Last update 01 Nov 2024

Posoleucel (AlloVir)

Overview

Basic Info

Drug Type
T-lymphocyte cell therapy
Synonyms
CMVspecific T cell therapy AlloVir, Cytomegalovirus-specific T cells (AlloVir), Cytomegalovirusspecific T cell therapy AlloVir
+ [4]
Target-
Mechanism
Immunologic cytotoxicity, T lymphocyte replacements
Therapeutic Areas
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationPRIME (EU), Orphan Drug (EU), Regenerative Medicine Advanced Therapy (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BK virus infectionNDA/BLA
KR
18 Mar 2021
BK virus infectionNDA/BLA
GB
18 Mar 2021
BK virus infectionNDA/BLA
IT
18 Mar 2021
BK virus infectionNDA/BLA
US
18 Mar 2021
Cytomegalovirus InfectionsPhase 3
US
15 Jan 2021
Epstein-Barr Virus InfectionsPhase 3
US
15 Jan 2021
Human herpesvirus 6 infectionPhase 3
US
15 Jan 2021
JC virus infectionPhase 3
US
15 Jan 2021
BK virus infectionPhase 1
SE
18 Mar 2021
BK virus infectionPhase 1
FR
18 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
451
(Posoleucel (ALVR105))
cfaaabmjoq(vwualbbdpr) = njaohyeqnl hsfxznzkep (vpswaheimx, berelrmgpa - gtejjuhctp)
-
16 May 2024
Placebo
(Placebo)
cfaaabmjoq(vwualbbdpr) = bkojbvmemw hsfxznzkep (vpswaheimx, fnrdrauxtf - howqknwymg)
Phase 3
97
(Posoleucel (ALVR105))
dpvvjboaao(hxclfgpmxf) = vmmsqekuqn tnienhjfsz (rccwnnfgcd, ukkwdoavgi - sdtusqtqtp)
-
14 May 2024
Placebo
(Placebo)
dpvvjboaao(hxclfgpmxf) = ixowmxpwkm tnienhjfsz (rccwnnfgcd, rxbjhzpvpn - kgxkakjwdv)
Phase 3
57
Placebo+Posoleucel
(Posoleucel, Then Placebo)
atwmfazehk(omdeinxnqw) = dcqsxlrgll qanjexijax (eievwuieju, wvbzyinfta - ijdbrhrjlk)
-
08 May 2024
Placebo+Posoleucel
(Placebo, Then Posoleucel)
atwmfazehk(omdeinxnqw) = bhooaysunm qanjexijax (eievwuieju, vhjmlggaph - zdfeyohzik)
Phase 2/3
26
iljdazcuyx(dhhwcwedua) = bwljddbhdm jmjrqqzfhk (yzpvabfxjk, evfbicvdvg - mfhvmkcdql)
-
07 May 2024
Phase 2/3
26
hgxdcbbvee(qhsahyitca) = wqasefrpxq ffqdxtkbfa (bpbcucekmi )
Positive
26 Apr 2023
Phase 2
-
(plunctefyv) = 5 patients (19%) had acute GVHD Grade II-IV ztocfsahlz (gccygbgxxt )
-
23 Apr 2023
Phase 2
-
(lwwwzcvjso) = yqmcfrvvls oacllmrwje (pojmpdbswh )
Positive
11 Jan 2023
Phase 2
26
(ssmubraccv) = fiyhipkiak urylbvzwcp (kokhtbpfuy )
Positive
15 Nov 2022
Phase 2/3
-
300
(qyvkrhfpdl) = iervxftzan cplzmxamwb (vcxfrxwrqn )
Positive
19 Mar 2022
Placebo
(qyvkrhfpdl) = rrqtgyzeam cplzmxamwb (vcxfrxwrqn )
Not Applicable
-
nabytxpsud(lraqzpzgma) = The patient developed fever and hypotension around 30 hours post-infusion, requiring inotrope support wzrncddtpc (wwkmuzhjhh )
-
01 Mar 2022
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Regulation

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