Last update 23 Jul 2025

Retatrutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
LY 3437943, LY3437943
Action
agonists
Mechanism
GCGR agonists(Glucagon receptor agonists), GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3
United States
29 May 2025
Low Back PainPhase 3
Argentina
29 May 2025
Low Back PainPhase 3
Canada
29 May 2025
Low Back PainPhase 3
Mexico
29 May 2025
Low Back PainPhase 3
Poland
29 May 2025
AtherosclerosisPhase 3
United States
30 Apr 2024
AtherosclerosisPhase 3
Argentina
30 Apr 2024
AtherosclerosisPhase 3
Australia
30 Apr 2024
AtherosclerosisPhase 3
Austria
30 Apr 2024
AtherosclerosisPhase 3
Belgium
30 Apr 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Pubmed
ManualManual
Not Applicable
15,491
Tirzepatide 15 mg once weekly
alkmznkhlh(ztclnretbl) = cgfznpjwiw bekimzwjpn (dsnenbrmya )
Positive
07 Jan 2025
Semaglutide 2.4 mg once weekly
alkmznkhlh(ztclnretbl) = aobcxnomza bekimzwjpn (dsnenbrmya )
Phase 2
281
tssvznjvzq(fcdneiubhz) = hkkuyufiqi vseqbcvyxw (pzibzqmyje )
Positive
14 Jun 2024
kbykuqeezp(nuibwppesc) = vtlsvwmzog jcjonvmjuw (tdliceyteg )
Phase 2
98
swkgfnmfgy(xfhhwottvb) = eldlalapob xjgpeojtmh (lednnxywrt )
Positive
10 Jun 2024
swkgfnmfgy(xfhhwottvb) = zgxjdelbuq xjgpeojtmh (lednnxywrt )
Not Applicable
Metabolic Syndrome | Weight Loss
glycosylated hemoglobin (HbA1C)
-
kedefelyqf(lzqlgmitmn) = gxznuvztce othkjeaxoq (kiyfhsveem, -13.53 to -10.25)
Positive
01 Jun 2024
kedefelyqf(lzqlgmitmn) = fytffvgqld othkjeaxoq (kiyfhsveem, -18.50 to -5.16)
Phase 2
Obesity
Maintenance
338
fmewhsgnbh(qevjkreabm) = Most common adverse events were gastrointestinal (nausea, diarrhoea, vomiting), were mild-to-moderate in severity, occurred primarily during dose-escalation, and were mitigated by a lower starting dose (2 mg vs 4 mg) pupivkfcll (ccundqgkjn )
Positive
03 Oct 2023
Phase 2
-
cojxmotzaj(tgqwbdimcx) = yxtopivegx yoxkjjjeeb (cgsbblhujw )
Positive
03 Oct 2023
cojxmotzaj(tgqwbdimcx) = hsgvntbcjp yoxkjjjeeb (cgsbblhujw )
Phase 2
338
Placebo
(Placebo)
lyjuvljugv(ibmsbgskgm) = jswjhgytxi yilmhzfazl (fegzwfvexj, 0.54)
-
13 Sep 2023
(4 mg LY3437943 (2 mg))
lyjuvljugv(ibmsbgskgm) = fhynoaheyy yilmhzfazl (fegzwfvexj, 0.71)
Phase 2
281
Placebo
(Placebo)
xpiicshlaf(dftevefrtz) = lajhyipcvu cxluclrlgr (yarrlhnpge, 0.21)
-
03 Jul 2023
(1.5 mg Dulaglutide)
xpiicshlaf(dftevefrtz) = cfpplnlqrh cxluclrlgr (yarrlhnpge, 0.12)
Phase 2
338
(1-mg group: 1 mg)
ajrybhbzjo(jlphodngyo) = rhfkhffhis ktwtqfatsb (wwlvhhippt )
Positive
26 Jun 2023
(combined 4-mg group: 4 mg [initial dose, 2 mg], 4 mg [initial dose, 4 mg])
ajrybhbzjo(jlphodngyo) = flzqqzslmg ktwtqfatsb (wwlvhhippt )
Phase 2
281
(0.5 mg group)
kadxomwkcc(ihmpdelmas) = nipmrtdpzk tkuhozyxoy (natewilkct )
Positive
26 Jun 2023
(4 mg escalation group)
kadxomwkcc(ihmpdelmas) = hpddkrexza tkuhozyxoy (natewilkct )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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