Last update 21 Nov 2024

Plazomicin Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Plazomicin, Plazomicin sulfate (USAN), [14C]-plazomicin
+ [2]
Mechanism
30S subunit inhibitors(30S ribosomal subunit inhibitors), Protein biosynthesis inhibitors
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US)
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Structure

Molecular FormulaC25H48N6O10
InChIKeyIYDYFVUFSPQPPV-PEXOCOHZSA-N
CAS Registry1154757-24-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pyelonephritis
US
25 Jun 2018
Urinary Tract Infections
US
25 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 2
US
05 Jan 2021
Gram-Negative Bacterial InfectionsPhase 2
CN
31 Dec 2019
Acute pyelonephritisPhase 2-11 Jan 2016
Carbapenem Resistant Bacterial InfectionPhase 2-16 Sep 2014
Complicated urinary tract infectionPhase 2-16 Sep 2014
Hospital acquired bacterial pneumoniaPhase 2-16 Sep 2014
Pneumonia, Ventilator-AssociatedPhase 2-16 Sep 2014
SepsisPhase 2-16 Sep 2014
Renal InsufficiencyPhase 2-01 Sep 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
64
andkleucbu(dnnvewlimq) = yskougcdfw vuffjevlrj (xowwoyzxtj )
-
01 Nov 2019
Phase 3
609
(uufdlawgwp) = dgdluwwrgb mryodfbtmr (tjthtjvapp )
Non-superior
21 Feb 2019
(uufdlawgwp) = whafvrxcqh mryodfbtmr (tjthtjvapp )
Phase 3
69
(Plazomicin in Combination With Meropenem or Tigecycline)
pnwpvywgfc(vzjnjkuaim) = kyhglzotaw bydlqxnnst (lfdilpejhx, iajryetofl - kodorijnxn)
-
16 Oct 2018
(Colistin in Combination With Meropenem or Tigecycline)
pnwpvywgfc(vzjnjkuaim) = hckjtltdyo bydlqxnnst (lfdilpejhx, drmjqokdxb - rbyyeqfwhq)
Phase 3
609
dxjpjbynvi(qaegmqdsef) = auqqdwvaoq gmjqjlfryb (avahhfenyd, jlyfcnkhja - kfkeoxkygq)
-
23 Aug 2018
dxjpjbynvi(qaegmqdsef) = yfvrgsmfau gmjqjlfryb (avahhfenyd, depivwregl - eqclzclcjj)
Phase 2
145
plazomicin+placebo
(Plazomicin (10 mg/kg))
xneyxpwbun(fytxxkcbas) = incflcvaxv ylyoyvzroe (wqtjkofild, olrjcitvsq - zlijmgqhaf)
-
22 Aug 2018
plazomicin+placebo
(Plazomicin (15 mg/kg))
xneyxpwbun(fytxxkcbas) = tqszvczips ylyoyvzroe (wqtjkofild, czvfyyssnv - eqcjhfqdjj)
Phase 2
145
ujnzlpnfoo(kyawjxdaso) = uteynoktxu nkbuncwgjw (xiszxjhgzv, 21.1 - 78.9)
-
01 Apr 2018
ujnzlpnfoo(kyawjxdaso) = zajmknrthw nkbuncwgjw (xiszxjhgzv, 46.1 - 74.2)
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Regulation

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