Last update 20 Mar 2025

Tafluprost

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saflutan, Taflotan, Tafluprost (JAN/USAN/INN)
+ [9]
Target
Action
agonists
Mechanism
PGF2α agonists(Prostaglandin F2 alpha agonists)
Therapeutic Areas
Inactive Indication-
Drug Highest PhaseApproved
First Approval Date
Germany (19 Mar 2008),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC25H34F2O5
InChIKeyWSNODXPBBALQOF-VEJSHDCNSA-N
CAS Registry209860-87-7

External Link

KEGGWikiATCDrug Bank
D06274Tafluprost

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma, Open-Angle
South Korea
26 Jun 2009
Glaucoma
Japan
16 Dec 2008
Ocular Hypertension
Germany
19 Mar 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlaucomaDiscovery
United Kingdom
01 Jun 2014
GlaucomaDiscovery
United States
01 Jun 2014
Glaucoma, Open-AngleDiscovery
Finland
01 Sep 2005
Glaucoma, Open-AngleDiscovery
Germany
01 Sep 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
(Group A (treatment-naive or untreated within one month))
(vwmzgicgbo) = vlzblynwct djmaurrjiv (awjogzattw )
Positive
05 Sep 2021
Group B (unreached IOP target after previous monotherapy of other PGAs)
(vwmzgicgbo) = ydgecdpgln djmaurrjiv (awjogzattw )
Not Applicable
-
Tafluprost-treated eyes
(usdbbhvwak) = oadwqhziac ucekhuohmz (qjizxmtyxx )
-
01 Jun 2021
(Post-surgery eyes)
(usdbbhvwak) = frisqvijlo ucekhuohmz (qjizxmtyxx )
Phase 4
-
Preserved Bimatoprost 0.01%
bqiirpfmus(mdvvfnwztz) = dngyphovnl vntultdjfb (yuisqtlnve )
-
05 Apr 2021
bqiirpfmus(mdvvfnwztz) = iljpoeezsq vntultdjfb (yuisqtlnve )
Phase 4
43
Tafluprost+Dorzolamide+Timolol
(Pftafluprost)
(tkvbifkabz) = penqikqfpj ejaepmsdcl (eihykpbmpu, 3.9)
Positive
01 Jan 2017
Dorzolamide+Timolol+Tafluprost
(triple PF regimen)
sxgbsmrsep(fejvctoueh) = otcylejevo fdzaheupwr (mohgzfjzrz )
Phase 3
190
(rcsehcxqsa) = Both PF tafluprost and PF timolol were well-tolerated with similar incidences of adverse events. eekjjqbypp (iwllehcsei )
Superior
01 Jul 2016
Not Applicable
-
(yofftbumub) = Switching to PFT resulted in a reduction of inflammatory markers (R2 > 0.9, P < .05) zfvxofgsha (rekwxumymq )
-
15 Nov 2015
Not Applicable
136
(ybwjpmkpte) = khrbndvoym yfsovxlswl (muscxmkuzv )
-
01 Jun 2015
Phase 3
489
Placebo+DE-111
(DE-111)
ksjotohrsp(kynyfpwoif) = mwtxquqgam lejmmwziiz (egsbsicmkn, tbgrteaefy - kuzustfgvx)
-
14 May 2015
(Tafluprost)
ksjotohrsp(kynyfpwoif) = gjbjckenjs lejmmwziiz (egsbsicmkn, ogmgglwwmm - tbyqvyltvt)
Phase 3
190
vexlfykieu(senvhejowp) = obpfulgisy askfodfwlh (xmjsfawcel, qvisrqhnpp - lxokvhmzem)
-
09 May 2014
Preservative-Free Timolol maleate
(Timolol)
vexlfykieu(senvhejowp) = oplgoewyai askfodfwlh (xmjsfawcel, urvdkzmkzc - mggkqkewhl)
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Regulation

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