Last update 20 Mar 2025

Acotiamide Hydrochloride Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acotiamide, Acotiamide hydrochloride (USAN), Acotiamide hydrochloride hydrate (JAN)
+ [8]
Action
antagonists, inhibitors
Mechanism
A1R antagonists(Adenosine A1 receptor antagonists), AChE inhibitors(Acetylcholinesterase inhibitors), M1 receptor antagonists(Muscarinic acetylcholine receptor M1 antagonists)
+ [1]
Inactive Indication
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Structure/Sequence

Molecular FormulaC21H37ClN4O8S
InChIKeyNPTDXIXCQCFGKC-UHFFFAOYSA-N
CAS Registry773092-05-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dyspepsia
Japan
25 Mar 2013
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Urinary Bladder, UnderactivePhase 2--
DyspepsiaPhase 1
Japan
01 Aug 2008
DyspepsiaPreclinical
Japan
01 Aug 2008
NauseaPreclinical
United States
10 Mar 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(Patients with EGJOO)
tchopntxew(ybzzyyhsmb) = Acotiamide was administered to address severe symptoms in six out of 13 patients with EGJOO. Acotiamide normalized impaired receptive LES relaxation and substantially improved symptoms. dkcgirlans (fqhxpxlwvz )
-
01 Oct 2016
(Normal subjects)
Phase 3
-
(pfxrvkuwmk) = hjyxrzbkci eqrmpugcoi (wkbowhunxw )
Positive
01 Jun 2012
Placebo
(pfxrvkuwmk) = bijjruohli eqrmpugcoi (wkbowhunxw )
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Approval

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Regulation

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