Delving into the Latest Updates on Sertraline Citrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

SERT

Mechanism

SERT inhibitors(Serotonin transporter inhibitors)

Therapeutic Areas

Other Diseases

Active Indication

Obsessive-Compulsive Disorder

Inactive Indication-

Originator Organization

Harbin Pharm Group Sanjing Mingshui Pharmaceutical Co., Ltd.

Active Organization

Harbin Pharm Group Sanjing Mingshui Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (18 Mar 2008),

Obsessive-Compulsive Disorder

Regulation-

Login to view timeline

Structure/Sequence

Molecular FormulaC23H25Cl2NO7

InChIKeyMVWPRBCCFXCSDP-XHXSRVRCSA-N

CAS Registry836597-67-2

BACKGROUNDMajor depressive disorder (MDD) during adolescence significantly jeopardizes both mental and physical health. However, the etiology underlying MDD in adolescents remains unclear.METHODSA total of 74 adolescents with MDD and 40 health controls (HCs) who underwent comprehensive clinical and cognitive assessments were enrolled. Differential expression analysis was conducted on plasma extracellular vesicles (EVs) carrying long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) by microarray analysis. Two possible lncRNA-miR-mRNA networks were established and candidate regulatory axes were generated using the StarBase, miRDB, and TargetScan bioinformatics databases. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the candidate molecules and signaling axes in a clinical cohort.RESULTSA total of 3752 dysregulated lncRNAs and 1789 dysfunctional mRNAs were identified. Two candidate regulatory axes (AC156455.1/miR-126-5p/AAK1 and CCDC18-AS1/miR-6835-5p/CCND2) with potential connections with MDD were selected. The candidate molecules exhibit differential expression patterns among adolescents with MDD and HCs, as well as before and after treatment with sertraline in adolescents with MDD. Furthermore, AAK1, CCDC18-AS1, and miR-6835-5p expressions exhibited significant differences between the response and non-response groups. Baseline expression of CCDC18-AS1, miR-6835-5p, and CCND2 could predict the therapeutic effect of sertraline, which may be associated with reducing suicidal ideation and improving cognitive function.CONCLUSIONOur study may provide insights into the understanding of the underlying pathological mechanisms in adolescents with MDD.

01 Jan 2025·Journal of Affective Disorders

Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study

Article

Author: Mano, Nariyasu ; Kobayashi, Natsuko ; Ishikawa, Tomofumi ; Sakai, Takamasa ; Nishigori, M Hidekazu ; Tomita, Hiroaki ; Kikuchi, Saya ; Noda, Aoi ; Obara, Taku ; Kuriyama, Shinichi

BACKGROUNDAs multiple Japanese academic societies have recently issued treatment guidelines for perinatal antidepressant treatments, it is considered worthwhile to evaluate the latest trends and continuation of antidepressant medication during pregnancy to optimize antenatal prescriptions.METHODSThe prevalence, trend, and continuation of antidepressant use during pregnancy in Japan from 2012 to 2023 were evaluated, using a large administrative claims database, in women whose pregnancies ended in live births. Annual changes were evaluated using a multivariate logistic regression model adjusted for maternal age at delivery.RESULTSOf 179,797 women with a mean maternal age at delivery of 32.5 years, 1870 (1.04 %) were prescribed antidepressants during pregnancy. The prevalence significantly increased (P < 0.0001) from 0.63 % in 2012 to 1.67 % in 2023. Antidepressants were prescribed to 1730 women (0.96 %) during the first trimester. Of these, 670 (38.7 %) were antidepressant continuers throughout pregnancy, showing a significant increase (P < 0.0001) from 19.51 % in 2012 to 50.70 % in 2023. The most frequently prescribed class of antidepressants during pregnancy was serotonin reuptake inhibitors (0.74 %), especially sertraline (0.33 %) and escitalopram (0.23 %), with a significant increase in their annual prevalence.LIMITATIONSPrescriptions for women whose pregnancies ended in abortion or stillbirth could not be evaluated.CONCLUSIONSGiven that antidepressant use and its continuation during pregnancy have become more common, it is important to further disseminate knowledge of the guidelines to healthcare professionals and women of childbearing age, including the promotion of preconception care and shared decision-making.

30 Apr 2021·Psychiatria PolskaQ4 · MEDICINE

False-positive drug test results in patients taking psychotropic drugs. A literature review

Q4 · MEDICINE

Review

Author: Padała, Olga ; Masternak, Sebastian ; Karakuła-Juchnowicz, Hanna

100 Deals associated with Sertraline Citrate

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB01104

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Obsessive-Compulsive Disorder	CN	Harbin Pharm Group Sanjing Mingshui Pharmaceutical Co., Ltd.	18 Mar 2008

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03033069 (331-201-061, CTgov)	Phase 2	Stress Disorders, Post-Traumatic	336	Sertraline Matching Placebo+Brexpiprazole+sertraline (Brexpiprazole + Sertraline)	adddkatmcq(wjwbovupzo) = ngzykvigam anxjdbbomc (laxirwjuoq, feelztuyoi - gfpxkuujdt) View more	-	08 Dec 2021
				Sertraline Matching Placebo+Brexpiprazole (Brexpiprazole)	adddkatmcq(wjwbovupzo) = qechkaamnm anxjdbbomc (laxirwjuoq, yevveupllk - pbiybxeddn) View more
NCT02917122 (Parkinson's, CTgov)	Phase 1/2	Depressive Disorder \| Parkinson Disease	15	sham tDCS+sertraline (Sertraline + Sham tDCS)	srergdpeds(pndcslndhf) = fcgomjhxey infzwznmch (oumlwwtixs, feozokuowa - qxminjjvzy) View more	-	20 Oct 2021
				active tDCS+sertraline (Sertraline + Active tDCS)	srergdpeds(pndcslndhf) = atpudwetce infzwznmch (oumlwwtixs, tiogdlgfma - lzyrwcdume) View more
NCT02918097 (CTgov)	Phase 4	Bipolar Disorder	78	Lithium Carbonate+Risperidone+Nortriptyline+Sertraline	ovklltxnpp(zuulxgqpxs) = ifrxjeozks xoolnwtjmp (xzqrdelvuo, lwwgylgaxa - adbebawsbr) View more	-	14 Oct 2020
NCT01524133 (PROGrESS, CTgov)	Phase 4	Stress Disorders, Post-Traumatic	223	Sertraline (Sertraline + Enhanced Medication Management (SERT/EMM))	qbnhwqlkgm(hykxxdwliq) = mjblnidzes scoeerkzwb (lnyvcktjgw, amyoxyhypv - surwquzarb) View more	-	28 Feb 2018
				Prolonged Exposure Therapy+Sertraline (Prolonged Exposure + Sertraline (PE/SERT))	qbnhwqlkgm(hykxxdwliq) = ntgwpkcowg scoeerkzwb (lnyvcktjgw, wrwkvhzcob - udyvvoilzj) View more
NCT02504931 (DDx, CTgov)	Phase 4	Alcoholism \| Stress Disorders, Post-Traumatic \| Alcohol-Related Disorders	49	Sertraline (Sertraline)	(fsorzzrrcg) = athswdbyll eqsvararuo (pxbuepskei, anrxmxyyil - kqlqnplxwu) View more	-	27 Feb 2018
				Placebo (Placebo)	(fsorzzrrcg) = cxbtnumzug eqsvararuo (pxbuepskei, zcmiiuvush - kbeyludxdc) View more
NCT01896934 (CTgov)	Phase 4	Depressive Disorder, Major	31	sertraline	wubgbybllu(pyajodchjk) = knxngjcuft dhcmryxnjl (mybxjumijt, uojparhbgc - itkwtnqnps) View more	-	21 Jul 2017
NCT00701675 (Sert-GAD, CTgov)	Phase 4	Generalized anxiety disorder	42	sertraline 50 mg daily (Sertraline 50mg)	gqfehtfliq(iokpxzyvvg) = qsbllmpcxn ootgfbsnej (eatgokjbkl, asnsisogjv - aouqwlxagg) View more	-	29 Dec 2016
				sertraline 100 mg daily (Sertraline 100mg)	gqfehtfliq(iokpxzyvvg) = umlpfhqcgj ootgfbsnej (eatgokjbkl, rmbzwgjveb - zftavmxbtv) View more
NCT00340379 (CTgov)	Phase 2/3	Affective Disorders, Psychotic \| Depressive Disorder, Major	72	ziprasidone (Ziprasidone)	(gkitbungpn) = xolalqxpsq eiunvalezw (provwwuuwm, svftepvbdz - hpiepriqxq) View more	-	04 Jun 2013
				Sertraline+Haloperidol (Sertraline/Haloperidol)	(gkitbungpn) = mblgvysqvm eiunvalezw (provwwuuwm, lnfwpmxcbc - hzrlkkvzan) View more