Delving into the Latest Updates on Sodium Selenite with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

ASELEND, アセレンド

Target-

Action-

Mechanism-

Therapeutic Areas

Other DiseasesNeoplasmsDigestive System Disorders+ [1]

Active Indication

Selenium deficiencyColonic CancerCataract

Inactive Indication-

Originator Organization

Fujimoto Pharmaceutical Corp.

Active Organization

Illinois CollegeSenju Pharmaceutical Co., Ltd.

Fujimoto Pharmaceutical Corp.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (26 Mar 2019),

Selenium deficiency

Regulation-

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Structure/Sequence

Molecular FormulaH2Na2O3Se

InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N

CAS Registry10102-18-8

This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED:
β- Carotene (30 mg)
Vit C (100 mg)
Vit E (Alpha-Tocopherol Acetate): 60-200 IU
Calcium phosphate dihydrate (40 mg)
Zinc oxide (4 mg, elemental)
Copper gluconate (3.5 mg)
Sodium selenite 23 mg= Selenium 100 µg
Nicotinamide (a form of vit.B3) (10 mg)
in patients with mild Thyroid eye disease according to EUGOGO classification. To be given twice a day.

Start Date15 Jul 2019

Sponsor / Collaborator

Iran University of Medical Sciences & Health Services

IRCT20110123005670N28

/ CompletedPhase 3IIT

The effects of Na- selenite and Na- selenite -enriched yeast supplementation on glycemic status, lipid profile, oxidative and nitrosative stress in patients with coronary artery diseases.

Start Date02 Jun 2019

Sponsor / Collaborator

Tabriz University of Medical Sciences

NCT03081949

/ CompletedPhase 4IIT

Peripartum Cardiomyopathy in Nigeria (PEACE) A Registry to Study the Demographics, Social and Clinical Characteristics, Pathophysiology and Outcomes of Peripartum Cardiomyopathy in Nigeria

Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world. Unfortunately, much about the disease including its aetiology, epidemiology and treatment is not yet well described. This will be a prospective, national, multicenter cohort study, conducted in centres in Nigeria. It is expected that approximately 500 patients with PPCM and 500 apparently healthy pregnant women will be recruited over a 6-month period with follow-up at 3-monthly intervals for 18 months.

Start Date12 Jun 2017

Sponsor / Collaborator-

100 Clinical Results associated with Sodium Selenite

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100 Translational Medicine associated with Sodium Selenite

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100 Patents (Medical) associated with Sodium Selenite

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9,193

Literatures (Medical) associated with Sodium Selenite

15 Apr 2025·Journal of Applied Polymer Science

Plasma Assisted Surface Decoration of PLA Nonwoven Materials With Selenium Nanoparticles for Improvement of Antibacterial and Biocompatible Properties

Author: Luan, Rui ; Ren, Yu ; Yuan, Yuan ; Wang, Chunxia ; Zhao, Ziyao ; Li, Mei‐Xian

ABSTRACTThis study aimed to enhance the antibacterial and biocompatible properties of PLA nonwoven materials by plasma‐assisted surface decoration with selenium nanoparticles. PLA nonwoven materials were pretreated by plasma surface modification technology for varying durations. Subsequently, Se nanoparticles obtained from the redox reaction of sodium selenite were loaded onto the PLA surfaces through impregnation. SEM images demonstrated that plasma pretreatment enhances the uniformity of Se nanoparticles as well as the contents loaded onto the PLA nonwoven materials. Based on EDS analysis, the relative concentration of Se elements increased with longer plasma pretreatment durations, reaching 6.38% after 6 min of treatment. XPS analysis confirmed the presence of elemental selenium nanoparticles. Furthermore, the results of surface wettability showed that the surface of Se/PLA composites changed from hydrophobic to super hydrophilic after the plasma and Se combined treatment. Moreover, bacterial inhibition of the Se/PLA composites substantially improved with increasing plasma pretreatment time. The Se/PLA composites with 6 min of plasma pretreatment showed the best antibacterial performance and biocompatibility, with inhibition rates against Staphylococcus aureus and Escherichia coli reaching 95.75% and 75.54%, respectively, and cell viability was over 99% for L929 cells. These functionalized Se/PLA composites exhibit tremendous potential for applications in novel antibacterial materials.

01 Apr 2025·Journal of Photochemistry and Photobiology A: Chemistry

LaSrO3 perovskite quantum dots as a fluorescent probe for the detection of bilirubin and epinephrine via FRET and IFE mechanisms

Author: Park, Tae Jung ; Makwana, Kartik Pankajbhai ; Malek, Naved I. ; Deshpande, Madhura Pradeep ; Kailasa, Suresh Kumar

In this study, blue-emitting LaSrO₃ perovskite quantum dots (PQDs) were synthesized using a microwave-assisted sol-gel method.The as-prepared LaSrO₃ PQDs acted as a nano-fluorescent probe for detection of two biomarkers: bilirubin (BR) and epinephrine (EP).The fluorescence spectra of LaSrO₃ PQDs showed λEm/Ex at 421/336 nm, displaying quantum yield of 36.91%.Based on the remarkable fluorescence properties of LaSrO₃ PQDs, fluorescence sensing studies were performed for biomarkers assay.The emission spectral results of LaSrO₃ PQDs displayed remarkable fluorescence quenching by BR and EP via Forster resonance energy transfer and inner filter effect, resp.The detection limits were 10.48 and 17.04 nM for BR and EP, resp.The fluorescence quenching mechanisms were discussed in detail by various anal. techniques (fluorescence, UV-visible absorption, transmission electron microscopy, Fourier transform IR, and zeta potential).In addition, LaSrO₃ PQDs-based fluorescence sensing approach was successfully applied to quant. assays of EP in pharmaceutical samples and of BR in biofluids with satisfactory recovery results.

01 Apr 2025·Plant Physiology and Biochemistry

Molecular and physiological response of chives (Allium schoenoprasum) under different concentrations of selenium application by transcriptomic, metabolomic, and physiological approaches

Article

Author: Chen, Qiangwen ; Yu, Li ; Cheng, Shuiyuan ; Xu, Feng ; Zhang, WeiWei ; Cong, Xin

Selenium (Se) is a vital trace element for human health, and its uneven distribution in soil triggers Se deficiencies in some regions. Se biofortification has been demonstrated to mitigate this issue by producing Se-enriched crops. Chives (Allium schoenoprasum cv. 'sijixiaoxiangcong'), a simple-to-cultivate and fast-growing vegetable, offers a promising Se-accumulation ability. However, the physiological and molecular mechanisms underlying Se responses in chives remain unclear. This study applied sodium selenite at various doses to chives via root irrigation, and integrated strategies including multi-omics were employed to unfold the response mechanism. (1) Physiological data reveal that sodium selenite irrigation adversely affects the height, shoot weight, chlorophyll, and soluble sugar content of chives' aerial parts. However, chives exhibit a remarkable ability to accumulate selenium, reaching up to 40.21 mg kg^-1 DW under high Se exposure (160 mg L^-1); (2) Transcriptomic analysis revealed significant enrichment of the phenylpropanoid biosynthesis and plant hormone signal transduction pathways under Se treatment. Key DEGs, such as MAPKKK17_18, JAZs, and PCL, were identified as Se response candidates. Our findings show that selenomethionine is the primary form of Se accumulation, and DEGs linked to antioxidant defense and phenylpropanoid biosynthesis are crucial for mitigating Se stress; (3) Importantly, plant hormone signaling plays a central role by regulating phenylpropanoid metabolism and enhancing the antioxidant enzyme system, highlighting its significance in chives' Se tolerance. These results clarify the Se response mechanisms in chives and enable Se-enriched chive cultivation.

100 Deals associated with Sodium Selenite

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R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Selenium deficiency	Japan	Fujimoto Pharmaceutical Corp.	26 Mar 2019

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Colonic Cancer	Preclinical	United States	Illinois College	01 May 2009
Cataract	Preclinical	United States	Senju Pharmaceutical Co., Ltd.	01 May 2003

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SECAR study (WCLC2013)	Not Applicable	Neoplasms	34	Sodiumselenite	(lklocnlavt) = One patient had a complete remission nqeupnilhf (udqvqwuome ) View more	-	28 Oct 2013
ASTRO2007	Not Applicable	-	-	Sodium Selenite	lpkxwppmvd(xjbdwmwgsy) = jvmwmibbfc lxokqgftkj (gjzjzzpjbf ) View more	-	01 Nov 2007
				Sodium Selenite (Observation)	lpkxwppmvd(xjbdwmwgsy) = sprporylcj lxokqgftkj (gjzjzzpjbf ) View more
ASTRO2005	Not Applicable	-	-	Sodium Selenite supplementation	(gstynatadc) = iykbidwfwq xnwkglmywd (ndusjozlbo ) View more	-	01 Oct 2005
				Sodium Selenite (Control group (no supplementation))	(gstynatadc) = itpintoatq xnwkglmywd (ndusjozlbo ) View more