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Last update 04 Sep 2026
Sodium Selenite
Last update 04 Sep 2026
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms FPF3400, ASELEND, アセレンド |
Target- |
Action- |
Mechanism- |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date Japan (26 Mar 2019), |
Regulation- |
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Structure/Sequence
Molecular FormulaH2Na2O3Se |
InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N |
CAS Registry10102-18-8 |
Related
16
Clinical Trials associated with Sodium SeleniteCTRI/2026/05/110152
A Phase II, Open-Label, Single Arm Study to Evaluate the Safety and Efficacy of Oral Sodium Selenite in Patients with Cancer-Related Lymphedema (Breast and Head & Neck Cancers).
NCT04296578
A Phase 1 Study Evaluating the Efficacy and Safety of Sodium Selenite in Combination With Abiraterone in Patients With Castrate Resistant Prostate Cancer Progressing on Abiraterone
NCT02393183
The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease, a Placebo Controlled Randomized Clinical Trial
100 Clinical Results associated with Sodium Selenite
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100 Translational Medicine associated with Sodium Selenite
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100 Patents (Medical) associated with Sodium Selenite
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5,404
Literatures (Medical) associated with Sodium Selenite01 Sep 2026Veterinary Medicine and Science
Transcriptional Regulation of HSP60, HSP70, and HSP90 in Response to Selenium Nanoparticles and Sodium Selenite in Periparturient Cloned Saanen Goats and Their Offspring
Article
Author: Yousefi, Ahmad ; Kojouri, Gholam‐Ali ; Hassanpour, Hossein
ABSTRACT:
Objectives:
This study investigated the effects of selenium supplementation in the form of selenium nanoparticles (SeNPs) and sodium selenite (SSe) on the transcriptional regulation of heat shock proteins (HSP60, HSP70, and HSP90) in periparturient cloned and non‐cloned Saanen goats and their offspring.
Methods:
A total of 24 pregnant goats (12 cloned via somatic cell nuclear transfer and 12 non‐cloned) were divided into three groups: SeNPs, SSe and control. Supplementation was administered orally from 21 days before expected parturition. Serum selenium levels and HSP gene expression were measured at multiple time points relative to parturition.
Results:
Both SeNPs and SSe significantly increased serum selenium levels, with SeNPs demonstrating superior bioavailability. Supplemented groups exhibited significantly lower transcriptional levels of HSP60, HSP70 and HSP90 during the periparturient period, with SeNPs showing a more potent suppressive effect. A significant negative correlation was observed between serum selenium and HSP transcription. No differences were found between cloned and non‐cloned animals in selenium levels or HSP expression.
Conclusions:
These findings suggest that selenium supplementation, particularly as SeNPs, enhances antioxidant capacity and reduces cellular stress, as reflected by the downregulation of HSP genes. This study highlights the potential of nano‐selenium to improve stress resilience during the critical transition period in goats and their offspring, irrespective of cloning status.
01 Sep 2026PATHOLOGY RESEARCH AND PRACTICE
Corrigendum to “Sodium selenite attenuates hyperglycemia-exacerbated cerebral ischemia/reperfusion injury by inhibiting the Fas/FasL/PUMA apoptotic pathway” [Pathol. - Res. Pract. 283 (2026) 156494]
Author: Chang, Yue ; Yin, Xida ; Wang, Wenjun ; Zhao, Shuai ; Huang, Ningbo ; Zhang, Jingwen ; Yang, Lan ; Ding, Feng ; Jing, Li
01 Sep 2026Animal Nutrition
Dietary coated sodium selenite enhances muscle growth associated with mitochondrial function in sub-adult grass carp (Ctenopharyngodon idellus)
Article
Author: Liu, Yang ; Feng, Lin ; Kuang, Yinggu ; Zhang, Hongyun ; Jin, Xiaowan ; Ren, Hongmei ; Zhao, Fei ; Zhou, Xiaoqiu ; Wu, Pei ; Ma, Yaobin ; Jiang, Weidan
Selenium (Se) is a vital trace element necessary for fish growth and health. This research aimed to elucidate the beneficial impacts of coated sodium selenite (CSS) on sub-adult grass carp muscle and compared effects of CSS and sodium selenite (SS). A total of 450 healthy fish with an initial average body weight of 687.33 ± 1.15 g were randomly assigned to six groups. Fish in these groups were fed experimental diets supplemented with graded levels of CSS (0.028, 0.25, 0.50, 0.75, and 1.00 mg/kg Se) and one diet containing SS at 0.50 mg/kg Se, respectively, for an 8-week feeding trial. Results indicated that optimal CSS increased body length and Se concentrations in muscle and hepatopancreas (P < 0.05). The accumulated Se further up-regulated the expressions of selenoproteins (such as gpx1 and selp), which collectively improved antioxidant capacity (such as glutathione peroxidase [GPX] activity and L-glutathione [GSH] content]) and mitochondrial quality (such as fusion, biogenesis, and respiratory chain) (P < 0.05). These alterations improved muscle fiber development by upregulating the expression of genes related to protein synthesis (pi3k, akt, and s6k1) and extracellular matrix synthesis (col1α1, smad2, smad4, tgf-β1, and phd) (P < 0.05). Interestingly, at the 0.50 mg/kg Se supplementation, CSS and SS showed similar growth and muscle development, but different responses in signaling pathways, implying that CSS may confer additional physiological benefits. Overall, dietary Se could enhance muscle growth in sub-adult grass carp by dual mechanisms: enhancing antioxidant defenses and improving mitochondrial quality.
1
News (Medical) associated with Sodium Selenite
100 Deals associated with Sodium Selenite
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D10530 | - | - | - |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Selenium deficiency | Japan | 26 Mar 2019 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Colonic Cancer | Preclinical | United States | 01 May 2009 | |
| Cataract | Preclinical | United States | 01 May 2003 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 3 | 1,416 | bpcinnkxwg(dxxohspsit) = ufpgjzpmua nwnarzopcj (mfwsekylwm ) | Negative | 11 Jan 2023 | |||
Placebo | bpcinnkxwg(dxxohspsit) = xtnjfgygxd nwnarzopcj (mfwsekylwm ) | ||||||
Phase 3 | 1,089 | fkrlnmcuhd(xsqqvfsdar) = pxufewzyph wpohdpavhb (ghfsllwips, 24.5 - 32.3) | Negative | 01 Sep 2016 | |||
Placebo | fkrlnmcuhd(xsqqvfsdar) = fgczbemwqg wpohdpavhb (ghfsllwips, 21.8 - 29.4) |
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