Delving into the Latest Updates on Nepafenac with Synapse

In South Punjab, Pakistan, where tertiary hospitals manage a high cataract workload, data on nepafenac sodium to reduce this inflammatory response is not up to the mark. Relative benefit of low-dose versus high-dose regimens remains unclear in routine clinical practice. Therefore, this study was performed with the objective to compare the effectiveness of low-dose nepafenac sodium with high-dose nepafenac sodium in preventing macular edema after cataract surgery.

Start Date01 Jan 2026

Sponsor / Collaborator

RESnTEC, Institute of Research

ChiCTR2500110461

/ SuspendedNot ApplicableIIT

Effect of Topical NSAIDs on Pain Management During Intravitreal Injections

Start Date17 Oct 2025

Sponsor / Collaborator-

100 Clinical Results associated with Nepafenac

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100 Translational Medicine associated with Nepafenac

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100 Patents (Medical) associated with Nepafenac

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324

Literatures (Medical) associated with Nepafenac

13 Oct 2026·Drug Metabolism and Bioanalysis

Emerging Trends in Ophthalmic Drug Delivery: Focus on NSAIDs and Corticosteroids

Article

Author: Mehan, Navneet ; Dushyant ; Narwal, Smita ; Saini, Vipin ; Kumar, Manish ; Singh, Gurvirender ; Devi, Sheetal ; Dhingra, Ashwani K.

Abstract::

Ocular drug delivery is severely affected by anatomical and physiological ocular barriers, preventing drug permeation and therapeutic effects. Uveitis, keratitis, and inflammatory postoperative ocular complications demand accurate, sustained, and localized therapy. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Steroidal Anti-inflammatory Drugs (Corticosteroids) are cornerstones for managing anterior and posterior ocular inflammation. Their traditional formulations, however, are flawed, with compromised bioavailability, tear clearance, and systemic toxicity. Nano-formulations prepared using the latest breakthroughs in nanotechnology have transformed ophthalmic drug delivery by offering enhanced solubility, prolonged retention time, and extended drug release. Liposomes, nanoemulsions, dendrimers, and polymeric nanoparticle-based nanocarriers enhance the therapeutic index of Corticosteroids and NSAIDs by improving penetration across ocular barriers and reducing dosing intervals at the systemic level. Of particular interest, prodrug medications, such as nepafenac, are metabolized intraocularly and provide greater inhibition of cyclooxygenase-2 (COX-2). To this end, biopharmaceutical drug evaluation tools, e.g., in vitro models of the cornea, pharmacokinetic profiling, and ocular imaging, are of utmost significance for determining the drug's efficacy and safety. Immunopharmacology, by the design of immunosuppressive drugs such as cyclosporine A, is also another branch of anti-inflammatory therapies, such as for chronic ocular surface diseases, such as dry eye. Nano-based and combination corticosteroids have been effective methods for controlled inflammation and synergy. Together with nanotechnology and the incorporation of biopharmaceutical screening, the era is opening to a new generation of ophthalmic anti-inflammatory therapy with lower risk, greater efficacy, and a patient-centered approach.

01 Sep 2026·Journal of vitreoretinal diseases

Progressive Intramembranous Cystic Changes in Macular Hole–Associated Epiretinal Proliferation Over 3 Years

Article

Author: Ravindran, Ram Sudarshan ; Abdul Khader, Syed Mohideen ; Gopalakrishnan, Nikhil

Purpose: To describe the progressive morphologic changes of macular hole (MH)-associated epiretinal proliferation over long-term follow-up and to explore potential pathologic mechanisms. Methods: A single case was retrospectively reviewed. Results: A patient with a history of open-angle glaucoma and proliferative diabetic retinopathy maintained stable visual acuity (VA) of 6/9 OD and 6/18 OS over 2 years. On examination, MH-associated epiretinal proliferation was noted in the left eye, demonstrating increased thickness and cystic changes compared with the previous visit, for which topical nepafenac eye drops were advised. A follow-up visit 1 year later showed a marked increase in the volume of epiretinal proliferation with associated intraretinal fluid, despite no change in VA. Conclusions: This report documents progressive structural changes in this infrequently encountered entity and explores the possible pathologic mechanisms through a review of relevant literature. Cystic changes with epiretinal proliferation may represent a benign process attributable to chronicity and often may not require intervention.

01 May 2026·Veterinary Medicine and Science

Effects of Topical Steroids and Non‐Steroidal Anti‐Inflammatory Drugs on Gastrointestinal Bleeding in Rats

Article

Author: Ozlem Ozmen ; Aybike Ozbeyli ; Harun Cinar ; Beyza Bektas ; Latif Emrah Yanmaz

ABSTRACT:

Objective:

This study aimed to investigate the potential systemic gastrointestinal (GI) effects of short‐term topical administration of ocular steroids and non‐steroidal anti‐inflammatory drugs (NSAIDs) in rats.

Animals:

A total of 56 adult male Wistar rats were assigned to seven treatment groups ( n = 8 for each group), receiving topical applications of saline, prednisolone acetate, dexamethasone phosphate, loteprednol etabonate, ketorolac tromethamine, nepafenac or diclofenac sodium for 1 week.

Methods:

GI bleeding was assessed using faecal occult blood tests, gastric and duodenal tissues were analysed histopathologically, and endoscopic evaluations were performed.

Results:

Positive faecal occult blood results were observed in the prednisolone acetate group (3/8; 37.5%), dexamethasone phosphate (2/8; 25%), diclofenac sodium (1/8; 12.5%) and loteprednol etabonate (1/8; 12.5%). No positive results were recorded in the ketorolac tromethamine, nepafenac, or saline groups (0%). Differences between groups were not statistically significant ( p > 0.05). No significant within‐group differences between baseline and post‐treatment results were detected ( p > 0.05). Endoscopic scores ranged from 0 to 1 across all groups, and histopathology revealed no abnormalities.

Conclusions and clinical relevance:

Short‐term topical ocular steroid and NSAID treatments were not associated with statistically significant systemic gastrointestinal alterations under the conditions of this study.

8

News (Medical) associated with Nepafenac

18 Mar 2026

·www.globenewswire.com

Harrow Announces Three Abstracts Accepted for Presentation at ASCRS 2026 Annual Meeting

NASHVILLE, Tenn., March 18, 2026 (GLOBE NEWSWIRE) -- Harrow (Nasdaq: HROW), a leading provider of ophthalmic disease management solutions in North America, today announced that three scientific abstracts highlighting its commercial products VEVYE® (cyclosporine ophthalmic solution) 0.1% and ILEVRO® (nepafenac ophthalmic suspension) 0.3% have been accepted for presentation at the American Society of Cataract and Refractive Surgery (ASCRS) 2026 Annual Meeting, taking place April 10–13 at the Walter E. Washington Convention Center in Washington, D.C. The accepted research underscores Harrow’s continued commitment to advancing evidence-based treatment options for ophthalmic diseases, including dry eye disease and post-cataract surgery complications. The abstracts will be presented in the following scientific sessions: Ocular Surface DiseaseDate: Saturday¸ April 11, 2026Time: 8:00 AM – 9:30 AM VEVYE: Real-World Treatment Patterns and Clinical Outcomes with Cyclosporine 0.1% in Semifluorinated Alkane for Dry Eye Disease Presenter: A. Epitropoulos, MD VEVYE: Dual-Function Cyclosporine 0.1% in Perfluorobutylpentane as an Alternative to Corticosteroids in Post-Fungal Keratoplasty Presenter: T. Shoshany, MD Medications (Preoperative, Postoperative, Intraoperative)Date: Sunday, April 12, 2026Time: 8:00 AM – 9:30 AM ILEVRO: Post-Hoc Analysis of the Effect of Nepafenac 0.3% on Reducing Clinically Significant Visual Acuity Loss Associated with Cataract Surgery in subjects with Macular Edema Presenter: I. Mac, MD The ASCRS Annual Meeting is one of the world’s premier gatherings for ophthalmic surgeons and ophthalmic professionals, showcasing the latest clinical research, surgical techniques, and therapeutic innovations in ophthalmology. Additional details regarding the abstracts and supporting data will be available at the time of presentation. About Harrow Harrow, Inc. (Nasdaq: HROW) is a leading provider of ophthalmic disease management solutions in North America, offering a comprehensive portfolio of products that address conditions affecting both the front and back of the eye, such as dry eye disease, wet (or neovascular) age-related macular degeneration, cataracts, refractive errors, glaucoma and a range of other ocular surface conditions and retina diseases. Harrow was founded with a commitment to deliver safe, effective, accessible, and affordable medications that enhance patient compliance and improve clinical outcomes. For more information about Harrow, please visit harrow.com and connect with us on LinkedIn. Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Any statements in this release that are not historical facts may be considered such “forward-looking statements.” Forward-looking statements are based on management's current expectations and are subject to risks and uncertainties which may cause results to differ materially and adversely from the statements contained herein. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include, among others, risks related to: liquidity or results of operations; our ability to successfully implement our business plan, develop and commercialize our products, product candidates and proprietary formulations in a timely manner or at all, identify and acquire additional products, manage our pharmacy operations, service our debt, obtain financing necessary to operate our business, recruit and retain qualified personnel, manage any growth we may experience and successfully realize the benefits of our previous acquisitions and any other acquisitions and collaborative arrangements we may pursue; competition from pharmaceutical companies, outsourcing facilities and pharmacies; general economic and business conditions, including inflation and supply chain challenges; regulatory and legal risks and uncertainties related to our pharmacy operations and the pharmacy and pharmaceutical business in general, including the ongoing communications with the U.S. Food and Drug Administration relating to compliance and quality plans at our outsourcing facility in New Jersey; physician interest in and market acceptance of our current and any future formulations and compounding pharmacies generally. These and additional risks and uncertainties are more fully described in Harrow’s filings with the Securities and Exchange Commission (SEC), including its Annual Report on Form 10-K for the year ended December 31, 2025, and other filings with the SEC. Such documents may be read free of charge on the SEC's web site at sec.gov. Undue reliance should not be placed on forward-looking statements, which speak only as of the date they are made. Except as required by law, Harrow undertakes no obligation to update any forward-looking statements to reflect new information, events, or circumstances after the date they are made, or to reflect the occurrence of unanticipated events. Contacts:Mike BiegaVice President of Investor Relations and Communications mbiega@harrowinc.com617-913-8890

26 Sep 2023

·www.prnewswire.com

MATI THERAPEUTICS ANNOUNCES PROMOTION OF CHRIS MULLER TO CHIEF OPERATING OFFICER

Industry Veteran with over 30 years of ophthalmic experience to guide development and commercial efforts for Mati's expanding late-stage pipeline, including two products about to enter Phase III trials. AUSTIN, Texas, Sept. 26, 2023 /PRNewswire/ -- Mati Therapeutics Inc. ("Mati") announced that it has promoted Chris Muller to the position of Chief Operating Officer. He formerly held the position of Chief Commercial Officer. Mr Muller's expanded responsibilities include broad management of all operating activities, and preparation for and execution of the commercial launch of Mati's proprietary Evolute® sustained ocular drug delivery platform. "Chris has an outstanding record of achievement from his 30+ years of ophthalmic industry experience, including multiple product launches in glaucoma, inflammation, and anti-infectives, followed by extensive experience in refractive surgery, cataract surgery, dry eye, contact lens, and OTC care. Chris has unique qualifications to help Mati achieve our development and commercialization goals, especially since our first three programs focus on the post-operative cataract market and glaucoma," said Bob Butchofsky, CEO of Mati. "Following the recently announced completion of our dedicated manufacturing facility, Chris will lead efforts to complete our upcoming Phase III trial for nepafenac for post-cataract pain and hire personnel and lead our commercial efforts as we pursue FDA approval." Mr. Muller started his ophthalmic career at Allergan, where he held various positions of increasing responsibility from 1990 to 2005. He held positions in Field Sales, Medical Marketing, as well as senior leadership positions in U.S. and global marketing. Chris then joined AMO/Abbott and was head of their Eye Care, Medical Marketing and Refractive divisions globally. About Mati Therapeutics Inc. Mati is developing the Evolute® sustained ocular drug delivery platform, which Mati believes has the potential to treat a range of ocular indications. The platform utilizes a device called a punctal plug, which is easily inserted into a patient's punctum, or tear duct. The device has already been approved to treat dry eye syndrome, but Mati is the first company to conduct clinical trials in the U.S. using punctal plugs as an anchoring device for a drug delivery platform. A drug-eluting core is inserted into Mati's proprietary punctal plug, which allows medication to be continuously released into the tear film of the eye over a period of time. Mati believes the Evolute® platform has the potential to become a more reliable alternative to several eye drop therapies, which can be ineffective because many patients are unwilling or unable to adhere to self-administered eye-drop regimens. Mati's proprietary punctal plug design has demonstrated excellent lower punctum retention rates of 92% and 96% over a 12-week follow-up period in two separate multi-center U.S. clinical trials. Mati has two candidates ready to enter Phase III pivotal trials including nepafenac for post-operative pain and dexamethasone for post-operative inflammation, both following cataract surgery. Additionally, Mati is developing travoprost, which is in Phase II trials for the treatment of glaucoma and ocular hypertension. To learn more about Mati Therapeutics, visit . Contact: Bob Butchofsky, CEO Mati Therapeutics Inc. +1 512 720-1333 [email protected] SOURCE Mati Therapeutics

Executive ChangePhase 2Phase 3

12 Sep 2023

·www.prnewswire.com

MATI THERAPEUTICS ANNOUNCES COMPLETION OF MANUFACTURING FACILITY DEDICATED TO GLOBAL PRODUCTION OF ALL PUNCTAL PLUG DELIVERY SYSTEM (PPDS) PRODUCTS

Completion of Facility Enables Initiation of Phase 3 Clinical Trial of Nepafenac in Patients Undergoing Cataract Surgery AUSTIN, Texas, Sept. 12, 2023 /PRNewswire/ -- Mati Therapeutics Inc. ("Mati") announced that it has completed and now occupies a facility dedicated to manufacturing all products formulated in Mati's proprietary Evolute® sustained ocular drug delivery platform. The 10,000 square foot facility is located in Bryan, Texas and has the capacity to fulfill all manufacturing needs for both development and commercial purposes for the foreseeable future. Mati engineers designed, built, and programmed each of the robotic devices used in a multi-step process to manufacture each product in the Evolute® platform. "Following pandemic-related disruptions to global supply chains, we determined it was both time and cost effective to directly control the manufacturing process for all of the product candidates in our pipeline," said Bob Butchofsky, CEO of Mati. "Following completion and occupancy of this facility, we are now in position to initiate a Phase 3 trial of nepafenac to treat post-operative pain in patients undergoing cataract surgery. We expect to begin this trial in the coming weeks. Our ability to control our manufacturing schedule will reduce potential delays from ongoing supply chain interruptions, provide more flexibility in our development efforts, and will greatly reduce our commercial cost of goods sold." About Mati Therapeutics Inc. Mati is developing the Evolute® sustained ocular drug delivery platform, which Mati believes has the potential to treat a range of ocular indications. The platform utilizes a device called a punctal plug, which is easily inserted into a patient's punctum, or tear duct. The device has already been approved to treat dry eye syndrome, but Mati is the first company to conduct clinical trials in the U.S. using punctal plugs as an anchoring device for a drug delivery platform. A drug-eluting core is inserted into Mati's proprietary punctal plug, which allows medication to be continuously released into the tear film of the eye over a period of time. Mati believes the Evolute® platform has the potential to become a more reliable alternative to several eye drop therapies, which can be ineffective because many patients are unwilling or unable to adhere to self-administered eye-drop regimens. Mati has two candidates ready to enter Phase III pivotal trials including nepafenac for post-operative pain and dexamethasone for post-operative inflammation, both following cataract surgery. Additionally, Mati is developing travoprost, which is in Phase II trials for the treatment of glaucoma and ocular hypertension. Mati's proprietary punctal plug design has demonstrated excellent lower punctum retention rates of 92% and 96% over a 12-week follow-up period in two separate multi-center U.S. clinical trials. To learn more about Mati Therapeutics, visit . Contact: Bob Butchofsky, CEO Mati Therapeutics Inc. +1 512 720-1333 [email protected] SOURCE Mati Therapeutics

Phase 2Phase 3

100 Deals associated with Nepafenac

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KEGG	Wiki	ATC	Drug Bank
D05143	Nepafenac	S01BC10	DB06802

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Macular Edema	Australia	Novartis Pharmaceuticals Australia Pty Ltd.	04 Nov 2015
Post procedural inflammation	Australia	Novartis Pharmaceuticals Australia Pty Ltd.	04 Nov 2015
Ocular inflammation	Japan	Novartis Pharma KK	27 Oct 2010
Diabetic macular oedema	European Union	Novartis Europharm Ltd.	11 Dec 2007
Diabetic macular oedema	Iceland	Novartis Europharm Ltd.	11 Dec 2007
Diabetic macular oedema	Liechtenstein	Novartis Europharm Ltd.	11 Dec 2007
Diabetic macular oedema	Norway	Novartis Europharm Ltd.	11 Dec 2007
Pain, Postoperative	European Union	Novartis Europharm Ltd.	11 Dec 2007
Pain, Postoperative	Iceland	Novartis Europharm Ltd.	11 Dec 2007
Pain, Postoperative	Liechtenstein	Novartis Europharm Ltd.	11 Dec 2007
Pain, Postoperative	Norway	Novartis Europharm Ltd.	11 Dec 2007
Inflammation	United States	Harrow, Inc.	19 Aug 2005
Pain	United States	Harrow, Inc.	19 Aug 2005

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Nonproliferative diabetic retinopathy	Phase 3	-	Alcon Research Ltd.	01 Jun 2013
Eye Pain	Phase 3	France	Alcon Research Ltd.	01 Nov 2005
Cataract	Phase 3	United States	Alcon Research Ltd.	01 Sep 2005
Conjunctivitis, Bacterial	Phase 2	-	Alcon Research Ltd.	01 Jan 2011
Diabetic Retinopathy	Phase 2	-	Alcon Research Ltd.	01 Nov 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03499873 (CTgov)	Phase 3	Cataract \| Pain \| Inflammation ... View more	448	Nepafenac (Nepafenac 0.3% Opthalmic Suspension)	ygcazyrvzm: Mean Difference (Net) = -0.026 (90% CI, -0.124 to 0.073)	-	16 Feb 2021
				Nepafenac (Ilevro 0.3% Opthalmic Suspension)
NCT03025945 (CTgov)	Not Applicable	Macular Edema	662	Nepafenac 0.3% (Nepafenac 0.3%)	uzwdiytblc(fawtmsciei) = gcrlyisptt ssqbcfceyg (bocfrccxmb, 0.13) View more	-	14 Dec 2018
				Saline Solution (Saline Solution)	uzwdiytblc(fawtmsciei) = brjuztyqac ssqbcfceyg (bocfrccxmb, 0.18) View more
NCT01847638 (QD, CTgov)	Not Applicable	Cataract \| Ocular inflammation \| Retinal oedema	50	bromfenac (Prolensa (Bromfenac 0.07%))	vhvieshvuu(mugbtxkfhq) = bvdvsxdezi nbxeywjiyw (sfnsytsxmu, .3) View more	-	14 Nov 2018
				nepafenac (Ilevro (Nepafenac 0.3%))	vhvieshvuu(mugbtxkfhq) = gunndbgczj nbxeywjiyw (sfnsytsxmu, .4) View more
NCT02515045 (CTgov)	Phase 4	Cataract	59	triamcinolone+moxifloxacin+vancomycin (TriMoxiVanc)	crqeivtuty(wfbdogpksh) = tnscrqqopc rnukfodvgx (frojybelfx, 13.05) View more	-	22 Aug 2017
				triamcinolone+moxifloxacin+vancomycin+Ilevro (TriMoxiVanc + Ilevro)	crqeivtuty(wfbdogpksh) = tuomfxtnbw rnukfodvgx (frojybelfx, 11.55) View more
NCT01853072 (Pubmed \| Ophthalmology) Manual	Phase 3	Diabetic Retinopathy	615	Nepafenac	lvorpmfmsy(nnfitpilae) = lzssfzxybx wvjzqtfacj (nbzkufhade ) View more	Positive	01 Jun 2017
				vehicle	lvorpmfmsy(nnfitpilae) = vanxbmpmzm wvjzqtfacj (nbzkufhade ) View more
NCT00939276 \| NCT00782717 (Pubmed \| Br J Ophthalmol)	Phase 2	Diabetic Retinopathy	175	Nepafenac ophthalmic suspension 0.1%	xraxzweonu(sevyjnqywy) = xwuepyjbdr gyrypckzwj (etexlshzpg, 1.4 - 12.3) View more	-	01 Apr 2017
				Vehicle	xraxzweonu(sevyjnqywy) = cxlhtrurcz gyrypckzwj (etexlshzpg, 9.9 - 27.6) View more
APAO2017	Phase 3	Diabetic cataract	-	Nepafenac 0.3%	lcjnffsfks(dbamybdncp) = Rates of treatment-related adverse events were low in both groups (study-1: 2.7% vs 2.3%; study-2: 2.0% vs 2.7%) ofeytspwfh (mvdmnomnaj )	Positive	01 Mar 2017
				Vehicle
NCT03025945 (Pubmed \| BMC Ophthalmol)	Not Applicable	Macular Edema	1,000	Topical nepafenac 0.3%	iqvdjnahfs(jeuyvbiyip) = siwridjwpy wddwfyqlfg (pehmzrwbnh )	-	20 Feb 2017
				Placebo	iqvdjnahfs(jeuyvbiyip) = srznuidrin wddwfyqlfg (pehmzrwbnh )
NCT01331005 (Pubmed \| Retina) Manual	Phase 2	Diabetic macular oedema	125	nepafenec	gacjbbmqyy(yjpxstlpok) = lfnbjxgief xjbywuqxoe (jijgpihjav ) View more	Negative	01 May 2015
				Placebo	gacjbbmqyy(yjpxstlpok) = uyyieninlo xjbywuqxoe (jijgpihjav ) View more
NCT01331005 (CTgov)	Phase 2	Diabetic macular oedema	125	Nepafenac Vehicle (Placebo)	gqmhmatddv(eejeabqrvk) = nzsfhkjmzx mtofrhaxwm (mkdinqdkjg, pcojuampye - nplnssaykf) View more	-	16 Jan 2015
				nepafenac (Nepafenac 0.1% Drops)	gqmhmatddv(eejeabqrvk) = zgwlkenybt mtofrhaxwm (mkdinqdkjg, fperqjxdwy - vovrwddnhn) View more