Delving into the Latest Updates on Sodium Selenite with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

ASELEND, アセレンド

Target-

Mechanism-

Therapeutic Areas

Other DiseasesNeoplasmsDigestive System Disorders+ [1]

Active Indication

Selenium deficiencyColonic CancerCataract

Inactive Indication-

Originator Organization

Fujimoto Pharmaceutical Corp.

Active Organization

Illinois CollegeSenju Pharmaceutical Co., Ltd.

Fujimoto Pharmaceutical Corp.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (26 Mar 2019),

Selenium deficiency

Regulation-

Login to view timeline

Structure/Sequence

Molecular FormulaH2Na2O3Se

InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N

CAS Registry10102-18-8

This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED:
β- Carotene (30 mg)
Vit C (100 mg)
Vit E (Alpha-Tocopherol Acetate): 60-200 IU
Calcium phosphate dihydrate (40 mg)
Zinc oxide (4 mg, elemental)
Copper gluconate (3.5 mg)
Sodium selenite 23 mg= Selenium 100 µg
Nicotinamide (a form of vit.B3) (10 mg)
in patients with mild Thyroid eye disease according to EUGOGO classification. To be given twice a day.

Start Date15 Jul 2019

Sponsor / Collaborator

Iran University of Medical Sciences & Health Services

IRCT20110123005670N28

/ CompletedPhase 3IIT

The effects of Na- selenite and Na- selenite -enriched yeast supplementation on glycemic status, lipid profile, oxidative and nitrosative stress in patients with coronary artery diseases.

Start Date02 Jun 2019

Sponsor / Collaborator

Tabriz University of Medical Sciences

NCT03081949

/ CompletedPhase 4IIT

Peripartum Cardiomyopathy in Nigeria (PEACE) A Registry to Study the Demographics, Social and Clinical Characteristics, Pathophysiology and Outcomes of Peripartum Cardiomyopathy in Nigeria

Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world. Unfortunately, much about the disease including its aetiology, epidemiology and treatment is not yet well described. This will be a prospective, national, multicenter cohort study, conducted in centres in Nigeria. It is expected that approximately 500 patients with PPCM and 500 apparently healthy pregnant women will be recruited over a 6-month period with follow-up at 3-monthly intervals for 18 months.

Start Date12 Jun 2017

Sponsor / Collaborator-

100 Clinical Results associated with Sodium Selenite

Login to view more data

100 Translational Medicine associated with Sodium Selenite

Login to view more data

100 Patents (Medical) associated with Sodium Selenite

Login to view more data

2,817

Literatures (Medical) associated with Sodium Selenite

01 Mar 2025·Food Chemistry

Characterization of the effect of low-concentration sodium selenite on the microstructure and quality of yeast-leavened steamed bread using X-ray computed tomography

Article

Author: Chen, Xiong ; Dai, Jun ; Ding, Wenping ; Chen, Xuan ; Zhuang, Kun ; Yao, Lan

Dough fermentation is an effective method for selenium conversion. This study investigated the effects of low Na₂SeO₃ concentrations on the morphology, texture, fermentation properties, Se species, Se bioaccessibility, and antioxidant capacity of two types of yeast-leaved steamed bread. The results indicated that Na₂SeO₃ did not significantly affect the specific volume; but it did result in increased hardness. X-ray computed tomography revealed that the center of steamed bread became denser owing to Na₂SeO₃, and the porosity was reduced by approximately half at the highest addition level, although the cell number remained relatively unchanged. The fermentation property test demonstrated that Na₂SeO₃ reduced the gas production rate in dough. The conversion rate of seleno-amino acids increased with the addition of Na₂SeO₃, reaching a maximum of over 7 %, as did the antioxidant capacity, although the Se bioaccessibility decreased. In conclusion, this Se-enriched steamed bread reveals its potential functional benefits as a staple food.

01 Feb 2025·International Journal of Biological Macromolecules

Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action

Article

Author: Rani, Sarita ; Tejavath, Kiran Kumar ; Gupta, Shruti ; Gupta, Umesh

Combinatorial drug delivery has shown promising results over single drug for cancer therapy. Here, we aimed to explore combination of proteasome inhibitor; bortezomib (BTZ) with natural antioxidants (AOs); polyphenols like caffeic acid (CFA), resveratrol (RES), fucoidan (FD), and synthetic AO; sodium selenite (Na₂SeO₃) for cellular cytotoxicity in breast cancer cell lines; MCF-7 and MDA MB-231. The combination of RES + BTZ, FD + BTZ, and Na₂SeO₃ + BTZ showed synergism while CFA showed antagonism with BTZ. The EC₅₀ values of different combinations were found to be significantly less than the individual AOs in ABTS and DPPH assay. Furthermore, the effect of combination of drugs on migratory properties of MCF-7 cells were evaluated by in-vitro wound healing assay, resulting in the reduction of such behavior. In support of this, RT-qPCR was performed to analyze differential gene expressions of apoptotic and Epithelial-Mesenchymal Transition (EMT) markers with and without treatment. In results, the combination of Na₂SeO₃ + BTZ reduced the expression of Bcl-XL and N-Cad causing cytotoxicity and suggested that the combination of Na₂SeO₃ + BTZ (IC₅₀ = 1.40 ± 0.45 μM) could be a better option among other combinations for breast cancer therapy. Overall, the outcome indicates that the combination of BTZ with AOs may yield potential therapeutic benefit.

01 Jan 2025·Poultry Science

Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway

Article

Author: Lin, Xu ; Chen, Xinzhang

Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT-induced viral hepatitis in poultry. To fill this gap, AA broiler models exposed to TMT for 42 d were established and fed a Se-enriched diet at the same time. H&E staining showed that selenium could significantly alleviate TMT-induced liver inflammation. Further analysis of the underlying mechanism revealed that TMT induced nitrosation stress (RNS), increased NO content and iNOS expression, which in turn activated the NF-κB/NLRP3 pathway and induced pyroptosis. However, selenium enrichment can reverse this situation, that is, reduce the occurrence of RNS, reduce the degree of pyroptosis, and thus alleviate the occurrence of inflammation. In our study, we demonstrated for the first time that TMT could induce hepatotoxicity other than neurotoxicity in poultry and that selenium could antagonize TMT-induced hepatotoxic hepatitis in chickens through the RNS/NF-κB/NLRP3 pathway.

100 Deals associated with Sodium Selenite

Login to view more data

R&D Status

Approved

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Selenium deficiency	JP	Fujimoto Pharmaceutical Corp.	26 Mar 2019

Developing

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Colonic Cancer	Preclinical	US	Illinois College	01 May 2009
Cataract	Preclinical	US	Senju Pharmaceutical Co., Ltd.	01 May 2003

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


WCO_IOF_ESCEO2023	Not Applicable	-	120	Sodium Benzoate 500 mg/kg	bjwnctgwmd(wmjbovhioz) = tbbamrcsym ynviyqoizf (qocqbzoodt ) View more	Positive	04 May 2023
				Sodium Benzoate 1000 mg/kg	bjwnctgwmd(wmjbovhioz) = gphlzcrxqa ynviyqoizf (qocqbzoodt ) View more
SECAR study (WCLC2013)	Not Applicable	Neoplasms	34	Sodiumselenite	(buokzorucg) = One patient had a complete remission aklmgcthfo (bpysueikbn ) View more	-	28 Oct 2013
ASTRO2007	Not Applicable	-	-	Sodium Selenite	fbxgxqbybe(euezkaakka) = majowvmytu pdihslahlt (vhmyfnpowc ) View more	-	01 Nov 2007
				Sodium Selenite (Observation)	fbxgxqbybe(euezkaakka) = aixfmopnkb pdihslahlt (vhmyfnpowc ) View more
ASTRO2005	Not Applicable	-	-	Sodium Selenite supplementation	(sckrpcnsme) = tzaiquhjrw jrhxwbgoug (gohqblicqf ) View more	-	01 Oct 2005
				Sodium Selenite (Control group (no supplementation))	(sckrpcnsme) = rbuqpkhrcd jrhxwbgoug (gohqblicqf ) View more