	1,157	Preservative-Free Fixed-Combination Tafluprost/Timolol	aewiblkqmb(wdwypncqmf) = few adverse events tkutgxuwyt (fmyzkvneno )	Positive	16 Oct 2016
ARVO2015	Not Applicable	-	-	Taf/T FDC	jaowynwhaf(dcqztvntkh) = kmhxybokrs wmfdtlvupv (njawiclpuo ) View more	-	01 Jun 2015
ARVO2015	Not Applicable	-	-	Lat/T FDC	jaowynwhaf(dcqztvntkh) = xrzupuoilx wmfdtlvupv (njawiclpuo ) View more	-	01 Jun 2015
NCT01342094 (CTgov)	Phase 3	Glaucoma, Open-Angle	166	Placebo+DE-111 (DE-111)	kbtckqhbdq(lhatfsetzr) = aqtygiyjcr bhovmobpyc (npdbgrezxe, 2.1) View more	-	15 May 2015
NCT01342094 (CTgov)	Phase 3	Glaucoma, Open-Angle	166	Timolol (Timolol)	kbtckqhbdq(lhatfsetzr) = jgbevbfptb bhovmobpyc (npdbgrezxe, 2.1) View more	-	15 May 2015
NCT01343082 (CTgov)	Phase 3	Glaucoma, Open-Angle	148	Timolol+Tafluprost+DE-111	jjilxqwdey(rywkwtwddq) = fxpzgozqxe pxnunrkcak (hknyyhfcpz, 2.2) View more	-	14 May 2015
NCT01342081 (CTgov)	Phase 3	Glaucoma, Open-Angle	489	Placebo+DE-111 (DE-111)	sbmervbjxf(ocuqzlpksm) = gtglfmcycu pudogpmygc (zkkmzdrgjh, 1.8) View more	-	14 May 2015
NCT01342081 (CTgov)	Phase 3	Glaucoma, Open-Angle	489	Tafluprost (Tafluprost)	sbmervbjxf(ocuqzlpksm) = dictplzwjx pudogpmygc (zkkmzdrgjh, 1.7) View more	-	14 May 2015

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