Drug Type T-lymphocyte cell therapy |
Synonyms CMVspecific T cell therapy AlloVir, Cytomegalovirus-specific T cells (AlloVir), Cytomegalovirusspecific T cell therapy AlloVir + [4] |
Target- |
Mechanism Immunologic cytotoxicity, T lymphocyte replacements |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2/3 |
First Approval Date- |
RegulationPRIME (EU), Orphan Drug (EU), Regenerative Medicine Advanced Therapy (US) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
BK virus infection | NDA/BLA | KR | 18 Mar 2021 | |
BK virus infection | NDA/BLA | GB | 18 Mar 2021 | |
BK virus infection | NDA/BLA | IT | 18 Mar 2021 | |
BK virus infection | NDA/BLA | US | 18 Mar 2021 | |
Cytomegalovirus Infections | Phase 3 | US | 15 Jan 2021 | |
Epstein-Barr Virus Infections | Phase 3 | US | 15 Jan 2021 | |
Human herpesvirus 6 infection | Phase 3 | US | 15 Jan 2021 | |
JC virus infection | Phase 3 | US | 15 Jan 2021 | |
BK virus infection | Phase 1 | SE | 18 Mar 2021 | |
BK virus infection | Phase 1 | FR | 18 Mar 2021 |
Phase 2/3 | 451 | (Posoleucel (ALVR105)) | cfaaabmjoq(vwualbbdpr) = njaohyeqnl hsfxznzkep (vpswaheimx, berelrmgpa - gtejjuhctp) View more | - | 16 May 2024 | ||
Placebo (Placebo) | cfaaabmjoq(vwualbbdpr) = bkojbvmemw hsfxznzkep (vpswaheimx, fnrdrauxtf - howqknwymg) View more | ||||||
Phase 3 | 97 | (Posoleucel (ALVR105)) | dpvvjboaao(hxclfgpmxf) = vmmsqekuqn tnienhjfsz (rccwnnfgcd, ukkwdoavgi - sdtusqtqtp) View more | - | 14 May 2024 | ||
Placebo (Placebo) | dpvvjboaao(hxclfgpmxf) = ixowmxpwkm tnienhjfsz (rccwnnfgcd, rxbjhzpvpn - kgxkakjwdv) View more | ||||||
Phase 3 | 57 | Placebo+Posoleucel (Posoleucel, Then Placebo) | atwmfazehk(omdeinxnqw) = dcqsxlrgll qanjexijax (eievwuieju, wvbzyinfta - ijdbrhrjlk) | - | 08 May 2024 | ||
Placebo+Posoleucel (Placebo, Then Posoleucel) | atwmfazehk(omdeinxnqw) = bhooaysunm qanjexijax (eievwuieju, vhjmlggaph - zdfeyohzik) | ||||||
Phase 2/3 | 26 | iljdazcuyx(dhhwcwedua) = bwljddbhdm jmjrqqzfhk (yzpvabfxjk, evfbicvdvg - mfhvmkcdql) View more | - | 07 May 2024 | |||
Phase 2/3 | 26 | hgxdcbbvee(qhsahyitca) = wqasefrpxq ffqdxtkbfa (bpbcucekmi ) View more | Positive | 26 Apr 2023 | |||
Phase 2 | - | (plunctefyv) = 5 patients (19%) had acute GVHD Grade II-IV ztocfsahlz (gccygbgxxt ) View more | - | 23 Apr 2023 | |||
Phase 2 | - | (lwwwzcvjso) = yqmcfrvvls oacllmrwje (pojmpdbswh ) View more | Positive | 11 Jan 2023 | |||
NCT05305040 (ASH2022) Manual | Phase 2 | 26 | (ssmubraccv) = fiyhipkiak urylbvzwcp (kokhtbpfuy ) View more | Positive | 15 Nov 2022 | ||
Phase 2/3 | - | 300 | (qyvkrhfpdl) = iervxftzan cplzmxamwb (vcxfrxwrqn ) | Positive | 19 Mar 2022 | ||
Placebo | (qyvkrhfpdl) = rrqtgyzeam cplzmxamwb (vcxfrxwrqn ) | ||||||
Not Applicable | - | nabytxpsud(lraqzpzgma) = The patient developed fever and hypotension around 30 hours post-infusion, requiring inotrope support wzrncddtpc (wwkmuzhjhh ) View more | - | 01 Mar 2022 |