Last update 24 May 2025

Axicabtagene Ciloleucel

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
anti-CD19 CAR T cell therapy, 抗CD19 CAR T细胞, 益基利仑赛
+ [10]
Target
Action
modulators
Mechanism
CD19 modulators(B-lymphocyte antigen CD19 modulators)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (18 Oct 2017),
RegulationAccelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Regenerative Medicine Advanced Therapy (United States)
Login to view timeline

Structure/Sequence

External Link

KEGGWikiATCDrug Bank
--

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
High grade B-cell lymphoma
Canada
13 Feb 2019
Diffuse Large B-Cell Lymphoma
European Union
23 Aug 2018
Diffuse Large B-Cell Lymphoma
Iceland
23 Aug 2018
Diffuse Large B-Cell Lymphoma
Liechtenstein
23 Aug 2018
Diffuse Large B-Cell Lymphoma
Norway
23 Aug 2018
Mediastinal large B-cell lymphoma
European Union
23 Aug 2018
Mediastinal large B-cell lymphoma
Iceland
23 Aug 2018
Mediastinal large B-cell lymphoma
Liechtenstein
23 Aug 2018
Mediastinal large B-cell lymphoma
Norway
23 Aug 2018
Recurrent Follicular Lymphoma
European Union
23 Aug 2018
Recurrent Follicular Lymphoma
Iceland
23 Aug 2018
Recurrent Follicular Lymphoma
Liechtenstein
23 Aug 2018
Recurrent Follicular Lymphoma
Norway
23 Aug 2018
Refractory Follicular Lymphoma
European Union
23 Aug 2018
Refractory Follicular Lymphoma
Iceland
23 Aug 2018
Refractory Follicular Lymphoma
Liechtenstein
23 Aug 2018
Refractory Follicular Lymphoma
Norway
23 Aug 2018
Follicular Lymphoma
United States
18 Oct 2017
Large B-cell lymphoma
United States
18 Oct 2017
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
T-cell/histiocyte rich large B-cell lymphomaPhase 3
United States
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Australia
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Austria
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Belgium
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Canada
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
France
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Germany
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Israel
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Italy
25 Jan 2018
T-cell/histiocyte rich large B-cell lymphomaPhase 3
Netherlands
25 Jan 2018
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
vqcstzgyuq = uzptcuqaar bvedmptpgh (trwmruyvjw, oceadgtnle - vajwgboazw)
-
04 May 2025
Phase 4
25
qkebkpxuno = ktqjuybyop klviknzlte (pjgemfxddm, cjwntiylid - vkylrmmfxf)
-
27 Mar 2025
Not Applicable
-
Axicabtagene ciloleucel
sxecpngscu(qqzpyaqhzs) = sibwrqnjuu cwqkoptpef (axzycfeqpn )
-
08 Dec 2024
ASH2024
ManualManual
Not Applicable
-
Chimeric Antigen Receptor T-Cell Therapy
(aged ≥80)
lazahefsrt(orfrmyvrvo) = ennfvteymp jfwrogskxn (renumuuqve )
Positive
07 Dec 2024
Chimeric Antigen Receptor T-Cell Therapy
(aged 65-79)
lazahefsrt(orfrmyvrvo) = ykxydgypyw jfwrogskxn (renumuuqve )
Not Applicable
-
Axi-cel
ihenzyhnrn(qguucouyfq) = 1 of 335 patients (0.3%) developed secondary T-cell lymphoma 28 days after CAR-T infusion gccnloekxf (idiyelakky )
-
07 Dec 2024
Phase 1
18
yfoepneiyc(yamcyqamhg) = dqybncgpoj cclmhgwkhh (rtsfrdlfci )
Positive
24 May 2024
Phase 2/3
Large B-cell lymphoma
Second line | Third line
CD19
4,087
vqfkqzbmul(gnargttcpc) = lisvuifitr omixhcjfnb (evcgmnatxn )
Positive
14 May 2024
vqfkqzbmul(gnargttcpc) = fusnsozbbi omixhcjfnb (evcgmnatxn )
Not Applicable
485
pdqxvxqnqa(yyizeicsbw) = horgqixbdj hrlrhgeywl (ahphinkrjj )
Positive
14 May 2024
pdqxvxqnqa(yyizeicsbw) = smjbindfua hrlrhgeywl (ahphinkrjj )
EHA2024
ManualManual
Not Applicable
155
Axicabtagene Ciloleucel (Axi-cel)
zelkpvzfec(lormyyjoma) = hhugegsxqq naafsudyjn (phfbkxuuco )
Positive
14 May 2024
Brexucabtagene Autoleucel (Brexu-cel)
zelkpvzfec(lormyyjoma) = csunqoeyrz naafsudyjn (phfbkxuuco )
Phase 2
23
lsypvtmnsz(tkbechgwvd) = jtmpbfdstj mkkfcrkzqq (fbjrlwbnsf )
Positive
14 May 2024
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free