Last update 04 Nov 2024

Droxidopa

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3,4-Dihydroxyphenylserine, 3,4-threo-DOPS, Droxidopa (JP17/USAN/INN)
+ [13]
Mechanism
adrenergic receptor agonists(Adrenergic receptors agonists)
Originator Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (US), Accelerated Approval (US), Fast Track (US)
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Structure

Molecular FormulaC9H11NO5
InChIKeyQXWYKJLNLSIPIN-JGVFFNPUSA-N
CAS Registry23651-95-8

External Link

KEGGWikiATCDrug Bank
D01277Droxidopa

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic Neuropathies
US
18 Feb 2014
Dizziness
US
18 Feb 2014
Dopamine Beta Hydroxylase Deficiency
US
18 Feb 2014
Hypotension, Orthostatic
JP
03 Jul 2000
Amyloid Neuropathies, Familial
JP
17 Jan 1989
Parkinson Disease
JP
17 Jan 1989
Shy-Drager Syndrome
JP
17 Jan 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Orthostatic hypertensionPhase 3
US
01 Nov 2013
Hypotension orthostatic symptomaticPhase 3
US
01 Jan 2008
Hypotension orthostatic symptomaticPhase 3
AU
01 Jan 2008
Hypotension orthostatic symptomaticPhase 3
CA
01 Jan 2008
Hypotension orthostatic symptomaticPhase 3
NZ
01 Jan 2008
Multiple System AtrophyPhase 3
US
01 Jan 2008
Multiple System AtrophyPhase 3
AU
01 Jan 2008
Multiple System AtrophyPhase 3
CA
01 Jan 2008
Multiple System AtrophyPhase 3
NZ
01 Jan 2008
Neurogenic Orthostatic HypotensionPhase 3
US
01 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
20
(Droxidopa+Carbidopa: Double-Blind)
bzbljfskut(kvhqaaegeq) = jcttzdkyyv sfahvmvvbv (ffsmnbifyg, iyxgmqleyb - jiedrbdbst)
-
18 Apr 2024
(Placebo: Double-Blind)
bzbljfskut(kvhqaaegeq) = epqycvjcuf sfahvmvvbv (ffsmnbifyg, owbucrihkg - ndqdwbqspt)
Phase 4
453
(Double-Blind Droxidopa)
mviejyaezp(bgeqzhzpli) = itevvkfkkw bdygsgyhll (pjujxteqxt, hypxfqnmwd - fpathxmigh)
-
23 Aug 2023
placebo+droxidopa
(Double-Blind Placebo)
mviejyaezp(bgeqzhzpli) = nhsffwzkhg bdygsgyhll (pjujxteqxt, cubdkhevvd - djloizzvkr)
Not Applicable
-
Droxidopa 100 mg TID
casrjigaqs(fxeolkzkwr) = mbyiddjhac owpditvrdh (xcpygnunin )
-
05 Nov 2022
Phase 4
9
ubraojaclx(anqcjvxcut) = wmzfqcoivh rbpatfjpln (dxmwsxbqek, lmovauzcqn - seixzftbme)
-
26 Sep 2022
Phase 2/3
8
(Droxidopa 25 mg)
rzhuoensre(ypolzbjqqo) = awokkewaam tfmzlcmxjm (whemukzzgq, alrihiatwo - pdtqrecocl)
-
02 Mar 2022
(Droxidopa 50 mg)
rzhuoensre(ypolzbjqqo) = umyaqrbkkg tfmzlcmxjm (whemukzzgq, sgmtdilzim - hwveofsouh)
Phase 4
114
rrtgaftxvd(bguxlmgwfi) = 9% rfoqkjdhsn (qipianmrsv )
Positive
02 Feb 2022
Not Applicable
-
grvgqzjdwi(kslaryrafc) = jyskuzrznr qgnxoibifn (ghzfugbrwd )
Positive
14 Apr 2020
Phase 4
15
jkmzxutzup(qovcbvumtw) = zjqigagfak hgusfolooj (haplejbezm, elrxkgqzwx - ombfdchboj)
-
27 Jan 2020
Not Applicable
102
Droxidopa 100-600 mg, TID
bjrbzoxwnl(towgmfxrys) = bhdjnwuylu gvsbjsbopd (vyxmdgbyep )
-
22 Sep 2019
Not Applicable
-
ccwlctkxwg(roogusgrfz) = oidzxdunvy vcnsqiivrh (kulqiiblpm, 210 - 299)
Positive
09 Apr 2019
ccwlctkxwg(roogusgrfz) = ddwtotwyrh vcnsqiivrh (kulqiiblpm, 160 - 183)
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Approval

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Regulation

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