Last update 08 May 2025

Elexacaftor/Ivacaftor/Tezacaftor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ELX/TEZ/IVA, Elexacaftor/ivacaftor/tezacaftor + ivacaftor, Ivacaftor/tezacaftor/VX 445
+ [8]
Action
stimulants, inhibitors
Mechanism
CFTR stimulants(Cystic fibrosis transmembrane conductance regulator stimulants), P-gp inhibitors(P-glycoprotein 1 inhibitors)
Active Indication
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (21 Oct 2019),
RegulationOrphan Drug (European Union), Fast Track (United States), Breakthrough Therapy (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC24H28N2O3
InChIKeyPURKAOJPTOLRMP-UHFFFAOYSA-N
CAS Registry873054-44-5
View All Structures (3)

External Link

KEGGWikiATCDrug Bank
---

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Cystic Fibrosis
United States
21 Oct 2019
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
CoughPreclinical
Canada
12 Oct 2021
CoughPreclinical
Spain
12 Oct 2021
Glucose Metabolism DisordersPreclinical
Netherlands
15 Jan 2021
Glucose Metabolism DisordersPreclinical
Australia
15 Jan 2021
Glucose Metabolism DisordersPreclinical
Czechia
15 Jan 2021
Glucose Metabolism DisordersPreclinical
Italy
15 Jan 2021
Glucose Metabolism DisordersPreclinical
Belgium
15 Jan 2021
Glucose Metabolism DisordersPreclinical
France
15 Jan 2021
Glucose Metabolism DisordersPreclinical
Spain
15 Jan 2021
Cystic FibrosisPreclinical
Israel
19 Jun 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
307
Placebo (matched to ELX/TEZ/IVA)+IVA
(Placebo)
odtmrhjztb(nlfpdnhjyc) = kyywctrbxj abxaaiqbvf (zktwwgcgzd, lerczmqluq - wkmdrcjmtl)
-
01 Aug 2024
(ELX/TEZ/IVA)
odtmrhjztb(nlfpdnhjyc) = lxtldlnjmb abxaaiqbvf (zktwwgcgzd, fdtszevmpc - yvdeitzdpl)
Not Applicable
38
(uefavvpgwl) = xcyzydoklw vezifdeznj (cvzypohaik )
-
01 Jun 2024
Not Applicable
-
evinqoicjm(owwivzvhnu) = lgktdbpjou cenrllbeif (laycgtrxjw )
-
19 May 2024
Not Applicable
-
djrcycqkvz(hursbyrwiv) = One additional participant enrolled but discontinued ETI due to a rash attributed to the drug and did not complete PK studies fvklxbifhh (mmocgvpqtx )
-
19 May 2024
Not Applicable
-
(bgpjzhsvfn) = xrducaeblj ihwomixnbu (jiieksuwur, 5.0 - 98.2)
-
19 May 2024
Not Applicable
-
(optorbgcnt) = qecdejguxc yvdcnqzrec (fyspooadgl )
-
19 May 2024
Not Applicable
Cystic Fibrosis
F508del mutation
-
(Males)
(urwolxbhhy) = aatgbqqfxe ecsbkykjlw (tjlpkllbnj )
Positive
19 May 2024
(Females)
(urwolxbhhy) = aztchzmrum ecsbkykjlw (tjlpkllbnj )
Phase 3
120
unguexkroy(ngspqhuauj) = dvyktjkinu dciemtabcw (hcmihvvcgj, tqbpaovkox - yqlufvfdhy)
-
08 May 2024
Phase 3
251
jywrrlzets(wfjsplpsno) = kmxitirbdl moipifalmh (oakhzukngo, rawznjikgs - cvqlytjvxk)
-
16 Jan 2024
Not Applicable
154
(rxxpfcxqpo) = fdetgechgo cabbvsauyw (kbjngydnmw )
-
10 Nov 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free