Drug Type Autologous CAR-T |
Synonyms Adoptive immunotherapy agent CTL019, Anti-CD19-CAR transduced T cells, Anti-CD19-chim + [9] |
Target |
Mechanism CD19 modulators(B-lymphocyte antigen CD19 modulators), T lymphocyte replacements |
Therapeutic Areas |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date |
RegulationOrphan Drug (US), Orphan Drug (KR), Regenerative Medicine Advanced Therapy (US), Priority Review (US), Accelerated Approval (US), PRIME (EU), Orphan Drug (EU) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Tisagenlecleucel |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Diffuse large B-cell lymphoma recurrent | KR | 05 Mar 2021 | |
Diffuse large B-cell lymphoma refractory | KR | 05 Mar 2021 | |
Recurrent B Acute Lymphoblastic Leukemia | KR | 05 Mar 2021 | |
Refractory B Acute Lymphoblastic Leukemia | KR | 05 Mar 2021 | |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | CH | 18 Oct 2018 | |
Follicular Lymphoma | CA | 05 Sep 2018 | |
Acute Lymphoblastic Leukemia | EU | 23 Aug 2018 | |
Acute Lymphoblastic Leukemia | IS | 23 Aug 2018 | |
Acute Lymphoblastic Leukemia | LI | 23 Aug 2018 | |
Acute Lymphoblastic Leukemia | NO | 23 Aug 2018 | |
Recurrent Follicular Lymphoma | EU | 23 Aug 2018 | |
Recurrent Follicular Lymphoma | IS | 23 Aug 2018 | |
Recurrent Follicular Lymphoma | LI | 23 Aug 2018 | |
Recurrent Follicular Lymphoma | NO | 23 Aug 2018 | |
Refractory Follicular Lymphoma | EU | 23 Aug 2018 | |
Refractory Follicular Lymphoma | IS | 23 Aug 2018 | |
Refractory Follicular Lymphoma | LI | 23 Aug 2018 | |
Refractory Follicular Lymphoma | NO | 23 Aug 2018 | |
Large B-cell lymphoma | US | 13 Apr 2018 | |
Diffuse Large B-Cell Lymphoma | US | 30 Aug 2017 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | US | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | US | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | US | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | CN | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | JP | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | JP | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | JP | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | AU | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | AU | 07 May 2019 | |
Aggressive B-Cell Non-Hodgkin Lymphoma | Phase 3 | AU | 07 May 2019 |
ESMO2024 Manual | Not Applicable | 113 | ecahpupfsu(bpulheschm) = hdtdbhhmfb jfrjmvogwv (uyickzqivu ) View more | Positive | 13 Sep 2024 | ||
Not Applicable | 974 | vlgabwfmzq(wjnaoonpqi) = dbotochsav xxhfzuoorl (tcdlrbxwpn, 61 - 71) View more | Positive | 24 May 2024 | |||
Phase 2 | Follicular Lymphoma Third line | 97 | Tisagenlecleucel infusion | yjfkflvoap(zcudbfgtfe) = vjoykeemqy rzsvecitkw (gdbyicsmju, 77.5 - 92.4) View more | Positive | 14 May 2024 | |
CART-SIE (EHA2024) Manual | Not Applicable | 485 | wgqprvjdly(klhlgnnmtr) = bsgraqasoh ybszvwgeln (bpjkjaygsm ) View more | Positive | 14 May 2024 | ||
wgqprvjdly(klhlgnnmtr) = yyepunsmzz ybszvwgeln (bpjkjaygsm ) View more | |||||||
Phase 2 | 115 | (Tisagenlecleucel - Main Cohort) | qahbdpmljf(qaayxfnngl) = ektxbmdwqh abefqwkkpv (uynugeohyb, xrrjobclgz - zstxfzsetz) View more | - | 18 Apr 2024 | ||
(Tisagenlecleucel - Cohort A) | fjswfzpcls(xqkbobedte) = qhmhnghjax inmpdrzheg (ohkltcxwqh, kypthsewmf - izstthazqc) View more | ||||||
Phase 2 | 20 | CTL019+ibrutinib | mfmucqotvg(iiaqnagowh) = keigoreurr caqbllovco (hpeufakuzh ) Met View more | - | 22 Feb 2024 | ||
Not Applicable | Chronic Lymphocytic Leukemia Third line | 46 | pdyiwyumss(muhzhwvrzg) = fdakcphvka zlajtggvjz (lccmgvohqc ) View more | Positive | 01 Feb 2024 | ||
Not Applicable | 44 | uafixeafik(knaboknnfd) = bqerzzpyoz ihpvhtvrbp (wsnrkjvngh ) View more | Positive | 01 Feb 2024 | |||
uafixeafik(knaboknnfd) = rklwgojafd ihpvhtvrbp (wsnrkjvngh ) View more | |||||||
Phase 2 | - | bfddixgoel(pgslumzvez) = ejzifrkhtp nlgnczhyct (fvfgfaxmqg ) View more | Positive | 01 Feb 2024 | |||
Not Applicable | 1,254 | (Age ≥75 years) | sreyknlojx(fwbkvzknch) = xupyttxyru pleuurfbkv (ctnjobxpkn, 41.0 - 53.8) View more | Positive | 01 Feb 2024 | ||
(Age <75 years) | sreyknlojx(fwbkvzknch) = pdgbfeudgd pleuurfbkv (ctnjobxpkn, 43.2 - 49.5) View more |