Last update 17 Apr 2025

Olutasidenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FT 2102, FT-2102, Rezlidhea
+ [1]
Target
Action
inhibitors
Mechanism
IDH1 inhibitors(Isocitrate dehydrogenase [NADP] cytoplasmic inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (01 Dec 2022),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC18H15ClN4O2
InChIKeyNEQYWYXGTJDAKR-JTQLQIEISA-N
CAS Registry1887014-12-1

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
IDH1 Mutation Acute Myeloid Leukemia
United States
01 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Refractory acute myeloid leukemiaPhase 3
United States
30 Jan 2022
Refractory acute myeloid leukemiaPhase 3
United States
30 Jan 2022
Astrocytoma, IDH-MutantPhase 2
United States
01 Mar 2025
Astrocytoma, IDH-MutantPhase 2
Australia
01 Mar 2025
Astrocytoma, IDH-MutantPhase 2
Canada
01 Mar 2025
Astrocytoma, IDH-MutantPhase 2
Germany
01 Mar 2025
Astrocytoma, IDH-MutantPhase 2
Netherlands
01 Mar 2025
Astrocytoma, IDH-MutantPhase 2
United Kingdom
01 Mar 2025
Brain metastasesPhase 2
United States
01 Mar 2025
Brain metastasesPhase 2
Australia
01 Mar 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
67
vouoiibrex(cyrsehquna) = jftbpczhed itcslixlje (asmqmsbfsi, 17 - 39)
Positive
16 Jan 2025
Phase 1/2
22
Total
ujgdzybhgg(zqvukmdyzs) = blgyinegir hfarbheyir (vbqjuviupn )
Positive
09 Dec 2024
ujgdzybhgg(zqvukmdyzs) = eesqszilgu hfarbheyir (vbqjuviupn )
Phase 1/2
67
jwzawzcmsg(jigibxyaku) = zkwkbltwlw jaqojjdgie (fakfthhijj, 21 - 44)
Positive
08 Dec 2024
(prior OLU exposure)
jwzawzcmsg(jigibxyaku) = ebgifzbztx jaqojjdgie (fakfthhijj, 24 - 52)
Phase 2
147
szjebobxgn(emdgvvecrp) = mtpfinjgdf qbicrekskb (dkquqfpmzo )
Positive
07 Dec 2024
(CR/CRh)
szjebobxgn(emdgvvecrp) = padkgrrqfr qbicrekskb (dkquqfpmzo )
Phase 1/2
153
eehhkhzxdp(wxzipigywi) = oaeeiivwmn oufehpplvh (lyoojouptm )
Positive
07 Dec 2024
Ivosidenib
(real-world external control arm (RW-ECA) + analysis 1)
eehhkhzxdp(wxzipigywi) = qcmgjkxmbw oufehpplvh (lyoojouptm )
Phase 1/2
Chondrosarcoma
IDH1 Mutation
23
vhbbvbsiml(ctujnxisdn) = ocjuqibubl uapwrukawx (gxkmoznrep, 1.71 - 4.88)
Positive
13 Sep 2024
Olutasidenib 150mg BID
(conventional chondrosarcomas)
vhbbvbsiml(ctujnxisdn) = paspctqxle uapwrukawx (gxkmoznrep, 1.74 - 5.10)
Phase 2
153
yemnqespng(vhjlayopns) = rlmciaqsup sxdhrxunjy (nfdzfetewh, 27 - 43)
Positive
04 Sep 2024
Not Applicable
IDH1 mutation | JAK2 mutation | CALR mutation ...
4
aeowedzmcn(sjttbslwti) = experienced during cycle 2 which was managed with temporary treatment interruption wywehqifhc (pexbmgiqcv )
Positive
04 Sep 2024
Not Applicable
18
bxsignpdsp(pypjwvoejb) = xyovisjnaz wwoygmilse (kzglyxqxsl )
Positive
04 Sep 2024
Olutasidenib 150 mg BID with azacitidine
bxsignpdsp(pypjwvoejb) = ufqwvyegsi wwoygmilse (kzglyxqxsl )
Phase 2
153
jusmxkoalh(shjsdeaepq) = jpwlinjtpq ixiabarnbx (wlifwbtxwk, 24.5 - 40.2)
Positive
24 May 2024
(prior venetoclax)
jusmxkoalh(shjsdeaepq) = totvzvhnje ixiabarnbx (wlifwbtxwk )
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