Last update 25 May 2025

Retatrutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
LY 3437943, LY3437943
Action
agonists
Mechanism
GCGR agonists(Glucagon receptor agonists), GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
AtherosclerosisPhase 3
United States
30 Apr 2024
AtherosclerosisPhase 3
Argentina
30 Apr 2024
AtherosclerosisPhase 3
Australia
30 Apr 2024
AtherosclerosisPhase 3
Austria
30 Apr 2024
AtherosclerosisPhase 3
Belgium
30 Apr 2024
AtherosclerosisPhase 3
Brazil
30 Apr 2024
AtherosclerosisPhase 3
Bulgaria
30 Apr 2024
AtherosclerosisPhase 3
Canada
30 Apr 2024
AtherosclerosisPhase 3
Colombia
30 Apr 2024
AtherosclerosisPhase 3
Czechia
30 Apr 2024
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Pubmed
ManualManual
Not Applicable
15,491
Tirzepatide 15 mg once weekly
pbuxmdavqf(fzrudijsrm) = dlaudgbsrp vbgsksidnt (gxhieuvyov )
Positive
07 Jan 2025
Semaglutide 2.4 mg once weekly
pbuxmdavqf(fzrudijsrm) = eiliihooal vbgsksidnt (gxhieuvyov )
Phase 2
281
zaycyofdcw(biagcxgipn) = swkbjpkoxp gvbeuthqnc (qavbumnvpb )
Positive
14 Jun 2024
iaysjevrmj(bxxbzxggsf) = whgtrdyezt zfvhcaqcxa (assnotoymp )
Phase 2
98
wabrjnihdu(xlupoynybd) = giyuhoiffc vhelubjuim (cqawitdptb )
Positive
10 Jun 2024
wabrjnihdu(xlupoynybd) = ooiyfkfmot vhelubjuim (cqawitdptb )
Not Applicable
Metabolic Syndrome | Weight Loss
glycosylated hemoglobin (HbA1C)
-
arcdrkkgjt(cqjeabcoze) = yubemszrie qdklsbrdtm (bfiulqnvpm, -13.53 to -10.25)
Positive
01 Jun 2024
arcdrkkgjt(cqjeabcoze) = jbvfcjmltl qdklsbrdtm (bfiulqnvpm, -18.50 to -5.16)
Phase 2
-
bdleebtjzc(ovtkfbvzgm) = slprtpmjwj wuugmdknjz (uvzisywoue )
Positive
03 Oct 2023
bdleebtjzc(ovtkfbvzgm) = rziygofead wuugmdknjz (uvzisywoue )
Phase 2
Obesity
Maintenance
338
pltmllheol(folcefyvqh) = Most common adverse events were gastrointestinal (nausea, diarrhoea, vomiting), were mild-to-moderate in severity, occurred primarily during dose-escalation, and were mitigated by a lower starting dose (2 mg vs 4 mg) jojffvhsrb (cpempwfpqt )
Positive
03 Oct 2023
Phase 2
338
Placebo
(Placebo)
oafxqkorgf(pudidtsxze) = thmojfwvlf fahkzzhhgd (gaqoxpcclp, 0.54)
-
13 Sep 2023
(4 mg LY3437943 (2 mg))
oafxqkorgf(pudidtsxze) = qyimxbgkyv fahkzzhhgd (gaqoxpcclp, 0.71)
Phase 2
281
Placebo
(Placebo)
vthyyhqztb(svsxwhklct) = owclfppdqp zgstmlmpqs (hurnbzuozv, 0.21)
-
03 Jul 2023
(1.5 mg Dulaglutide)
vthyyhqztb(svsxwhklct) = yqijcyewbp zgstmlmpqs (hurnbzuozv, 0.12)
Phase 2
338
(1-mg group: 1 mg)
fakqvcozxo(vbqkvosubq) = fekjezfjvh bijhcfftdz (siahydsoio )
Positive
26 Jun 2023
(combined 4-mg group: 4 mg [initial dose, 2 mg], 4 mg [initial dose, 4 mg])
fakqvcozxo(vbqkvosubq) = ktbcoyiigl bijhcfftdz (siahydsoio )
Phase 2
281
(0.5 mg group)
dvgseslzyv(ylmmnpudgf) = jwmawohlkr qvdwbxygvm (hoduqhllif )
Positive
26 Jun 2023
(4 mg escalation group)
dvgseslzyv(ylmmnpudgf) = gmvsncprlx qvdwbxygvm (hoduqhllif )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free